ORCID Profile
0000-0002-5346-3135
Current Organisation
University of Queensland
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Sensor technology (incl. chemical aspects) | Nanomaterials | Nanotechnology | Nanofabrication growth and self assembly |
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TB02003F
Abstract: The fabrication of a bimetallic mesoporous Au–Ag biosensor for achieving attomolar sensitive detection of magnetically purified target miRNA without any lification or enzymatic process is reported.
Publisher: Wiley
Date: 11-10-2020
Abstract: Mesoporous noble metals and their patterning techniques for obtaining unique patterned structures are highly attractive for electrocatalysis, photocatalysis, and optoelectronics device applications owing to their expedient properties such as high level of exposed active locations, cascade electrocatalytic sites, and large surface area. However, patterning techniques for mesoporous substrates are still limited to metal oxide and silica films, although there is growing demand for developing techniques related to patterning mesoporous metals. In this study, the first demonstration of mesoporous metal films on patterned gold (Au) substrates, prefabricated using photolithographic techniques, is reported. First, different growth rates of mesoporous Au metal films on patterned Au substrates are demonstrated by varying deposition times and voltages. In addition, mesoporous Au films are also fabricated on various patterns of Au substrates including stripe and mesh lines. An alternative fabrication method using a photoresist insulating mask also yields growth of mesoporous Au within the patterning. Moreover, patterned mesoporous films of palladium (Pd) and palladium-copper alloy (PdCu) are demonstrated on the same types of substrates to show versatility of this method. Patterned mesoporous Au films (PMGFs) show higher electrochemically active surface area (ECSA) and higher sensitivity toward glucose oxidation than nonpatterned mesoporous Au films (NMGF).
Publisher: Elsevier BV
Date: 12-2017
DOI: 10.1016/J.BIOS.2017.06.051
Abstract: Despite having reliable and excellent diagnostic performances, the currently available messenger RNA (mRNA) detection methods mostly use enzymatic lification steps of the target mRNA which is generally affected by the s le manipulations, lification bias and longer assay time. This paper reports an lification-free electrochemical approach for the sensitive and selective detection of mRNA using a screen-printed gold electrode (SPE-Au). The target mRNA is selectively isolated by magnetic separation and adsorbed directly onto an unmodified SPE-Au. The surface-attached mRNA is then measured by differential pulse voltammetry (DPV) in the presence of [Fe(CN)
Publisher: Elsevier BV
Date: 04-2021
Publisher: Elsevier BV
Date: 03-2018
DOI: 10.1016/J.BIOS.2017.09.027
Abstract: A crucial issue in microRNA (miRNA) detection is the lack of sensitive method capable of detecting the low levels of miRNA in RNA s les. Herein, we present a sensitive and specific method for the electrocatalytic detection of miR-107 using gold-loaded nanoporous superparamagnetic iron oxide nanocubes (Au-NPFe
Publisher: Wiley
Date: 17-08-2020
Publisher: Wiley
Date: 24-09-2020
Publisher: American Chemical Society (ACS)
Date: 26-09-2017
DOI: 10.1021/ACS.ANALCHEM.7B02880
Abstract: The enzyme-mimicking activity of iron oxide based nanostructures has provided a significant advantage in developing advanced molecular sensors for biomedical and environmental applications. Herein, we introduce the horseradish peroxidase (HRP)-like activity of gold-loaded nanoporous ferric oxide nanocubes (Au-NPFe
Publisher: Springer Science and Business Media LLC
Date: 23-08-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CC04789D
Abstract: A nonenzymatic, lification-free, and sensitive method for microRNA detection is reported using Au@NPFe 2 O 3 NC nanocubes.
Publisher: The Chemical Society of Japan
Date: 15-08-2022
Publisher: American Chemical Society (ACS)
Date: 19-04-2021
Publisher: Wiley
Date: 04-02-2019
Publisher: Wiley
Date: 27-06-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CS00174C
Abstract: Synthesis, bio-functionalization, and multifunctional activities of superparamagnetic-nanostructures have been extensively reviewed with a particular emphasis on their uses in a range of disease-specific biomarker detection and associated challenges.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TB00989B
Abstract: Next-generation nanozyme based biosensing: mesoporous nanocrystalline α- or γ-iron oxide?
