ORCID Profile
0000-0002-2463-2956
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Photonics, Optoelectronics and Optical Communications | Electrical and Electronic Engineering | Optical Physics | Nanotechnology | Photonics and Electro-Optical Engineering (excl. Communications) | Communications Technologies | Nanotechnology | Microelectronics and Integrated Circuits | Optical And Photonic Systems | Nanophotonics | Nanofabrication, Growth and Self Assembly | Photodetectors, Optical Sensors and Solar Cells | Optical Physics Not Elsewhere Classified | Nonlinear optics and spectroscopy | Optics And Opto-Electronic Physics | Microwave And Millimetrewave Technology | Nanoscale Characterisation | Quantum Information, Computation and Communication | Fluidization And Fluid Mechanics | Materials Engineering | Lasers and Quantum Electronics | Optical Fibre Communications | Optical Networks and Systems | Biochemistry And Cell Biology Not Elsewhere Classified | Quantum Physics | Analytical Spectrometry | Physical Chemistry Of Macromolecules | Instruments And Techniques | Photonics optoelectronics and optical communications | Integrated Circuits | Functional Materials | Other Electronic Engineering | Compound Semiconductors | Biosensor Technologies | Communications Technologies Not Elsewhere Classified | Haematology | Atomic molecular and optical physics not elsewhere classified | Solid State Chemistry | Antenna Technology | Astronomical instrumentation | Nanomanufacturing | Nanomaterials | Interdisciplinary Engineering Not Elsewhere Classified | Microelectromechanical Systems (MEMS) | Materials Engineering Not Elsewhere Classified | Photonic and electro-optical devices sensors and systems (excl. communications) | Quantum Optics | Nanoelectronics | Atomic molecular and optical physics | Signal Processing | Ceramics | Nanofabrication growth and self assembly | Manufacturing Processes and Technologies (excl. Textiles) | Interdisciplinary Engineering | Nonlinear Optics and Spectroscopy | Condensed Matter Physics—Structural Properties | Analytical Chemistry | Macromolecular and Materials Chemistry | Sensor (Chemical And Bio-) Technology | Biotechnology Not Elsewhere Classified | Wireless Communications | Image Processing | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Cardiorespiratory Medicine and Haematology | Fluidisation and Fluid Mechanics | Electronics sensors and digital hardware
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in Engineering | Integrated circuits and devices | Integrated Circuits and Devices | Expanding Knowledge in Technology | Physical sciences | Emerging Defence Technologies | Scientific Instruments | Fixed Line Data Networks and Services | Scientific instrumentation | Communication equipment not elsewhere classified | Combined operations | Treatments (e.g. chemicals, antibiotics) | Network Infrastructure Equipment | Network switching equipment | Network transmission equipment | Ceramics, Glass and Industrial Mineral Products not elsewhere classified | Instrumentation not elsewhere classified | Ceramics | Other | Manufacturing not elsewhere classified | Cancer and related disorders | Integrated systems | Polymeric materials (e.g. paints) | Medical Instruments | Telecommunications | Solar-photoelectric | Chemical sciences | Ceramics, glass and industrial mineral products not elsewhere classified | Cardiovascular System and Diseases | Clinical health not specific to particular organs, diseases and conditions | Blood Disorders | Manufactured products not elsewhere classified | Diagnostics | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |
Publisher: Wiley
Date: 21-01-2016
Abstract: Dielectrophoresis is a widely used means of manipulating suspended particles within microfluidic systems. In order to efficiently design such systems for a desired application, various numerical methods exist that enable particle trajectory plotting in two or three dimensions based on the interplay of hydrodynamic and dielectrophoretic forces. While various models are described in the literature, few are capable of modeling interactions between particles as well as their surrounding environment as these interactions are complex, multifaceted, and computationally expensive to the point of being prohibitive when considering a large number of particles. In this paper, we present a numerical model designed to enable spatial analysis of the physical effects exerted upon particles within microfluidic systems employing dielectrophoresis. The model presents a means of approximating the effects of the presence of large numbers of particles through dynamically adjusting hydrodynamic drag force based on particle density, thereby introducing a measure of emulated particle-particle and particle-liquid interactions. This model is referred to as "dynamic drag force based on iterative density mapping." The resultant numerical model is used to simulate and predict particle trajectory and velocity profiles within a microfluidic system incorporating curved dielectrophoretic microelectrodes. The simulated data are compared favorably with experimental data gathered using microparticle image velocimetry, and is contrasted against simulated data generated using traditional "effective moment Stokes-drag method," showing more accurate particle velocity profiles for areas of high particle density.
Publisher: AIP Publishing
Date: 2021
DOI: 10.1063/5.0033070
Abstract: We experimentally demonstrate supercontinuum (SC) generation in a germanium-on-silicon waveguide. This waveguide exhibits propagation loss between 1.2 dB/cm and 1.35 dB/cm in the 3.6 µm–4.5 µm spectral region for both transverse electric (TE) and transverse magnetic (TM) polarizations. By pumping the waveguide with ∼200 fs pulses at 4.6 µm wavelength, we generate a mid-infrared (IR) SC spanning nearly an octave from 3.39 µm to 6.02 µm at the −40 dB level. Through numerical analysis of the evolution of the SC, we attribute the current limit to further extension into the mid-IR mainly to free-carrier absorption.
Publisher: Wiley
Date: 19-05-2016
Publisher: OSA
Date: 2019
Publisher: Springer Science and Business Media LLC
Date: 17-03-2010
Publisher: IEEE
Date: 07-2013
Publisher: Elsevier BV
Date: 06-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2014
Publisher: IEEE
Date: 10-2019
Publisher: IEEE
Date: 2005
Publisher: Optica Publishing Group
Date: 10-05-2021
DOI: 10.1364/OL.423858
Abstract: Optical directed logic is a novel logic operation scheme that employs electrical signals as operands to control the working states of optical switches to perform the logic operations. In this Letter, we propose and demonstrate an integrated photonic circuit which can implement five different optical logic operations by utilizing two optical modes. The proposed device is fabricated on a silicon-on-insulator substrate by using electron beam lithography and inductively coupled plasma etching processes. The static experimental results show that the fabricated device can implement five different operations correctly—XOR, XNOR, NOR, NOT, and AND—from which we can see that the signal-to-noise ratios are larger than 17.6 dB over the entire C band for all five logic functions. At last, all five logic operations with the speed of 10 Kbps are demonstrated. The proposed device with simple structure, large bandwidth, and versatility would be a promising candidate for information processing in optical mode ision multiplexing networks.
Publisher: American Physical Society (APS)
Date: 18-09-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-09-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2023
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2541228
Publisher: Optica Publishing Group
Date: 22-03-2023
DOI: 10.1364/OE.484052
Abstract: Reservoir computing is an analog bio-inspired computation scheme for efficiently processing time-dependent signals, the photonic implementations of which promise a combination of massive parallel information processing, low power consumption, and high-speed operation. However, most of these implementations, especially for the case of time-delay reservoir computing, require extensive multi-dimensional parameter optimization to find the optimal combination of parameters for a given task. We propose a novel, largely passive integrated photonic TDRC scheme based on an asymmetric Mach-Zehnder interferometer in a self-feedback configuration, where the nonlinearity is provided by the photodetector, and with only one tunable parameter in the form of a phase shifting element that, as a result of our configuration, allows also to tune the feedback strength, consequently tuning the memory capacity in a lossless manner. Through numerical simulations, we show that the proposed scheme achieves good performance -when compared to other integrated photonic architectures- on the temporal bitwise XOR task and various time series prediction tasks, while greatly reducing hardware and operational complexity.
Publisher: The Optical Society
Date: 13-08-2015
DOI: 10.1364/OE.23.022087
Publisher: Optica Publishing Group
Date: 09-2023
DOI: 10.1364/OL.500232
Publisher: OSA
Date: 2017
Publisher: Elsevier BV
Date: 07-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-02-2019
Publisher: IEEE
Date: 12-2012
Publisher: OSA
Date: 2017
Publisher: Optica Publishing Group
Date: 12-10-2023
DOI: 10.1364/OE.496387
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: Optica Publishing Group
Date: 24-03-2010
DOI: 10.1364/OE.18.007243
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2018
Publisher: IEEE
Date: 06-2009
Publisher: IOP Publishing
Date: 04-08-2011
Publisher: Wiley
Date: 03-2010
Abstract: This work demonstrates the application of dielectrophoretic (DEP) control of silica nanoparticles to form tuneable optical elements within a microfluidic system. The implementation consisted of a microfluidic channel with an array of curved microelectrodes along its base. Various DEP conditions were investigated at alternating current voltage litudes, flow rates and frequencies from 5 to 15 V, 2 to 10 microL/min and 0 to 20 MHz, respectively. The fluid channel was filled with deionized water suspending silica particles with diameters of 230 and 450 nm. Experiments were conducted to demonstrate DEP concentration and deflection of the particles and the impact of these particles distributions on the optical transmission through the fluid channel. Both confinement and scattering of the light were observed depending on the particle dimensions and the parameters of the DEP excitation. The results of this investigation illustrate the feasibility of DEP control in an optofluidic system and represent a significant step toward the dynamic formation of electrically controlled liquid optical waveguides.
Publisher: Frontiers Media SA
Date: 25-10-2019
Publisher: The Optical Society
Date: 09-09-2009
DOI: 10.1364/OL.34.002751
Publisher: Optica Publishing Group
Date: 23-12-2023
DOI: 10.1364/OE.473131
Abstract: Integrated photonic resonators based on bound states in the continuum (BICs) on the silicon-on-insulator (SOI) platform have the potential for novel, mass-manufacturable resonant devices. While the nature of BIC-based ridge resonators requires the resonators to be extended in the (axial) propagation direction of the resonant mode, the requirement for excitation from the quasi-continuum extends the resonator structures also in the lateral dimensions, resulting in large device footprints. To overcome this footprint requirement, we investigate the translation of BIC-based ridge resonators into a guided mode system with finite lateral dimensions. We draw analogies between the resulting waveguide system and the BIC-based resonators and numerically demonstrate that, analog to the BIC-based resonators, such a waveguide system can exhibit spectrally narrow-band inversion of its transmissive behavior.
Publisher: AIP Publishing
Date: 02-2019
DOI: 10.1063/1.5080246
Publisher: AIP Publishing
Date: 07-2020
DOI: 10.1063/5.0012240
Abstract: The application of lab-on-a-chip systems to biomedical engineering and medical biology is rapidly growing. Reciprocating micropumps show significant promise as automated bio-fluid handling systems and as active reagent-to-s le mixers. Here, we describe a thorough fluid dynamic analysis of an active micro-pump-mixer designed for applications of preclinical blood analysis and clinical diagnostics in hematology. Using high-speed flow visualization and micro-particle image velocimetry measurements, a parametric study is performed to investigate the fluid dynamics of six discrete modes of micropump operation. With this approach, we identify an actuation regime that results in optimal s le flow rates while concomitantly maximizing reagent-to-s le mixing.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2541201
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2009
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2541202
Publisher: IEEE
Date: 07-2013
Publisher: Wiley
Date: 04-2010
Abstract: This study presents the dielectrophoretic (DEP) assembly of multi-walled carbon nanotubes (MWCNTs) between curved microelectrodes for the purpose of trapping polystyrene microparticles within a microfluidic system. Under normal conditions, polystyrene particles exhibit negative DEP behaviour and are repelled from microelectrodes. Interestingly, the addition of MWCNTs to the system alters this situation in two ways: first, they coat the surface of particles and change their dielectric properties to exhibit positive DEP behaviour second, the assembled MWCNTs are highly conductive and after the deposition serve as extensions to the microelectrodes. They establish an array of nanoelectrodes that initiates from the edge of microelectrodes and grow along the electric field lines. These nanoelectrodes can effectively trap the MWCNT-coated particles, since they cover a large portion of the microchannel bottom surface and also create a much stronger electric field than the primary microelectrodes as confirmed by our numerical simulations. We will show that the presence of MWCNT significantly changes performance of the system, which is investigated by trapping s le polystyrene particles with plain, COOH and goat anti-mouse IgG surfaces.
Publisher: AIP Publishing
Date: 03-12-2007
DOI: 10.1063/1.2821111
Abstract: We present evidence of etching LiNbO3 when annealing two wafers in contact with an intermediate Ti strip. Etched features are characterized qualitatively using atomic force microscopy. The impact of the Ti strip thickness on the depth and roughness of the etched surface is quantified. Etched trenches of similar depths to the original Ti film are achieved with very smooth etched surface.
Publisher: OSA
Date: 2014
Publisher: IEEE
Date: 06-2019
Publisher: AIP Publishing
Date: 07-2017
DOI: 10.1063/1.4995996
Abstract: Nanoscale plasmonic structures can offer unique functionality due to extreme sub-wavelength optical confinement, but the realization of complex plasmonic circuits is h ered by high propagation losses. Hybrid approaches can potentially overcome this limitation, but only few practical approaches based on either single or few element arrays of nanoantennas on dielectric nanowire have been experimentally demonstrated. In this paper, we demonstrate a two dimensional hybrid photonic plasmonic crystal interfaced with a standard silicon photonic platform. Off resonance, we observe low loss propagation through our structure, while on resonance we observe strong propagation suppression and intense concentration of light into a dense lattice of nanoscale hot-spots on the surface providing clear evidence of a hybrid photonic plasmonic crystal bandgap. This fully integrated approach is compatible with established silicon-on-insulator (SOI) fabrication techniques and constitutes a significant step toward harnessing plasmonic functionality within SOI photonic circuits.
Publisher: Wiley
Date: 22-11-2010
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2540360
Publisher: Optica Publishing Group
Date: 27-09-2023
DOI: 10.1364/OE.498428
Publisher: AIP Publishing
Date: 2020
DOI: 10.1063/1.5136270
Abstract: Integrated silicon nitride (SiN) waveguides with anomalous dispersion have the potential to bring practical nonlinear optics to mainstream photonic integrated circuits. However, high-stress and high-processing temperatures remain an obstacle to mass adoption. We report low-stress, high-confinement, dispersion-engineered SiN waveguides utilizing low temperature grown reactive sputtered thin-films. We demonstrate a microring resonator with an intrinsic quality factor of 6.6 × 105, which enabled us to generate a native free spectral range spaced frequency comb with an estimated on-chip pump power of 850 mW. Importantly, the peak processing temperature is 400 °C making this approach fully back-end compatible for hybrid integration with preprocessed CMOS substrates and temperature sensitive photonic platforms such as lithium niobate on insulator.
