ORCID Profile
0000-0002-8986-3405
Current Organisation
UNSW Sydney
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Publisher: Informa UK Limited
Date: 09-2020
DOI: 10.2147/IJN.S262690
Publisher: Wiley
Date: 02-08-2022
Abstract: Antimicrobial polymers (AMPs) have emerged as a promising approach to combat multidrug‐resistant pathogens. Developed from binary polymers, which contain cationic and hydrophobic groups, ternary polymers are enhanced by adding neutral hydrophilic monomers to improve their biocompatibility. Cationic groups have attracted significant attention owing to their pivotal role in AMPs. Although many studies have investigated the effect of cationic groups on antimicrobial activity of binary AMPs, there is a lack of comprehensive and systematic evaluation for ternary AMPs. Therefore, a library of 31 statistical hiphilic ternary polymers containing different cationic groups, including primary amine, guanidine, and sulfonium groups is prepared to investigate the impact of cationic groups on antimicrobial activity and biocompatibility. It is shown that the cationic balance appears to be a critical factor influencing polymers' antibacterial activity and selectivity. The results reveal that the polymers that have the ratio of the cationic groups ranging between 50% and 60%, coupled with a cationic/hydrophobic ratio in the range of [1.4–2] and an appropriate neutral hydrophilic/hydrophobic balance, exhibited the highest selectivity toward mammalian cells. This study elucidates a structure–property‐performance relationship for ternary AMPs, which contributes to the development of AMPs capable of selectively targeting gram‐negative pathogens.
Publisher: American Chemical Society (ACS)
Date: 13-11-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0BM01197E
Abstract: Polymers can facilitate delivery of nitric oxide, improving stability and control of release for effective treatment of common skin disorders.
Publisher: Wiley
Date: 09-2022
Abstract: Antibiotic resistance has become a critical issue, alarming the healthcare and agriculture sectors worldwide. Thanks to rapid advancements in polymer science, antimicrobial polymers (AMPs) have been developed as a mimic version of host‐defense peptides (a part of natural immune systems of multicellular organisms) to mitigate antibiotic resistance. By exploiting advanced polymerization techniques, polymer structures are easily manipulated in a well‐defined controlled manner, enabling precise and accurate evaluation of the structure–activity relationship. Recent years have witnessed the blossoming of antimicrobial polymer development. This review provides comprehensive insight into antimicrobial polymers from concept to structure design, to biofunction control. Along with the optimization of intrinsic factors, including compositional and topological features, external factors like induced conformation upon exposure to specific targeting pathogens should be considered in AMP design and optimization. Furthermore, the new design approaches of smart response platforms (or bacterial‐induced triggering systems) and targeting specific administration dosage forms for specific pathogens are also discussed as prospective strategies to address the remaining challenge of toxicity while maintaining or even enhancing antimicrobial potency.
Publisher: Elsevier BV
Date: 11-2018
DOI: 10.1016/J.COLSURFB.2018.07.016
Abstract: Chlorin e6 (Ce6) has attracted considerable interest as a promising second-generation photosensitizer for photodynamic therapy (PDT). However, the in vivo availability of Ce6 is significantly restricted by its low water solubility and poor ability to target tumors. We sought to overcome the limitations of Ce6 by using albumin nanoparticles with nab
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1PY01075A
Abstract: Antimicrobial polymers have recently been investigated as potential treatments to combat multidrug-resistant pathogens.
No related grants have been discovered for Phuong Pham.