ORCID Profile
0000-0001-9255-6054
Current Organisations
Washington State University
,
USDA-ARS
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Publisher: Public Library of Science (PLoS)
Date: 30-08-2013
Publisher: American Association for the Advancement of Science (AAAS)
Date: 06-06-2014
Abstract: Sheep-specific genetic changes underlie differences in lipid metabolism between sheep and other mammals, and may have contributed to the production of wool. Jiang et al. sequenced the genome of two Texel sheep, a breed that produces high-value meat, milk, and wool. The genome information will provide an important resource for livestock production and aid in the understanding of mammalian evolution. Science , this issue p. 1168
Publisher: Wiley
Date: 24-07-2016
DOI: 10.1111/AGE.12466
Publisher: Proceedings of the National Academy of Sciences
Date: 12-08-2003
Abstract: Toll-like receptor 4 (TLR4) is a cell-surface receptor that activates innate and adaptive immune responses. Because it recognizes a broad class of pathogen-associated molecular patterns presented by lipopolysaccharides and lipoteichoic acid, TLR4 is a candidate gene for resistance to a large number of diseases. In particular, mouse models suggest TLR4 as a candidate gene for resistance to major agents in bovine respiratory disease and Johne's disease. The coding sequence of bovine TLR4 is ided into three exons, with intron/exon boundaries and intron sizes similar to those of human TLR4 transcript variant 1. We lified each exon in 40 in iduals from 11 breeds and screened the sequence for single-nucleotide polymorphisms (SNPs). We identified 32 SNPs, 28 of which are in the coding sequence, for an average of one SNP per 90 bp of coding sequence. Eight SNPs were nonsynonymous and potentially alter specificity of pathogen recognition or efficiency of signaling. To evaluate the functional importance of these SNPs, we used codon-substitution models to detect ersifying selection in an extracellular region that may physically interact with ligands. One nonsynonymous SNP is located within this region, and other substitutions are in adjacent regions that may interact with coreceptor molecules. The 32 SNPs were found in 20 haplotypes that can be assigned to geographic ranges of origin. Haplotype-tagging SNP analysis indicated that 12 SNPs need to be genotyped to distinguish these 20 haplotypes. These data provide a basic understanding of bovine TLR4 sequence variation and supply haplotype markers for disease association studies.
Publisher: Springer Science and Business Media LLC
Date: 25-03-2015
No related grants have been discovered for Stephen N. White.