ORCID Profile
0000-0001-9174-8097
Current Organisation
RMIT University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Nanomaterials | Biomedical Instrumentation | Optical Properties of Materials | Nanotechnology | Central nervous system | Photonic and electro-optical devices sensors and systems (excl. communications) | Electronics sensors and digital hardware | Atomic molecular and optical physics not elsewhere classified | Animal neurobiology | Biomedical imaging | Nonlinear optics and spectroscopy | Neurosciences
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |
Publisher: Royal Society of Chemistry (RSC)
Date: 15-05-2013
DOI: 10.1039/C3LC50382H
Abstract: Thermal loading effects in flow-through electroporation microfluidic devices have been systematically investigated by using dye-based ratiometric luminescence thermometry. Fluorescence measurements have revealed the crucial role played by both the applied electric field and flow rate on the induced temperature increments at the electroporation sections of the devices. It has been found that Joule heating could raise the intra-channel temperature up to cytotoxic levels (>45 °C) only when conditions of low flow rates and high applied voltages are applied. Nevertheless, when flow rates and electric fields are set to those used in real electroporation experiments we have found that local heating is not larger than a few degrees, i.e. temperature is kept within the safe range (<32 °C). We also provide thermal images of electroporation devices from which the heat affected area can be elucidated. Experimental data have been found to be in excellent agreement with numerical simulations that have also revealed the presence of a non-homogeneous temperature distribution along the electroporation channel whose magnitude is critically dependent on both applied electric field and flow rate. Results included in this work will allow for full control over the electroporation conditions in flow-through microfluidic devices.
Publisher: American Chemical Society (ACS)
Date: 07-05-2019
Abstract: The development of ultrathin flat lenses has revolutionized the lens technologies and holds great promise for miniaturizing the conventional lens system in integrated photonic applications. In certain applications, the lenses are required to operate in harsh and/or extreme environments, for ex le aerospace, chemical, and biological environments. Under such circumstances, it is critical that the ultrathin flat lenses can be resilient and preserve their outstanding performance. However, the majority of the demonstrated ultrathin flat lenses are based on metal or semiconductor materials that have poor chemical, thermal, and UV stability, which limit their applications. Herein, we experimentally demonstrate a graphene ultrathin flat lens that can be applied in harsh environments for different applications, including a low Earth orbit space environment, strong corrosive chemical environments (pH = 0 and pH = 14), and biochemical environment. The graphene lenses have extraordinary environmental stability and can maintain a high level of structural integrity and outstanding focusing performance under different test conditions. Thus, it opens tremendous practical application opportunities for ultrathin flat lenses.
Publisher: Wiley
Date: 23-12-2016
Abstract: There is an urgent need to develop new diagnosis tools for real in vivo detection of first stages of ischemia for the early treatment of cardiovascular diseases and accidents. However, traditional approaches show low sensitivity and a limited penetration into tissues, so they are only applicable for the detection of surface lesions. Here, it is shown how the superior thermal sensing capabilities of near infrared-emitting quantum dots (NIR-QDs) can be efficiently used for in vivo detection of subcutaneous ischemic tissues. In particular, NIR-QDs make possible ischemia detection by high penetration transient thermometry studies in a murine ischemic hindlimb model. NIR-QDs nanothermometers are able to identify ischemic tissues by means of their faster thermal dynamics. In addition, they have shown to be capable of monitoring both the revascularization and damage recovery processes of ischemic tissues. This work demonstrates the applicability of fluorescence nanothermometry for ischemia detection and treatment, as well as a tool for early diagnosis of cardiovascular disease.
Publisher: Informa UK Limited
Date: 16-09-2022
Publisher: Cambridge University Press (CUP)
Date: 04-2020
DOI: 10.1017/S1446181120000140
Abstract: The population dynamics for the replicator equation has been well studied in continuous time, but there is less work that explicitly considers the evolution in discrete time. The discrete-time dynamics can often be justified indirectly by establishing the relevant evolutionary dynamics for the corresponding continuous-time system, and then appealing to an appropriate approximation property. In this paper we study the discrete-time system directly, and establish basic stability results for the evolution of a population defined by a positive definite system matrix, where the population is disrupted by random perturbations to the genotype distribution either through migration or mutation, in each successive generation.