Publisher: Wiley
Date: 27-05-2022
Abstract: The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D hydrogel structures can be modified by integrating with nanostructures. Such modifications can enhance their responsiveness to mechanical, optical, thermal, magnetic, and electric stimuli, which in turn can enhance the practicality of biosensors in clinical settings. This review describes the synthesis and kinetics of gel networks and exploitation of nanostructure‐integrated hydrogels in biosensing. With an emphasis on different integration strategies of hydrogel with nanostructures, this review highlights the importance of hydrogel nanostructures as one of the most favorable candidates for developing ultrasensitive biosensors. Moreover, hydrogel nanoarchitectonics are also portrayed as a promising candidate for fabricating next‐generation robust biosensors.
Publisher: Wiley
Date: 05-06-2017
Publisher: The Chemical Society of Japan
Date: 15-04-2019
Publisher: Elsevier BV
Date: 09-2022
Publisher: Elsevier BV
Date: 2021
Publisher: American Chemical Society (ACS)
Date: 06-02-2023
Publisher: Wiley
Date: 04-07-2018
Publisher: Elsevier BV
Date: 08-2017
DOI: 10.1016/J.BIOS.2017.02.026
Abstract: DNA methylation is one of the key epigenetic modifications of DNA that results from the enzymatic addition of a methyl group at the fifth carbon of the cytosine base. It plays a crucial role in cellular development, genomic stability and gene expression. Aberrant DNA methylation is responsible for the pathogenesis of many diseases including cancers. Over the past several decades, many methodologies have been developed to detect DNA methylation. These methodologies range from classical molecular biology and optical approaches, such as bisulfite sequencing, microarrays, quantitative real-time PCR, colorimetry, Raman spectroscopy to the more recent electrochemical approaches. Among these, electrochemical approaches offer sensitive, simple, specific, rapid, and cost-effective analysis of DNA methylation. Additionally, electrochemical methods are highly amenable to miniaturization and possess the potential to be multiplexed. In recent years, several reviews have provided information on the detection strategies of DNA methylation. However, to date, there is no comprehensive evaluation of electrochemical DNA methylation detection strategies. Herein, we address the recent developments of electrochemical DNA methylation detection approaches. Furthermore, we highlight the major technical and biological challenges involved in these strategies and provide suggestions for the future direction of this important field.
Publisher: American Chemical Society (ACS)
Date: 23-06-2021
Publisher: American Chemical Society (ACS)
Date: 08-02-2019
DOI: 10.1021/ACS.ANALCHEM.8B03619
Abstract: Most of the current exosome-analysis strategies are time-consuming and largely dependent on commercial extraction kit-based preisolation step, which requires extensive s le manipulations, costly isolation kits, reagents, tedious procedures, and sophisticated equipment and is prone to bias/artifacts. Herein we introduce a simple method for direct isolation and subsequent detection of a specific population of exosomes using an engineered superparamagnetic material with multifunctional properties, namely, gold-loaded ferric oxide nanocubes (Au-NPFe
Publisher: Wiley
Date: 03-07-2021
Abstract: Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as natural carriers for drugs and biologics. However, the challenges associated with EVs isolation, heterogeneity, coexistence with homologous biomolecules, and lack of site‐specific delivery, have impeded their potential. In recent years, the amalgamation of EVs with rationally engineered nanostructures has been proposed for achieving effective drug loading and site‐specific delivery. With the advancement of nanotechnology and nanoarchitectonics, different nanostructures with tunable size, shapes, and surface properties can be integrated with EVs for drug loading, target binding, efficient delivery, and therapeutics. Such integration may enable improved cellular targeting and the protection of encapsulated drugs for enhanced and specific delivery to target cells. This review summarizes the recent development of nanostructure amalgamated EVs for drug delivery, therapeutics, and real‐time monitoring of disease progression. With a specific focus on the exosomal cargo, erse drug delivery system, and biomimetic nanostructures based on EVs for selective drug delivery, this review also chronicles the needs and challenges of EV‐based biomimetic nanostructures and provides a future outlook on the strategies posed.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0AN01096K
Abstract: A nanostructured mesoporous gold electrode is demonstrated to detect the phosphorylated protein over non-phosphorylated in cancer using electrochemical signal lification through differential pulse voltammetry in the presence of the [Fe(CN) 6 ] 3−/4− .