Publisher: OSA
Date: 2016
Publisher: Springer Science and Business Media LLC
Date: 20-08-2016
DOI: 10.1007/S00018-015-2018-8
Abstract: Mechanosensitive ion channels are implicated in the biology of touch, pain, hearing and vascular reactivity however, the identity of these ion channels and the molecular basis of their activation is poorly understood. We previously found that transient receptor potential vanilloid 4 (TRPV4) is a receptor operated ion channel that is sensitised and activated by mechanical stress. Here, we investigated the effects of mechanical stimulation on TRPV4 localisation and activation in native and recombinant TRPV4-expressing cells. We used a combination of total internal reflection fluorescence microscopy, cell surface biotinylation assay and Ca(2+) imaging with laser scanning confocal microscope to show that TRPV4 is expressed in primary vascular endothelial cells and that shear stress sensitises the response of TRPV4 to its agonist, GSK1016790A. The sensitisation was attributed to the recruitment of intracellular pools of TRPV4 to the plasma membrane, through the clathrin and dynamin-mediated exocytosis. The translocation was dependent on ILK/Akt signalling pathway, release of Ca(2+) from intracellular stores and we demonstrated that shear stress stimulated phosphorylation of TRPV4 at tyrosine Y110. Our findings implicate calcium-sensitive TRPV4 translocation in the regulation of endothelial responses to mechanical stimulation.
Publisher: Walter de Gruyter GmbH
Date: 06-2020
Abstract: Mode ision multiplexing (MDM) technology has been well known to researchers for its ability to increase the link capacity of photonic network. While various mode processing devices were demonstrated in recent years, the reconfigurability of multi-mode processing devices, which is vital for large-scale multi-functional networks, is rarely developed. In this paper, we first propose and experimentally demonstrate a scalable mode-selective converter using asymmetrical micro-racetrack resonators (MRRs) for optical network-on-chip. The proposed device, composed of cascaded MRRs, is able to convert the input monochromatic light to an arbitrary supported mode in the output waveguide as required. Thermo-optical effect of silicon waveguides is adopted to tune the working states of the device. To test the utility, a device for proof-of-concept is fabricated and experimentally demonstrated based on silicon-on-insulator substrate. The measured spectra of the device show that the extinction ratios of MRRs are larger than 18 dB, and modal crosstalk for selected modes are all less than −16.5 dB. The switching time of the fabricated device is in the level of about 40 μs. The proposed device is believed to have potential applications in multi-functional and intelligent network-on-chip, especially in reconfigurable MDM networks.
Publisher: SPIE
Date: 05-2014
DOI: 10.1117/12.2050118
Publisher: SPIE
Date: 02-01-2018
DOI: 10.1117/12.2282642
Publisher: American Association for the Advancement of Science (AAAS)
Date: 06-01-2023
Abstract: Lithium niobate (LN), first synthesized 70 years ago, has been widely used in erse applications ranging from communications to quantum optics. These high-volume commercial applications have provided the economic means to establish a mature manufacturing and processing industry for high-quality LN crystals and wafers. Breakthrough science demonstrations to commercial products have been achieved owing to the ability of LN to generate and manipulate electromagnetic waves across a broad spectrum, from microwave to ultraviolet frequencies. Here, we provide a high-level Review of the history of LN as an optical material, its different photonic platforms, engineering concepts, spectral coverage, and essential applications before providing an outlook for the future of LN.
Publisher: SPIE
Date: 02-01-2018
DOI: 10.1117/12.2282641
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CS35515B
Abstract: Raman microscopy systems are becoming increasingly widespread and accessible for characterising chemical species. Microfluidic systems are also progressively finding their way into real world applications. Therefore, it is anticipated that the integration of Raman systems with microfluidics will become increasingly attractive and practical. This review aims to provide an overview of Raman microscopy-microfluidics integrated systems for researchers who are actively interested in utilising these tools. The fundamental principles and application strengths of Raman microscopy are discussed in the context of microfluidics. Various configurations of microfluidics that incorporate Raman microscopy methods are presented, with applications highlighted. Data analysis methods are discussed, with a focus on assisting the interpretation of Raman-microfluidics data from complex s les. Finally, possible future directions of Raman-microfluidic systems are presented.
Publisher: IEEE
Date: 10-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2021
Publisher: OSA
Date: 2016
Publisher: Optica Publishing Group
Date: 14-04-2008
DOI: 10.1364/OE.16.005991
Abstract: We study theoretically and observe experimentally polychromatic gap solitons generated by supercontinuum light in an array of optical waveguides. The solitons are formed through a sharp transition from diffraction-induced broadening and color separation to the simultaneous spatio-spectral localization of supercontinuum light inside the photonic bandgap with the formation of the characteristic staggered phase structure for all colors.
Publisher: Optica Publishing Group
Date: 19-09-2005
Abstract: We introduce a novel method of attaining all-optical beam control in an optofluidic device by displacing an optically trapped microsphere through a light beam. The micro-sphere causes the beam to be refracted by various degrees as a function of the sphere position, providing tunable attenuation and beam-steering in the device. The device itself consists of the manipulated light beam extending between two buried waveguides which are on either side of a microfluidic channel. This channel contains the micro-spheres which are suspended in water. We simulate this geometry using the Finite Difference Time Domain method and find good agreement between simulation and experiment.
Publisher: SPIE
Date: 14-04-2008
DOI: 10.1117/12.785975
Publisher: IEEE
Date: 08-2014
Publisher: Wiley
Date: 24-05-2011
Publisher: IEEE
Date: 07-2017
Publisher: IOP Publishing
Date: 16-10-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2013
Publisher: The Optical Society
Date: 07-11-2019
DOI: 10.1364/OE.27.034370
Publisher: IEEE
Date: 12-2012
Publisher: The Optical Society
Date: 08-01-2014
DOI: 10.1364/OME.4.000241
Publisher: SPIE-Intl Soc Optical Eng
Date: 07-2002
DOI: 10.1117/1.1484160
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2020
Publisher: The Optical Society
Date: 25-07-2017
Publisher: Optica Publishing Group
Date: 23-12-2023
DOI: 10.1364/OL.478104
Abstract: Lithium niobate on insulator (LNOI) is a promising platform for high-speed photonic integrated circuits (PICs) that are used for communication systems due to the excellent electro-optic properties of lithium niobate (LN). In such circuits, the high-speed electro-optical modulators and switches need to be integrated with passive circuit components that are used for routing the optical signals. Polarization beam splitters (PBSs) are one of the fundamental passive circuit components for high-speed PICs that can be used to (de)multiplex two orthogonal polarization optical modes, enabling on-chip polarization ision multiplexing (PDM) systems, which are suitable for enhancing the data capacity of PICs. In this Letter, we design and experimentally demonstrate a high-performance PBS constructed by a photonic crystal (PC)-assisted multimode interference (MMI) coupler. The measured polarization extinction ratio (ER) of the fabricated device is 15 dB in the wavelength range from 1525 to 1565 nm, which makes them suitable for the high-speed and large data capacity PICs required for future communication systems.
Publisher: SPIE
Date: 28-12-2005
DOI: 10.1117/12.651733
Publisher: American Physical Society (APS)
Date: 23-08-2006
Publisher: The Optical Society
Date: 23-07-2015
DOI: 10.1364/OE.23.019969
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7LC00524E
Abstract: This work presents an on-chip valve-based microfluidic automation module, capable of performing the complex fluid handling required for photonic biosensors.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2021
Publisher: OSA
Date: 2016
Publisher: AIP Publishing
Date: 30-09-2013
DOI: 10.1063/1.4823702
Abstract: We report ferroelectric domain inversion in strontium barium niobate (SBN) single crystals by irradiating the surface locally with a strongly focused ultraviolet (UV) laser beam. The generated domains are investigated using piezoresponse force microscopy. We propose a simple model that allows predicting the domain width as a function of the irradiation intensity, which indeed applies for both SBN and LiNbO3. Evidently, though fundamentally different, the domain structure of both SBN and LiNbO3 can be engineered through similar UV irradiation.
Publisher: AIP Publishing
Date: 05-08-2013
DOI: 10.1063/1.4817271
Abstract: We report the presence of surface acoustic wave (SAW) band gap on acoustic superlattice (ASL) in a single-crystal lithium niobate structure. The band gap behavior is determined by calculating the SAW band structure and also by simulating the transmission of an acoustic wave through a finite length section of ASL using finite element analysis. The calculated band gap appears at a frequency twice the value expected from purely acoustic Bragg scattering. We have identified the band gap as originating from a polariton-based mechanism due to the coupling between the electromagnetic wave and the surface vibrations. We have examined the influence of the band gap on SAW generation with the ASL and have shown that the calculated frequency resonance of the SAW lies in the vicinity of the upper stop-band edges. This results in the localization of the SAW in the ASL. Experimental confirmation is achieved through direct measurement of the SAW displacement by laser vibrometry on an actual ASL SAW transducer. The localization of generated SAW to the ASL transducer is observed confirming the prediction of the existence of a band gap.
Publisher: Wiley
Date: 05-02-2016
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.903183
Publisher: Wiley
Date: 07-2012
Abstract: The emergence of optofluidics has brought a high degree of tuneability and reconfigurability to optical devices. These possibilities are provided by characteristics of fluids including mobility, wide range of index modulation, and abrupt interfaces that can be easily reshaped. In this work, we created a new class of optofluidic waveguides, in which suspended mesoparticles were employed to greatly enhance the flexibility of the system. We demonstrated tuneable quasi single mode waveguides using spatially controllable mesoparticles in optofluidics. The coupling of waveguiding modes into the assembly of mesoparticles produces strong interactions and resonant conditions, which promote the transitions of the waveguiding modes. The modal response of the system depends on the distribution of packed particles above the polymeric rib waveguide which can be readily controlled under the appropriate combination of dielectrophoresis and hydrodynamic forces.
Publisher: IOP Publishing
Date: 22-09-2016
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2023
Publisher: IEEE
Date: 11-2008
Publisher: AIP Publishing
Date: 10-2022
DOI: 10.1063/5.0103558
Abstract: High efficiency and a compact footprint are desired properties for electro-optic modulators. In this paper, we propose, theoretically investigate, and experimentally demonstrate a recirculating phase modulator, which increases the modulation efficiency by modulating the optical field several times in a non-resonant waveguide structure. The “recycling” of light is achieved by looping the optical path that exits the phase modulator back and coupling it to a higher order waveguide mode, which then repeats its passage through the phase modulator. By looping the light back twice, we were able to demonstrate a recirculating phase modulator that requires nine times lower power to generate the same modulation index of a single pass phase modulator. This approach to modulation efficiency enhancement is promising for the design of advanced tunable electro-optical frequency comb generators and other electro-optical devices with defined operational frequency bandwidths.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2015
Publisher: Wiley
Date: 13-10-2017
Publisher: OSA
Date: 2018
Publisher: AIP Publishing
Date: 06-2021
DOI: 10.1063/5.0052700
Abstract: Increasing demand for every faster information throughput is driving the emergence of integrated photonic technology. The traditional silicon platform used for integrated electronics cannot provide all of the functionality required for fully integrated photonic circuits, and thus, the last decade has seen a strong increase in research and development of hybrid and heterogeneous photonic integrated circuits. These approaches have enabled record breaking experimental demonstrations, harnessing the most favorable properties of multiple material platforms, while the robustness and reliability of these technologies are suggesting entirely new approaches for precise mass manufacture of integrated circuits with unprecedented variety and flexibility. This Tutorial provides an overview of the motivation behind the integration of different photonic and material platforms. It reviews common hybrid and heterogeneous integration methods and discusses the advantages and shortcomings. This Tutorial also provides an overview of common photonic elements that are integrated in photonic circuits. Finally, an outlook is provided about the future directions of the hybrid/heterogeneous photonic integrated circuits and their applications.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2006
Publisher: OSA
Date: 2019
Publisher: IEEE
Date: 12-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-10-2018
Publisher: AIP Publishing
Date: 25-12-2017
DOI: 10.1063/1.5008445
Abstract: Nonlinear optical waveguides enable the integration of entangled photon sources and quantum logic gates on a quantum photonic chip. One of the major challenges in such systems is separating the generated entangled photons from the pump laser light. In this work, we experimentally characterize double-N-shaped nonlinear optical adiabatic couplers designed for the generation of spatially entangled photon pairs through spontaneous parametric down-conversion, while simultaneously providing spatial pump filtering and keeping photon-pair states pure. We observe that the pump photons at a wavelength of 671 nm mostly remain in the central waveguide, achieving a filtering ratio of over 20 dB at the outer waveguides. We also perform classical characterization at the photon-pair wavelength of 1342 nm and observe that light fully couples from an input central waveguide to the outer waveguides, showing on chip separation of the pump and the photon-pair wavelength.
Publisher: AIP Publishing
Date: 03-11-2014
DOI: 10.1063/1.4901267
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA20688C
Abstract: We report a novel injection moulding technique for fabrication of complex multi-layer microfluidic structures, allowing one-step robust integration of functional components with microfluidic channels and fabrication of elastomeric valves.
Publisher: AIP Publishing
Date: 21-01-2013
DOI: 10.1063/1.4788918
Abstract: A low-profile pneumatically switchable graded index metamaterial lens operating at 9 GHz is proposed and practically demonstrated. An effective graded refractive index is engineered using an array of electric resonators of differing resonant frequency. Normal orientation of the resonators allows ultrathin single metamaterial layer lens design. Switching between focusing and non-focusing states is practically demonstrated by shorting the gaps in split ring resonators and eliminating the resonant response and the phase difference between the elements across the lens with pneumatically actuated metal patches that are pressed against the gaps of the resonators as the pressure in the chamber is reduced.
Publisher: The Optical Society
Date: 12-2007
Publisher: AIP Publishing
Date: 08-2010
DOI: 10.1063/1.3457226
Abstract: This work describes the separation of polystyrene microparticles suspended in deionized (DI) water according to their dimensions using a dielectrophoretic (DEP) system. The DEP system utilizes curved microelectrodes integrated into a microfluidic system. Microparticles of 1, 6, and 15 μm are applied to the system and their response to the DEP field is studied at different frequencies of 100, 200, and 20 MHz. The microelectrodes act as a DEP barrier for 15 μm particles and retain them at all frequencies whereas the response of 1 and 6 μm particles depend strongly on the applied frequency. At 100 kHz, both particles are trapped by the microelectrodes. However, at 200 kHz, the 1 μm particles are trapped by the microelectrodes while the 6 μm particles are pushed toward the sidewalls. Finally, at 20 MHz, both particles are pushed toward the sidewalls. The experiments show the tunable performance of the system to sort the microparticles of various dimensions in microfluidic systems.