Publisher: American Chemical Society (ACS)
Date: 26-04-2018
Abstract: Advanced diagnostic procedures are required to satisfy the continuously increasing demands of modern biomedicine while also addressing the need for cost reduction in public health systems. The development of infrared luminescence-based techniques for in vivo imaging as reliable alternatives to traditional imaging enables applications with simpler and more cost-effective apparatus. To further improve the information provided by in vivo luminescence images, the design and fabrication of enhanced infrared-luminescent contrast agents is required. In this work, we demonstrate how simple dopant engineering can lead to infrared-emitting rare-earth-doped nanoparticles with tunable (0.1-1.5 ms) and medium-independent luminescence lifetimes. The combination of these tunable nanostructures with time-gated infrared imaging and time domain analysis is employed to obtain multiplexed in vivo images that are used for complex biodistribution studies.
Publisher: Wiley
Date: 31-10-2018
Publisher: Springer Science and Business Media LLC
Date: 10-06-2020
DOI: 10.1038/S41467-020-16333-2
Abstract: Optical probes operating in the second near-infrared window (NIR-II, 1,000-1,700 nm), where tissues are highly transparent, have expanded the applicability of fluorescence in the biomedical field. NIR-II fluorescence enables deep-tissue imaging with micrometric resolution in animal models, but is limited by the low brightness of NIR-II probes, which prevents imaging at low excitation intensities and fluorophore concentrations. Here, we present a new generation of probes (Ag 2 S superdots) derived from chemically synthesized Ag 2 S dots, on which a protective shell is grown by femtosecond laser irradiation. This shell reduces the structural defects, causing an 80-fold enhancement of the quantum yield. PEGylated Ag 2 S superdots enable deep-tissue in vivo imaging at low excitation intensities ( mW cm −2 ) and doses ( .5 mg kg −1 ), emerging as unrivaled contrast agents for NIR-II preclinical bioimaging. These results establish an approach for developing superbright NIR-II contrast agents based on the synergy between chemical synthesis and ultrafast laser processing.
Publisher: Elsevier BV
Date: 05-2018
Publisher: Elsevier BV
Date: 06-2020
Publisher: Wiley
Date: 16-08-2018
Publisher: Emerald
Date: 26-01-2021
DOI: 10.1108/IJRDM-04-2020-0130
Abstract: A review of 67 articles in the indoor environmental quality (IEQ) literature published from 2010 to 2020 reveals that none of prior studies have determined the IEQ of physical retailers and its impact on consumers. To fill such a gap, this study investigates the influence of physical retailers' IEQ on consumer purchase intention. The mediating roles of hedonic experience and perceived brand value (PBV) in this relationship are also determined. Furthermore, the moderating effect of perceived service quality (PSQ) on the link between physical retailers' IEQ and PBV is clarified in this study. This study uses structural equation modeling (SEM) to analyze a s le data of 996 consumers in China. Results show that physical retailers' IEQ has a positive impact on consumer purchase intention. Hedonic experience mediates the link between IEQ and purchase intention. PBV also mediates the relationship between IEQ and purchase intention and that between hedonic experience and purchase intention. In addition, PSQ moderates the relationship between IEQ and PBV. To the best of the authors’ knowledge, this study is the first to determine the impact of IEQ on consumers in the physical retailer context. Specifically, this study enriches our knowledge about the relationship between physical retailers' IEQ and consumer purchase intention with the mediating and moderating mechanisms of hedonic experience, PBV and PSQ. The findings fill the research gaps in the IEQ literature that has ignored the impact of IEQ on consumers' perception and behavioral intention in the physical retailer context. Furthermore, this research provides evidence for retailer managers to understand and improve physical stores' IEQ.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NR03644H
Abstract: We report on the first experimental observation of stable optical trapping of dielectric NaYF4:Er(3+),Yb(3+) upconverting fluorescent nanoparticles (~26 nm in diameter) using a continuous wave 980 nm single-beam laser. The laser serves both to optically trap and to excite visible luminescence from the nanoparticles. Sequential loading of in idual nanoparticles into the trap is observed from the analysis of the emitted luminescence. We demonstrate that the trapping strength and the number of in idual nanoparticles trapped are dictated by both the laser power and nanoparticle density. The possible contribution of thermal effects has been investigated by performing trapping experiment in both heavy water and into distilled water. For the case of heavy water, thermal gradients are negligible and optical forces dominate the trap loading behaviour. The results provide a promising path towards real three dimensional manipulation of single NaYF4:Er(3+),Yb(3+) nanoparticles for precise fluorescence sensing in biophotonics experiments.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4NR00708E
Abstract: The state of the art regarding the use of nanoparticles for photothermal therapies is reviewed in detail.
