ORCID Profile
0000-0001-8125-3111
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Publisher: IEEE
Date: 30-08-2023
Publisher: American Chemical Society (ACS)
Date: 07-03-2007
DOI: 10.1021/EF060574A
Publisher: Informa UK Limited
Date: 05-2002
Publisher: Springer Science and Business Media LLC
Date: 19-12-2014
Publisher: American Chemical Society (ACS)
Date: 26-05-2007
DOI: 10.1021/EF070041H
Publisher: American Chemical Society (ACS)
Date: 12-12-2007
DOI: 10.1021/EF700485K
Publisher: Elsevier BV
Date: 06-2011
Publisher: Hindawi Limited
Date: 05-2014
DOI: 10.1002/HUMU.22554
Publisher: Elsevier BV
Date: 09-2009
Publisher: Oxford University Press (OUP)
Date: 31-01-2013
DOI: 10.1093/BRAIN/AWS348
Abstract: Mutations in the TPM2 gene, which encodes β-tropomyosin, are an established cause of several congenital skeletal myopathies and distal arthrogryposis. We have identified a TPM2 mutation, p.K7del, in five unrelated families with nemaline myopathy and a consistent distinctive clinical phenotype. Patients develop large joint contractures during childhood, followed by slowly progressive skeletal muscle weakness during adulthood. The TPM2 p.K7del mutation results in the loss of a highly conserved lysine residue near the N-terminus of β-tropomyosin, which is predicted to disrupt head-to-tail polymerization of tropomyosin. Recombinant K7del-β-tropomyosin incorporates poorly into sarcomeres in C2C12 myotubes and has a reduced affinity for actin. Two-dimensional gel electrophoresis of patient muscle and primary patient cultured myotubes showed that mutant protein is expressed but incorporates poorly into sarcomeres and likely accumulates in nemaline rods. In vitro studies using recombinant K7del-β-tropomyosin and force measurements from single dissected patient myofibres showed increased myofilament calcium sensitivity. Together these data indicate that p.K7del is a common recurrent TPM2 mutation associated with mild nemaline myopathy. The p.K7del mutation likely disrupts head-to-tail polymerization of tropomyosin, which impairs incorporation into sarcomeres and also affects the equilibrium of the troponin/tropomyosin-dependent calcium switch of muscle. Joint contractures may stem from chronic muscle hypercontraction due to increased myofibrillar calcium sensitivity while declining strength in adulthood likely arises from other mechanisms, such as myofibre decompensation and fatty infiltration. These results suggest that patients may benefit from therapies that reduce skeletal muscle calcium sensitivity, and we highlight late muscle decompensation as an important cause of morbidity.
Publisher: Elsevier BV
Date: 2009
Publisher: Elsevier BV
Date: 12-2008
Publisher: American Chemical Society (ACS)
Date: 20-01-2009
DOI: 10.1021/EF8007823
Publisher: Elsevier BV
Date: 2013
Publisher: Springer Science and Business Media LLC
Date: 08-07-2021
DOI: 10.1038/S41586-021-03767-X
Abstract: The genetic make-up of an in idual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases 3–7 . They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
Publisher: American Chemical Society (ACS)
Date: 31-08-2006
DOI: 10.1021/EF0600309
Publisher: American Chemical Society (ACS)
Date: 15-10-2009
DOI: 10.1021/EF900458R
Publisher: Cold Spring Harbor Laboratory
Date: 07-2023
DOI: 10.1101/2023.06.29.23292056
Abstract: Infections can lead to persistent or long-term symptoms and diseases such as shingles after varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal infections 1, 2 . Similarly, infection by SARS-CoV-2 can result in Long COVID, a condition characterized by symptoms of fatigue and pulmonary and cognitive dysfunction 3–5 . The biological mechanisms that contribute to the development of Long COVID remain to be clarified. We leveraged the COVID-19 Host Genetics Initiative 6, 7 to perform a genome-wide association study for Long COVID including up to 6,450 Long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We identified the first genome-wide significant association for Long COVID at the FOXP4 locus. FOXP4 has been previously associated with COVID-19 severity 6 , lung function 8 , and cancers 9 , suggesting a broader role for lung function in the pathophysiology of Long COVID. While we identify COVID-19 severity as a causal risk factor for Long COVID, the impact of the genetic risk factor located in the FOXP4 locus could not be solely explained by its association to severe COVID-19. Our findings further support the role of pulmonary dysfunction and COVID-19 severity in the development of Long COVID.
