ORCID Profile
0000-0003-4836-1369
Current Organisation
Fiona Stanley Hospital
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Publisher: Wiley
Date: 07-12-2019
Publisher: Impact Journals, LLC
Date: 04-01-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2016
Publisher: Wiley
Date: 09-11-2017
Abstract: To assess the impact of delayed vs immediate pre-operative lymphoscintigraphy (LSG) for sentinel lymph node biopsy in a single Australian tertiary breast cancer centre. Retrospective cohort study analysing patients with breast cancer or DCIS who underwent lumpectomy or mastectomy with pre-operative LSG and intra-operative sentinel lymph node biopsy from January 2015 to June 2016. A total of 182 LSG were performed. Group A patients had day before pre-operative LSG mapping (n = 79) and Group B had LSG mapping on the day of surgery (n = 103). The overall LSG localisation rate was 97.3% and no statistical difference was detected between the two groups. The overall sentinel lymph node biopsies (SLN) were identified in 99.6% of patients. The number of nodes excised was slightly higher in Group A (1.90 vs 1.72) however, this was not statistically significant. In addition, the number of nodes on histopathology and the incidence of second echelon nodal detection were also similar between the two groups without statistical significance. In conclusion, the 2-day LSG protocol had no impact on overall SLNB and LSG detection rates although slightly higher second tier nodes but this did not translate to any difference between the number of harvest nodes between the two groups. The 2-day LSG allows for greater flexibility in theatre planning and more efficient use of theatre time. We recommend a dose of 40 Mbq of Tc99 m pertechnetate-labelled colloid be given day prior to surgery within a 24-hour timeframe.
Publisher: SAGE Publications
Date: 26-09-2016
Abstract: To illustrate the neuropsychiatric and imaging findings in a confirmed case of voltage-gated potassium channel antibody limbic encephalitis. Case report and review of the literature. A 64-year-old man presented with several months’ history of obsessive thoughts and compulsions associated with faciobrachial dystonic seizures. He had no significant past medical and psychiatric history. Physical examinations revealed only mildly increased tone in the left upper limb. Bedside cognitive testing was normal. Positron-emission tomography showed intense symmetrical uptake in the corpus striatum. No underlying malignancy was identified on whole body imaging. Magnetic resonance imaging, lumbar puncture and electroencephalogram were normal. Serum voltage-gated potassium channel antibodies were strongly positive. The patient had a favourable response to antiepileptic drugs, oral steroids and immunotherapy. Voltage-gated potassium channel limbic encephalitis characteristically presents with neuropsychiatric symptoms and temporal lobe seizures. Positron-emission tomography–computed tomography can be a useful adjunct to the clinical and biochemical work-up.
Publisher: Wiley
Date: 24-05-2021
DOI: 10.1111/ANS.16963
Abstract: The umbilical fissure vein (UFV) is a hepatic vein that travels within the umbilical fissure (or its proximity), providing venous drainage for hepatic segments 3 and 4. Its preservation carries a potential importance in extended right hemi‐hepatectomy, left lateral segmentectomy and extended segment 2 resections. Consecutive 1‐mm slice thickness portovenous phase intravenous contrast computed tomography (CT) scans of the abdomen performed were retrospectively reviewed during the period of June 2019 to July 2019, with two independent investigators investigating the presence of UFV, its course, insertion and relation to the umbilical fissure. A total of 244 CTs were identified and 186 included. The UFV was identified on 72.8% of participants, 109 (81.4%) drained into the main left hepatic vein, while the remaining ones drained either from the main middle hepatic vein (16.4%) or the bifurcation between main left and middle hepatic vein (2.2%). The veins course lay 2 mm or less along the length of umbilical fissure in 39.5%, while 57.5% ran within 1 cm along the length of the umbilical fissure. Pre‐operative identification of UFV could assist in operative planning. The vein can be used as a landmark in surgery and should be preserved in left lateral segmentectomy and extended right hepatectomy to avoid parenchymal congestion of remnant segments.
Publisher: Wiley
Date: 08-11-2015
Abstract: The aim of this study is to identify and describe the computed tomography and scintigraphic imaging patterns of osseous metastasis from invasive lobular breast cancer (ILC). CT and skeletal scintigraphy (SS) studies of 23 patients with diagnosis of ILC and osseous metastasis on their initial presentation were reviewed. Osseous metastases in 14 patients (60.8%) appear as uniform small sclerotic lesions (USSL) on CT scan. The SS in these patients were interpreted as negative for metastasis (either normal or with some equivocal findings not typical for metastasis). Osseous metastasis from ILC can have a characteristic imaging pattern on CT and SS. The pattern of USSL on CT scan with negative SS is highly suggestive of osseous metastasis from ILC.