Publisher: Elsevier BV
Date: 11-2014
Publisher: American Chemical Society (ACS)
Date: 02-2023
Publisher: Elsevier BV
Date: 06-2020
Publisher: Future Medicine Ltd
Date: 05-2014
DOI: 10.2217/NNM.14.59
Abstract: The importance of high-resolution intracellular thermal sensing and imaging in the field of modern biomedicine has boosted the development of novel nanosized fluorescent systems (fluorescent nanothermometers) as the next generation of probes for intracellular thermal sensing and imaging. This thermal mapping requires fluorescent nanothermometers with good biocompatibility and high thermal sensitivity in order to obtain submicrometric and subdegree spatial and thermal resolutions, respectively. This review describes the different nanosized systems used up to now for intracellular thermal sensing and imaging. We also include the later advances in molecular systems based on fluorescent proteins for thermal mapping. A critical overview of the state of the art and the future perspective is also included.
Publisher: Poincare Publishers
Date: 30-12-2018
Publisher: Springer Science and Business Media LLC
Date: 28-09-2020
Publisher: Emerald
Date: 12-08-2022
Abstract: Previous research has yielded mixed results on the relationship between consumer perception and purchase intention towards organic food products. Although the prior literature has widely applied planned behaviour theory, using a single theoretical approach often provides limited understanding of organic food consumption. This study builds upon consumer perception and social cognitive theories to examine the effects of perceived food healthiness and environmental consciousness on the purchase intention of organic drinking products. The current research also assesses the mediating role of consumer extrinsic motivation and moderating role of corporate social responsibility (CSR) beliefs in these effects. A survey method was applied to collect data from 606 consumers from different food retailers in Vietnam. Data were analysed using multivariate analysis techniques, such as structural equation modelling and bootstrap analysis. Results of hypothesis testing support the predictive ability of perception and social cognitive theories in explaining consumers' perceptions, motivation and behavioural intention towards organic drinking products. Furthermore, results provide evidence for the moderating effect of CSR beliefs on the relationship between consumer extrinsic motivation and purchase intention. This study may be amongst the first that explains consumption of organic drinking products from the perspectives of consumer perception and social cognitive theories. It provides a unique research model that explains the influence of perceived food healthiness and environmental consciousness on purchase intention of organic drinking products with the mediating role of consumer extrinsic motivation and moderating role of CSR beliefs. The current research provides fresh insights into the consumption of organic drinking products in an emerging market based on a mediated moderation mechanism, which has been limited in the prior literature.
Publisher: Institute for Operations Research and the Management Sciences (INFORMS)
Date: 03-2023
Abstract: We propose an analytic solution to the problem of finding optimal driving strategies that minimize total tractive energy consumption for a fleet of trains traveling on the same track in the same direction subject to clearance-time equality constraints that ensure safe separation and compress the headway timespan. We assume the track is ided into sections by a set of trackside signals at fixed positions. For each intermediate signal there is an associated signal segment consisting of the two adjacent sections. Successive trains are safely separated only if the leading train leaves the signal segment before the following train enters. Although the fleet can be safely separated by a complete set of clearance times and associated clearance-time inequality constraints the problem of finding optimal schedules with safe separation rapidly becomes intractable as the number of trains and signals increases. The main difficulty is in distinguishing between active equality constraints and inactive inequality constraints. The curse of dimensionality means it is not feasible to check every different combination of active constraints, find the optimal strategies for each train, optimize the corresponding prescribed times and calculate the cost. Nevertheless we can formulate and solve an alternative problem with active clearance-time equality constraints for successive trains defined at selected signals. We show that this problem can be formulated as an unconstrained convex optimization and propose a solution algorithm that finds the optimal schedule and the associated optimal strategies for each train. Finally we find optimal schedules for a case study using realistic parameters on a busy metropolitan line.
