ORCID Profile
0000-0003-0872-185X
Current Organisations
University Of Strathclyde
,
Istituto Italiano di Tecnologia Center for Life Nano- & Neuro-Science
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Publisher: Elsevier BV
Date: 07-2022
Publisher: Elsevier BV
Date: 09-2021
Publisher: Morressier
Date: 07-07-2022
Publisher: Elsevier BV
Date: 2022
Publisher: Cold Spring Harbor Laboratory
Date: 26-08-2020
DOI: 10.1101/2020.08.26.268631
Abstract: Mutations in the RNA-binding protein (RBPs) FUS have been genetically associated with the motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced pluripotent stem cells and mouse models, we found that FUS-ALS causative mutations affect the activity of two relevant RBPs with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP. Mechanistically, mutant FUS leads to upregulation of HuD protein levels through competition with FMRP for HuD mRNA 3’UTR binding. In turn, increased HuD levels overly stabilize the transcript levels of its targets, NRN1 and GAP43. As a consequence, mutant FUS motoneurons show increased axon branching and growth upon injury, which could be rescued by d ening NRN1 levels. Since similar phenotypes have been previously described in SOD1 and TDP-43 mutant models, increased axonal growth and branching might represent broad early events in the pathogenesis of ALS.
Publisher: American Society for Cell Biology (ASCB)
Date: 15-05-2023
Abstract: A cytogenetic feature of human centromeres is a long array of repetitive α-satellite DNA at the primary constriction of mitotic chromosomes. A combination of the centromere chromosome orientation FISH (Cen-CO-FISH) technique together with SIM was used to visualize centromere organization within a single chromatid. Collectively, the data indicate a structural organization for α-satellite repeats in a ring-like conformation, with CENP-A preferentially distributed on the lateral surface of the primary constriction, and showcase superresolution imaging methods that can be used for further understanding of centromere structures.
Publisher: Elsevier BV
Date: 07-2021
Publisher: EDP Sciences
Date: 2021
DOI: 10.1051/EPJCONF/202125006008
Abstract: The study of deformation and fracturing properties of concrete is essential to understand failure mechanisms of concrete material, especially under extreme and complex loading conditions, e.g. high strain rates and multiple confinements. In this study, dynamic deformation and fracturing behaviour of ordinary concrete under biaxial confinements are investigated by using a triaxial Hopkinson bar system, three-dimensional digital image correlation, and synchrotron X-ray computed tomography techniques. Results show that compressive strain localisation areas appear around aggregates due to the elastic difference between aggregate and matrix, where accompanied with initiation of interfacial cracks and propagation of main cracks. Transgranular cracks can also be observed in the central of specimen in CT slices due to the effect of strain concentration. In addition, CT slices with distinct properties in various directions indicate the anisotropic fracturing behaviour of concrete due to the effect of biaxial confinements.
Publisher: Elsevier BV
Date: 06-2022
Publisher: University of Chile, Santiago
Date: 2020
Publisher: Elsevier BV
Date: 07-2021
Publisher: Elsevier BV
Date: 09-2022
Publisher: CRC Press
Date: 30-11-2022
Publisher: CRC Press
Date: 12-2022
Publisher: Springer Science and Business Media LLC
Date: 09-2021
DOI: 10.1038/S42003-021-02538-8
Abstract: Mutations in the RNA-binding protein (RBP) FUS have been genetically associated with the motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced pluripotent stem cells and mouse models, we found that FUS-ALS causative mutations affect the activity of two relevant RBPs with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP. Mechanistically, mutant FUS leads to upregulation of HuD protein levels through competition with FMRP for HuD mRNA 3’UTR binding. In turn, increased HuD levels overly stabilize the transcript levels of its targets, NRN1 and GAP43. As a consequence, mutant FUS motoneurons show increased axon branching and growth upon injury, which could be rescued by d ening NRN1 levels. Since similar phenotypes have been previously described in SOD1 and TDP-43 mutant models, increased axonal growth and branching might represent broad early events in the pathogenesis of ALS.
Location: United Kingdom of Great Britain and Northern Ireland
Location: France
Location: Italy
Location: Italy
Location: Italy
Location: United States of America
No related grants have been discovered for Valeria de Turris.