Publisher: Optica Publishing Group
Date: 14-02-2023
DOI: 10.1364/OE.479658
Abstract: Photon-pair sources based on thin film lithium niobate on insulator technology have a great potential for integrated optical quantum information processing. We report on such a source of correlated twin-photon pairs generated by spontaneous parametric down conversion in a silicon nitride (SiN) rib loaded thin film periodically poled lithium niobate (LN) waveguide. The generated correlated photon pairs have a wavelength centred at 1560 nm compatible with present telecom infrastructure, a large bandwidth (21 THz) and a brightness of ∼2.5 × 10 5 pairs/s/mW/GHz. Using the Hanbury Brown and Twiss effect, we have also shown heralded single photon emission, achieving an autocorrelation g H ( 2 ) ( 0 ) ≃ 0.04 .
Publisher: SPIE
Date: 02-04-2020
DOI: 10.1117/12.2564640
Publisher: IEEE
Date: 11-2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-12-2019
Publisher: SPIE
Date: 05-03-2021
DOI: 10.1117/12.2584011
Publisher: OSA
Date: 2019
Publisher: IEEE
Date: 07-2019
Publisher: Springer Science and Business Media LLC
Date: 11-09-2007
Publisher: American Chemical Society (ACS)
Date: 12-2012
DOI: 10.1021/JA208893Q
Abstract: The fundamental mechanism proposed to explain surface-enhanced Raman scattering (SERS) relies on electromagnetic field enhancement at optical frequencies. In this work, we demonstrate the use of microfabricated, silver nanotextured electrode pairs to study, in situ, the influence of low frequency (5 mHz to 1 kHz) oscillating electric fields on the SERS spectra of thiophenol. This applied electric field is shown to affect SERS peak intensities and influence specific vibrational modes of the analyte. The applied electric field perturbs the polar analyte, thereby altering the scattering cross section. Peaks related to the sulfurous bond which binds the molecule to the silver nanotexture exhibit strong and distinguishable responses to the applied field, due to varying bending and stretching mechanics. Density functional theory simulations are used to qualitatively verify the experimental observations. Our experimental and simulation results demonstrate that the SERS spectral changes relate to electric field induced molecular reorientation, with dependence on applied field strength and frequency. This demonstration creates new opportunities for external dynamic tuning and multivariate control of SERS measurements.
Publisher: American Physical Society (APS)
Date: 15-09-2008
Publisher: IOP Publishing
Date: 2021
Abstract: In this contribution, we investigate second harmonic generation (SHG) in periodically poled lithium niobate (LN) on insulator waveguides and examine under what conditions such waveguides suffer from undesirable loss due to lateral leakage. We investigate the lateral leakage losses in X-cut and Z-cut LN for the fundamental (1550 nm) and second harmonic (775 nm) wavelengths. Our findings show that Z-cut lithium niobate on insulator (LNOI) is more likely to suffer from lateral leakage and has a lower SHG efficiency. We further provide design guidelines for highly efficient nonlinear optical waveguides in LNOI and show how lateral leakage can be avoided.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3LC51124C
Abstract: This review discusses biomarkers and outlines microfluidic platforms developed for biomarker analysis.
Publisher: Optica Publishing Group
Date: 12-2009
DOI: 10.1364/OE.17.022983
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-12-2021
Publisher: IOP Publishing
Date: 04-02-2015
Publisher: Optica Publishing Group
Date: 30-01-2023
DOI: 10.1364/AOP.470264
Abstract: Optical microcombs represent a new paradigm for generating laser frequency combs based on compact chip-scale devices, which have underpinned many modern technological advances for both fundamental science and industrial applications. Along with the surge in activity related to optical microcombs in the past decade, their applications have also experienced rapid progress: not only in traditional fields such as frequency synthesis, signal processing, and optical communications but also in new interdisciplinary fields spanning the frontiers of light detection and ranging (LiDAR), astronomical detection, neuromorphic computing, and quantum optics. This paper reviews the applications of optical microcombs. First, an overview of the devices and methods for generating optical microcombs is provided, which are categorized into material platforms, device architectures, soliton classes, and driving mechanisms. Second, the broad applications of optical microcombs are systematically reviewed, which are categorized into microwave photonics, optical communications, precision measurements, neuromorphic computing, and quantum optics. Finally, the current challenges and future perspectives are discussed.
Publisher: The Optical Society
Date: 31-10-2019
DOI: 10.1364/OL.44.005378
Publisher: IEEE
Date: 06-2009
Publisher: OSA
Date: 2019
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.C3C_4
Abstract: We present a design for compact and efficient spectral filters with an extinction ratio of ~190 dB/cm in lithium niobate on insulator, which are essential for the on-chip integration of quantum-correlated photon pair sources.
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.C3C_3
Abstract: Silicon nitride (Si 3 N4) waveguides and microring resonators were designed and fabricated for operation at a wavelength of 780 nm, reporting a loss of 11 dB/cm and Q value of 5×10 4 .
Publisher: The Optical Society
Date: 30-01-2015
DOI: 10.1364/OE.23.002846
Publisher: The Optical Society
Date: 22-07-2013
DOI: 10.1364/OE.21.018196
Publisher: SPIE
Date: 04-03-2019
DOI: 10.1117/12.2508152
Publisher: OSA
Date: 2014
Publisher: Elsevier BV
Date: 11-2002
Publisher: IEEE
Date: 2006
Publisher: SPIE
Date: 13-05-2011
DOI: 10.1117/12.887184
Publisher: SPIE
Date: 26-12-2008
DOI: 10.1117/12.813946
Publisher: IEEE
Date: 06-2007
Publisher: Walter de Gruyter GmbH
Date: 17-04-2020
Abstract: The burgeoning research into two-dimensional (2D) materials opens a door to novel photonic and optoelectronic devices utilizing their fascinating electronic and photonic properties in thin-layered architectures. The hybrid integration of 2D materials onto integrated optics platforms thus becomes a potential solution to tackle the bottlenecks of traditional optoelectronic devices. In this paper, we present the recent advances of hybrid integration of a wide range of 2D materials on integrated optics platforms for developing high-performance photodetectors, modulators, lasers, and nonlinear optics. Such hybrid integration enables fully functional on-chip devices to be readily accessible researchers and technology developers, becoming a potential candidate for next-generation photonics and optoelectronics industries.
Publisher: SPIE
Date: 26-12-2008
DOI: 10.1117/12.813943
Publisher: SPIE
Date: 09-12-2016
DOI: 10.1117/12.2242885
Publisher: SPIE
Date: 26-12-2008
DOI: 10.1117/12.810678
Publisher: The Optical Society
Date: 27-03-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-03-2023
Publisher: American Physical Society (APS)
Date: 28-02-2011
Publisher: SPIE
Date: 05-03-2021
DOI: 10.1117/12.2584014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2023
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.BIOS.2013.05.053
Abstract: For understanding cells functionalities and their communications, there is a need for highly sensitive cell analysis platforms capable of assessing non-specific chemicals on the surface and in the vicinity of cells. We report a microfluidic system integrating dielectrophoresis and surface enhanced Raman scattering (SERS) for the trapping and real time monitoring of cell functions in isolated and grouped cell clusters. Yeast cells are coated with silver nanoparticles to enable highly sensitive SERS analysis. The SERS responses of cells are examined under various conditions: live vs. dead and isolated vs. grouped. This work illustrates the feasibility of the system for in situ cell monitoring and analysis of secreted chemicals during their growth, metabolism, proliferation and apoptosis.
Publisher: SPIE
Date: 05-03-2021
DOI: 10.1117/12.2584017
Publisher: SPIE
Date: 04-03-2019
DOI: 10.1117/12.2508146
Publisher: SPIE
Date: 05-03-2021
DOI: 10.1117/12.2584018
Publisher: SPIE
Date: 28-09-2001
DOI: 10.1117/12.442934
Publisher: Springer Science and Business Media LLC
Date: 12-01-2018
DOI: 10.1038/LSA.2017.143
Abstract: Integrated photonics is a leading platform for quantum technologies including nonclassical state generation 1, 2, 3, 4 , demonstration of quantum computational complexity 5 and secure quantum communications 6 . As photonic circuits grow in complexity, full quantum tomography becomes impractical, and therefore an efficient method for their characterization 7, 8 is essential. Here we propose and demonstrate a fast, reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit. By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light, we overcome the limitations of previous approaches for lossy multi-mode devices 9, 10 . We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31% fidelity between classical and quantum characterization. This technique enables fast and precise evaluation of nonlinear quantum photonic networks, a crucial step towards complex, large-scale, device production.
Publisher: IEEE
Date: 06-2007
Publisher: Wiley
Date: 26-09-2007
Abstract: Switchable surfaces are highly useful materials with surface properties that change in response to external stimuli. These surfaces can be employed in both research and industrial applications, where the ability to actively control surface properties can be used to develop smart materials and intelligent surfaces. Herein, we review a range of surfaces in which hydrophobicity can be controlled. We present the principal ideas of surface switching, discuss recent developments, explore experimental issues and examine factors that influence surface switching, including the nature of the stimuli, the underlying material, the morphology of the surface and the surrounding environment. We have categorised switchable surfaces according to the stimuli that trigger changes in surface hydrophobicity. These are electrically, electrochemically, thermally, mechanically, photo- and environmentally inducible surfaces. In addition, we review the use of chemical reactions to modify the properties of switchable surfaces and produce changes in the molecular structure and nanoscale features of the surface.
Publisher: Springer Science and Business Media LLC
Date: 11-11-2011
Publisher: AIP Publishing
Date: 06-02-2012
DOI: 10.1063/1.3665180
Abstract: In this work, we characterize the electromagnetic properties of polydimethylsiloxane (PDMS) and use this as a free-standing substrate for the realization of flexible fishnet metamaterials at terahertz frequencies. Across the 0.2–2.5 THz band, the refractive index and absorption coefficient of PDMS are estimated as 1.55 and 0–22 cm−1, respectively. Electromagnetic modeling, multi-layer flexible electronics microfabrication, and terahertz time-domain spectroscopy are used in the design, fabrication, and characterization of the metamaterials, respectively. The properties of PDMS add a degree of freedom to terahertz metamaterials, with the potential for tuning by elastic deformation or integrated microfluidics.
Publisher: Optica Publishing Group
Date: 11-07-2022
DOI: 10.1364/OL.463445
Abstract: The manipulation of optical modes directly in a multimode waveguide without affecting the transmission of undesired signal carriers is of significance to realize a flexible and simple structured optical network-on-chip. In this Letter, an arbitrary optical mode and wavelength carrier access scheme is proposed based on a series of multimode microring resonators and one multimode bus waveguide with constant width. As a proof-of-concept, a three-mode (de)multiplexing device is designed, fabricated, and experimentally demonstrated. A new, to the best of our knowledge, phase-matching idea is employed to keep the bus waveguide width constant. The mode coupling regions and transmission regions of the microring resonators are designed carefully to selectively couple and transmit different optical modes. The extinction ratio of the microring resonators is larger than 21.0 dB. The mode and wavelength cross-talk for directly (de)multiplexing are less than −12.8 dB and −19.0 dB, respectively. It would be a good candidate for future large-scale multidimensional optical networks.
Publisher: The Optical Society
Date: 11-03-2011
DOI: 10.1364/OE.19.005635
Publisher: IEEE
Date: 05-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2006
Publisher: Optica Publishing Group
Date: 24-10-2023
DOI: 10.1364/OE.503072
Publisher: IEEE
Date: 07-2013
Publisher: American Physical Society (APS)
Date: 15-09-2016
Publisher: Springer Science and Business Media LLC
Date: 06-01-2202
Publisher: SPIE
Date: 02-01-2018
DOI: 10.1117/12.2283456
Publisher: Optica Publishing Group
Date: 06-01-2021
DOI: 10.1364/OE.415982
Abstract: In this paper, we propose and demonstrate a 4×4 non-blocking optical router utilizing 8 mode (de)multiplexers and a 4×4 microring-based grid network, which can passively assign signals carried by optical wavelength and mode channels from an arbitrary input port to corresponding output ports without additional switch time, realizing the non-blocking property. The proposed device is fabricated on a silicon-on-insulator platform using the standard Complementary Metal-Oxide-Semiconductor (CMOS) fabrication processes. The insertion loss is lower than 5.7 dB including the loss of the auxiliary mode (de)multiplexers (AMUXs), while the crosstalk is lower than −15.6 dB for all routing states. Moreover, the transmission spectra from the input ports to the next cascading device are also measured to demonstrate the feasibility of further expanding via cascading multiple blocks, with the insertion loss and crosstalk lower than 7.1 dB (including the mode coupling loss of AMUXs) and −16.4 dB, respectively. The 12 Gbps dynamic transmission experiment is demonstrated with clear and open eye diagrams, illustrating the utility of the device. The device has high geometrical symmetry and good scalability, we exhibit all solutions to expand the 4×4 optical router to 8×8 and 16×16 optical routers with the advantages and deficiencies of each solution discussed.
Publisher: AIP Publishing
Date: 10-2019
DOI: 10.1063/1.5113569
Abstract: Signal processing using on-chip nonlinear or linear optical effects has shown tremendous potential for RF photonic applications. Combining nonlinear and linear elements on the same photonic chip can further enable advanced functionality and enhanced system performance in a robust and compact form. However, the integration of nonlinear and linear optical signal processing units remains challenging due to the competing and demanding waveguide requirements, specifically the combination of high optical nonlinearity in single-pass waveguides, which is desirable for broadband signal processing with low linear loss and negligible nonlinear distortions required for linear signal processing. Here, we report the first demonstration of integrating Brillouin-active waveguides and passive ring resonators on the same integrated photonic chip, enabling an integrated microwave photonic notch filter with ultradeep stopband suppressions of & dB, a low filter passband loss of & −10 dB, flexible center frequency tuning over 15 GHz, and reconfigurable filter shape. This demonstration paves the way for implementing high-performance integrated photonic processing systems that merge complementary linear and nonlinear properties, for advanced functionality, enhanced performance, and compactness.
Publisher: Wiley
Date: 28-05-2018
Abstract: Single-cell analysis of cytokine secretion is essential to understand the heterogeneity of cellular functionalities and develop novel therapies for multiple diseases. Unraveling the dynamic secretion process at single-cell resolution reveals the real-time functional status of in idual cells. Fluorescent and colorimetric-based methodologies require tedious molecular labeling that brings inevitable interferences with cell integrity and compromises the temporal resolution. An innovative label-free optofluidic nanoplasmonic biosensor is introduced for single-cell analysis in real time. The nanobiosensor incorporates a novel design of a multifunctional microfluidic system with small volume microchamber and regulation channels for reliable monitoring of cytokine secretion from in idual cells for hours. Different interleukin-2 secretion profiles are detected and distinguished from single lymphoma cells. The sensor configuration combined with optical spectroscopic imaging further allows us to determine the spatial single-cell secretion fingerprints in real time. This new biosensor system is anticipated to be a powerful tool to characterize single-cell signaling for basic and clinical research.
