ORCID Profile
0000-0003-2521-0365
Current Organisations
INRAE
,
Université Pierre et Marie Curie
,
Université Lyon 1
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Publications
The NORMAN Association and the European Partnership for Chemicals Risk Assessment (PARC): let’s cooperate!
Publisher: Springer Science and Business Media LLC
Date: 20-07-2020
DOI: 10.1186/S12302-020-00375-W
Abstract: The Partnership for Chemicals Risk Assessment (PARC) is currently under development as a joint research and innovation programme to strengthen the scientific basis for chemical risk assessment in the EU. The plan is to bring chemical risk assessors and managers together with scientists to accelerate method development and the production of necessary data and knowledge, and to facilitate the transition to next-generation evidence-based risk assessment, a non-toxic environment and the European Green Deal. The NORMAN Network is an independent, well-established and competent network of more than 80 organisations in the field of emerging substances and has enormous potential to contribute to the implementation of the PARC partnership. NORMAN stands ready to provide expert advice to PARC, drawing on its long experience in the development, harmonisation and testing of advanced tools in relation to chemicals of emerging concern and in support of a European Early Warning System to unravel the risks of contaminants of emerging concern (CECs) and close the gap between research and innovation and regulatory processes. In this commentary we highlight the tools developed by NORMAN that we consider most relevant to supporting the PARC initiative: (i) joint data space and cutting-edge research tools for risk assessment of contaminants of emerging concern (ii) collaborative European framework to improve data quality and comparability (iii) advanced data analysis tools for a European early warning system and (iv) support to national and European chemical risk assessment thanks to harnessing, combining and sharing evidence and expertise on CECs. By combining the extensive knowledge and experience of the NORMAN network with the financial and policy-related strengths of the PARC initiative, a large step towards the goal of a non-toxic environment can be taken.
Inter-laboratory mass spectrometry dataset based on passive sampling of drinking water for non-target analysis
Publisher: Springer Science and Business Media LLC
Date: 24-08-2021
DOI: 10.1038/S41597-021-01002-W
Abstract: Non-target analysis (NTA) employing high-resolution mass spectrometry is a commonly applied approach for the detection of novel chemicals of emerging concern in complex environmental s les. NTA typically results in large and information-rich datasets that require computer aided (ideally automated) strategies for their processing and interpretation. Such strategies do however raise the challenge of reproducibility between and within different processing workflows. An effective strategy to mitigate such problems is the implementation of inter-laboratory studies (ILS) with the aim to evaluate different workflows and agree on harmonized/standardized quality control procedures. Here we present the data generated during such an ILS. This study was organized through the Norman Network and included 21 participants from 11 countries. A set of s les based on the passive s ling of drinking water pre and post treatment was shipped to all the participating laboratories for analysis, using one pre-defined method and one locally (i.e. in-house) developed method. The data generated represents a valuable resource (i.e. benchmark) for future developments of algorithms and workflows for NTA experiments.
Kinetic accumulation processes and models for 43 micropollutants in pharmaceutical POCIS.
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.SCITOTENV.2017.08.311
Abstract: The "pharmaceutical" polar organic integrative s ler (POCIS) is a passive s ler composed of an outer polyethersulfone (PES) membrane and an inner receiving Hydrophilic-Lipophilic Balance (HLB) phase. Target micropollutants can accumulate in the POCIS HLB phase following different uptake patterns. Two of the most common ones are a first-order kinetic uptake (Chemical Reaction Kinetic 1, CRK1 model), and a first-order kinetic uptake with an inflexion point (CRK2 model). From a previous study, we identified 30 and 13 micropollutants following CRK1 and CRK2 accumulation model in the POCIS HLB phase, respectively. We hypothesized that uptake in the outer PES membrane of POCIS may influence the uptake pathway. Thus, novel measurements of uptake in PES membrane were performed for these micropollutants to characterise kinetic accumulation in the membrane with and without the HLB phase. We determined, for the first time, the membrane-water distribution coefficient for 31 micropolluants. Moreover, the lag times for molecules to breakthrough the POCIS membrane increased with increasing hydrophobicity, defined by the octanol-water dissociation constant D
SEMIPERMEABLE MEMBRANE DEVICE-AVAILABILITY OF POLYCYCLIC AROMATIC HYDROCARBONS IN RIVER WATERS AND WASTEWATER TREATMENT PLANT EFFLUENTS
Publisher: Informa UK Limited
Date: 2004
An interlaboratory study on passive sampling of emerging water pollutants
Publisher: Elsevier BV
Date: 02-2016
Related Organisations
Related Funding Activities
No related grants have been discovered for Cecile Miege.