ORCID Profile
0000-0001-7769-6008
Current Organisation
Hong Kong University of Science and Technology
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Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2010
Publisher: Wiley
Date: 08-2013
DOI: 10.1002/RMV.1753
Abstract: Dendritic cells (DCs) are found at the portals of pathogen entry such as the mucosal surfaces of the respiratory, gastrointestinal and genital tracts where they represent the first line of contact between the immune system and the foreign invaders. They are found throughout the body in multiple subsets where they express unique combinations of C-type lectin receptors to best aid them in detection of pathogens associated with their anatomical location. DCs are important in the establishment in HIV infection for two reasons. Firstly, they are one of the first cells to encounter the virus, and the specific interaction that occurs between these cells and HIV is critical to HIV establishing a foothold infection. Secondly and most importantly, HIV is able to efficiently transfer the virus to its primary target cell, the CD4(+) T lymphocyte, in which it replicates explosively. Infection of CD4(+) T lymphocytes via DCs is far more efficient than direct infection. This review surveys the various DCs subsets found within the human sexual mucosa and their interactions with HIV. Mechanisms of HIV uptake are discussed as well as how the virus then traffics through the DC and is transferred to T cells. Until recently, most research has focussed on vaginal transmission despite the increased transmission rate associated with anal intercourse. Here, we also discuss recent advances in our understanding of HIV transmission in the colon.
Publisher: IEEE
Date: 06-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2008
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2008
Publisher: Elsevier BV
Date: 2014
Publisher: IEEE
Date: 2008
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Vincent Kin Nang Lau.