Publisher: Association for Computing Machinery (ACM)
Date: 17-02-2015
DOI: 10.1145/2700265
Abstract: We study the water quality in an urban district, where the surface wind distribution is an essential input but undergoes high spatial and temporal variations due to the impact of surrounding buildings. In this work, we develop an optimal sensor placement scheme to measure the wind distribution over a large urban reservoir using a limited number of wind sensors. Unlike existing solutions that assume Gaussian process of target phenomena, this study measures the wind that inherently exhibits strong non-Gaussian yearly distribution. By leveraging the local monsoon characteristics of wind, we segment a year into different monsoon seasons that follow a unique distribution respectively. We also use computational fluid dynamics to learn the spatial correlation of wind. The output of sensor placement is a set of the most informative locations to deploy the wind sensors, based on the readings of which we can accurately predict the wind over the entire reservoir in real time. Ten wind sensors are deployed. The in-field measurement results of more than 3 months suggest that the proposed sensor placement and spatial prediction scheme provides accurate wind measurement that outperforms the state-of-the-art Gaussian model based on interpolation-based approaches.
Publisher: Springer Science and Business Media LLC
Date: 21-06-2018
Publisher: Informa UK Limited
Date: 16-03-2005
Publisher: American Chemical Society (ACS)
Date: 19-04-2007
DOI: 10.1021/EF060546S
Publisher: Elsevier BV
Date: 10-2009
Publisher: SAE International
Date: 19-05-2003
DOI: 10.4271/2003-01-1853
Publisher: Elsevier BV
Date: 10-2007
Publisher: SAGE Publications
Date: 02-2008
Abstract: Combustion characteristics were analysed in a compression ignition engine fuelled with diesel—ethanol blends with and without a cetane number improver. The results show that, for the same brake mean effective pressure and engine speed, the maximum cylinder pressure P max , the ignition delay, the premixed combustion duration, and the fraction of heat release in premixed combustion phase will increase, while the diffusive combustion duration, the fraction of diffusive combustion phase, and the total combustion duration decrease with increase in the ethanol fraction in the blends. Meanwhile, the centre of the heat release curve moves close to the top dead centre, and the maximum rate (d Q b /d φ) max of heat release and the maximum rate (d p/d φ) max of pressure rise increase with increase in the ethanol fraction in the blends. The addition of a cetane number improver is beneficial to the decrease in the ignition delay, the cylinder peak pressure, the maximum rate of pressure rise, and the combustion noise when operating on diesel—ethanol blends.
Publisher: ACM
Date: 05-08-2011
Publisher: SAGE Publications
Date: 07-2009
DOI: 10.1243/09544070JAUTO1093
Abstract: The influences of dimethoxymethane (DMM content), exhaust gas recirculation (EGR) and post-processor on combustion and emission were studied experimentally, and the approaches to meet the Euro III regulation were discussed. Results showed that, for diesel blending fuel with 50 per cent DMM volume fraction, on setting the EGR rate at 28 per cent for low and medium loads and at 7 per cent at high loads, nitrogen oxide and soot emissions are both reduced markedly a diesel oxidation catalyst (DOC) reduces hydrocarbon and carbon monoxide emissions. Comparison of the combustion process with diesel fuel indicated that application of DMM—diesel blended fuel increases both premixed and diffusion combustion, leading to a higher peak pressure and a pressure rise. EGR does not lengthen the combustion duration significantly. A naturally aspirated diesel engine in the test fuelled with a high percentage of DMM component in the blend, together with EGR and DOC, makes it possible to meet the Euro III emission standard for a vehicle diesel engine.
