ORCID Profile
0000-0002-1988-0701
Current Organisation
Griffith University
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Publisher: Wiley
Date: 07-10-2017
DOI: 10.1111/JICD.12294
Abstract: The purpose of the present study was to develop techniques to evaluate and quantify the primary components of dental medicament paste mixtures for root canal treatment, and to evaluate if degradation of the primary components occurred during storage. The first part of the study developed a mass spectrometry (MS) method for determination of best recovery process. For this process, analytical grades of triamcinolone acetonide, clindamycin HCl, and doxycycline hyclate were sourced and analyzed. This was followed by solid-phase extraction (SPE) and an analysis of active components in dental pastes. By utilizing the targeted analytical properties of multiple reaction monitoring MS methods, coupled with SPE technique, the active components of endodontic dental pastes could be quantified and compared. The developed methods showed consistency over multiple runs, with a high level of reproducibility. None of the active components of the tested pastes degraded over the periods of product life tested. The inactivation or destruction of any of the primary components of endodontic medicaments in storage, or when mixed with other pastes, could affect treatment outcomes. The present study provides a reliable technique for the analysis of the active components of root canal medicaments.
Publisher: Elsevier BV
Date: 05-2022
Publisher: American Chemical Society (ACS)
Date: 09-06-2017
Publisher: Elsevier BV
Date: 2018
DOI: 10.1016/J.SCIJUS.2017.09.001
Abstract: Plastic cable ties can be utilised in a range of serious criminal activities and a comparison of cable ties, or fragments, may form part of the physical evidence presented to a Court of law. This research assessed the potential value of evidence based on the analysis of plastic cable ties. Twenty packets of black coloured plastic cable ties (nominally 200mm×4.8mm) were purchased in pack sizes ranging from 25 to 100 in idual cable ties (Brisbane, Australia, March 2015). Representative s les from each packet were visually examined, compared and tested to determine their physical dimensions, chemical compositions and stable isotopic compositions (δ
Publisher: Springer Singapore
Date: 2019
Publisher: Elsevier BV
Date: 09-2022
Publisher: American Chemical Society (ACS)
Date: 24-04-2020
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 2015
DOI: 10.1016/J.SCIJUS.2014.09.001
Abstract: Advances in analytical technology and emerging techniques have resulted in the increased exploitation of chemical and isotopic profiling for source linkage/discrimination of illicit drugs for forensic purposes. Although not routinely used for illicit drug investigations, such information has been obtained and its application demonstrated through the use of isotope ratio mass spectrometry (IRMS). There is a solid platform of research available relating to the isotopic analysis of methylenedioxymeth hetamine (MDMA) and meth hetamine (MA), however with the recently flourishing designer drug market it was of interest to examine the isotopic profiles of the popular 'party drug' benzylpiperazine hydrochloride (BZP·HCl). A preliminary analysis of δ13C and δ15N isotopic ratios in BZP·HCl products and corresponding synthetic intermediates (piperazine·HCl) synthesized in-house from three different precursor suppliers was conducted using IRMS. Analysis of the δ13C and δ15N isotopic data indicated that discrimination and correct grouping of all the intermediates and some of the product s les examined in this study were achievable.
Publisher: American Chemical Society (ACS)
Date: 12-08-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 1995
DOI: 10.1039/DT9950002315
Publisher: Informa UK Limited
Date: 09-10-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3AN01112G
Publisher: Wiley
Date: 26-07-2018
DOI: 10.1111/DAR.12848
Abstract: Following the introduction of smoke-free policies in prisons in several countries, there have been anecdotal reports of prisoners creating cigarettes by mixing nicotine patches or lozenges with tea leaves ('teabacco'). Among a s le of people recently released from smoke-free prisons in Queensland, Australia, the aims of this study were to explore the perceived popularity of teabacco use, motivations for its use and describe the process of creating teabacco to identify potential associated health risks. This study used a mixed-methods design. Eighty-two people recently released from prison in Queensland, Australia completed surveys at parole offices measuring teabacco use while incarcerated. Twenty-one teabacco smokers took part in follow-up, qualitative interviews to explore survey responses in greater depth. The majority of survey participants (57%) reported smoking teabacco while incarcerated, with 37% smoking teabacco frequently (> once per week). Teabacco use was primarily motivated by cigarette cravings. Participants described the perceived inevitability of prisoners finding substitutes for tobacco. Multivariate analyses found that self-rated poor physical health, having been incarcerated five or more times, experiencing cigarette cravings while incarcerated, and use of illicit drugs while incarcerated were positively associated with frequent teabacco use in prison. Our findings suggest that teabacco use has become common practice in Queensland's smoke-free prisons. Correctional smoking bans are an important public health initiative but should be complemented with demand and harm reduction measures cognisant of the risk environment.
Publisher: CSIRO Publishing
Date: 2010
DOI: 10.1071/CH09414
Abstract: This review paper updates the previous literature in relation to the continued and developing use of stable isotope ratio analysis in s les which are relevant to forensic science. Recent advances in the analysis of drug s les, explosive materials, and s les derived from human and animal s les are discussed. The paper also aims to put the use of isotope ratio mass spectrometry into a forensic context and discuss its evidential potential.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5AY01715G
Abstract: Simple sensing methods for the detection of meth hetamine precursors were developed by utilising photoluminescence quenching of Amine-functionalised carbon dots.