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2033734
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4LC01213E
Abstract: We present a novel switchable Fresnel zone plate, created using nanoparticle suspensions which are controlled by dielectrophoresis.
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B916757A
Abstract: This paper reports the development of a platform technology for measuring platelet function and aggregation based on localized strain rate micro-gradients. Recent experimental findings within our laboratories have identified a key role for strain rate micro-gradients in focally triggering initial recruitment and subsequent aggregation of discoid platelets at sites of blood vessel injury. We present the design justification, hydrodynamic characterization and experimental validation of a microfluidic device incorporating contraction-expansion geometries that generate strain rate conditions mimicking the effects of pathological changes in blood vessel geometry. Blood perfusion through this device supports our published findings of both in vivo and in vitro platelet aggregation and confirms a critical requirement for the coupling of blood flow acceleration to downstream deceleration for the initiation and stabilization of platelet aggregation, in the absence of soluble platelet agonists. The microfluidics platform presented will facilitate the detailed analysis of the effects of hemodynamic parameters on the rate and extent of platelet aggregation and will be a useful tool to elucidate the hemodynamic and platelet mechano-transduction mechanisms, underlying this shear-dependent process.
Publisher: Elsevier BV
Date: 12-2016
Publisher: SPIE
Date: 03-2016
DOI: 10.1117/12.2218883
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2012
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.C2C_3
Abstract: We demonstrate fully CMOS-compatible anomalous dispersive SiN microring resonators with an intrinsic Q factor of 6.6 x 10 5 based on reactive sputtering SiN, yielding in a 250 nm wide modulation-instability frequency comb.
Publisher: IEEE
Date: 2002
Publisher: Wiley
Date: 06-11-2013
Abstract: This paper demonstrates the utilization of 3D semispherical shaped microelectrodes for dielectrophoretic manipulation of yeast cells. The semispherical microelectrodes are capable of producing strong electric field gradients, and in turn dielectrophoretic forces across a large area of channel cross-section. The semispherical shape of microelectrodes avoids the formation of undesired sharp electric fields along the structure and also minimizes the disturbance of the streamlines of nearby passing fluid. The advantage of semispherical microelectrodes over the planar microelectrodes is demonstrated in a series of numerical simulations and proof-of-concept experiments aimed toward immobilization of viable yeast cells.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2002
DOI: 10.1109/22.999142
Publisher: IEEE
Date: 10-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-01-2020
Publisher: Optica Publishing Group
Date: 09-04-2020
DOI: 10.1364/OL.391067
Abstract: An on-chip biochemical sensor based on two-dimensional waveguide-integrated plasmonic crystal formed by a nanogap tile (NGT) array is realized. By using on-chip optical lenses, an ultra-wide collimated Gaussian beam is launched, coupled with surface plasmonic crystals and collected with relatively low additional insertion loss, allowing a large sensing area. The optical field enhancement and stop-band shift of the NGT device for biochemical sensing are numerically and experimentally demonstrated with sensitivity reaching up to ∼ 260 n m / R I U . Our sensor is demonstrated with monolayer thiol molecules illustrating that it can be functionalized with this class of molecule which is commonly used with bulk surface plasmon resonance sensors.
Publisher: OSA
Date: 2014
Publisher: The Optical Society
Date: 23-04-2010
DOI: 10.1364/OL.35.001371
Publisher: IEEE
Date: 10-2018
Publisher: The Optical Society
Date: 13-06-2019
DOI: 10.1364/OL.44.003154
Publisher: IEEE
Date: 06-2009
Publisher: Optica Publishing Group
Date: 12-12-2022
Abstract: Programmable photonic integrated circuits (PICs), offering erse signal processing functions within a single chip, are promising solutions for applications ranging from optical communications to artificial intelligence. While the scale and complexity of programmable PICs are increasing, their characterization, and thus calibration, becomes increasingly challenging. Here we demonstrate a phase retrieval method for programmable PICs using an on-chip fractional-delay reference path. The impulse response of the chip can be uniquely and precisely identified from only the insertion loss using a standard complex Fourier transform. We demonstrate our approach experimentally with a four-tap finite-impulse-response chip. The results match well with expectations and verify our approach as effective for in idually determining the taps’ weights without the need for additional ports or photodiodes.
Publisher: AIP Publishing
Date: 19-05-2014
DOI: 10.1063/1.4879457
Abstract: Here, we demonstrate the unique features of a hydrodynamic based microchip for creating continuous chains of model yeast cells. The system consists of a disk shaped microfluidic structure, containing narrow orifices that connect the main channel to an array of spoke channels. Negative pressure provided by a syringe pump draws fluid from the main channel through the narrow orifices. After cleaning process, a thin layer of water is left between the glass substrate and the polydimethylsiloxane microchip, enabling leakage beneath the channel walls. A mechanical cl is used to adjust the operation of the microchip. Relaxing the cl allows leakage of liquid beneath the walls in a controllable fashion, leading to formation of a long cell chain evenly distributed along the channel wall. The unique features of the microchip are demonstrated by creating long chains of yeast cells and model 15 μm polystyrene particles along the side wall and analysing the hydrogen peroxide induced death of patterned cells.
Publisher: IEEE
Date: 05-2011
Publisher: American Chemical Society (ACS)
Date: 18-12-2009
DOI: 10.1021/CG901165J
Publisher: AIP Publishing
Date: 21-10-2013
DOI: 10.1063/1.4826923
Abstract: We demonstrate photochemically induced actuation of liquid metal marbles, which are liquid metal droplets encased in micro/nanoparticles. The WO3 nanoparticles coated marbles are placed in H2O2 solution, and their surfaces are illuminated with UV light. The semiconducting WO3 coating behaves as a photocatalyst to trigger a photochemical reaction, generating oxygen bubbles that propel the marble. The actuation of the marbles is investigated under different H2O2 concentrations, light intensities, and marble dimensions. Equations describing the fundamentals of such actuations are presented.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2540180
Publisher: Springer Science and Business Media LLC
Date: 22-05-2020
DOI: 10.1038/S41467-020-16265-X
Abstract: Micro-combs - optical frequency combs generated by integrated micro-cavity resonators – offer the full potential of their bulk counterparts, but in an integrated footprint. They have enabled breakthroughs in many fields including spectroscopy, microwave photonics, frequency synthesis, optical ranging, quantum sources, metrology and ultrahigh capacity data transmission. Here, by using a powerful class of micro-comb called soliton crystals, we achieve ultra-high data transmission over 75 km of standard optical fibre using a single integrated chip source. We demonstrate a line rate of 44.2 Terabits s −1 using the telecommunications C-band at 1550 nm with a spectral efficiency of 10.4 bits s −1 Hz −1 . Soliton crystals exhibit robust and stable generation and operation as well as a high intrinsic efficiency that, together with an extremely low soliton micro-comb spacing of 48.9 GHz enable the use of a very high coherent data modulation format (64 QAM - quadrature litude modulated). This work demonstrates the capability of optical micro-combs to perform in demanding and practical optical communications networks.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2014
Publisher: IOP Publishing
Date: 04-2021
DOI: 10.1088/1674-4926/42/4/041305
Abstract: We review recent work on narrowband orthogonally polarized optical RF single sideband generators as well as dual-channel equalization, both based on high- Q integrated ring resonators. The devices operate in the optical telecommunications C-band and enable RF operation over a range of either fixed or thermally tuneable frequencies. They operate via TE/TM mode birefringence in the resonator. We achieve a very large dynamic tuning range of over 55 dB for both the optical carrier-to-sideband ratio and the dual-channel RF equalization for both the fixed and tunable devices.
Publisher: IOP Publishing
Date: 04-2021
DOI: 10.1088/1674-4926/42/4/041302
Abstract: We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters, with microcombs having channel spacings of 200 and 49 GHz. This approach to realizing RF channelizers offers reduced complexity, size, and potential cost for a wide range of applications to microwave signal detection.
Publisher: SPIE
Date: 21-12-2007
DOI: 10.1117/12.759388
Publisher: Springer Science and Business Media LLC
Date: 04-07-2009
DOI: 10.1007/S00216-009-2922-6
Abstract: Dielectrophoretic (DEP) force is exerted when a neutral particle is polarized in a non-uniform electric field, and depends on the dielectric properties of the particle and the suspending medium. The integration of DEP and microfluidic systems offers numerous applications for the separation, trapping, assembling, transportation, and characterization of micro/nano particles. This article reviews the applications of DEP forces in microfluidic systems. It presents the theory of dielectrophoresis, different configurations, and the applications of such systems for particle manipulation and device fabrication.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2006
Publisher: American Chemical Society (ACS)
Date: 27-01-2011
DOI: 10.1021/NN103561U
Abstract: Nanostructured piezoelectric and ferroelectric thin films are being increasingly used in sensing and actuating microdevices. In this work, we report the experimental discovery of localized electric field enhancement in nanocolumnar piezoelectric thin films and its significant impact on piezoresponse. The magnitude of electric field enhancement is associated with nonflat surface morphologies and is in agreement with theoretical and finite element models. The influence of this surface morphology induced enhancement on piezoresponse is demonstrated using phase field simulations, which also illustrates surface morphology induced strain enhancement. The observed enhancement can be effectively harnessed to improve the sensitivity of related piezoelectric thin film applications.
Publisher: IEEE
Date: 09-2011
Publisher: AIP Publishing
Date: 08-2022
DOI: 10.1063/5.0097880
Abstract: We present a novel approach to high bandwidth laser frequency modulation. A lithium niobate chip is used as an intracavity electro-optic modulator in a tunable cateye external cavity diode laser. The modulator is conveniently integrated with the cateye output coupler, providing a unique approach to high bandwidth frequency stabilization and linewidth narrowing. The intracavity modulator feedback was successfully operated below 1 V and achieved superior frequency noise suppression compared to conventional feedback through diode injection current modulation. A closed loop bandwidth of 1.8 MHz was demonstrated, and the laser linewidth reduced to around 1 Hz as measured by the heterodyne measurement.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2541260
Publisher: American Chemical Society (ACS)
Date: 04-02-2016
Abstract: Pure gallium is a soft metal with a low temperature melting point of 29.8 °C. This low melting temperature can potentially be employed for creating optical components with changeable configurations on demand by manipulating gallium in its liquid state. Gallium is a smooth and highly reflective metal that can be readily maneuvered using electric fields. These features allow gallium to be used as a reconfigurable optical reflector. This work demonstrates the use of gallium for creating reconfigurable optical reflectors manipulated through the use of electric fields when gallium is in a liquid state. The use of gallium allows the formed structures to be frozen and preserved as long as the temperature of the metal remains below its melting temperature. The lens can be readily reshaped by raising the temperature above the melting point and reapplying an electric field to produce a different curvature of the gallium reflector.
Publisher: Elsevier BV
Date: 2011
DOI: 10.1016/J.BIOS.2010.09.022
Abstract: Dielectrophoresis, the induced motion of polarisable particles in a nonuniform electric field, has been proven as a versatile mechanism to transport, accumulate, separate and characterise micro/nano scale bioparticles in microfluidic systems. The integration of DEP systems into the microfluidics enables the inexpensive, fast, highly sensitive, highly selective and label-free detection and analysis of target bioparticles. This review provides an in-depth overview of state-of-the-art dielectrophoretic (DEP) platforms integrated into microfluidics aimed towards different biomedical applications. It classifies the current DEP systems in terms of different microelectrode configurations and operating strategies devised to generate and employ DEP forces in such processes, and compares the features of each approach. Finally, it suggests the future trends and potential applications of DEP systems in single cell analysis, stem cell research, establishing novel devices, and realising fully DEP-activated lab-on-a-chip systems.
Publisher: AIP Publishing
Date: 20-04-2017
DOI: 10.1063/1.4981392
Abstract: We propose and experimentally demonstrate the enhancement in the filtering quality (Q) factor of an integrated micro-ring resonator (MRR) by embedding it in an integrated Fabry-Perot (FP) cavity formed by cascaded Sagnac loop reflectors. By utilizing coherent interference within the FP cavity to reshape the transmission spectrum of the MRR, both the Q factor and the extinction ratio (ER) can be significantly improved. The device is theoretically analyzed and practically fabricated on a silicon-on-insulator wafer. Experimental results show that up to 11-times improvement in the Q factor, together with an 8-dB increase in the ER, can be achieved via our proposed method. The impact of varying structural parameters on the device performance is also investigated and verified by the measured spectra of the fabricated devices with different structural parameters.
Publisher: IEEE
Date: 07-2012
Publisher: The Optical Society
Date: 11-01-2013
DOI: 10.1364/OE.21.001344
Publisher: AIP Publishing
Date: 02-06-2008
DOI: 10.1063/1.2939563
Abstract: A general technique for three-dimensional nanofabrication is demonstrated by employing photolithographic standing wave corrugations as nanoscale templates. The line-of-sight deposition of a variety of materials demonstrates vertical stacks of nanowires and nanoribbons that take the forms of straight lengths, circular rings, and multilayer structures. Contact photolithography is used to fabricate the micron-scale corrugated templates from which nanofeatures with widths ranging from 65to∼20nm are derived.
Publisher: The Optical Society
Date: 16-05-2016
DOI: 10.1364/OL.41.002410
Publisher: AIP Publishing
Date: 18-04-2016
DOI: 10.1063/1.4947272
Abstract: Here, we investigate the directional control of Galinstan liquid metal droplets when transferring from the high-viscosity glycerol core into the parallel low-viscosity NaOH sheath streams within a flow focusing microfluidic system. In the presence of sufficient flow mismatch between the sheath streams, the droplets are driven toward the higher velocity interface and cross the interface under the influence of surface tension gradient. A minimum flow mismatch of 125 μl/min is required to enable the continuous transfer of droplets toward the desired sheath stream. The response time of droplets, the time required to change the direction of droplet transfer, is governed by the response time of the syringe pump driven microfluidic system and is found to be 3.3 and 8.8 s when increasing and decreasing the flow rate of sheath stream, respectively.
