ORCID Profile
0000-0002-6538-2033
Current Organisations
UNSW Sydney
,
SEHHAT Foundation Hospital
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Publications
Myopia Progression in Adults: A Retrospective Analysis
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 27-07-2023
DOI: 10.1097/OPX.0000000000002045
Abstract: Studies on adult myopia progression are limited. This retrospective analysis of a large dataset of young adult myopes characterizes myopia progression during adulthood. Purpose. To determine the mean annual progression of myopia and to estimate the proportion of progressors in adult myopes. Longitudinal, non-cycloplegic subjective refraction data for young adult myopes (spherical equivalent refractive error -0.5D or more), age ranging from 18-30 years, was retrospectively analyzed. The mean annual progression, as well as the proportion of progressors (at least -0.50 D shift between visits and annualized progression of -0.25D or more), were estimated. A total of 354 myopes, 230 (64.7%) females, with a mean [SD] age of 22.2 [3.8] years were considered. Mean [SD] annualized progression was -0.10 [0.21] D, -0.08 [0.2] D and -0.04 [0.21] D in 18–21-year, 22–26 year and 27–30-year age groups respectively ( P = .003). The difference between 18–21 and 27–30 year age groups was significant ( P = .05 ) while all other pairwise comparisons were not significant. The proportion (95% CI) of progressors in the 18-21, -26, and 26-30 year groups was 18.3% (14.9, 21.7), 10.9% (7.1, 14.7), and 8.8% (4.4, 13.1) respectively. The proportion of progressors working or studying in a higher learning/academic environment was 16.2% with an OR (95%CI) for progression of 2.07 (1.15 – 3.74) compared to those in non-academic environments ( P = .02 ), with no significant effect of gender or ethnicity. This study is consistent with other studies on myopia in young adults which show that myopia does not progress by substantial amounts throughout the adult years, particularly after the age of 21 years. While future studies may be challenged by the small rates of change and the small proportion of progressors, further research is needed to understand the implications of adult myopia progression on clinical management.
Multimodal Imaging of Serpiginous Choroiditis
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 02-2017
DOI: 10.1097/OPX.0000000000001015
Abstract: To report a case of atypical serpiginous choroiditis with previously unreported findings on optical coherence tomographic angiography. A 35-year-old otherwise healthy man had a 1-week history of vision loss in his right eye. The visual acuity in right eye was counting fingers at 1 meter. Fundoscopy showed a classic peripapillary serpiginous lesion and a solitary macular lesion. Fundus fluorescein angiography revealed early hypofluorescence of active lesions with gradual increase in fluorescence across the phase of angiogram. Optical coherence tomography showed hyperreflectivity in outer retinal layers and loss of ellipsoid zone band. The patient was treated with oral prednisone and visual acuity returned to near normal. The inflammation recurred once the patient discontinued corticosteroid therapy. The flare-up was treated with intravenous methylprednisolone followed by oral steroids. Oral azathioprine was added as a steroid-sparing agent and oral prednisone was tapered slowly and discontinued. The visual acuity returned to normal with settlement of all lesions after initiating azathioprine. Optical coherence tomography showed reintegration of retinal anatomy. No recurrence was seen after discontinuation of corticosteroids. Optical coherence tomographic angiography in resolved serpiginous choroiditis was consistent with loss of choriocapillaris homogeneity. Serpiginous choroiditis may manifest with multifocal lesions and may be confused with relentless placoid chorioretinitis. However, it ends up in a typical geographic scar. Optical coherence tomography can be used to monitor the changes in retinal structure. Choriocapillaris changes as seen on optical coherence tomographic angiography may be a possible mechanism behind the development of choroidal neovascularization in later stages of the disease.
