ORCID Profile
0000-0001-6088-7828
Current Organisation
Mater Research Institute The University of Queensland
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Publisher: American Geophysical Union (AGU)
Date: 07-2020
DOI: 10.1029/2020JG005697
Abstract: Salt accumulation gradually changes the cycling of carbon (C), nitrogen (N), and phosphorus (P) and may even transform sinks into sources in arid wetlands. However, it's not clear how hydrochemical characteristics affect the wetland's source or sink function or how they affect C, N, and P cycling in arid regions. To clarify these relationships, we conducted field measurement in arid northern China. We simulated the variations of hydrochemical characteristics and the storage and stoichiometry of C, N, and P using the process‐based DeNitrification‐DeComposition (DNDC) and Hydrus‐1D models. The meteorological and hydrological processes had obvious characteristics of seasonal and interannual changes. The measured evapotranspiration averaged 660.23 and 587.94 mm year −1 in the saltmarsh and riparian wetlands, respectively. The soil showed a clear trend with higher SO 4 2− , Na + , Ca 2+ , and Cl − fractions in comparison with lower Mg 2+ , K+, and HCO 3 − fractions, with the major ion and nutrient concentrations gradually decreasing with increasing depth in the soil. The major ion types had characteristics of Na + ‐Ca 2+ ‐SO 4 2− ‐Cl − in the saltmarsh wetland and riparian wetland. The storage of total C, N, and P were 372.72 ± 66.52 t C/hm 2 , 10.92 ± 2.59 t N/hm 2 , and 17.55 ± 1.54 t P/hm 2 in the saltmarsh wetland versus 119.72 ± 27.88 t C/hm 2 , 4.38 ± 1.24 t N/hm 2 , and 13.17 ± 1.46 t P/hm 2 in the riparian wetland. Therefore, wetland salinization in our study led to increased soil C, N, and P contents and storage and thereby enhanced the sink function of the wetlands.
Publisher: Elsevier BV
Date: 2020
Publisher: MDPI AG
Date: 23-03-2021
DOI: 10.3390/JCM10061319
Abstract: Although the risk of neonatal mortality is generally low for late preterm and early term infants, they are still significantly predisposed to severe neonatal morbidity (SNM) despite being born at relatively advanced gestations. In this study, we investigated maternal and intrapartum risk factors for early SNM in late preterm and early term infants. This was a retrospective cohort study of non-anomalous, singleton infants (34+0–38+6 gestational weeks) born at the Mater Mother’s Hospital in Brisbane, Australia from January 2015 to May 2020. Early SNM was defined as a composite of any of the following severe neonatal outcome indicators: admission to neonatal intensive care unit (NICU) in conjunction with an Apgar score at 5 min, severe respiratory distress, severe neonatal acidosis (cord pH 7.0 or base excess −12 mmol/L). Multivariable binomial logistic regression analyses using generalized estimating equations (GEE) were used to identify risk factors. Of the total infants born at 34+0–38+6 gestational weeks, 5.7% had at least one component of the composite outcome. For late preterm infants, pre-existing diabetes mellitus, instrumental birth and emergency caesarean birth for non-reassuring fetal status were associated with increased odds for early SNM, whilst for early term infants, pre-existing and gestational diabetes mellitus, antepartum hemorrhage, instrumental, emergency caesarean and elective caesarean birth were significant risk factors. In conclusion, we identified several risk factors contributing to early SNM in late preterm and early term cohort. Our results suggest that predicted probability of early SNM decreased as gestation increased.
Publisher: Elsevier BV
Date: 08-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1BM01352A
Abstract: Interleukin (IL)-22 is a multifunctional cytokine with a very short half-life that activates STAT3 and can elicit an anti-inflammatory response. We show encapsulation of IL-22 in LPMSN enhances its biological activity and stability in in vitro and human colonic organoids.