Publisher: IEEE
Date: 12-2012
Publisher: Optica Publishing Group
Date: 05-08-2021
DOI: 10.1364/OE.434574
Abstract: Photonic resonators based on bound states in the continuum are attractive for sensing and telecommunication applications, as they have the potential to achieve ultra-high Q-factor resonators in a compact footprint. Recently, ridge resonators – leaky mode resonators based on a bound state in the continuum – have been demonstrated on a scalable photonic integrated circuit platform. However, high Q-factor ridge resonators have thus far not been achieved. In this contribution, we investigate the influence of excitation beam width and optical losses on the spectral response of ridge resonators. We show that for practical applications, the space required of the excitation beam is the limiting factor on the highest achievable Q-factor.
Publisher: Wiley
Date: 22-09-2020
Publisher: American Chemical Society (ACS)
Date: 11-04-2012
DOI: 10.1021/AC203381N
Abstract: We demonstrate an active microfluidic platform that integrates dielectrophoresis for the control of silver nanoparticles spacing, as they flow in a liquid channel. By careful control of the nanoparticles spacing, we can effectively increase the surface-enhanced Raman scattering (SERS) signal intensity based on augmenting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles. The system is benchmarked using dipicolinate (2,6-pyridinedicarboxylic acid) (DPA), which is a biomarker of Bacillus anthracis. The validity of the results is discussed using several complementing characterization scenarios.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2541248
Publisher: Wiley
Date: 10-03-2014
Publisher: Springer Science and Business Media LLC
Date: 29-12-2009
Publisher: Proceedings of the National Academy of Sciences
Date: 18-02-2014
Abstract: The utilization of small-scale pumps is presently h ered by their limited flow rates with respect to the input power or their rather complicated fabrication process. These issues arise as many conventional pumping effects rely on moving elements. Here, we demonstrate the concept of a liquid metal enabled pump with no mechanical parts by simply incorporating droplets of Galinstan. The liquid metal enabled pump creates high flow rates ( ,000 µL/min) at exceptionally low powers ( mW) by electrowetting/deelectrowetting the surface upon application of electric field. The presented pump is both efficient and simple hence, it has the potential to advance the field of actuation in small-scale systems.
Publisher: American Chemical Society (ACS)
Date: 25-07-2019
DOI: 10.1021/ACS.ANALCHEM.9B02486
Abstract: There is a need for scalable automated lab-on-chip systems incorporating precise hemodynamic control that can be applied to high-content screening of new more efficacious antiplatelet therapies. This paper reports on the development and characterization of a novel active micropump-mixer microfluidic to address this need. Using a novel reciprocating elastomeric micropump design, we take advantage of the flexible structural and actuation properties of this framework to manage the hemodynamics for on-chip platelet thrombosis assay on type 1 fibrillar collagen, using whole blood. By characterizing and harnessing the complex three-dimensional hemodynamics of the micropump operation in conjunction with a microvalve controlled reagent injection system we demonstrate that this prototype can act as a real-time assay of antiplatelet drug pharmacokinetics. In a proof-of-concept preclinical application, we utilize this system to investigate the way in which rapid dosing of human whole blood with isoform selective inhibitors of phosphatidylinositol 3-kinase dose dependently modulate platelet thrombus dynamics. This modular system exhibits utility as an automated multiplexable assay system with applications to high-content chemical library screening of new antiplatelet therapies.
Publisher: AIP Publishing
Date: 25-03-2013
DOI: 10.1063/1.4773238
Abstract: Electromagnetic device design and flexible electronics fabrication are combined to demonstrate mechanically tunable metamaterials operating at terahertz frequencies. Each metamaterial comprises a planar array of resonators on a highly elastic polydimethylsiloxane substrate. The resonance of the metamaterials is controllable through substrate deformation. Applying a stretching force to the substrate changes the inter-cell capacitance and hence the resonance frequency of the resonators. In the experiment, greater than 8% of the tuning range is achieved with good repeatability over several stretching-relaxing cycles. This study promises applications in remote strain sensing and other controllable metamaterial-based devices.
Publisher: The Optical Society
Date: 24-01-2018
DOI: 10.1364/OE.26.002569
Publisher: Elsevier BV
Date: 03-1996
Publisher: SPIE
Date: 31-08-2006
DOI: 10.1117/12.678008
Publisher: OSA
Date: 2018
Publisher: The Optical Society
Date: 12-12-2019
DOI: 10.1364/OE.380758
Publisher: IEEE
Date: 2006
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-02-2016
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-07-2014
Publisher: American Chemical Society (ACS)
Date: 09-2009
DOI: 10.1021/JP904832Z
Publisher: Springer Science and Business Media LLC
Date: 07-07-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C1CE06112G
Publisher: AIP Publishing
Date: 07-2014
DOI: 10.1063/1.4893272
Abstract: Shear stress is the major mechanical force applied on vascular endothelial cells by blood flow, and is a crucial factor in normal vascular physiology and in the development of some vascular pathologies. The exact mechanisms of cellular mechano-transduction in mammalian cells and tissues have not yet been elucidated, but it is known that mechanically sensitive receptors and ion channels play a crucial role. This paper describes the use of a novel and efficient microfluidic device to study mechanically-sensitive receptors and ion channels in vitro, which has three independent channels from which recordings can be made and has a small surface area such that fewer cells are required than for conventional flow chambers. The contoured channels of the device enabled examination of a range of shear stresses in one field of view, which is not possible with parallel plate flow chambers and other previously used devices, where one level of flow-induced shear stress is produced per fixed flow-rate. We exposed bovine aortic endothelial cells to different levels of shear stress, and measured the resulting change in intracellular calcium levels ([Ca2+]i) using the fluorescent calcium sensitive dye Fluo-4AM. Shear stress caused an elevation of [Ca2+]i that was proportional to the level of shear experienced. The response was temperature dependant such that at lower temperatures more shear stress was required to elicit a given level of calcium signal and the magnitude of influx was reduced. We demonstrated that shear stress-induced elevations in [Ca2+]i are largely due to calcium influx through the transient receptor potential vanilloid type 4 ion channel.
Publisher: The Optical Society
Date: 16-08-2016
DOI: 10.1364/OE.24.019616
Publisher: IEEE
Date: 12-2010
Publisher: IEEE
Date: 12-2010
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2TC00516F
Publisher: AIP Publishing
Date: 11-2015
DOI: 10.1063/1.4938391
Abstract: Microfluidic based blood plasma extraction is a fundamental necessity that will facilitate many future lab-on-a-chip based point-of-care diagnostic systems. However, current approaches for providing this analyte are h ered by the requirement to provide external pumping or dilution of blood, which result in low effective yield, lower concentration of target constituents, and complicated functionality. This paper presents a capillary-driven, dielectrophoresis-enabled microfluidic system capable of separating and extracting cell-free plasma from small amounts of whole human blood. This process takes place directly on-chip, and without the requirement of dilution, thus eliminating the prerequisite of pre-processed blood s les and external liquid handling systems. The microfluidic chip takes advantage of a capillary pump for driving whole blood through the main channel and a cross flow filtration system for extracting plasma from whole blood. This filter is actively unblocked through negative dielectrophoresis forces, dramatically enhancing the volume of extracted plasma. Experiments using whole human blood yield volumes of around 180 nl of cell-free, undiluted plasma. We believe that implementation of various integrated biosensing techniques into this plasma extraction system could enable multiplexed detection of various biomarkers.
Publisher: ASMEDC
Date: 2010
Abstract: In this work, DEP platforms with funnelled and micro-tip electrode patterns were fabricated, and integrated with polydimethylsiloxane (PDMS) microchannel blocks. The DEP platforms were employed to manipulate polystyrene particles of 1 and 3 μm. The response of the system was characterised in a wide range of signal magnitudes (1–30 V peak-to-peak) and frequencies (100 kHz to 200 MHz), as well as the liquid flow rates (1 to 10 μL/min). Calculations were also carried out to analyse the DEP spectra of polystyrene particles when suspended in the medium (deionised water) to determine the optimum operating frequency of the DEP systems. Both experimental results and theoretical calculations indicated that polystyrene particles can experience positive and negative DEP forces within certain frequency ranges of the applied electric field, and the crossover frequency (where the DEP force is zero) of the system strongly depends on the conductivities of the particles. Additionally, larger particles experience stronger DEP forces and can be more efficiently concentrated at or repelled along the electrodes. The concentration performance of the DEP systems were evaluated by measuring the thickness of particle streams at different flow rates. Finally, the ability of funnelled and micro-tip electrodes to trap the particles was compared.
Publisher: MDPI AG
Date: 13-02-2019
DOI: 10.3390/APP9040621
Abstract: Water jacket systems are routinely used to control the temperature of Petri dish cell culture chambers. Despite their widespread use, the thermal characteristics of such systems have not been fully investigated. In this study, we conducted a comprehensive set of theoretical, numerical and experimental analyses to investigate the thermal characteristics of Petri dish chambers under stable and transient conditions. In particular, we investigated the temperature gradient along the radial axis of the Petri dish under stable conditions, and the transition period under transient conditions. Our studies indicate a radial temperature gradient of 3.3 °C along with a transition period of 27.5 min when increasing the s le temperature from 37 to 45 °C for a standard 35 mm diameter Petri dish. We characterized the temperature gradient and transition period under various operational, geometric, and environmental conditions. Under stable conditions, reducing the diameter of the Petri dish and incorporating a heater underneath the Petri dish can effectively reduce the temperature gradient across the s le. In comparison, under transient conditions, reducing the diameter of the Petri dish, reducing s le volume, and using glass Petri dish chambers can reduce the transition period.
Publisher: Elsevier BV
Date: 11-2017
Publisher: SPIE
Date: 28-02-2005
DOI: 10.1117/12.582267
Publisher: The Optical Society
Date: 10-11-2016
DOI: 10.1364/OL.41.005278
Publisher: OSA
Date: 2016
Publisher: IEEE
Date: 05-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2009
Publisher: IEEE
Date: 12-2010
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2020
Publisher: AIP Publishing
Date: 09-2017
DOI: 10.1063/1.4989871
Abstract: We propose and experimentally demonstrate a microwave photonic intensity differentiator based on a Kerr optical comb generated by a compact integrated micro-ring resonator (MRR). The on-chip Kerr optical comb, containing a large number of comb lines, serves as a high-performance multi-wavelength source for implementing a transversal filter, which will greatly reduce the cost, size, and complexity of the system. Moreover, owing to the compactness of the integrated MRR, frequency spacings of up to 200-GHz can be achieved, enabling a potential operation bandwidth of over 100 GHz. By programming and shaping in idual comb lines according to calculated tap weights, a reconfigurable intensity differentiator with variable differentiation orders can be realized. The operation principle is theoretically analyzed, and experimental demonstrations of the first-, second-, and third-order differentiation functions based on this principle are presented. The radio frequency litude and phase responses of multi-order intensity differentiations are characterized, and system demonstrations of real-time differentiations for a Gaussian input signal are also performed. The experimental results show good agreement with theory, confirming the effectiveness of our approach.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2006
Publisher: IEEE
Date: 05-2008
Publisher: IEEE
Date: 05-2015
Publisher: Oxford University Press (OUP)
Date: 15-01-2009
DOI: 10.1017/S1431927609090072
Abstract: This article discusses the results of transmission electron microscopy (TEM)-based characterization of strontium-doped lead zirconate titanate (PSZT) thin films. The thin films were deposited by radio frequency magnetron sputtering at 300°C on gold-coated silicon substrates, which used a 15 nm titanium adhesion layer between the 150 nm thick gold film and (100) silicon. The TEM analysis was carried out using a combination of high-resolution imaging, energy filtered imaging, energy dispersive X-ray (EDX) analysis, and hollow cone illumination. At the interface between the PSZT films and gold, an amorphous silicon-rich layer (about 4 nm thick) was observed, with the film composition remaining uniform otherwise. The films were found to be polycrystalline with a columnar structure perpendicular to the substrate. Interdiffusion between the bottom metal layers and silicon was observed and was confirmed using secondary ion mass spectrometry. This occurs due to the temperature of deposition (300°C) being close to the eutectic point of gold and silicon (363°C). The diffused regions in silicon were composed primarily of gold (analyzed by EDX) and were bounded by (111) silicon planes, highlighted by the triangular diffused regions observed in the two-dimensional TEM image.
Publisher: OSA
Date: 2019
Publisher: The Optical Society
Date: 15-08-2018
DOI: 10.1364/OE.26.022366
Publisher: Wiley
Date: 19-09-2014
Abstract: Intercellular signalling has been identified as a highly complex process, responsible for orchestrating many physiological functions. While conventional methods of investigation have been useful, their limitations are impeding further development. Microfluidics offers an opportunity to overcome some of these limitations. Most notably, microfluidic systems can emulate the in-vivo environments. Further, they enable exceptionally precise control of the microenvironment, allowing complex mechanisms to be selectively isolated and studied in detail. There has thus been a growing adoption of microfluidic platforms for investigation of cell signalling mechanisms. This review provides an overview of the different signalling mechanisms and discusses the methods used to study them, with a focus on the microfluidic devices developed for this purpose.
Publisher: OSA
Date: 2019
Publisher: Wiley
Date: 14-07-2014
Publisher: Springer Science and Business Media LLC
Date: 04-08-2016
DOI: 10.1038/NCOMMS12402
Abstract: Components with self-propelling abilities are important building blocks of small autonomous systems and the characteristics of liquid metals are capable of fulfilling self-propulsion criteria. To date, there has been no exploration regarding the effect of electrolyte ionic content surrounding a liquid metal for symmetry breaking that generates motion. Here we show the controlled actuation of liquid metal droplets using only the ionic properties of the aqueous electrolyte. We demonstrate that pH or ionic concentration gradients across a liquid metal droplet induce both deformation and surface Marangoni flow. We show that the Lippmann dominated deformation results in maximum velocity for the self-propulsion of liquid metal droplets and illustrate several key applications, which take advantage of such electrolyte-induced motion. With this finding, it is possible to conceive the propulsion of small entities that are constructed and controlled entirely with fluids, progressing towards more advanced soft systems.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5LC00415B
Abstract: This work presents a microfluidic chip, which integrates continuous generation of micro scale galinstan droplets in glycerol, and the hydrodynamic transfer of these droplets into sodium hydroxide (NaOH) solution.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7LC00498B
Abstract: We present the development of a strain rate gradient microfluidic device and apply it to the screening of von Willebrand's disease.
