ORCID Profile
0000-0001-6721-0828
Current Organisations
Glenferrie Dermatology
,
Alfred Health
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Publications
Use of dermoscopy in Australia
Publisher: AMPCo
Date: 08-2007
Simple modification to the punch biopsy technique to minimize handling and crush artefact.
Publisher: Wiley
Date: 30-09-2005
DOI: 10.1111/J.1440-0960.2005.00202.X
Abstract: A number of techniques have been described to retrieve the tissue core after punch biopsy. We describe a simple modification to the punch-biopsy technique that minimizes instrumentation, handling and the subsequent risk of crush artefact. Our technique is simple, quick and economical and essentially involves rotation of the punch through 90 degrees then lateral extraction with a degree of upward traction, which usually leaves the tissue core deposited beside the skin defect. At this point it can be easily grasped with a square of gauze or detached if required using scissors or a scalpel blade.
Clinical practice guidelines for the diagnosis and management of melanoma: melanomas that lack classical clinical features
Publisher: AMPCo
Date: 10-2017
DOI: 10.5694/MJA17.00123
Abstract: A Cancer Council Australia multidisciplinary working group is currently revising and updating the 2008 evidence-based clinical practice guidelines for the management of cutaneous melanoma. While there have been many recent improvements in treatment options for metastatic melanoma, early diagnosis remains critical to reducing mortality from the disease. Improved awareness of the atypical presentations of this common malignancy is required to achieve this. A chapter of the new guidelines was therefore developed to aid recognition of atypical melanomas. Main recommendations: Because thick, life-threatening melanomas may lack the more classical ABCD (asymmetry, border irregularity, colour variegation, diameter > 6 mm) features of melanoma, a thorough history of the lesion with regard to change in morphology and growth over time is essential. Any lesion that is changing in morphology or growing over a period of more than one month should be excised or referred for prompt expert opinion. Changes in management as a result of the guidelines: These guidelines provide greater emphasis on improved recognition of the atypical presentations of melanoma, in particular nodular, desmoplastic and acral lentiginous subtypes, with particular awareness of hypomelanotic and amelanotic lesions.
Significance of iron status in hair loss in women.
Publisher: Oxford University Press (OUP)
Date: 08-2003
Methods of melanoma detection and of skin monitoring for individuals at high risk of melanoma: new Australian clinical practice.
Publisher: AMPCo
Date: 02-12-2018
DOI: 10.5694/MJA2.12033
Abstract: The evidence-based national clinical practice guidelines for the management of cutaneous melanoma published in 2008 are currently being updated. This article summarises the findings from multiple chapters of the guidelines on different methods of melanoma detection and of monitoring the skin for patients at high risk of melanoma. Early detection of melanoma is critical, as thinner tumours are associated with enhanced survival therefore, strategies to improve early detection are important to reduce melanoma-related mortality. Clinicians who perform skin examinations for the purpose of detecting skin cancer should be trained in and use dermoscopy. The use of short term sequential digital dermoscopy imaging to detect melanomas that lack dermoscopic features of melanoma is recommended to assess in idual melanocytic lesions of concern. The use of long term sequential digital dermoscopy imaging to detect melanomas that lack dermoscopic features of melanoma is recommended to assess in idual or multiple melanocytic lesions for routine surveillance of high risk patients. The use of total body photography should be considered in managing patients at increased risk for melanoma, particularly those with high naevus counts and dysplastic naevi. There is insufficient evidence to recommend the routine use of automated instruments for the clinical diagnosis of primary melanoma. Determining the relative indications for each diagnostic method and how each method should be introduced into the surveillance of a patient requires careful consideration and an in idualised approach.
Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: a manifestation of immune restoration.
Publisher: Elsevier BV
Date: 11-2004
DOI: 10.1016/J.JAAD.2004.04.020
Abstract: Tumid lupus erythematosus (LE) is a relatively rare and only recently recognized subset of chronic cutaneous lupus. We report a case occurring in a male with HIV infection whereby his rash was only unmasked by immune restoration following highly active antiretroviral therapy (HAART). The phenomenon of latent inflammatory or autoimmune disease appearing following HAART is now recognized as the "immune restoration syndrome" and tumid LE has not been reported in this setting previously. Fortunately this variant of lupus does not result in scarring and is responsive to anti-malarials, allowing continuation of HAART in this patient.