Publisher: Elsevier BV
Date: 2009
Publisher: Hindawi Limited
Date: 24-11-2014
DOI: 10.1002/HUMU.22693
Publisher: American Chemical Society (ACS)
Date: 15-02-2008
DOI: 10.1021/EF700629J
Publisher: Elsevier BV
Date: 10-2007
Publisher: American Chemical Society (ACS)
Date: 17-07-2007
DOI: 10.1021/EF070140V
Publisher: Elsevier BV
Date: 09-2008
Publisher: Elsevier BV
Date: 12-2008
Publisher: Elsevier BV
Date: 07-2009
Publisher: Elsevier BV
Date: 09-2008
Publisher: Elsevier BV
Date: 05-2011
Publisher: Elsevier BV
Date: 26-02-2009
Publisher: Elsevier BV
Date: 11-2008
Publisher: SAGE Publications
Date: 12-02-2010
DOI: 10.1243/09544070JAUTO1326
Abstract: The effect of fuel constituents on the combustion and particle emission characteristics of a compression ignition engine fuelled with diesel—dimethoxymethane (DMM) blends is investigated experimentally. Four engine loads at the maximum torque engine speed of 1600r/min and rated engine speed of 2200r/min were carried out respectively. Three diesel—DMM blended fuels containing 15 vol %, 30 vol %, and 50 vol % DMM, corresponding to 6.35 mass %, 12.67 mass %, and 21.11 mass % oxygen in the blends were used. The study showed that the ignition delay experienced a slight increase while the rapid combustion duration and the total combustion duration decreased with increase in the DMM fraction in the fuel blends. The maximum cylinder pressure, the maximum rate of pressure rise, and the maximum rate of heat release increase with the addition of DMM to the blended fuels. Moreover, the smoke concentration decreases with increase in the oxygen mass fraction in the blends and the reduction rate reaches 80 per cent for 50 vol % DMM in the blend under a high engine load. The influence of DMM on the nanoparticulate distribution was also studied in the tests and it was found that the total number of nanosized particulates are all reduced with increase in the oxygen content in the blends.
Publisher: SAE International
Date: 08-03-2004
DOI: 10.4271/2004-01-0531
Publisher: Springer Science and Business Media LLC
Date: 28-01-2010
Publisher: Elsevier BV
Date: 04-2008
Publisher: American Chemical Society (ACS)
Date: 15-08-2007
DOI: 10.1021/EF0701586
Publisher: Springer Berlin Heidelberg
Date: 2013
Publisher: Elsevier BV
Date: 07-2008
Publisher: Elsevier BV
Date: 07-2008
Publisher: Elsevier BV
Date: 04-2014
Publisher: ASME International
Date: 21-03-2019
DOI: 10.1115/1.4042588
Abstract: This article presents a numerical study of particle deposition in two fluids, i.e., liquid and droplet flow in a single row tube bundle heat exchanger. The tubes in the heat exchanger are modeled as heating sources. Two level-set functions are used to capture the liquid-droplet interface and the liquid-deposit front. The effects of different parameters, including Damköhler number, thermal conductivity of the deposit, viscosity of the liquid, and the heating power of the tube on the flow and heat transfer, are investigated. The deposit profiles on the tube surface are analyzed. Comparison is made for the averaged Nusselt number for the case without and with deposition. It is found that the tube surface has a thicker deposit at the upstream facing side compared with that of the downstream facing side. Generally, the heat transfer rate reduces with the growth of the deposit. Under certain conditions, heat transfer can be increased because of the increase in fluid velocity due to blockage of the flow area by the deposit. The averaged Nusselt number oscillated temporally in response to the droplet movement across the tube. Generally, the temperature at the liquid-deposit front decreases with thicker deposit formed. The averaged Nusselt number along the liquid-deposit front increases to a critical value initially, and it starts to decrease with the growth of the deposit.
Publisher: IEEE
Date: 04-2014
Publisher: Elsevier BV
Date: 11-2009
Publisher: Elsevier BV
Date: 04-2009
Publisher: Elsevier BV
Date: 2009
Publisher: Hindawi Limited
Date: 12-1999
DOI: 10.1002/(SICI)1099-114X(199912)23:15<1359::AID-ER560>3.0.CO;2-7
Publisher: SAGE Publications
Date: 03-2000
Abstract: Combustion characteristics and hydrocarbon emissions in a spark ignition engine operating on oxygenated fuel blends are studied, and the mass fraction burned and engine hydrocarbon emissions are analysed. Calculation results, based on the recorded pressure diagram, show that the flame development and rapid burn angles of gasoline-ether blends generally decrease and the maximum cylinder pressure increases as compared with those of gasoline. The flame development angle and rapid burn angle decrease when the fraction of alcohol fuels in gasoline is small, whereas they increase when the fraction of alcohol fuels is large. The experimental results show that engine exhaust hydrocarbon emissions can be reduced by blending oxygenated fuels in gasoline rather than operating on neat gasoline. Operating on gasoline-ether blends rather than on gasoline-alcohol fuel blends and neat gasoline greatly reduces hydrocarbon emissions.
Publisher: American Chemical Society (ACS)
Date: 19-10-2006
DOI: 10.1021/EF060334V
Publisher: Elsevier BV
Date: 08-2009
No related grants have been discovered for Haiyan Miao.