Publisher: IEEE
Date: 12-2013
Publisher: IEEE
Date: 12-2007
Publisher: The Optical Society
Date: 08-01-2019
Publisher: Informa UK Limited
Date: 12-11-2020
Publisher: AIP Publishing
Date: 08-2021
DOI: 10.1063/5.0055213
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2006
Publisher: Springer Science and Business Media LLC
Date: 03-09-2009
Publisher: Springer Science and Business Media LLC
Date: 17-02-2009
Publisher: IEEE
Date: 06-2019
Publisher: AIP Publishing
Date: 22-09-2014
DOI: 10.1063/1.4896629
Abstract: Semiconducting properties of nanoparticle coating on liquid metal marbles can present opportunities for an additional dimension of control on these soft objects with functional surfaces in aqueous environments. We show the unique differences in the electrochemical actuation mechanisms of liquid metal marbles with n- and p-type semiconducting nanomaterial coating. A systematic study on such liquid metal marbles shows voltage dependent nanoparticle cluster formation and morphological changes of the liquid metal core during electrochemical actuations and these observations are unique to p-type nanomaterial coated liquid metal marbles.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7LC01320E
Abstract: Using a battery of biological and haemodynamic testing we identify a pneumatic microvalve geometry with optimised haemocompatibility.
Publisher: IEEE
Date: 02-2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0LC90091E
Publisher: Wiley
Date: 24-09-2010
Abstract: This article compares the operation of a dielectrophoretic (DEP) platform before and after pattering carbon nanotubes (CNTs) between its microelectrodes. The erse performance of the DEP system is assessed by separating 1 and 5 μm polystyrene particles. In the absence of CNTs, both particles can only be trapped by operating the system at low medium conductivities, (<10(-3) S/m) and frequencies (<75 kHz). Alternatively, applying CNTs to the system, some CNTs coat the surface of particles and increase their overall conductivity and permittivity, whereas the rest of them are patterned between the microelectrodes and induce strong DEP forces at their free ends, which can effectively trap the coated particles. The first development extends the range of medium conductivities and frequencies at which the trapping of both particles is achievable, whereas the second development facilitates the selective deposition of particles along the surface of curved microelectrodes. Setting the medium conductivity to 2×10(-3) S/m and the frequency to 20 MHz, most of 5 μm particles are trapped at the entry region of the first microelectrode pair, whereas most of 1 μm particles are trapped at the tips, and this distinction facilitates their separation. The trapping of 1 μm particles can be improved by decreasing the frequency to 1.5 MHz. This study demonstrates how the integration of CNTs into microfluidic systems enables them to operate beyond their capabilities.
Publisher: Wiley
Date: 09-06-2015
Publisher: IOP Publishing
Date: 07-2022
Abstract: Achieving a high level of pulsed squeezing, in a platform which offers integration and stability, is a key requirement for continuous-variable quantum information processing. Typically highly squeezed states are achieved with narrow band optical cavities and bulk crystals, limiting scalability. Using single-pass parametric down conversion in an integrated optical device, we demonstrate quadrature squeezing of picosecond pulses in a thin-film lithium niobate strip-loaded waveguide. For on-chip peak powers of less than 0.3 W, we measure up to −0.33 ± 0.07 dB of squeezing with an inferred on-chip value of −1.7 ± 0.4 dB. This work highlights the potential of the strip-loaded waveguide platform for broadband squeezing applications and the development of photonic quantum technologies.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-1999
DOI: 10.1109/22.763169
Publisher: IEEE
Date: 08-2014
Publisher: Optica Publishing Group
Date: 04-09-2020
DOI: 10.1364/OL.402159
Abstract: We demonstrate coherent supercontinuum generation spanning over an octave from a silicon germanium-on-silicon waveguide using ∼ 200 f s pulses at a wavelength of 4 µm. The waveguide is engineered to provide low all-normal dispersion in the TM polarization. We validate the coherence of the generated supercontinuum via simulations, with a high degree of coherence across the entire spectrum. Such a generated supercontinuum could lend itself to pulse compression down to 22 fs.
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.C7F_4
Abstract: We demonstrate RF channelizers based on 49GHz microcombs. 92 parallel channels and an instantaneous bandwidth of 8.08GHz are achieved for high-resolution RF spectral channelization. This approach is promising for integrated photonic RF receivers.
Publisher: IEEE
Date: 07-2017
Publisher: The Optical Society
Date: 06-08-2019
DOI: 10.1364/OE.27.023919
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.C4B_3
Abstract: In this contribution, we present electro-optically tuneable quasi-phase matching in a periodically poled lithium niobate on insulator waveguide and experimentally demonstrate a tuning efficiency of 56 pm/100 V.
Publisher: Springer Science and Business Media LLC
Date: 22-02-2011
Publisher: Springer Science and Business Media LLC
Date: 24-05-2009
DOI: 10.1038/NM.1955
Abstract: Platelet aggregation at sites of vascular injury is essential for hemostasis and arterial thrombosis. It has long been assumed that platelet aggregation and thrombus growth are initiated by soluble agonists generated at sites of vascular injury. By using high-resolution intravital imaging techniques and hydrodynamic analyses, we show that platelet aggregation is primarily driven by changes in blood flow parameters (rheology), with soluble agonists having a secondary role, stabilizing formed aggregates. We find that in response to vascular injury, thrombi initially develop through the progressive stabilization of discoid platelet aggregates. Analysis of blood flow dynamics revealed that discoid platelets preferentially adhere in low-shear zones at the downstream face of forming thrombi, with stabilization of aggregates dependent on the dynamic restructuring of membrane tethers. These findings provide insight into the prothrombotic effects of disturbed blood flow parameters and suggest a fundamental reinterpretation of the mechanisms driving platelet aggregation and thrombus growth.
Publisher: IEEE
Date: 02-2008
Publisher: AIP Publishing
Date: 22-03-2010
DOI: 10.1063/1.3367742
Abstract: We investigate the physical origins of etching observed during Ti diffusion. The relationship between observed etch depth and water vapor content in the annealing environment is quantified. The dynamics of the etching process are also identified. It is discovered that water vapor content is essential for etching and that there is a characteristic delay before etching is observed. From these observations we can conclude that the process is electrochemical in nature with ionic defects diffusing into the Ti strip from the lithium niobate and these defects catalyzing the dissociation of water into reactive ions.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2001
DOI: 10.1109/8.914259
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.BIOS.2021.113770
Abstract: Cancer is one of the leading cause of death worldwide. Lung cancer (LCa) and prostate cancer (PCa) are the two most common ones particularly among men with about 20% of aggressive metastatic form leading to shorter overall survival. In recent years, circulating tumor cells (CTCs) have been investigated extensively for their role in metastatic progression and their involvement in reduced overall survival and treatment responses. Analysis of these cells and their associated biomarkers as "liquid biopsy" can provide valuable real-time information regarding the disease state and can be a potential avenue for early-stage detection and possible selection of personalized treatments. This review focuses on the role of CTCs and their associated biomarkers in lung and prostate cancer, as well as the shortcomings of conventional methods for their isolation and analysis. To overcome these drawbacks, biosensors are an elegant alternative because they are capable of providing valuable multiplexed information in real-time and analyzing biomarkers at lower concentrations. A comparative analysis of different transducing elements specific for the analysis of cancer cell and cancer biomarkers have been compiled in this review.
Publisher: The Optical Society
Date: 2006
Abstract: We predict a sharp crossover from nonlinear self-defocusing to discrete self-trapping of a narrow Gaussian beam with the increase of the refractive index contrast in a periodic photonic lattice. We demonstrate experimentally nonlinear discrete localization of light with defocusing nonlinearity by single site excitation in LiNbO(3) waveguide arrays.
Publisher: IEEE
Date: 12-2012
Publisher: IEEE
Date: 2006
Publisher: The Optical Society
Date: 21-12-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2013
Publisher: OSA
Date: 2017
Publisher: Elsevier BV
Date: 2009
DOI: 10.1016/J.BIOS.2008.10.016
Abstract: Optical fibre surface-enhanced Raman scattering (SERS) sensors offer a potential solution for monitoring low chemical concentrations in remote or in situ sensing scenarios. The SERS effect relies on the interaction of analyte molecules with nanostructured metal surfaces. We demonstrate a nanoscale biotemplating approach to fabricating these sensors, using nanoimprint lithography to replicate cicada wing antireflective nanostructures onto the end faces of standard silica optical fibres. These SERS-compatible nanoarrays are coated with silver to make them SERS active, and thiophenol and rhodamine 6G are used as test analytes, from which strong SERS spectra are collected using both direct endface illumination and through-fibre interrogation. This combination of biological templates with nanoscale replication and optical fibres demonstrates a high-resolution, low-cost approach to fabricating high-performance optical fibre SERS sensors.
Publisher: Springer Science and Business Media LLC
Date: 21-11-2017
DOI: 10.1038/S41598-017-16276-7
Abstract: Localized Ca 2+ influx via TRPV4 on the surface of endothelial cells greatly influences endothelial adaptation to blood flow, but how mechanical stress from blood flow controls TRPV4 integration into this physiological function is not fully understood. Here, we studied the spatial organization of TRPV4 and its relationship to the adherens junction component β-catenin using single- and dual-color direct stochastic optical reconstruction microscopy (dSTORM). In non-stimulated endothelial cells, TRPV4 is clustered in small protein islands, as is β-catenin. Using dual-color imaging, we found that TRPV4 and β-catenin reside in similar islands and can be found at both the basolateral and basal membranes. Following shear stress stimulation, TRPV4 molecules formed smaller clusters, with the majority residing outside of clusters. Further shear stress stimulation changed the molecular distribution of TRPV4 molecules, limiting them to the basal membrane. This redistribution and the smaller clusters resulted in the segregation of TRPV4 from β-catenin. Furthermore, TRPV4 trafficking was controlled by focal adhesion kinase and activation of the α5ß1 integrin. These highly differentiated spatial redistributions suggest that mechanotransduction of blood flow is controlled via a more complex hierarchy than previously thought.
Publisher: Elsevier BV
Date: 11-2018
Publisher: IEEE
Date: 07-2008
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7LC00350A
Abstract: This work introduces a highly porous PDMS sponge for the storage and passive release of aqueous solutions, acting as a building block for self-sufficient microfluidic systems.
Publisher: Optica Publishing Group
Date: 2006
DOI: 10.1364/OE.14.011265
Abstract: We study propagation of polychromatic light near the edge of a nonlinear waveguide array. We describe simultaneous spatial and spectral beam reshaping associated with power and wavelength-dependent tunneling between the waveguides. We present experimental verifications of the effects predicted theoretically including the first observation of supercontinuum nonlinear surface modes.
Publisher: The Optical Society
Date: 08-02-2012
DOI: 10.1364/OL.37.000572
Publisher: Wiley
Date: 15-04-2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NR00185G
Abstract: Controlled actuation of soft objects with functional surfaces in aqueous environments presents opportunities for liquid phase electronics, novel assembled super-structures and unusual mechanical properties. We show the extraordinary electrochemically induced actuation of liquid metal droplets coated with nanoparticles, so-called "liquid metal marbles". We demonstrate that nanoparticle coatings of these marbles offer an extra dimension for affecting the bipolar electrochemically induced actuation. The nanoparticles can readily migrate along the surface of liquid metals, upon the application of electric fields, altering the capacitive behaviour and surface tension in a highly asymmetric fashion. Surprising actuation behaviours are observed illustrating that nanoparticle coatings can have a strong effect on the movement of these marbles. This significant novel phenomenon, combined with unique properties of liquid metal marbles, represents an exciting platform for enabling erse applications that cannot be achieved using rigid metal beads.
Publisher: IEEE
Date: 12-2012
Publisher: The Optical Society
Date: 16-07-2019
DOI: 10.1364/OE.27.021532
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-11-2020
Publisher: SPIE
Date: 22-12-2015
DOI: 10.1117/12.2202367
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2019
Publisher: AIP Publishing
Date: 27-03-2006
DOI: 10.1063/1.2190899
Abstract: An application is demonstrated for the much maligned standing wave in photolithography that is responsible for the sidewall corrugations in photoresist patterns. We demonstrate the realization of a polydimethylsiloxane (PDMS) scattering mask through the casting of these sidewall corrugations and their application as the masking components in an otherwise transparent bulk of PDMS. Photoresist structures with widths in the order of 80nm are realized by the application of this mask, demonstrating excellent correlation with the lateral depths of the sidewall corrugations. The continuity of the sidewall corrugations around corners makes both straight and curved lines realizable with equal simplicity.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7LC00046D
Abstract: This review discusses the opportunities provided by gallium liquid metal alloys for making various microfluidic components.
Publisher: IEEE
Date: 07-2008
Publisher: Wiley
Date: 27-10-2009
Abstract: This paper presents the development and experimental analysis of a dielectrophoresis (DEP) system, which is used for the manipulation and separation of microparticles in liquid flow. The system is composed of arrays of microelectrodes integrated to a microchannel. Novel curved microelectrodes are symmetrically placed with respect to the centre of the microchannel with a minimum gap of 40 microm. Computational fluid dynamics method is utilised to characterise the DEP field and predict the dynamics of particles. The performance of the system is assessed with microspheres of 1, 5 and 12 microm diameters. When a high-frequency potential is applied to microelectrodes a spatially varying electric field is induced in the microchannel, which creates the DEP force. Negative-DEP behaviour is observed with particles being repelled from the microelectrodes. The particles of different dimensions experience different DEP forces and thus settle to separate equilibrium zones across the microchannel. Experiments demonstrate the capability of the system as a field flow fraction tool for sorting microparticles according to their dimensions and dielectric properties.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2020
Publisher: IEEE
Date: 2006
Publisher: AIP Publishing
Date: 08-03-2010
DOI: 10.1063/1.3358384
Abstract: We present a tuneable optical waveguide using dielectrophoretically controlled nanoparticles in microfluidics. Silicon dioxide nanoparticles of different sizes in de-ionized water are channelled through a microfluidic system. An array of microelectrodes generates the dielectrophoretic force to funnel nanoparticles, forming narrowbands at the center of the microfluidics at different applied voltages and frequencies. It is observed that these narrowbands either scatter or guide the coupled light under selected conditions. The realization of such a system offers exciting possibilities for the development of a new class of optofluidics, which are tuned by the positioning of nanoparticles on demand.
Publisher: Wiley
Date: 05-03-2014
Abstract: The flat tip of an optical fiber is a unique and unconventional platform for micro and nanotechnologies. The small cross-section and large aspect ratio of the fiber provide an inherently light-coupled substrate that is uniquely suited to remote, in vivo and in situ applications. However, these same characteristics challenge established fabrication technologies, which are best suited to large planar substrates. This review presents a broad overview of strategies for patterning the flat tip of an optical fiber. Techniques discussed include self-assembly, numerous lithographies, through-fiber patterning, hybrid techniques, and strategies for mass manufacture, while the erse applications are discussed in context throughout.
