ORCID Profile
0000-0001-6972-0741
Current Organisations
Harbin Institute of Technology (Shenzhen)
,
University of California, San Diego
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Publisher: Public Library of Science (PLoS)
Date: 19-08-2010
Publisher: MDPI AG
Date: 20-03-2022
DOI: 10.3390/MI13030485
Abstract: Understanding the mechanism of particle transport and sedimentation in pulmonary alveolus is important for deciphering the causes of respiratory diseases and helping the development of drug delivery. In this study, taking advantage of the microfluidic technique, an experimental platform was developed to study particle behavior in a rhythmically expanding alveolar chip for a sufficient number of cycles. The alveolar flow patterns at different generations were measured for two cases with the gravity direction parallel or vertical to the alveolar duct. Affected by both the vortex flow inside the alveoli and the shear flow in the duct simultaneously, it was observed that particles inside the alveoli either escaped from the inlet of the alveolar duct or stayed in the alveoli, revealing the irreversibility of particle transport in the alveoli. At the earlier acinar generations, particles were inclined to deposit on the distal alveolar wall. The settling rates of particles of different sizes in the alveoli were also compared. This study provides valuable data for understanding particle transport and sedimentation in the alveoli.
Publisher: MDPI AG
Date: 23-11-2022
DOI: 10.3390/MI13122052
Abstract: Metal foams have been widely used in heat pipes as wicking materials. The main issue with metal foams is the surface property capillary limit. In this paper, a chemical blackening process for creating a superhydrophilic surface on copper foams is studied with seven different NaOH and NaClO2 solution concentrations (1.5~4.5 mol/L), in which the microscopic morphology of the treated copper foam surface is analyzed by scanning electron microscopy. The capillary experiments are carried out to quantify the wicking characteristics of the treated copper foams and the results are compared with theoretical models. A the microscope is used to detect the flow stratification characteristics of the capillary rise process. The results show that the best wicking ability is obtained for the oxidation of copper foam using 3.5 mol/L of NaOH and NaClO2 solution. Gravity plays a major role in defining the permeability and effective pore radius, while the effect of evaporation can be ignored. The formation of a fluid stratified interface between the unsaturated and saturated zone results in capillary performance degradation. The current study is important for understanding the flow transport in porous materials.
Publisher: Elsevier BV
Date: 09-2005
DOI: 10.1016/J.NEURON.2005.06.036
Abstract: Dendritic spikes that propagate toward the soma are well documented, but their physiological role remains uncertain. Our in vitro patch-cl recordings and two-photon calcium imaging show that direction-selective retinal ganglion cells (DSGCs) utilize orthograde dendritic spikes during physiological activity. DSGCs signal the direction of image motion. Excitatory subthreshold postsynaptic potentials are observed in DSGCs for motion in all directions and provide a weakly tuned directional signal. However, spikes are generated over only a narrow range of motion angles, indicating that spike generation greatly enhances directional tuning. Our results indicate that spikes are initiated at multiple sites within the dendritic arbors of DSGCs and that each dendritic spike initiates a somatic spike. We propose that dendritic spike failure, produced by local inhibitory inputs, might be a critical factor that enhances directional tuning of somatic spikes.
Publisher: Public Library of Science (PLoS)
Date: 27-08-2010
Publisher: AIP Publishing
Date: 03-2022
DOI: 10.1063/5.0084415
Abstract: Understanding the dynamics of airflow in alveoli and its effect on the behavior of particle transport and deposition is important for understanding lung functions and the cause of many lung diseases. The studies on these areas have drawn substantial attention over the last few decades. This Review discusses the recent progress in the investigation of behavior of airflow in alveoli. The information obtained from studies on the structure of the lung airway tree and alveolar topology is provided first. The current research progress on the modeling of alveoli is then reviewed. The alveolar cell parameters at different generation of branches, issues to model real alveolar flow, and the current numerical and experimental approaches are discussed. The findings on flow behavior, in particular, flow patterns and the mechanism of chaotic flow generation in the alveoli are reviewed next. The different flow patterns under different geometrical and flow conditions are discussed. Finally, developments on microfluidic devices such as lung-on-a-chip devices are reviewed. The issues of current devices are discussed.
Location: United States of America
No related grants have been discovered for Nicholas Oesch.