Methods of evaluating hair growth.
Publisher: Wiley
Date: 02-2003
DOI: 10.1046/J.1440-0960.2002.T01-1-00631.X
Abstract: For decades, scientists and clinicians have examined methods of measuring scalp hair growth. With the development of drugs that stem or even reverse the miniaturization of androgenetic alopecia, there has been a greater need for reliable, economical and minimally invasive means of measuring hair growth and, specifically, response to therapy. We review the various methods of measurement described to date, their limitations and value to the clinician. In our opinion, the potential of computer-assisted technology in this field is yet to be maximized and the currently available tools are less than ideal. The most valuable means of measurement at the present time are global photography and phototrichogram-based techniques (with digital image analysis) such as the 'TrichoScan'. Subjective scoring systems are also of value in the overall assessment of response to therapy and these are under-utilized and merit further refinement.
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases.
Publisher: Wiley
Date: 13-12-2014
DOI: 10.1111/AJD.12206
AnsteyA.Under the Skin – A Dermatologist's Fight to Save the NHSLondon: Whitefox Publishing Ltd; 2022
Publisher: Wiley
Date: 09-09-2022
DOI: 10.1111/AJD.13914
Subungual fibro-osseous pseudotumour of the toe.
Publisher: Wiley
Date: 20-05-2015
DOI: 10.1111/AJD.12346
Abstract: Subungual fibro-osseous pseudotumour of the toe is a rare osseous soft tissue tumour of which only six cases have been described in the literature. We present a case in a teenage boy that posed an instructive diagnostic challenge and discuss the distinguishing features of the various differential diagnoses. The subungual location is very rare. For such tumours, radiology is as vital as histopathology in making a diagnosis and excluding neoplasia. Accurate diagnosis requires careful clinico-pathological and radiological correlation. These sorts of lesions may present to the dermatologist, not always the foot surgeon.
Nodular melanomas and older men: a major challenge for community surveillance programs
Publisher: AMPCo
Date: 04-2004
New onset vitiligo following commencement of infliximab in Crohn disease.
Publisher: Wiley
Date: 08-2017
DOI: 10.1111/IMJ.13498
Dermatoscopy aids in the diagnosis of the solitary red scaly patch or plaque-features distinguishing superficial basal cell carcinoma, intraepidermal carcinoma, and psoriasis.
Publisher: Elsevier BV
Date: 08-2008
Paraneoplastic immunobullous disease with an epidermolysis bullosa acquisita phenotype: two cases demonstrating remission with treatment of gynaecological malignancy.
Publisher: Wiley
Date: 07-04-2004
Photodynamic Therapy
Publisher: Springer Science and Business Media LLC
Date: 2003
DOI: 10.2165/00128071-200304030-00001
Abstract: Photodynamic therapy (PDT) is proposed as an effective therapy with a good safety profile for patients with actinic keratoses. PDT involves the application of a photosensitizer to dysplastic or neoplastic tissue such that when exposed to light of an appropriate wavelength, the target tissue undergoes a cytotoxic reaction. Studies to date have demonstrated that PDT for the treatment of patients with actinic keratoses achieves clearance of lesions with minimal morbidity, maintenance of functional integrity of underlying tissues, and excellent cosmetic results. We present a review of the treatment of patients with actinic keratoses and the role of PDT in this context.
Partial biopsy of pigmented lesions: proceed with caution.
Publisher: Wiley
Date: 05-01-2006
Nodular type and older age as the most significant associations of thick melanoma in Victoria, Australia.
Publisher: American Medical Association (AMA)
Date: 05-2002
DOI: 10.1001/ARCHDERM.138.5.609
Abstract: To explore the clinical associations of thick melanoma and to compare the clinicopathological variables of nodular and superficial spreading types. Cross-sectional study of all invasive primary melanomas recorded by the Victorian Cancer Registry for 1998 and those reviewed by the Victorian Melanoma Service between October 1, 1994, and April 31, 1999. Population-based cancer registry and public hospital-based multidisciplinary melanoma clinic. This study included 1422 patients recorded by the Victorian Cancer Registry and 674 patients who had attended the Victorian Melanoma Service unclassifiable tumor types were excluded, leaving 1144 and 645 patients, respectively, eligible for analysis. Melanomas were categorized by thickness into thin ( 1-3 mm), and thick (>3 mm) and compared according to patient age, sex, and tumor type and site. Superficial spreading and nodular types were also compared in this manner. Use of the Victorian Melanoma Service database enabled a more comprehensive analysis of historical and phenotypic characteristics. Thick melanoma was predominantly nodular, occurring in older men, mostly on the head and neck and associated with fewer nevi. Nodular melanoma was thicker and found mostly on the lower limbs or head and neck it had a greater association with a history of solar keratoses than did superficial spreading melanoma. Nodular type and older age are the most significant associations of thick melanoma.