Publisher: Optica Publishing Group
Date: 18-03-2020
DOI: 10.1364/OE.390164
Abstract: Data exchange between different data channels can offer more flexible and advanced functions for many optical networks. In this paper, we propose a switchable and reconfigurable data exchange device for arbitrary two optical mode channels based on three-waveguide-coupling (TWC) switches in mode- ision multiplexing (MDM) networks. The working principle of the TWC switches is numerically analyzed using the coupled supermode theory. As a proof of concept, switchable data exchange between arbitrary two mode channels among the first three-order quasi-transverse electric modes is experimentally demonstrated successfully. The insertion losses of the device are less than 5.6 dB, including the coupling loss of the multiplexer and demultiplexer, while the mode crosstalk is less than -13.0 dB for all functions. The proposed device is expected to offer more flexibility to on-chip MDM networks due to its low loss, low crosstalk and good scalability.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-12-2020
Publisher: Optica Publishing Group
Date: 02-06-2021
DOI: 10.1364/OE.426442
Abstract: In this contribution we present a new approach to achieve high extinction short and long pass wavelength filters in the integrated photonic platform of lithium niobate on insulator. The filtering of unwanted wavelengths is achieved by employing lateral leakage and is related to the bound state in the continuum phenomenon. We show that it is possible to control the filter edge wavelength by adjusting the waveguide dimensions and that an extinction of hundreds of dB/cm is readily achievable. This enabled us to design a pump wavelength suppression of more than 100 dB in a 3.5 mm long waveguide, which is essential for on-chip integration of quantum-correlated photon pair sources. These findings pave the way to integrate multi wavelength experiments on chip for the next generation of photonic integrated circuits.
Publisher: Springer Science and Business Media LLC
Date: 19-07-2017
DOI: 10.1038/S41598-017-06260-6
Abstract: The laminar nature of microfluidic flows is most elegantly demonstrated via the confluence of two fluids forming two stable parallel flows within a single channel meeting at a highly stable interface. However, maintenance of laminar conditions can become complicated when there is a large viscosity contrast between the neighbouring flows leading to unique instability patterns along their interface. Here, we study the dynamics of high viscosity contrast confluent flows – specifically a core flow made of highly viscous glycerol confined by sheath flows made of water within a microfluidic flow focusing system. Our experiments indicate the formation of tapered core structures along the middle of the channel. Increasing the sheath flow rate shortens the tapered core, and importantly induces local instability patterns along the interface of core-sheath flows. The dynamics of such tapered core structures is governed by the intensity of instability patterns and the length of the core, according to which the core structure can experience stable, disturbed, broken or oscillated regimes. We have studied the dynamics of tapered core structures under these regimes. In particular, we have analysed the litude and frequency of core displacements during the broken core and oscillating core regimes, which have not been investigated before.
Publisher: Public Library of Science (PLoS)
Date: 23-10-2013
Publisher: SPIE
Date: 16-02-2018
DOI: 10.1117/12.2292938
Publisher: Wiley
Date: 04-04-2011
Publisher: Optica Publishing Group
Date: 29-11-2021
DOI: 10.1364/OL.446222
Abstract: Electro-optic (EO) modulators, which convert signals from the electrical to optical domain plays a key role in modern optical communication systems. Lithium niobate on insulator (LNOI) technology has emerged as a competitive solution to realize high-performance integrated EO modulators. In this Letter, we design and experimentally demonstrate a Mach–Zehnder interferometer-based modulator on a silicon nitride loaded LNOI platform, which not only takes full advantage of the excellent EO effect of L i N b O 3 , but also avoids the direct etching of L i N b O 3 thin film. The measured half-wave voltage length product of the fabricated modulator is 2.24 V·cm, and the extinction ratio is ∼ 20 d B . Moreover, the 3 dB EO bandwidth is ∼ 30 G H z , while the modulated data rate for on–off key signals can reach up to 80 Gbps.
Publisher: Wiley
Date: 15-04-2019
Abstract: Simultaneous broadband and high efficiency merits of designer metasurfaces are currently attracting widespread attention in the field of nanophotonics. However, contemporary metasurfaces rarely achieve both advantages simultaneously. For the category of transmissive metadevices, plasmonic or conventional dielectric metasurfaces are viable for either broadband operation with relatively low efficiency or high efficiency at only a selection of wavelengths. To overcome this limitation, dielectric nanoarcs are proposed as a means to accomplish two advantages. Continuous nanoarcs support different electromagnetic resonant modes at localized areas for generating phase retardation. Meanwhile, the geometric nature of nanoarc curvature endows the nanoarcs with full phase coverage of 0-2π due to the Pancharatnam-Berry phase principle. Experimentally incorporated with the chiral-detour phase principle, a few compelling functionalities are demonstrated, such as chiral beamsplitting, broadband holography, and helicity-selective holography. The continuous nanoarc metasurfaces prevail over plasmonic or dielectric discretized building block strategies and the findings lead to novel designs of spin-controllable metadevices.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2540414
Publisher: Springer Science and Business Media LLC
Date: 23-07-2015
DOI: 10.1038/SREP11973
Abstract: Immobilisation of cells is an important feature of many cellular assays, as it enables the physical/chemical stimulation of cells whilst, monitoring cellular processes using microscopic techniques. Current approaches for immobilising cells, however, are h ered by time-consuming processes, the need for specific antibodies or coatings and adverse effects on cell integrity. Here, we present a dielectrophoresis-based approach for the robust immobilisation of cells and analysis of their responses under high shear flows. This approach is quick and label-free and more importantly, minimises the adverse effects of electric field on the cell integrity, by activating the field for a short duration of 120 s, just long enough to immobilise the cells, after which cell culture media (such as HEPES) is flushed through the platform. In optimal conditions, at least 90% of the cells remained stably immobilised, when exposed to a shear stress of 63 dyn/cm 2 . This approach was used to examine the shear-induced calcium signalling of HEK-293 cells expressing a mechanosensitive ion channel, transient receptor potential vaniloid type 4 (TRPV4), when exposed to the full physiological range of shear stress.
Publisher: IEEE
Date: 12-2007
Publisher: The Optical Society
Date: 17-07-2018
DOI: 10.1364/OL.43.003493
Publisher: Optica Publishing Group
Date: 20-03-2009
DOI: 10.1364/OL.34.000980
Abstract: The leakage loss due to TM-TE mode coupling of TM-like whispering gallery mode in silicon-on-insulator (SOI) thin-ridge disk resonators is investigated for the first time to the best of our knowledge. We show that the propagation losses of TM-like mode in thin-ridge SOI disk resonators are significantly impacted by the radius of the disk. This behavior is predicted by a simple phenomenological model as well as a rigorous mode matching simulation.
Publisher: OSA
Date: 2010
Publisher: Wiley
Date: 18-03-2021
Publisher: IEEE
Date: 07-2006
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2009
Publisher: SPIE
Date: 17-01-2005
DOI: 10.1117/12.579457
Publisher: AIP Publishing
Date: 07-2023
DOI: 10.1063/5.0149324
Abstract: We report the realization of a silicon–germanium on silicon ring resonator with high Q-factor at mid-infrared wavelengths. The fabricated ring exhibits a loaded Q-factor of 236 000 at the operating wavelength of 4.18 µm. Considering the combined waveguide propagation losses and bending losses, which are measured to be below 0.2 dB/cm, even higher Q-factors could be achieved on this platform. Furthermore, our dispersion engineering of the waveguides should make these microrings suitable for nonlinear optical applications. These results pave the way for sensing applications and nonlinear optics in the mid-infrared range.
Publisher: Optica Publishing Group
Date: 10-03-2023
DOI: 10.1364/JOSAB.482507
Abstract: Thin-film lithium niobate on insulator (LNOI) is emerging as one of the promising platforms for integrated photonics due to the excellent material properties of lithium niobate, which includes a strong electro-optic effect, high second-order optical nonlinearity, a large optical transparency window, and low material loss. Although direct etching of lithium niobate has been adopted more widely in recent years, it remains to be seen if it will be adopted in foundry processes due to the incompatibility with standard CMOS fabrication processes. Thus, the scalability of the LNOI platform is currently still limited when compared with other platforms such as silicon photonics. Dielectrically loaded LNOI waveguides may present an alternative. These waveguides have been used to demonstrate a range of optical components with a simplified fabrication process while demonstrating competitive performance. In this contribution, we review the recent progress in dielectrically loaded LNOI waveguides, summarize the advantages and disadvantages of different loading materials, compare the performance of different platforms, and discuss the future of these platforms for photonic integrated circuits.
Publisher: SPIE
Date: 02-03-2007
DOI: 10.1117/12.726976
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEO_AT.2020.JTH2F.17
Abstract: We demonstrate fully CMOS-compatible anomalous dispersive SiN microring resonators with an intrinsic Q factor of 6.6 × 10 5 based on reactive sputtering SiN, yielding in a 250 nm wide modulation-instability frequency comb.
Publisher: American Chemical Society (ACS)
Date: 03-02-2015
DOI: 10.1021/AC5043335
Abstract: The localized motion of cells within a cluster is an important feature of living organisms and has been found to play roles in cell signaling, communication, and migration, thus affecting processes such as proliferation, transcription, and organogenesis. Current approaches for inducing dynamic movement into cells, however, focus predominantly on mechanical stimulation of single cells, affect cell integrity, and, more importantly, need a complementary mechanism to pattern cells. In this article, we demonstrate a new strategy for the mechanical stimulation of large cell clusters, taking advantage of dielectrophoresis. This strategy is based on the cellular spin resonance mechanism, but it utilizes coating agents, such as bovine serum albumin, to create consistent rotation and vibration of in idual cells. The treatment of cells with coating agents intensifies the torque induced on the cells while reducing the friction at the cell-cell and cell-substrate interfaces, resulting in the consistent motion of the cells. Such localized motion can be modulated by varying the frequency and voltage of the applied sinusoidal AC signal and can be achieved in the absence and presence of flow. This strategy enables the survival and functioning of moving cells within large-scale clusters to be investigated.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2540404
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.904802
Publisher: Springer Science and Business Media LLC
Date: 11-11-2008
DOI: 10.1007/S11671-008-9197-2
Abstract: We report the first instance of deposition of preferentially oriented, nanocrystalline, and nanocolumnar strontium-doped lead zirconate titanate (PSZT) ferroelectric thin films directly on thermal silicon dioxide. No intermediate seed or activation layers were used between PSZT and silicon dioxide. The deposited thin films have been characterised using a combination of diffraction and microscopy techniques.
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0CE00713G
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.P3_13
Abstract: Dual frequency combs are used to extract a linear phase response of interferometric biosensors while being independent of the bias point and offering common-mode rejection and low noise.
Publisher: AIP Publishing
Date: 09-2014
DOI: 10.1063/1.4895387
Abstract: We report the realization of high-resolution bulk domains achieved using a shallow, structured, domain inverted surface template obtained by UV laser-induced poling inhibition in MgO-doped lithium niobate. The quality of the obtained bulk domains is compared to those of the template and their application for second harmonic generation is demonstrated. The present method enables domain structures with a period length as small as 3 μm to be achieved. Furthermore, we propose a potential physical mechanism that leads to the transformation of the surface template into bulk domains.
Publisher: Wiley
Date: 10-09-2019
Publisher: IEEE
Date: 2003
Publisher: The Optical Society
Date: 12-04-2018
DOI: 10.1364/PRJ.6.000B30
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2004
Publisher: The Optical Society
Date: 11-06-2013
DOI: 10.1364/OL.38.002104
Publisher: American Physical Society (APS)
Date: 21-11-2014
Publisher: Wiley
Date: 23-02-2018
Publisher: American Chemical Society (ACS)
Date: 14-01-2015
DOI: 10.1021/AM5077364
Abstract: Solvothermally synthesized Ga2O3 nanoparticles are incorporated into liquid metal/metal oxide (LM/MO) frameworks in order to form enhanced photocatalytic systems. The LM/MO frameworks, both with and without incorporated Ga2O3 nanoparticles, show photocatalytic activity due to a plasmonic effect where performance is related to the loading of Ga2O3 nanoparticles. Optimum photocatalytic efficiency is obtained with 1 wt % incorporation of Ga2O3 nanoparticles. This can be attributed to the sub-bandgap states of LM/MO frameworks, contributing to pseudo-ohmic contacts which reduce the free carrier injection barrier to Ga2O3.
Publisher: Research Square Platform LLC
Date: 06-04-2022
DOI: 10.21203/RS.3.RS-1486220/V1
Abstract: Lithium niobate on insulator (LNOI) has been demonstrated as a promising platform for photonic integrated circuits (PICs), thanks to its excellent properties such as strong electro-optic effect, low material loss and wide transparency window. In this paper, we propose and demonstrate a monolithic PIC for high-speed data communication application on a lithium-niobate-etchless platform with silicon nitride (Si3N4) as a loading material. The fabricated PIC consists of four racetrack resonator modulators and a pair of four-channel mode (de)multiplexers, which shows high data modulation rate of 70 Gbps for single channel and the total data throughput reaches up to 280 Gbps. To the best of our knowledge, this is the first demonstration of PIC consisting of high-speed electro-optical modulators and (de)multiplexers with such high data capacity on Si3N4-LNOI hybrid platform, which opens up new avenues for achieving large-scale monolithic integration on LNOI platform in future.
Publisher: IEEE
Date: 12-2010
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-1999
DOI: 10.1109/22.750246
Publisher: AIP Publishing
Date: 18-07-2012
DOI: 10.1063/1.4736796
Abstract: The advent of optofluidic systems incorporating suspended particles has resulted in the emergence of novel applications. Such systems operate based on the fact that suspended particles can be manipulated using well-appointed active forces, and their motions, locations and local concentrations can be controlled. These forces can be exerted on both in idual and clusters of particles. Having the capability to manipulate suspended particles gives users the ability for tuning the physical and, to some extent, the chemical properties of the suspension media, which addresses the needs of various advanced optofluidic systems. Additionally, the incorporation of particles results in the realization of novel optofluidic solutions used for creating optical components and sensing platforms. In this review, we present different types of active forces that are used for particle manipulations and the resulting optofluidic systems incorporating them. These systems include optical components, optofluidic detection and analysis platforms, plasmonics and Raman systems, thermal and energy related systems, and platforms specifically incorporating biological particles. We conclude the review with a discussion of future perspectives, which are expected to further advance this rapidly growing field.