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR90194A
Abstract: Correction for ‘Gold-loaded nanoporous iron oxide nanocubes: a novel dispersible capture agent for tumor-associated autoantibody analysis in serum’ by Sharda Yadav et al. , Nanoscale , 2017, 9 , 8805–8814.
Publisher: Elsevier BV
Date: 09-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC03082D
Abstract: This work introduces transparent SiC-on-glass as a new platform for biosensing applications which enables cell culturing, stimulating, microscopy-imaging and bioelectrochemical detection.
Publisher: Elsevier BV
Date: 2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR03006A
Abstract: An electrochemical and colorimetric method for detecting autoantibodies using gold-loaded nanoporous Fe 2 O 3 nanocubes as capture agents is reported for the first time.
Publisher: Elsevier BV
Date: 11-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB01132J
Abstract: Peroxidase-mimetic activity of mesoporous Fe 2 O 3 nanomaterials in global DNA methylation detection using naked eye and electrochemical readout.
Publisher: Elsevier BV
Date: 05-2021
Publisher: Elsevier BV
Date: 07-2017
DOI: 10.1016/J.ACA.2017.04.034
Abstract: Development of simple and inexpensive method for the analysis of gene-specific DNA methylation is important for the diagnosis and prognosis of patients with cancer. Herein, we report a relatively simple and inexpensive electrochemical method for the sensitive and selective detection of gene-specific DNA methylation in oesophageal cancer. The underlying principle of the method relies on the affinity interaction between DNA bases and unmodified gold electrode. Since the affinity trend of DNA bases towards the gold surface follows as adenine (A) > cytosine (C) > guanine (G)> thymine (T), a relatively larger amount of bisulfite-treated adenine-enriched unmethylated DNA adsorbs on the screen-printed gold electrodes (SPE-Au) in comparison to the guanine-enriched methylated s le. The methylation levels were (i.e., different level of surface attached DNA molecules due to the base dependent differential adsorption pattern) quantified by measuring saturated amount of charge-compensating [Ru(NH
Publisher: Wiley
Date: 20-12-2022
Abstract: Flexible and implantable electronics hold tremendous promises for advanced healthcare applications, especially for physiological neural recording and modulations. Key requirements in neural interfaces include miniature dimensions for spatial physiological mapping and low impedance for recognizing small biopotential signals. Herein, a bottom‐up mesoporous formation technique and a top‐down microlithography process are integrated to create flexible and low‐impedance mesoporous gold (Au) electrodes for biosensing and bioimplant applications. The mesoporous architectures developed on a thin and soft polymeric substrate provide excellent mechanical flexibility and stable electrical characteristics capable of sustaining multiple bending cycles. The large surface areas formed within the mesoporous network allow for high current density transfer in standard electrolytes, highly suitable for biological sensing applications as demonstrated in glucose sensors with an excellent detection limit of 1.95 µ m and high sensitivity of 6.1 mA cm −2 µM −1 , which is approximately six times higher than that of benchmarking flat/non‐porous films. The low impedance of less than 1 kΩ at 1 kHz in the as‐synthesized mesoporous electrodes, along with their mechanical flexibility and durability, offer peripheral nerve recording functionalities that are successfully demonstrated in vivo. These features highlight the new possibilities of our novel flexible nanoarchitectonics for neuronal recording and modulation applications.