Photographic artefact simulating regressing melanocytic lesion: a potential pitfall of total body photography.
Publisher: Wiley
Date: 11-2012
Pachydermodactyly: a forme fruste of knuckle pads?
Publisher: Wiley
Date: 30-04-2003
DOI: 10.1046/J.1440-0960.2003.00662.X
Abstract: A 16-year-old boy presented with painless swellings localized to the radial and ulnar aspects of his second through to the fifth fingers on the left hand, with more subtle changes affecting two fingers on the opposite hand. This had developed in the absence of mechanical trauma. Investigations for an arthropathy were negative, while a biopsy showed marked epidermal hyperplasia and an expanded dermis. These features are typical of pachydermodactyly, a benign dermatosis of uncertain aetiology. The interesting feature of this case is the presence of knuckle pads in the father of the patient, which raises the possibility that these two similar entities are related.
Intertriginous granular parakeratosis responsive to potent topical corticosteroids.
Publisher: Oxford University Press (OUP)
Date: 2003
DOI: 10.1046/J.1365-2230.2003.01159.X
Abstract: Granular parakeratosis is a recently recognized disorder of keratinization that is confined to intertriginous body sites. The histological features are distinctive. Aetiology is unclear at present but factors such as friction, perspiration and chemical irritation may be relevant. We describe three cases of granular parakeratosis that were notable for their rapid response to potent topical corticosteroids.
Cutaneous reactions to interferon and ribavirin
Publisher: Wiley
Date: 08-2004
PlayStation purpura.
Publisher: Wiley
Date: 08-2010
DOI: 10.1111/J.1440-0960.2010.00652.X
Abstract: A 16-year-old boy presented with a number of asymptomatic pigmented macules on the volar aspect of his index fingers. Dermoscopy of each macule revealed a parallel ridge pattern of homogenous reddish-brown pigment. We propose that these lesions were induced by repetitive trauma from a Sony PlayStation 3 (Sony Corporation, Tokyo, Japan) vibration feedback controller. The lesions completely resolved following abstinence from gaming over a number of weeks. Although the parallel ridge pattern is typically the hallmark for early acral lentiginous melanoma, it may be observed in a limited number of benign entities, including subcorneal haematoma.
Nodular melanoma: patients' perceptions of presenting features and implications for earlier detection.
Publisher: Elsevier BV
Date: 05-2003
DOI: 10.1067/MJD.2003.216
Successful palliation and significant remission of cutaneous calcinosis in CREST syndrome with carbon dioxide laser.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 09-2003
DOI: 10.1046/J.1524-4725.2003.29261.X
Abstract: There are few satisfactory medical or surgical therapies for cutaneous calcinosis in connective tissue disorders. Carbon dioxide laser vaporization allows precise ablation of superficial dystrophic calcification. This treatment modality was considered because of the severity of our patient's symptoms and failure to respond to various medical therapies. Over a 5-year period, six affected digits received a single treatment with carbon dioxide laser vaporization. Treated digits healed over a 6-week period and led to a significant remission in symptoms. The average remission time for affected digits to date is at least 3 years and has allowed our patient to remain in full-time employment. Carbon dioxide laser vaporization may offer effective remission of symptoms in cutaneous calcinosis of CREST syndrome (including cutaneous calcinosis, Raynaud's phenomenon, sclerodactyly, and telangiectasia).
Acquired periungal arteriovenous tumour (cirsoid aneurysm)
Publisher: Wiley
Date: 17-02-2005
Bullous pemphigoid complicated by nonfatal necrotizing fasciitis.
Publisher: Oxford University Press (OUP)
Date: 19-06-2003
Related Organisations
Related Funding Activities
No related grants have been discovered for Alexander John Chamberlain.