Publisher: Wiley
Date: 27-11-2023
DOI: 10.1002/BSE.3318
Abstract: Researchers have investigated the influence of green practices on consumer behavior in the last decades. However, findings indicate that consumers have different responses toward green practices. To advance the current literature, this study draws on the theoretical foundation of social identity theory to investigate the relationship between green practices and hotel guests' visit intention in the luxury hotel sector. The study also determines the mediating mechanisms of perceived value fit and promotion focus and the moderating mechanism of environmental behavior in this relationship. S le data were collected from 473 hotel guests in China's luxury hotels. The results of structural equation modeling indicate that green hotel practices enhance visit intention and that perceived value fit and promotion focus positively mediate this relationship. Moreover, environmental behavior has a positive moderating effect on the link between green hotel practices and perceived value fit, as well as that between perceived value fit and visit intention. A robustness test with another s le data of 266 hotel guests confirms the hypothesis testing results. The findings of this study provide implications for researchers and business managers in understanding and managing the influence of green practices on hotel guests' behavior in the luxury hotel sector.
Publisher: American Chemical Society (ACS)
Date: 07-01-2016
Abstract: Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles in one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential in the life sciences. In addition, such nanostructures could also offer therapeutic capabilities to achieve a wider variety of multifunctionalities. In this work, the encapsulation of both magnetic and infrared emitting nanoparticles into a polymeric matrix leads to a magnetic-fluorescent HNS with multimodal magnetic-fluorescent imaging abilities. The magnetic-fluorescent HNS are capable of simultaneous magnetic resonance imaging and deep tissue infrared fluorescence imaging, overcoming the tissue penetration limits of classical visible-light based optical imaging as reported here in living mice. Additionally, their applicability for magnetic heating in potential hyperthermia treatments is assessed.
Publisher: The Optical Society
Date: 06-01-2016
DOI: 10.1364/OME.6.000367
Publisher: Springer Science and Business Media LLC
Date: 11-10-2014
Publisher: Elsevier BV
Date: 09-2021
Publisher: Wiley
Date: 06-12-2014
Publisher: Wiley
Date: 19-06-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Publisher: Wiley
Date: 06-10-2016
Abstract: The always present and undesired contribution of autofluorescence is here completely avoided by combining a simple time gating technology with long lifetime neodymium doped infrared-emitting nanoparticles.
Publisher: Springer Science and Business Media LLC
Date: 07-08-2014
DOI: 10.1038/SREP05988
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1NA00502B
Abstract: This review highlights the very recent ex les of near infrared contrast agents employed for multivariate diagnostics, multimodal imaging, and theranostic. Considerations on how to further advance these probes towards real-life use are also given.
Publisher: AIP Publishing
Date: 13-10-2015
DOI: 10.1063/1.4932669
Abstract: The spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF3:Nd3+, SrF2:Nd3+, NaGdF4: Nd3+, NaYF4: Nd3+, KYF4: Nd3+, GdVO4: Nd3+, and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a “universal” optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymium-doped nanoparticle to be preferentially used in each case.
Publisher: Australian Mathematical Publishing Association, Inc.