Publisher: Springer Science and Business Media LLC
Date: 09-08-2021
DOI: 10.1038/S41416-021-01507-6
Abstract: The validity of circulating tumour DNA (ctDNA) as an indicator of disease progression compared to medical imaging in patients with metastatic melanoma requires detailed evaluation. Here, we carried out a retrospective ctDNA analysis of 108 plasma s les collected at the time of disease progression. We also analysed a validation cohort of 66 metastatic melanoma patients monitored prospectively after response to systemic therapy. ctDNA was detected in 62% of patients at the time of disease progression. For 67 patients that responded to treatment, the mean ctDNA level at progressive disease was significantly higher than at the time of response ( P 0.0001). However, only 30 of these 67 (45%) patients had a statistically significant increase in ctDNA by Poisson test. A validation cohort of 66 metastatic melanoma patients monitored prospectively indicated a 56% detection rate of ctDNA at progression, with only two cases showing increased ctDNA prior to radiological progression. Finally, a correlation between ctDNA levels and metabolic tumour burden was only observed in treatment naïve patients but not at the time of progression in a subgroup of patients failing BRAF inhibition ( N = 15). These results highlight the low efficacy of ctDNA to detect disease progression in melanoma when compared mainly to standard positron emission tomography imaging.
Publisher: Wiley
Date: 14-04-2018
Abstract: The reduced (attenuated) number of photons passing through the arm can result in a combination of fine and thick streak artefacts, particularly with the use of thin CT slices and lower radiation dose parameters. This phenomenon is known as photon starvation. We noted an abnormal appearance of the humerus when imaged with certain arm position. This appearance was thought to be artefact due to photon starvation. A human radius bone was imaged in different positions and the kV and mA were varied in an attempt to reproduce the artefact, which would support the hypothesis that the artefact may be caused by bone attenuation. Scanning the bone in a different angle and radiation dose parameters reproduced the artefactual appearance of the bone. Performing a chest CT scan with arms up can occasionally result in an abnormal appearance to the humerus due to photon starvation artefact. Familiarity with this artefact is essential to avoid misinterpretation.
Publisher: American Association for Cancer Research (AACR)
Date: 08-2020
DOI: 10.1158/1078-0432.CCR-19-3926
Abstract: Brain involvement occurs in the majority of patients with metastatic melanoma. The potential of circulating tumor DNA (ctDNA) for surveillance and monitoring systemic therapy response in patients with melanoma brain metastases merits investigation. This study examined circulating BRAF, NRAS, and c-KIT mutations in patients with melanoma with active brain metastases receiving PD-1 inhibitor–based therapy. Intracranial and extracranial disease volumes were measured using the sum of product of diameters, and response assessment performed using RECIST. Longitudinal plasma s les were analyzed for ctDNA over the first 12 weeks of treatment (threshold 2.5 copies/mL plasma). Of a total of 72 patients, 13 patients had intracranial metastases only and 59 patients had concurrent intracranial and extracranial metastases. ctDNA detectability was 0% and 64%, respectively, and detectability was associated with extracranial disease volume (P & 0.01). Undetectable ctDNA on-therapy was associated with extracranial response (P & 0.01) but not intracranial response. The median overall survival in patients with undetectable (n = 34) versus detectable (n = 38) ctDNA at baseline was 39.2 versus 10.6 months [HR, 0.51 95% confidence interval (CI), 0.28–0.94 P = 0.03] and on-therapy was 39.2 versus 9.2 months (HR, 0.32 95% CI, 0.16–0.63 P & 0.01). ctDNA remains a strong prognostic biomarker in patients with melanoma with brain metastases, especially in patients with concurrent extracranial disease. However, ctDNA was not able to detect or monitor intracranial disease activity, and we recommend against using ctDNA as a sole test during surveillance and therapeutic monitoring in patients with melanoma.
Publisher: Wiley
Date: 25-07-2012
DOI: 10.1111/J.1754-9485.2012.02413.X
Abstract: Veno-arterial extracorporeal membrane oxygenation (VA ECMO) causes changes in the filling and blood flow of the cardiac chambers and pulmonary vessels as well as alterations in the path of intravenous contrast injected during CT. We present a patient with a potentially misleading CT pulmonary angiogram while on full VA ECMO. We demonstrate circulatory changes as well as alterations in contrast flow when ECMO flows are reduced.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-07-2020
Publisher: Hindawi Limited
Date: 2014
DOI: 10.1155/2014/384271
Abstract: Laryngocele is an abnormal dilatation of the saccule of laryngeal ventricle, which is usually unilateral and filled with air or fluid. We present a case of bilateral laryngoceles colonized by Aspergillus species.
No related grants have been discovered for Zeyad Al-Ogaili.