ORCID Profile
0000-0002-4621-6128
Current Organisation
University of Helsinki
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Publisher: Springer Science and Business Media LLC
Date: 13-02-2023
Publisher: Elsevier BV
Date: 10-2017
Publisher: Springer Science and Business Media LLC
Date: 23-06-2016
DOI: 10.1038/BJC.2016.188
Publisher: Wiley
Date: 12-10-2017
DOI: 10.1002/IJC.31076
Publisher: Springer Science and Business Media LLC
Date: 20-12-2022
Publisher: Springer Science and Business Media LLC
Date: 14-05-2019
DOI: 10.1038/S41467-019-09775-W
Abstract: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
Publisher: Springer Science and Business Media LLC
Date: 04-2010
DOI: 10.1038/NATURE08979
Publisher: Springer Science and Business Media LLC
Date: 28-10-2012
DOI: 10.1038/NG.2435
Publisher: Wiley
Date: 06-04-2017
DOI: 10.1002/IJC.30709
Publisher: Oxford University Press (OUP)
Date: 22-03-2016
DOI: 10.1093/HMG/DDW087
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Kimmo Palin.