Date: 22-03-2018
Publisher: Elsevier BV
Date: 09-2021
Publisher: Wiley
Date: 11-10-2016
Publisher: Wiley
Date: 14-04-2021
Abstract: Fibrinolytic drugs have been successfully used to manage acute thrombotic and thromboembolic conditions. However, their narrow administration time window, rapid clearance, and possible inactivation limit their efficient and wider application. Most importantly, they present a substantial risk of fatal bleeding complications, which are a major cause of mortality and morbidity. Improving the therapeutic outcomes of pharmacological thrombolysis, including alleviating associated side effects, is an urgent challenge. In this context, nano‐drug delivery systems have attracted major interest. State‐of‐the‐art nanodelivery systems have achieved reduced immunogenicity and a significant prolongation of the biological half‐life of drugs, the latter allowing their application as boli instead of infusions. Recent research focuses on theranostic systems capable of image‐guided thrombolysis, clot targeting strategies, and stimuli‐responsive systems. The latter are designed so that an external or internal stimulus triggers the drug release, offering unique spatiotemporal control over the treatment and potentially minimizing side effects. In this review, the authors discuss the different nanodelivery platforms and focus on stimuli‐responsive systems, highlighting their therapeutic advantages and the challenges for their clinical translation.
Publisher: Elsevier BV
Date: 02-2021
Publisher: Wiley
Date: 02-11-2016
Publisher: Elsevier BV
Date: 09-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR02382D
Abstract: We report on rare-earth-doped fluoride nanoparticles with a long lifetime and intense infrared emission in the second biological window for in vivo luminescence lifetime imaging.
Publisher: SAGE Publications
Date: 20-03-2023
DOI: 10.1177/13567667231164630
Abstract: This study examines the relationship between green hotel practices and consumer revisit intention, with the mediating mechanisms of brand identification, promotion focus, and green consumption value. A paper-based survey was conducted to collect data from consumers in four-star or above hotels in China. Findings from multivariate data analysis show that green hotel practices positively influence consumer to revisit intention, which is mediated by brand identification and green consumption value. Moreover, consumer promotion focus positively mediates the relationship between green hotel practices and brand identification. The findings validate a unique multi-path mediating model of green hotel practices. They also have important implications for hotel managers interested in developing genuine environmental initiatives to generate positive customer responses.
Publisher: Australian Mathematical Publishing Association, Inc.
Date: 13-01-2021
DOI: 10.21914/ANZIAMJ.V62.14843
Abstract: The population dynamics for the replicator equation has been well studied in continuous time, but there is less work that explicitly considers the evolution in discrete time. The discrete-time dynamics can often be justified indirectly by establishing the relevant evolutionary dynamics for the corresponding continuous-time system, and then appealing to an appropriate approximation property. In this paper we study the discrete-time system directly, and establish basic stability results for the evolution of a population defined by a positive definite system matrix, where the population is disrupted by random perturbations to the genotype distribution either through migration or mutation, in each successive generation. doi: 10.1017/S1446181120000140
Publisher: Elsevier BV
Date: 08-2019
Publisher: IOP Publishing
Date: 26-02-2019
Abstract: UCNPs have attracted a great deal of attention as near infrared-excited luminescent probes for biomedical applications. UCNPs can provide contrast for in vivo imaging, act as luminescent temperature reporters and excite different molecules to trigger therapeutic processes. While the unique features of UCNPs are well-suited for certain applications, their intrinsic limitations may prevent their general use in preclinical and clinical settings as luminescent probes. In this work, we analyze the role of UCNPs in research in small animal models. The evolution in the field, from the early studies evaluating UCNPs for in vivo fluorescence imaging to the most recent applications, is described, and the advantages and limitations of UCNPs for different applications are discussed. Their adequacy for preclinical research and potential clinical application are also discussed.
Publisher: Wiley
Date: 03-08-2021
Abstract: In the article by J. Lifante et al (doi: 10.1002/jbio.202000154 ), published in J. Biophotonics 2020 :e202000154, a spectral feature corresponding to tissue reflectance was mistakenly attributed to autofluorescence. This corrigendum is published to correct the interpretation of the spectral data and images in the manuscript.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9NR05733A
Abstract: Research on near-infrared (NIR) bioimaging has progressed very quickly in the past few years, as fluorescence imaging is reaching a credible implementation as a preclinical technique. The applications of NIR bioimaging in theranostics have contributed to its increasing impact. This has brought about the development of novel technologies and, simultaneously, of new contrast agents capable of acting as efficient NIR optical probes. Among these probes, Ag
Publisher: Wiley
Date: 19-08-2020
Publisher: Elsevier BV
Date: 07-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NR01398G
Abstract: Quantum dot based-thermometry, in combination with double beam confocal microscopy and infrared thermal imaging, has been used to investigate the heating efficiency of multi-walled carbon nanotubes (MWCNTs) under optical excitation within the first (808 nm) and second (1090 nm) biological windows as well as in the spectral region separating them (980 nm). It has been found that for the three excitation wavelengths the heating efficiency of MWCNTs (10 nm in diameter and 1.5 μm in length) is close to 50%. Despite this "flat" heating efficiency, we have found that the excitation wavelength is, indeed, critical during in vivo experiments due to the spectral dependence of both tissue absorption and scattering coefficients. It has been concluded that efficiency and selectivity of in vivo photothermal treatments based on MWCNTs are simultaneously optimized when laser irradiation lies within the first or second biological window.