Publisher: Elsevier BV
Date: 05-2022
Publisher: Elsevier BV
Date: 2015
DOI: 10.1016/J.SCIJUS.2014.08.003
Abstract: This paper demonstrates the use of isotopic analysis of 23 benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) containing tablets seized on two independent occasions by the Northern Territory (NT) Police, Australia. Isolation (High Performance Liquid Chromatography (HPLC)) of BZP and TFMPP followed by Isotope Ratio Mass Spectrometry (IRMS) (carbon and nitrogen stable isotopes) analysis was performed. Results are presented for δ13C and δ15N values of the respective piperazine analogues. The isotopic data and statistical analysis suggest a common source of manufacture for the BZP s les but suggest different sources for the TFMPP isolated from the corresponding BZP containing tablets investigated. The use of IRMS in this case study demonstrated the ability to obtain information regarding the BZP/TFMPP sources unattainable via conventional chemical analysis.
Publisher: Elsevier BV
Date: 02-2014
DOI: 10.1016/J.FORSCIINT.2013.11.017
Abstract: The large scale industrial manufacture of the nasal decongestant pseudoephedrine is typically carried out by the reductive amination of l-phenylacetylcarbinol (l-PAC), which in turn is produced via the biotransformation of benzaldehyde using yeast. In recent years there has been increasing legislative control of the supply of pseudoephedrine due to it being erted for the clandestine production of methyl hetamine and there is some evidence that a number of clandestine drug laboratory chemists have considered the application of the l-PAC process to manufacture their own pseudoephedrine. This work examined the use of a number of substituted benzaldehydes for the manufacture of the corresponding substituted l-PAC analogue followed by reductive amination to the corresponding substituted pseudoephedrine/ephedrine analogues. These substituted pseudoephedrine/ephedrine analogues were either reduced or oxidised to determine the feasibility of producing the corresponding methyl hetamine or methcathinone analogues. As a result, the l-PAC process was identified as a viable route for synthesis of substituted methyl hetamines and methcathinones.
Publisher: Royal Society of Chemistry (RSC)
Date: 1999
DOI: 10.1039/A904391H
Publisher: Informa UK Limited
Date: 09-07-2023
Publisher: Elsevier BV
Date: 05-2023
Publisher: Wiley
Date: 14-08-2019
DOI: 10.1002/DTA.2471
Abstract: Following the implementation of prison smoke-free policies, there have been reports of prisoners creating substitute cigarettes made from nicotine replacement therapy patches or lozenges infused with tea leaves ("teabacco"). No studies have analyzed the chemical constituents of teabacco made from nicotine lozenges, so as to document any potential related health hazards. Teabacco s les were made by a participant who reported creating teabacco while incarcerated in a smoke-free prison in Queensland, Australia, and the process was video-recorded for replication in a laboratory. A simple linear smoking system captured the teabacco smoke for analysis. Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to analyze elemental composition and gas chromatography coupled with a mass spectrometer (GC-MS) analyzed the captured smoke using the National Institute of Standards and Technology mass spectral library. Analyses determined that quantities of copper, aluminum, and lead concentrations, and levels of inhaled total particulate matter, were above recommended guidelines for safe ingestion. Analysis of teabacco smoke using GC-MS identified potentially toxic compounds catechol and nicotine. However, our findings show that smoking this form of teabacco is less harmful than smoking teabacco made from nicotine patches, or smoking traditional tobacco cigarettes. Considering the limited potential health harm of smoking teabacco made from lozenges, and that nicotine lozenges represent the only form of smoking cessation support for in iduals entering smoke-free prisons, we caution against the removal of nicotine lozenges from Queensland's prisons, at least until further research directly establishes health harms associated with this form of teabacco.
Publisher: Elsevier BV
Date: 05-2021
Publisher: Elsevier BV
Date: 06-2021
Publisher: Wiley
Date: 23-12-2022
DOI: 10.1002/RCM.9446
Abstract: Stable isotopic ratios can provide information for illicit drug profiling. The research presented here investigated the variations in stable isotopic ratios of hydrogen ( δ 2 H), carbon ( δ 13 C), nitrogen ( δ 15 N) and oxygen ( δ 18 O) during the synthesis of MDP2P (3,4‐methylenedioxyphenyl‐2‐propanone) and MDA (3,4‐methylenedioxy hetamine) prepared via the ‘nitrostyrene’ route. S les of MDA and MDP2P were synthesised from two isotopically characterised starting materials, piperonal and nitroethane. The isotopic compositions of the nitrostyrene intermediate (3,4‐methylenedioxyphenyl‐2‐nitropropene, MDP2NP) and products MDP2P and MDA were also measured by isotope ratio mass spectrometry. A significantly negative change occurred to δ 2 H values during the production of MDP2NP, MDP2P and MDA, indicating a mechanism that favours inclusion or retention of 1 H over 2 H. This suggests that the δ 2 H compositions of MDA/MDP2P prepared from piperonal will not provide information on the synthetic history. Minimal changes were observed in δ 13 C composition during the synthesis of MDP2NP, MDP2P and MDA, and minimal δ 15 N compositional changes occurred in MDP2NP and MDA. Progressing from piperonal to MDP2NP, a minimal change occurred to δ 18 O composition. A variable change to δ 18 O was observed from MDP2NP with one s le becoming more positive in δ 18 O composition and two s les becoming more negative. Progressing from MDP2NP to MDA, a significant negative change occurred to δ 18 O composition. The changes to stable isotopic ratios observed during the preparation of MDA and MDP2P from piperonal may prove useful when attempting to compare batch‐to‐batch variations between seizures and provide information with tactical intelligence applications.
Publisher: SensePublishers
Date: 2015
Publisher: Elsevier BV
Date: 12-2019
Publisher: Informa UK Limited
Date: 20-09-2020
Publisher: American Chemical Society (ACS)
Date: 09-2015
Publisher: Elsevier
Date: 2002
Publisher: American Chemical Society (ACS)
Date: 29-03-2019
Publisher: American Chemical Society (ACS)
Date: 07-2001
DOI: 10.1021/ED078P900
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Sarah Cresswell.