ORCID Profile
0000-0002-8159-3658
Current Organisation
São Paulo Univeristy
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Publisher: Georg Thieme Verlag KG
Date: 15-05-2018
DOI: 10.1055/A-0614-2680
Abstract: Piperlongumine is an amide alkaloid found in Piperaceae species that shows a broad spectrum of biological properties, including antitumor and antiparasitic activities. Herein, the leishmanicidal effect of piperlongumine and its derivatives produced by a biomimetic model using metalloporphyrins was investigated. The results showed that IC50 values of piperlongumine in promastigote forms of Leishmania infantum and Leishmania amazonensis were 7.9 and 3.3 µM, respectively. The IC50 value of piperlongumine in the intracellular amastigote form of L. amazonensis was 0.4 µM, with a selectivity index of 25. The piperlongumine biomimetic derivatives, Ma and Mb, also showed leishmanicidal effects. We also carried out an in vitro metabolic degradation study showing that Ma is the most stable piperlongumine derivative in rat liver microsome incubations. The results presented here indicate that piperlongumine is a potential leishmanicidal candidate and support the biomimetic approach for development of new antileishmanial derivatives.
Publisher: Springer Science and Business Media LLC
Date: 08-2016
DOI: 10.1038/NBT.3597
Publisher: American Chemical Society (ACS)
Date: 14-05-2018
Publisher: Research Square Platform LLC
Date: 03-08-2023
DOI: 10.21203/RS.3.RS-3189768/V1
Abstract: MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of ,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbial-derived metabolites and relative producers, without a priori knowledge, will vastly enhance the understanding of microorganisms' role in ecology and human health.
Publisher: Springer Science and Business Media LLC
Date: 12-12-2014
DOI: 10.1038/SREP07449
Publisher: Informa UK Limited
Date: 23-04-2019
Publisher: Cold Spring Harbor Laboratory
Date: 20-07-2023
DOI: 10.1101/2023.07.20.549584
Abstract: MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of ,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbial-derived metabolites and relative producers, without a priori knowledge, will vastly enhance the understanding of microorganisms’ role in ecology and human health.
Location: Germany
Location: United Kingdom of Great Britain and Northern Ireland
Location: Brazil
No related grants have been discovered for Norberto Peporine Lopes.