Clinical utility of OCT-angio in age-related macular degeneration
Publisher: IOP Publishing
Date: 12-2021
A Novel Method of Quantifying the Choriocapillaris in Normal and Post-inflammatory Eyes
Publisher: Informa UK Limited
Date: 18-08-2020
DOI: 10.1080/09273948.2020.1800047
Abstract: To assess the reliability and validity of gray level co-occurrence matrices (GLCM) in the quantification of choriocapillaris and describe GLCM features in normal and eyes with resolved acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and serpiginous choroiditis (SC). In this, multicenter, reliability, validity and comparative study OCTA was performed on eyes with resolved APMPPE and SC and normal in iduals. CC texture classification, low flow area measurements and GLCM feature extraction were performed. A total of 13 normal, 8 APMPPE and 15 SC eyes were analyzed. All GLCM parameters demonstrated an excellent reliability. GLCM parameters were differently distributed across the three groups. Decision-tree based on the random forest predictive model provided an overall accuracy of 86% in classifying the three groups using GLCM features. These data demonstrated an excellent reliability and validity of GLCM features in quantifying the choriocapillaris in healthy and diseased eyes.
A TYPICAL FEATURES IN IRVAN SYNDROME DEMONSTRATED ON MULTIMODAL IMAGING
Publisher: Global Cooperation and Analytical Research Center Public Union
Date: 12-03-2021
DOI: 10.30546/2788-516X.2021.2.1.5
Abstract: Purpose:Thepurposeofthis workwastodescribeidiopathicretinalvasculitis,aneurysms,andneuroretinitis(IRVAN)syndrome ina32-year-oldmale.Methods: Casereport.Case report: A 32-year-old male presented with acute visualdisturbance. Multimodal imaging revealed retinal vasculitis,aneurysmsandneuroretinitisinadditiontovitreousinflammation,retinalischemiaandepiretinalmembrane.Opticalcoherencetomographyangiography(OCTA)demonstratedmultiplemicroaneurysm inbotheyes.Conclusion: Multimodal imaging was helpful in diagnosinganddifferentiatingIRVANsyndromefromothersimilar-lookingclinicalentities.Retinalaneurysmsandretinalischaemiaweredetectablebyfundusfluoresceinangiography(FFA). However, OCTA showed multiple microaneurysmsthatwerenotclearlydifferentiablebyFFAbecauseofvitreousinflammationandvascularleakage.MicroaneurysmsinIRVAN syndrome area previously unreportedobservation.OCTAmayhelpdetectthesechangeswithaccuratedetails
Clinical application of optical coherence tomography angiography in retinal diseases
Publisher: IOP Publishing
Date: 12-2021
Eyelid Myokymia—a Presumed Manifestation of Coronavirus Disease 2019 (COVID-19)
Publisher: Springer Science and Business Media LLC
Date: 10-01-2022
Suprachoroidal silicone oil migration following 27 gauge 3 ports pars plana vitrectomy – a rare complication and its management
Publisher: Pakistan Medical Association
Date: 15-05-2023
DOI: 10.47391/JPMA.6823
Abstract: Suprachoroidal silicone oil migration is an unusual complication of small gauge 3 ports Pars plana vitrectomy (3PPV) system. Our objective is to report a retrospective, observational case of an intra-operative suprachoroidal silicone oil (SO) migration during 27 gauge 3PPV and its successful surgical management. A 49 years old type 2 male patient with diabetes presented to the ophthalmology outpatient department with reduced visual acuity in his right eye. He was diagnosed as having tractional retinal detachment involving macula. During combined phaco-vitrectomy following injection of SO, peripheral choroidal elevations were noted suggesting suprachoroidal SO migration. In an attempt to drain this intra-operatively nasal sclerotomy was enlarged. Post-operative B scan showed significant choroidal detachment for which patient was re-scheduled for surgery after 1 day. Three radial trans-scleral incisions (2 nasal and 1 temporal) for drainage were made at the site of maximum choroidal detachment. ---Continue
A major review of optical coherence tomography angiography
Publisher: Informa UK Limited
Date: 20-07-2017
Comprehensive overview of IRVAN syndrome: a structured review of Case Reports and Case Series
Publisher: SAGE Publications
Date: 2022
DOI: 10.1177/25158414211070880
