ORCID Profile
0000-0002-1764-9514
Current Organisations
Universität für Bodenkultur Wien
,
King Abdullah University Hospital
,
Jordan University of Science and Technology
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Publisher: Elsevier BV
Date: 07-2022
Publisher: Elsevier BV
Date: 2021
Publisher: MDPI AG
Date: 30-11-2022
DOI: 10.3390/JCM11237132
Abstract: Objectives: Pneumothorax and pneumomediastinum are associated with high mortality in invasively ventilated coronavirus disease 2019 (COVID-19) patients however, the mortality rates among non-intubated patients remain unknown. We aimed to analyze the clinical features of COVID-19-associated pneumothorax neumomediastinum in non-intubated patients and identify risk factors for mortality. Methods: We searched PubMed Scopus and Embase from January 2020 to December 2021. We performed a pooled analysis of 151 patients with no invasive mechanical ventilation history from 17 case series and 87 case reports. Subsequently, we developed a novel scoring system to predict in-hospital mortality the system was further validated in multinational cohorts from ten countries (n = 133). Results: Clinical scenarios included pneumothorax neumomediastinum at presentation (n = 68), pneumothorax neumomediastinum onset during hospitalization (n = 65), and pneumothorax neumomediastinum development after recent COVID-19 treatment (n = 18). Significant differences were not observed in clinical outcomes between patients with pneumomediastinum and pneumothorax (±pneumomediastinum). The overall mortality rate of pneumothorax neumomediastinum was 23.2%. Risk factor analysis revealed that comorbidities bilateral pneumothorax and fever at pneumothorax neumomediastinum presentation were predictors for mortality. In the new scoring system, i.e., the CoBiF system, the area under the curve which was used to assess the predictability of mortality was 0.887. External validation results were also promising (area under the curve: 0.709). Conclusions: The presence of comorbidity bilateral pneumothorax and fever on presentation are significantly associated with poor prognosis in COVID-19 patients with spontaneous pneumothorax neumomediastinum. The CoBiF score can predict mortality in clinical settings as well as simplify the identification and appropriate management of patients at high risk.
Publisher: Springer Science and Business Media LLC
Date: 19-07-2023
Publisher: Springer Science and Business Media LLC
Date: 20-05-2021
Publisher: Elsevier BV
Date: 11-2022
Location: Jordan
Location: Germany
Location: Germany
No related grants have been discovered for Prof. Shadi Hamouri.