ORCID Profile
0009-0007-8370-9865
Current Organisations
The Walter and Eliza Hall Institute
,
University of Adelaide
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Publisher: Elsevier BV
Date: 2016
DOI: 10.1016/J.AJPATH.2015.09.008
Abstract: Granulocyte colony-stimulating factor (G-CSF) is a regulator of neutrophil production, function, and survival. Herein, we investigated the role of G-CSF in a murine model of human uveitis-experimental autoimmune uveoretinitis. Experimental autoimmune uveoretinitis was dramatically reduced in G-CSF-deficient mice and in anti-G-CSF monoclonal antibody-treated, wild-type (WT) mice. Flow cytometric analysis of the ocular infiltrate in WT mice with experimental autoimmune uveoretinitis showed a mixed population, comprising neutrophils, macrophages, and T cells. The eyes of G-CSF-deficient and anti-G-CSF monoclonal antibody-treated WT mice had minimal neutrophil infiltrate, but no change in other myeloid-derived inflammatory cells. Antigen-specific T-cell responses were maintained, but the differentiation of pathogenic type 17 helper T cells in experimental autoimmune uveoretinitis was reduced with G-CSF deficiency. We show that G-CSF controls the ocular neutrophil infiltrate by modulating the expression of C-X-C chemokine receptors 2 and 4 on peripheral blood neutrophils, as well as actin polymerization and migration. These data reveal an integral role for G-CSF-driven neutrophil responses in ocular autoimmunity, operating within and outside of the bone marrow, and also identify G-CSF as a potential therapeutic target in the treatment of human uveoretinitis.
Publisher: Portland Press Ltd.
Date: 21-12-2007
DOI: 10.1042/BJ20071114
Publisher: Elsevier BV
Date: 07-2005
Publisher: Humana Press
Date: 04-11-2013
Publisher: Elsevier BV
Date: 11-2009
Publisher: Elsevier BV
Date: 09-2003
Publisher: Springer Science and Business Media LLC
Date: 18-08-2010
No related grants have been discovered for Jane Murphy.