Abstract: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a rare spectrum of retinal vasculitis, aneurysms, and neuroretinitis affecting young in iduals in their third decade. Most of our current knowledge is based on case reports, case series, and a handful of collaborative studies. There is much ersity in treatment approaches and outcomes in the reported literature. We have aggregated published case reports and case series into quantitative and narrative synthesis to draw evidence-based conclusions toward clinical features, atypical and rare findings, systemic associations, disease course, and treatment outcomes. The analysis suggested the disease mostly affects young in iduals with a female predilection. Anterior chamber and vitreous inflammation are common than previously believed. The most prevalent pattern of retinal vasculitis in IRVAN eyes is mixed vasculitis, followed by arteritis and phlebitis. Most eyes at the time of presentation have capillary nonperfusion and require treatment. Most eyes retain good visual acuity however, treatment is required to maintain visual function. Intravitreal antivascular endothelial growth factors administered as an adjunct to retinal laser photocoagulation are more likely to improve visual outcomes. Besides, we have discussed the different hypotheses on the etiopathogenesis of the disease and stronger evidence suggests an inflammatory origin of the disease.
Textural properties of choriocapillaris on OCTA in healed inflammatory choriocapillaropathies
Publisher: SLACK, Inc.
Date: 09-2019
DOI: 10.3928/23258160-20190905-05
Abstract: To evaluate the flow characteristics and textural properties of choriocapillaris (CC) on optical coherence tomography angiography in eyes with resolved inflammatory choriocapillaropathies and Vogt-Koyanagi-Harada (VKH) disease. A cohort of eyes with healed acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and VKH disease were included. A 3 mm × 3 mm OCT angiogram of CC was acquired and graded for flow characteristics and textural properties. This study included 16 patients. Texture was heterogeneous in all eyes in the SC and VKH groups, and in four eyes (40%) in the APMPPE group. Most of the eyes with VKH disease had severe low flow, whereas most of the SC and APMPPE eyes demonstrated mild low flow. Heal duration had a strong negative correlation with severity of CC low flow and a weak, statistically nonsignificant correlation with texture heterogeneity. Despite the resolution of active inflammation, partial CC hypoperfusion and texture disruptions persist for longer durations and may resolve in a time dependent manner. [ Ophthalmic Surg Lasers Imaging Retina . 2019 :566–572.]
Atypical Acute Posterior Multifocal Placoid Pigment Epitheliopathy
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2015
Eyelid Myokymia as a presumed manifestation of Coronavirus Disease 2019 (COVID-19)
Publisher: Research Square Platform LLC
Date: 15-02-2021
DOI: 10.21203/RS.3.RS-203200/V1
Abstract: Purpose To report the eyelid myokymia in patients recovered from COVID-19 disease. Methods A cohort of 15 patients who developed eyelid myokymia during or immediate post-recovery of systemic disease were evaluated. Demographic, clinical characteristics, effect of age, and hospitalization on the disease course were studied. The disease course was evaluated every month for 3 months period. Results All, except 2, patients had complete resolution of lid myokymia within 3 months of onset. Mean ± SD myokymia recovery time was 44.1 ± 20.9 Days. Gender had no impact on the duration of disease. Age and duration of hospitalization had a strong positive correlation with myokymia recovery time (r = 0.8, p = 0.001 and r = 0.8, p = 0.01). Conclusion Eyelid myokymia may involve COVID-19 patients during or immediately after systemic recovery. While myokymia recovers gradually in all these patients older age and longer duration of hospitalization are associated with slower recovery.
Ophthalmological Aspects of von-Hippel–Lindau Syndrome
Publisher: Informa UK Limited
Date: 29-03-2021
Prepapillary vascular loop-a new classification
Publisher: Springer Science and Business Media LLC
Date: 14-04-2020
Related Organisations
Related Funding Activities
No related grants have been discovered for Hashim Ali Khan.