ORCID Profile
0000-0003-4146-0057
Current Organisations
University of Southampton
,
Universiti Teknologi Malaysia
,
Universiti Malaysia Sabah
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Related Links
Publications
The Morphology of Electrospun Titanium Dioxide Nanofibers and Its Influencing Factors
Publisher: EDP Sciences
Date: 2016
Environmental enrichment reduces cocaine neurotoxicity during cocaine-conditioned place preference in male rats
Publisher: Elsevier BV
Date: 06-2018
DOI: 10.1016/J.PBB.2018.04.001
Abstract: Environmental enrichment (EE) has a neuroprotective role and prevents the development of cocaine addiction behavior in rats. Studies showing the role of EE in cocaine toxicity are nonexistent. We hypothesized that rats exposed to EE are protected from cocaine-induced changes in the redox profile and DNA damage after undergoing conditioned place preference (CPP). Ten male Wistar rats were placed in EE cages equipped with toys, a ladder and tunnels, and ten were provided clean, standard laboratory housing (non-EE). EE and non-EE rats were randomly allocated to the classical CPP cocaine vs. saline (COC/Saline) group, where cocaine (15 mg/kg i.p.) was tested alternately with saline. Afterwards, intracellular reactive species and antioxidant enzymes were evaluated and the comet essay was performed in the prefrontal cortex and hippoc us of rats. As expected, EE rats spent less time in the cocaine-paired chamber, and as a new result, less cocaine-induced DNA damage was observed in the two brain structures. Altogether, our results demonstrate that EE decreases neurotoxicity in brain regions linked to cocaine addiction but does not extinguish it completely.
EFFECT OF POLYVINYLPYRROLIDONE AND FABRICATION PARAMETERS ON ELECTROSPUN TITANIUM OXIDE NANOFIBRES’ DIAMETER
Publisher: Penerbit UTM Press
Date: 28-11-2016
Abstract: Electrospinning is the most versatile and cost effective technique to produce titanium oxide (TiO2) nanofibres. An ethanolic solution containing titanium tetraisopropoxide, polyvinylpyrrolidone and acetic acid was loaded in the syringe to produce TiO2 nanofibres. In the present work, a custom-made electrospinning system was developed to investigate the fabrication and solution effects to the diameter of electrospun TiO2 fibres. The fabrication parameters were applied voltage (kV), flow rate (ml/hr) and tip to collector distance (cm). In addition, the effect of varying the weightage of polymer carrier on electrospun TiO2 nanofibres was investigated. The surface morphology of the fibres was examined with scanning electron microscope (SEM) and further analysed with the aid of JMicroVision. The significance of the influencing parameters was observed from high to low order as PVP content tip to collector distance applied voltage flow rate. In conclusion, the parameters of applied voltage (15 kV), flow rate (1 ml/hr), tip to collector distance (10 cm) and PVP content (6 wt. %) are able to produce uniform TiO2 nanofibres.
Response Surface Modeling of Electrospinning Parameters on Titanium Oxide Nanofibers’ Diameter: A Box-Behnken Design (BBD)
Publisher: American Scientific Publishers
Date: 11-2017
Effects of neonatal dopaminergic lesion on oral cocaine self-administration in rats: Higher female vulnerability to cocaine consumption
Publisher: Elsevier BV
Date: 2022
DOI: 10.1016/J.PBB.2021.173315
Abstract: The dopaminergic system is associated with cocaine-seeking behaviors, being influenced by other neurotransmitters such as GABA and deregulated by chronic cocaine self-administration. Administration of 6-hydroxydopamine (6-OHDA) to neonatal rats produces a depletion of brain dopamine, mainly, that results in behavioral alterations in adulthood. This model can be applied to better understanding of the role of the dopaminergic system in cocaine use and how its behavioral effects can modulate drug intake. Though there are well-established sex differences in the pattern of drug use, there are no published studies investigating sex-dependent effects of neonatal lesions with 6-OHDA on cocaine self-administration nor regarding GABA
Related Organisations
University Of Southampton
Location: United Kingdom of Great Britain and Northern Ireland
Universidade Federal De Ciências Da Saúde De Porto Alegre
Location: Brazil
Related Funding Activities
No related grants have been discovered for Felipe Borges Almeida.