Publisher: Emerald
Date: 17-01-2023
Abstract: On the basis of the approach-avoidance motivation theory, this study aims to examine the role of information confusion in influencing consumer switching intention among social commerce platforms, with the mediating effect of emotional exhaustion and the moderating role of social overload. This study applied a multi-method quantitative approach including a survey and two experiments. Data were obtained from consumers on popular social commerce platforms in China. The survey's s le size was 327 respondents, whereas a total of 1,621 consumers participated in the two experiments. Findings from the survey reveal that information confusion affects switching intention directly and indirectly via emotional exhaustion. Moreover, social overload moderates the emotional exhaustion–switching intention relationship and the indirect impact of information confusion on switching intention. Results of the two experiments further confirm the relationships found in the survey. This study develops and validates a mediation and moderation model which expectedly serves as a framework to better explain consumer switching intention on social commerce platforms. The study also offers fresh insights into consumer switching intention in the unique context of social commerce in an emerging market (i.e. China), which has been largely ignored in the prior literature.
Publisher: Wiley
Date: 19-01-2015
Publisher: Elsevier BV
Date: 2017
Publisher: Cambridge University Press (CUP)
Date: 21-12-2018
DOI: 10.1017/S1446788718000411
Abstract: We consider a linear operator pencil with complex parameter mapping one Hilbert space onto another. It is known that the resolvent is analytic in an open annular region of the complex plane centred at the origin if and only if the coefficients of the Laurent series satisfy a doubly-infinite set of left and right fundamental equations and are suitably bounded. If the resolvent has an isolated singularity at the origin we propose a recursive orthogonal decomposition of the domain and range spaces that enables us to construct the key nonorthogonal projections that separate the singular and regular components of the resolvent and subsequently allows us to find a formula for the basic solution to the fundamental equations. We show that each Laurent series coefficient in the singular part of the resolvent can be approximated by a weakly convergent sequence of finite-dimensional matrix operators and we show how our analysis can be extended to find a global expression for the resolvent of a linear pencil in the case where the resolvent has only a finite number of isolated singularities.
Publisher: Elsevier BV
Date: 12-2016
Publisher: Wiley
Date: 27-06-2016
Publisher: Elsevier BV
Date: 02-2020
DOI: 10.1016/J.IJPHARM.2019.118976
Abstract: Controlled release is at the forefront of modern bioscience as it aims to address challenges associated with the dosing of drugs within required levels for therapeutic effect. Many materials and approaches can be used to control the release from different reservoirs including nanoparticles, liposomes and hydrogels. Using thermoresponsive hydrogels, near infrared illumination of plasmonic nanoparticles can be used to control the hydrogel through localised surface plasmon resonance heating. This work extends beyond a material level and pursues detailed examination of the drug release characteristics of a variable acrylic acid poly(N-isopropylacrylamide) coated gold nanorod system using dexamethasone as a model drug. Release was examined under different irradiation power densities and exposure times. Bulk heating effects in all stimulation protocols did not exceed the lower critical solution temperature of the system, but a marked increase in release was seen following stimulation. This was likely due to more intense heating occurring around the nanorods. A release model was established to describe the amount of drug eluted relative to input energy, suggesting that shorter irradiation periods release the drug more efficiently. The data reported establishes plasmonically modulated thermosensitive hydrogels as a candidate material that can be tailored to specific clinical applications of stimulated release.
