ORCID Profile
0000-0003-4984-5410
Current Organisation
UNSW Sydney
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Publisher: Sultan Qaboos University Medical Journal
Date: 24-08-2015
Publisher: Springer Science and Business Media LLC
Date: 16-02-2018
Publisher: Informa UK Limited
Date: 05-2015
Publisher: Briefland
Date: 30-06-2017
DOI: 10.5812/IJCM.8174
Publisher: Biomedical Research Network, LLC
Date: 18-04-2019
Publisher: Elsevier BV
Date: 09-2014
DOI: 10.1016/J.INTIMP.2014.06.035
Abstract: Multiple sclerosis (MS) is considered an inflammatory and neurodegenerative disease of the central nervous system (CNS) which most often presents as relapsing-remitting episodes. Recent evidence suggests that activated astrocytes play a dual functional role in CNS inflammatory disorders such as MS. In this study, we tried to induce anti-inflammatory functions of astrocytes by curcumin. The effects of curcumin were examined on human a astrocyte cell line (U373-MG) induced by lipopolysaccharide (LPS) in vitro. Matrix metalloproteinase (MMP)-9 activity was assessed by gelatin zymography. Cytokine levels were evaluated by quantitative ELISA method and mRNA expression was measured by real-time PCR. We found that curcumin decreased the release of IL-6 and reduced MMP-9 enzyme activity. It down-regulated MCP-1 mRNA expression too. However, curcumin did not have significant effects on the expression of neurotrophin (NT)-3 and insulin-like growth factor (IGF)-1 mRNAs. Results suggest that curcumin might beneficially affect astrocyte population in CNS neuroinflammatory environment lean to anti-inflammatory response and help to components in respects of CNS repair. Our findings offer curcumin as a new therapeutic agent with the potential of regulating astrocyte-mediated inflammatory diseases in the CNS.
Publisher: Informa UK Limited
Date: 26-11-2015
DOI: 10.3109/08958378.2015.1116645
Abstract: Mustard lung is a major pulmonary complication in in iduals exposed to sulfur mustard (SM) gas during the Iran-Iraq war. It shares common pathological and clinical features with some chronic inflammatory lung disorders, particularly chronic obstructive pulmonary disease (COPD). Airway remodeling, which is one of the main causes of lung dysfunction and the dominant phenomenon of chronic pulmonary diseases, is seen in the mustard lung. Among all mediators involved in the remodeling process, the transforming growth factor (TGF)-β plays a pivotal role in lung fibrosis and consequently in the airway remodeling. Regarding the high levels of this mediator detected in mustard lung patients, in the present study, we have discussed the possible roles of TGF-β in airway remodeling (including epithelial layer damage, subepithelial fibrosis and angiogenesis). Finally, based on TGF-β targeting, we have reviewed new airway remodeling therapeutic approaches.
No related grants have been discovered for Mir Hadi Seyedzadeh.