Publisher: Elsevier BV
Date: 08-2019
DOI: 10.1016/J.BIOS.2019.111315
Abstract: Autoantibodies produced by the patients' own immune systems in response to foreign substances are emerging as an attractive biomarker for early detection of cancer. These serum immunobiomarkers are produced in large quantities despite the presence of very less amount of the corresponding antigens, and thus presenting themselves as a novel class of stable and minimally invasive disease biomarkers especially for cancer diagnosis. Although a plethora of research, including conventional molecular biology-based as well as cutting-edge optical and electrochemical strategies (biosensor), have been conducted to detect autoantibodies, most of these strategies are yet to be readily applicable in the off-laboratory settings at clinics. Herein, we detail the biogenesis, diagnostic, prognostic and therapeutic potential of autoantibodies as cancer biomarkers. With the particular emphasis on cutting-edge advances in electrochemistry, optical (surface plasmon resonance) and microfluidics techniques, this review entrusts the unmet needs and challenges of autoantibody detection approaches and provides a future perspective of the presented strategies. We believe this review can potentially guide the researchers towards the development of robust, reliable and sensitive detection strategies for tumor-associated autoantibodies and translation of these biomarkers to real clinical settings for diagnosis and prognosis of cancer.
Publisher: Elsevier BV
Date: 05-2019
DOI: 10.1016/J.TIBS.2018.11.012
Abstract: With revolutionary advances in next-generation sequencing, the human transcriptome has been comprehensively interrogated. These discoveries have highlighted the emerging functional and regulatory roles of a large fraction of RNAs suggesting the potential they might hold as stable and minimally invasive disease biomarkers. Although a plethora of molecular-biology- and biosensor-based RNA-detection strategies have been developed, clinical application of most of these is yet to be realized. Multifunctional nanomaterials coupled with sensitive and robust electrochemical readouts may prove useful in these applications. Here, we summarize the major contributions of engineered nanomaterials-based electrochemical biosensing strategies for the analysis of miRNAs. With special emphasis on nanostructure-based detection, this review also chronicles the needs and challenges of miRNA detection and provides a future perspective on the presented strategies.
Publisher: BENTHAM SCIENCE PUBLISHERS
Date: 2023
DOI: 10.2174/9789815079364123010017
Abstract: Biosensors are common analytical devices, capable of sensing a myriad of biological analytes, including cancer biomarkers. Although biosensors have different transducer types, electrochemical biosensors provide fast analysis time, high sensitivity, and the ability to perform complex measurements such as multiplexed analysis or screening tests for early diagnosis and prognosis of cancer. This chapter describes the background and theory of electrochemical sensors and introduces the main readout techniques. Innovative electrochemical biosensing strategies for analysis and quantification of important early cancer biomarkers, which include circulating nucleic acids (e.g., circulating tumour DNA, gene mutations, and microRNA) proteins, circulating tumour cells, and extracellular vesicles are discussed with the recent developments to provide an overview of the possible academic and clinical approaches br
Publisher: Springer Science and Business Media LLC
Date: 28-11-2022
Publisher: American Chemical Society (ACS)
Date: 18-10-2023
DOI: 10.1021/JACS.3C05846
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2MA00480A
Abstract: Electrochemical fabrication integrating templating strategies have paved the way for creating mesoporous metal alloy films with distinctive pores and functionalities for electrocatalysis, fuel cells, and sensor (bio) development.
Publisher: University of Queensland Library
Date: 2020
Publisher: American Chemical Society (ACS)
Date: 21-08-2019
Abstract: Implantable electronics are of great interest owing to their capability for real-time and continuous recording of cellular-electrical activity. Nevertheless, as such systems involve direct interfaces with surrounding biofluidic environments, maintaining their long-term sustainable operation, without leakage currents or corrosion, is a daunting challenge. Herein, we present a thin, flexible semiconducting material system that offers attractive attributes in this context. The material consists of crystalline cubic silicon carbide nanomembranes grown on silicon wafers, released and then physically transferred to a final device substrate (
Publisher: The Chemical Society of Japan
Date: 15-01-2022
Start Date: 2020
End Date: End date not available
Funder: Japan Society for the Promotion of Science
View Funded ActivityStart Date: 2024
End Date: 2024
Amount: $442,162.00
Funder: Australian Research Council
View Funded Activity