ORCID Profile
0000-0003-0732-131X
Current Organisation
London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health
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Publisher: Elsevier BV
Date: 07-2021
Publisher: BMJ
Date: 09-2019
DOI: 10.1136/BMJOPEN-2019-030874
Abstract: The global burden of dementia is rising, emphasising the urgent need to develop effective approaches to risk reduction. Recent evidence suggests that common bacterial infections may increase the risk of dementia, however the magnitude and timing of the association as well as the patient groups affected remains unclear. We will review existing evidence of the association between common bacterial infections and incident cognitive decline or dementia. We will conduct a comprehensive search of published and grey literature from inception to 18 March 2019. The following electronic databases will be searched MEDLINE, EMBASE, Global health, PsycINFO, Web of Science, Scopus, Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature, Open Grey and the British Library of Electronic Theses databases. There will be no restrictions on the date, language or geographical location of the studies. We will include longitudinal studies with a common clinically symptomatic bacterial infection as an exposure and incident cognitive decline or dementia as an outcome. Study selection, data extraction and risk of bias will be performed independently by two researchers. We will assess the risk of bias using the Cochrane collaboration approach. The overall quality of the studies will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations criteria. We will explore the heterogeneity of relevant studies and, if feasible, a meta-analysis will be performed, otherwise we will present a narrative synthesis. We will group the results by exposure and outcome definitions and differences will be described by subgroups and outcomes. Ethical approval will not be required as this is a systematic review of existing research in the public domain. Results will be disseminated in a peer-reviewed journal and presented at national and international meetings and conferences. CRD42018119294.
Publisher: Wiley
Date: 05-09-2021
DOI: 10.1111/DME.14671
Abstract: To investigate whether there is a bidirectional longitudinal association of depression with HbA 1c . We conducted a systematic literature search in PubMed, PsycINFO, CINAHL and EMBASE for observational, longitudinal studies published from January 2000 to September 2020, assessing the association between depression and HbA 1c in adults. We assessed study quality with the Newcastle‐Ottawa‐Scale. Pooled effect estimates were reported as partial correlation coefficients (r p ) or odds ratios (OR). We retrieved 1642 studies 26 studies were included in the systematic review and eleven in the meta‐analysis. Most studies (16/26) focused on type 2 diabetes. Study quality was rated as good (n = 19), fair (n = 2) and poor (n = 5). Of the meta‐analysed studies, six investigated the longitudinal association between self‐reported depressive symptoms and HbA 1c and five the reverse longitudinal association, with a combined s le size of n = 48,793 and a mean follow‐up of 2 years. Higher levels of baseline depressive symptoms were associated with subsequent higher levels of HbA 1c (partial r = 0.07 [95% CI 0.03, 0.12] I 2 38%). Higher baseline HbA 1c values were also associated with 18% increased risk of (probable) depression (OR = 1.18 [95% CI 1.12,1.25] I 2 0.0%). Our findings support a bidirectional longitudinal association between depressive symptoms and HbA 1c . However, the observed effect sizes were small and future research in large‐scale longitudinal studies is needed to confirm this association. Future studies should investigate the role of type of diabetes and depression, diabetes distress and diabetes self‐management behaviours. Our results may have clinical implications, as depressive symptoms and HbA 1c levels could be targeted concurrently in the prevention and treatment of diabetes and depression. PROSPERO ID CRD42019147551.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Rutendo Muzambi.