Publisher: Wiley
Date: 14-07-2015
Abstract: Hybrid nanostructures containing neodymium-doped nanoparticles and infrared-emitting quantum dots constitute highly sensitive luminescent thermometers operating in the second biological window. They demonstrate that accurate subtissue fluorescence thermal sensing is possible.
Publisher: Springer US
Date: 2021
Publisher: Frontiers Media SA
Date: 09-12-2014
Publisher: Wiley
Date: 17-11-2015
Abstract: Small animal deep-tissue fluorescence imaging in the second Biological Window (II-BW, 1000-1350 nm) is limited by the presence of undesirable infrared-excited, infrared-emitted (900-1700 nm) autofluorescence whose origin, spectral properties and dependence on strains is still unknown. In this work, the infrared autofluorescence and laser-induced whole body heating of five different mouse strains with distinct coat colors (black, grey, agouti, white and nude) has been systematically investigated. While neither the spectral properties nor the magnitude of organ autofluorescence vary significantly between mouse strains, the coat color has been found to strongly determine both the autofluorescence intensity as well as the laser-induced whole body heating. Results included in this work reveal mouse strain as a critical parameter that has to be seriously considered in the design and performance of small animal imaging experiments based on infrared-emitting fluorescent markers.
Publisher: Springer International Publishing
Date: 2020
Publisher: Wiley
Date: 04-12-2022
Abstract: Acute thrombosis is a leading cause of mortality and morbidity worldwide. Pharmacological thrombolysis relies on plasminogen activators (PAs), which are associated with major side effects including potentially fatal bleeding. Alternative therapeutic options that do not rely on PAs are urgently required. Here, the efficacy of targeted photothermal therapy is evaluated for thrombolysis using liposomes loaded with IR780 dye, which release heat upon near‐infrared (NIR) irradiation. Liposomes targeted to activated platelets—one of the main components of thrombi—accumulate preferentially in thrombi both in vitro and in vivo compared to non‐targeted controls. In a mouse model of thrombosis, targeted IR780 immunoliposomes (Tar‐IR‐L) produce ≈12 °C average local temperature increase upon NIR irradiation (5 min, 1 W cm −2 ). This causes a significant reduction in clot area compared to controls treated with non‐targeted liposomes or phosphate‐buffered saline, which only increase local temperature slightly (6 and 3 °C) when irradiated. Co‐loading a low‐dose single chain urokinase plasminogen activator (scuPA) to targeted IR780 liposomes (Tar‐scuPA‐IR‐L) does not result in a superior thrombolytic effect, which indicates that photothermal therapy alone may allow thrombolysis without the need for fibrinolytic drugs. This approach may prevent potential bleeding complications, promising a safer alternative to current pharmacological approaches.
Publisher: Elsevier BV
Date: 2015
Publisher: Wiley
Date: 28-12-2016
Publisher: Wiley
Date: 09-03-2016
Publisher: Wiley
Date: 09-02-2023
DOI: 10.1002/BSE.3381
Abstract: As a value‐added business strategy, many companies have planned and implemented green practices to promote their brands and contribute to sustainable development. This study aims to investigate how green practices build consumer brand identification for luxury hotel companies. Multivariate techniques and structural equation modeling were used to analyze a s le of 601 luxury hotel guests in China. The findings indicate that green hotel practices are positively related to consumer brand identification, and this relationship is positively mediated by perceived green service innovation, perceived utilitarian value, and perceived hedonic value. Furthermore, perceived utilitarian value and perceived hedonic value positively mediate the perceived green service innovation–consumer brand identification link. A robustness test with another s le data of 396 hotel guests was conducted, and this test confirmed the findings. This study provides several important implications for researchers and managers of the luxury hotel sector who aim to build customer brand identification from a green strategy perspective.
Publisher: Wiley
Date: 06-09-2018
Publisher: Wiley
Date: 06-10-2015
Start Date: 2020
End Date: 2022
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2020
End Date: 12-2024
Amount: $427,116.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2023
End Date: 12-2023
Amount: $852,787.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2023
End Date: 12-2025
Amount: $320,000.00
Funder: Australian Research Council
View Funded Activity