ORCID Profile
0000-0002-8567-7074
Current Organisation
Royal Holloway University of London
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Publisher: Proceedings of the National Academy of Sciences
Date: 09-04-2020
Abstract: PSGL-1 and CD43 are surface glycoproteins expressed on blood CD4 T cells to bind to selectins for T cell tethering, rolling, and migration into inflamed tissues. The PSGL-1 level is greatly up-regulated during inflammation. Here we found that PSGL-1 and CD43 expression inhibits HIV spreading infection. Mechanistically, PSGL-1 blocks the binding of virus particles to target cells. PSGL-1–mediated suppression of virus infectivity extends to another retrovirus—murine leukemia virus—and to influenza A virus. These results further our understanding of virus–host interactions and help elucidate mechanisms by which cellular host factors regulate viral infection and pathogenesis.
Publisher: Oxford University Press (OUP)
Date: 06-05-2023
Abstract: Cassava (Manihot esculenta Crantz) is an important staple crop for food security in Africa and South America. The present study describes an integrated genomic and metabolomic approach to the characterization of Latin American cassava germplasm. Classification based on genotyping correlated with the leaf metabolome and indicated a key finding of adaption to specific eco-geographical environments. In contrast, the root metabolome did not relate to genotypic clustering, suggesting the different spatial regulation of this tissue's metabolome. The data were used to generate pan-metabolomes for specific tissues, and the inclusion of phenotypic data enabled the identification of metabolic sectors underlying traits of interest. For ex le, tolerance to whiteflies (Aleurotrachelus socialis) was not linked directly to cyanide content but to cell wall–related phenylpropanoid or apocarotenoid content. Collectively, these data advance the community resources and provide valuable insight into new candidate parental breeding materials with traits of interest directly related to combating food security.
Publisher: Wiley
Date: 22-01-2020
DOI: 10.1111/TPJ.14649
Publisher: Elsevier BV
Date: 06-2022
Publisher: Cold Spring Harbor Laboratory
Date: 02-12-2022
DOI: 10.1101/2022.12.01.518686
Abstract: Cassava is an important staple crop for food security in Africa and South America. The present study describes an integrated genomic and metabolomic approach to the characterisation of Latin American cassava germplasm. Classification based on genotyping and the leaf metabolome correlates, the key finding being the adaption to specific eco-geographical environments. In contrast the root metabolome does not relate to the genotypic clustering, suggesting different spatial regulation of this tissue’s metabolome. The data has been used to generate pan-metabolomes for specific tissues and the inclusion of phenotypic data has enabled the identification of metabolic sectors underlying traits of interest. For ex le, tolerance to whiteflies was not linked to cyanide content but to cell wall related phenylpropanoids or apocarotenoids. Collectively, these data advance the communities resources and provides a valuable insight into new parental breeding materials with traits of interest directly related to combating food security. Cassava is a staple crop in developing countries of sub-tropical regions. Traditionally, cassava has been considered as a subsistence crop. However recently it has become a sustainable solution to fulfil both hunger and malnutrition needs, and drive economic development. Varietal improvement via classic breeding has successfully delivered products into the Asian market by including/exchanging germplasm from original Latin American collections. Conversely, modest progress has been achieved in Sub-Saharan countries since genetic resources are biased towards exploitation of local landraces and uncharacterised parental material. The present work explores the genetic and metabolic ersity of Latin American cassava’s genebank, one of the largest and most complete worldwide. These data provide a robust characterisation of valuable germplasm that can be exploited in breeding programmes.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: Spain
No related grants have been discovered for Laura Perez-Fons.