Publisher: Elsevier BV
Date: 07-2016
Publisher: Elsevier BV
Date: 2019
Publisher: Springer Science and Business Media LLC
Date: 19-08-2019
DOI: 10.1038/S41388-019-0951-Y
Abstract: Many adenocarcinomas, including colorectal cancer (CRC), overexpress the MUC13 cell surface mucin, but the functional significance and mechanisms are unknown. Here, we report the roles of MUC13 in colonic tumorigenesis and tumor progression. High-MUC13 expression is associated with poor survival in two independent patient cohorts. In a comprehensive series of in vivo experiments, we identified a critical role for MUC13 in the development of this malignancy, by promoting survival and proliferation of tumor-initiating cells and driving an immunosuppressive environment that protects tumors from checkpoint inhibitor immunotherapy. In Muc13-deficient mice, fewer tumors are generated after exposure to carcinogens and inflammation, they have markedly reduced β-catenin signaling, have more tumor-infiltrating CD103
Publisher: Wiley
Date: 04-05-2023
DOI: 10.1111/AJO.13689
Abstract: While a male infant is usually born with a higher birthweight than his female counterpart, he is more at risk of variety of adverse perinatal outcomes. Indeed, throughout life, females exhibit a marked survival advantage compared to males. The aetiology for such pertinent sex disparity remains unclear and is likely multifactorial. The aim of this study was to investigate obstetric and perinatal outcomes by infant sex from 28 weeks in a contemporary, large Australian birth cohort. A 14‐year retrospective cohort study of 130 133 births over 28 weeks gestation from a single tertiary centre. Male infants had overall higher rates of neonatal mortality (0.12% vs 0.06%, P 0.001) and severe neonatal morbidity (12% vs 9.1%, P 0.001) (adjusted odds ratio (aOR) 1.41, 95% CI 1.35–1.47). The odds of overall perinatal mortality (stillbirth and neonatal death) were higher for male infants (aOR 1.30, 95% CI 1.08–1.56). The difference in severe neonatal morbidity when stratified by gestational age at birth only remained significant from weeks gestation. Regardless of infant sex, rates of neonatal mortality and morbidity were lowest at 39 weeks gestation. Rates of preterm birth and operative birth were also higher for male infants. Our study demonstrates significant disparities in clinical outcomes by infant sex with males at a disadvantage to female infants.
Publisher: S. Karger AG
Date: 2015
DOI: 10.1159/000369934
Abstract: Before being able to develop a pharmacodynamic effect, a number of drugs have to be activated by enzymes, which are known to be potentially influenced by manifold factors, leading to a possible alteration of their activity behaviour. Based on capecitabine, we report a simple and rapid method for the estimation and comparison of the so-called ‘apparent enzyme activity' (R), not only intra- (different dose levels) but also inter-schedule, to contribute to therapeutic success. Dividing the area under the curve (AUC) of the product by the AUC of the precursor generates a factor which indicates the apparent activity of the enzyme involved in the biotransformation of a compound. Our own data as well as data from the literature was used to calculate those R levels revealing that the formation of 5′-DFUR - the immediate precursor of 5-fluorouracil - was not affected by concomitant medication within the dosing range investigated. Calculated hypothetical means of R for carboxylesterase (1.49 ± 0.66) and for cytidine deaminase (1.17 ± 0.65) were obtained. Additionally, it is important to note that the method described in this report is of general use and not limited to chemotherapeutic agents, as soon as enzymes are involved in drug activation.
Publisher: Elsevier BV
Date: 09-2014
DOI: 10.1016/J.BMCL.2014.07.085
Abstract: Since high MAO-B levels are present in early stages of AD, the MAO-B system can be designated as an appropriate and prospective tracer target of molecular imaging biomarkers for the detection of early AD. According to the preceding investigations of Mishra et al. the aim of this work was the development of a compound library of selective and reversible MAO-B inhibitors by performing bioisosteric modifications of the core structure of 3-(anthracen-9-yl)-5-phenyl-4,5-dihydro-1H-pyrazoles. In conclusion, 13 new pyrazoline based derivatives have been prepared, which will serve as precursor substances for future radiolabeling as well as reference compounds for the investigation of increased MAO-B levels in AD.
Publisher: Rockefeller University Press
Date: 11-09-2023
DOI: 10.1084/JEM.20230106
Location: Australia
No related grants have been discovered for Veronika Schreiber.