Publisher: OSA
Date: 2019
Publisher: SPIE
Date: 09-03-2013
DOI: 10.1117/12.2001467
Publisher: IOP Publishing
Date: 07-12-2006
Abstract: The miniaturization of optical devices and their integration for creating adaptive and reconfigurable photonic integrated circuits requires effective platforms and methods to control light over very short distances. We present here several techniques and objects that we have developed to harness light at the sub-micrometer scale. These new tools include planar photonic crystal on nonlinear chalcogenide glasses, tapered silica fibres, optofluidics, and optical trapping. Their association could provide the basic building blocks of completely new architectures and platforms that would have an impact on numerous applications, from optical logic to sensing.
Publisher: IEEE
Date: 07-2006
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.904901
Publisher: Elsevier BV
Date: 2009
DOI: 10.1016/J.MICRON.2008.01.012
Abstract: This article discusses the results of transmission electron microscopy (TEM)-based investigation of nickel silicide (NiSi) thin films grown on silicon. Nickel silicide is currently used as the CMOS technology standard for local interconnects and in electrical contacts. Films were characterized with a range of TEM-based techniques along with glancing angle X-ray diffraction. The nickel silicide thin films were formed by vacuum annealing thin films of nickel (50 nm) deposited on (100) silicon. The cross-sectional s les indicated a final silicide thickness of about 110 nm. This investigation studied and reports on three aspects of the thermally formed thin films: the uniformity in composition of the film using jump ratio maps the nature of the interface using high resolution imaging and the crystalline orientation of the thin films using selected-area electron diffraction (SAED). The analysis highlighted uniform composition in the thin films, which was also substantiated by spectroscopy techniques an interface exhibiting the desired abrupt transition from silicide to silicon and desired and preferential crystalline orientation corresponding to stoichiometric NiSi, supported by glancing angle X-ray diffraction results.
Publisher: American Chemical Society (ACS)
Date: 24-04-2019
Abstract: In this work, we show how domain-engineered lithium niobate can be used to selectively dope monolayer molybdenum selenide (MoSe
Publisher: The Optical Society
Date: 19-09-2013
DOI: 10.1364/OE.21.022705
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.BIOS.2021.113814
Abstract: The detection of cancer cells at the single-cell level enables many novel functionalities such as next-generation cancer prognosis and accurate cellular analysis. While surface-enhanced Raman spectroscopy (SERS) has been widely considered as an effective tool in a low-cost and label-free manner, however, it is challenging to discriminate single cancer cells with an accuracy above 90% mainly due to the poor biocompatibility of the noble-metal-based SERS agents. Here, we report a dual-functional nanoprobe based on dopant-driven plasmonic oxides, demonstrating a maximum accuracy above 90% in distinguishing single THP-1 cell from peripheral blood mononuclear cell (PBMC) and human embryonic kidney (HEK) 293 from human macrophage cell line U937 based on their SERS patterns. Furthermore, this nanoprobe can be triggered by the bio-redox response from in idual cells towards stimuli, empowering another complementary colorimetric cell detection, approximately achieving the unity discrimination accuracy at a single-cell level. Our strategy could potentially enable the future accurate and low-cost detection of cancer cells from mixed cell s les.
Publisher: Elsevier BV
Date: 07-2010
Publisher: Informa UK Limited
Date: 07-2013
DOI: 10.1080/08927014.2013.800192
Abstract: Biofouling, the unwanted growth of sessile microorganisms on submerged surfaces, presents a serious problem for underwater structures. While biofouling can be controlled to various degrees with different microstructure-based patterned surfaces, understanding of the underlying mechanism is still imprecise. Researchers have long speculated that microtopographies might influence near-surface microfluidic conditions, thus microhydrodynamically preventing the settlement of microorganisms. It is therefore very important to identify the microfluidic environment developed on patterned surfaces and its relation with the antifouling behaviour of those surfaces. This study considered the wall shear stress distribution pattern as a significant aspect of this microfluidic environment. In this study, patterned surfaces with microwell arrays were assessed experimentally with a real-time biofilm development monitoring system using a novel microchannel-based flow cell reactor. Finally, computational fluid dynamics simulations were carried out to show how the microfluidic conditions were affecting the initial settlement of microorganisms.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: SPIE
Date: 03-2019
DOI: 10.1117/12.2506942
Publisher: AIP Publishing
Date: 10-11-2014
DOI: 10.1063/1.4901735
Abstract: The capability of manipulating light at subwavelength scale has fostered the applications of flat metasurfaces in various fields. Compared to metallic structure, metasurfaces made of high permittivity low-loss dielectric resonators hold the promise of high efficiency by avoiding high conductive losses of metals at optical frequencies. This letter investigates the spectral and angular characteristics of a dielectric resonator metasurface composed of periodic sub-arrays of resonators with a linearly varying phase response. The far-field response of the metasurface can be decomposed into the response of a single grating element (sub-array) and the grating arrangement response. The analysis also reveals that coupling between resonators has a non-negligible impact on the angular response. Over a wide wavelength range, the simulated and measured angular characteristics of the metasurface provide a definite illustration of how different grating diffraction orders can be selectively suppressed or enhanced through antenna sub-array design.
Publisher: Springer Science and Business Media LLC
Date: 25-09-2014
Publisher: OSA
Date: 2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2018
Publisher: IEEE
Date: 12-2006
Publisher: IEEE
Date: 2000
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.913964
Publisher: American Physical Society (APS)
Date: 14-07-2014
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEOPR.2020.P2_13
Abstract: An elegant filter synthesis technique commonly used in microwave engineering is utilized to synthesize coupled resonator filters with close spacing using the recently reported ridge resonators, achieving different filtering functions including Butterworth or Chebyshev responses.
Publisher: OSA
Date: 2011
Publisher: OSA
Date: 2018
Publisher: OSA
Date: 2018
Publisher: IEEE
Date: 07-2017
Publisher: OSA
Date: 2018
Publisher: Elsevier BV
Date: 05-2010
Publisher: IEEE
Date: 07-2017
Publisher: AIP Publishing
Date: 03-2016
DOI: 10.1063/1.4945309
Abstract: Microfluidic platforms enable a variety of physical or chemical stimulation of single or multiple cells to be examined and monitored in real-time. To date, intracellular calcium signalling research is, however, predominantly focused on observing the response of cells to a single mode of stimulation consequently, the sensitising/desensitising of cell responses under concurrent stimuli is not well studied. In this paper, we provide an extended Discontinuous Dielectrophoresis procedure to investigate the sensitising of chemical stimulation, over an extensive range of shear stress, up to 63 dyn/cm2, which encompasses shear stresses experienced in the arterial and venus systems (10 to 60 dyn/cm2). Furthermore, the TRPV4-selective agonist GSK1016790A, a form of chemical stimulation, did not influence the ability of the cells' to remain immobilised under high levels of shear stress thus, enabling us to investigate shear stress stimulation on agonism. Our experiments revealed that shear stress sensitises GSK1016790A-evoked intracellular calcium signalling of cells in a shear-stimulus dependent manner, as observed through a reduction in the cellular response time and an increase in the pharmacological efficacy. Consequently, suggesting that the role of TRPV4 may be underestimated in endothelial cells—which experience high levels of shear stress. This study highlights the importance of conducting studies at high levels of shear stress. Additionally, our approach will be valuable for examining the effect of high levels of shear on different cell types under different conditions, as presented here for agonist activation.
Publisher: Wiley
Date: 06-08-2020
Publisher: IEEE
Date: 05-2011
Publisher: Wiley
Date: 02-10-2019
Publisher: Optica Publishing Group
Date: 2020
DOI: 10.1364/CLEO_SI.2020.SW4J.7
Abstract: We report photonic RF fractional Hilbert transformers and filters based on a 49GHz soliton crystal micro-comb source. By employing up to 80 wavelengths and controlling the channel weights, erse transfer functions are achieved.
Publisher: Wiley
Date: 24-01-2019
Abstract: Silicon photonics has demonstrated great potential in ultrasensitive biochemical sensing. However, it is challenging for such sensors to detect small ions which are also of great importance in many biochemical processes. A silicon photonic ion sensor enabled by an ionic dopant-driven plasmonic material is introduced here. The sensor consists of a microring resonator (MRR) coupled with a 2D restacked layer of near-infrared plasmonic molybdenum oxide. When the 2D plasmonic layer interacts with ions from the environment, a strong change in the refractive index results in a shift in the MRR resonance wavelength and simultaneously the alteration of plasmonic absorption leads to the modulation of MRR transmission power, hence generating dual sensing outputs which is unique to other optical ion sensors. Proof-of-concept via a pH sensing model is demonstrated, showing up to 7 orders improvement in sensitivity per unit area across the range from 1 to 13 compared to those of other optical pH sensors. This platform offers the unique potential for ultrasensitive and robust measurement of changes in ionic environment, generating new modalities for on-chip chemical sensors in the micro/nanoscale.
Publisher: AIP Publishing
Date: 13-07-2015
DOI: 10.1063/1.4926910
Abstract: We present a technique for domain engineering the surface of lithium niobate crystals with features as small as 100 nm. A film of chromium (Cr) is deposited on the lithium niobate surface and patterned using electron beam lithography and lift-off and then irradiated with a wide diameter beam of intense visible laser light. The regions patterned with chromium are domain inverted while the uncoated regions are not affected by the irradiation. With the ability to realize nanoscale surface domains, this technique could offer an avenue for fabrication of nano-photonic and phononic devices.
Publisher: Wiley
Date: 25-11-2016
Abstract: Liquid metal co-injected with electrolyte through a microfluidic flow-focusing orifice forms droplets with diameters and production frequencies controlled in real time by voltage. Applying voltage to the liquid metal controls the interfacial tension via a combination of electrochemistry and electrocapillarity. This simple and effective method can instantaneously tune the size of the microdroplets, which has applications in composites, catalysts, and microsystems.
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0LC00481B
Abstract: A microfluidic dielectrophoresis platform consisting of curved microelectrodes was developed and integrated with a Raman spectroscopy system. The electrodes were patterned on a quartz substrate, which has insignificant Raman response, and integrated with a microfluidic channel that was imprinted in poly-dimethylsiloxane (PDMS). We will show that this novel integrated system can be efficiently used for the determination of suspended particle types and the direct mapping of their spatial concentrations. We will also illustrate the system's unique advantages over conventional optical systems. Nanoparticles of tungsten trioxide (WO(3)) and polystyrene were used in the investigations, as they are Raman active and can be homogeneously suspended in water.
Publisher: Research Square Platform LLC
Date: 27-10-2023
Publisher: Elsevier BV
Date: 04-2011
DOI: 10.1016/J.JBIOMECH.2011.02.006
Abstract: Platelet activation under blood flow is thought to be critically dependent on the autologous secretion of soluble platelet agonists (chemical activators) such as ADP and thromboxane. However, recent evidence challenging this model suggests that platelet activation can occur independent of soluble agonist signalling, in response to the mechanical effects of micro-scale shear gradients. A key experimental tool utilized to define the effect of shear gradients on platelet aggregation is the murine intravital microscopy model of platelet thrombosis under conditions of acute controlled arteriolar stenosis. This paper presents a computational structural and hydrodynamic simulation of acute stenotic blood flow in the small bowel mesenteric vessels of mice. Using a homogeneous fluid at low Reynolds number (0.45) we investigated the relationship between the local hydrodynamic strain-rates and the severity of arteriolar stensosis. We conclude that the critical rates of blood flow acceleration and deceleration at sites of artificially induced stenosis (vessel side-wall compression or ligation) are a function of tissue elasticity. By implementing a structural simulation of arteriolar side wall compression, we present a mechanistic model that provides accurate simulations of stenosis in vivo and allows for predictions of the effects on local haemodynamics in the murine small bowel mesenteric thrombosis model.
Publisher: Research Square Platform LLC
Date: 31-01-2029
DOI: 10.21203/RS.3.RS-1310958/V1
Abstract: Lithium niobate on insulator (LNOI) has emerged as a promising platform for photonic integrated circuits, with a fast-growing toolbox of components. In this paper, we propose, design and experimentally demonstrate compact subwavelength grating (SWG) waveguides on a LNOI platform for on-chip mode and polarization manipulation. To overcome the limitation of waveguide fabrication, the SWGs are designed and formed on a silicon nitride thin film deposited onto the surface of LNOI chip. As proof-of-concept devices, the SWG-based spatial mode filters and a TM-pass polarizer are fabricated successfully on the same chip, with the device lengths of only ~50 μm. The measured insertion losses for the devices are lower than 3.1 dB, with high extinction ratio larger than 30 dB, at a wavelength of 1550 nm. The proposed and demonstrated SWGs can serve as important building blocks in a series of mode and polarization handling devices for LNOI integrated photonics.
No related organisations have been discovered for Arnan Mitchell.
Start Date: 06-2019
End Date: 12-2022
Amount: $420,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2011
End Date: 2014
Amount: $265,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 01-2006
End Date: 12-2009
Amount: $245,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2004
End Date: 06-2008
Amount: $148,281.00
Funder: Australian Research Council
View Funded ActivityStart Date: 10-2011
End Date: 12-2013
Amount: $279,215.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2015
End Date: 12-2019
Amount: $296,300.00
Funder: Australian Research Council
View Funded ActivityStart Date: 05-2005
End Date: 05-2006
Amount: $110,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 08-2006
End Date: 12-2006
Amount: $207,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2008
End Date: 04-2009
Amount: $750,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2006
End Date: 12-2006
Amount: $9,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2015
End Date: 12-2016
Amount: $270,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2010
End Date: 12-2010
Amount: $350,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2009
End Date: 12-2009
Amount: $300,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2009
End Date: 12-2009
Amount: $250,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2007
End Date: 12-2010
Amount: $375,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2010
End Date: 12-2011
Amount: $340,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 10-2014
End Date: 03-2015
Amount: $330,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2014
End Date: 12-2016
Amount: $500,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2021
End Date: 06-2024
Amount: $646,887.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2016
End Date: 06-2018
Amount: $367,900.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2023
End Date: 12-2023
Amount: $852,787.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2011
End Date: 04-2018
Amount: $23,800,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2017
End Date: 05-2018
Amount: $250,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2021
End Date: 03-2023
Amount: $535,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2023
End Date: 12-2029
Amount: $34,948,820.00
Funder: Australian Research Council
View Funded ActivityStart Date: 01-2012
End Date: 12-2015
Amount: $470,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 08-2019
End Date: 12-2022
Amount: $430,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2016
End Date: 12-2017
Amount: $400,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2021
End Date: 04-2022
Amount: $837,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2011
End Date: 12-2012
Amount: $400,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2003
End Date: 06-2004
Amount: $100,000.00
Funder: Australian Research Council
View Funded Activity