ORCID Profile
0000-0002-8281-3210
Current Organisations
University of Insubria
,
IRCCS Humanitas Research Hospital
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Publisher: ISMA SYC INT
Date: 05-2021
DOI: 10.35808/IJEBA/714
Publisher: Elsevier BV
Date: 08-2013
DOI: 10.1016/J.CELL.2013.07.039
Abstract: The epidemic of heart failure has stimulated interest in understanding cardiac regeneration. Evidence has been reported supporting regeneration via transplantation of multiple cell types, as well as replication of postmitotic cardiomyocytes. In addition, the adult myocardium harbors endogenous c-kit(pos) cardiac stem cells (eCSCs), whose relevance for regeneration is controversial. Here, using different rodent models of diffuse myocardial damage causing acute heart failure, we show that eCSCs restore cardiac function by regenerating lost cardiomyocytes. Ablation of the eCSC abolishes regeneration and functional recovery. The regenerative process is completely restored by replacing the ablated eCSCs with the progeny of one eCSC. eCSCs recovered from the host and recloned retain their regenerative potential in vivo and in vitro. After regeneration, selective suicide of these exogenous CSCs and their progeny abolishes regeneration, severely impairing ventricular performance. These data show that c-kit(pos) eCSCs are necessary and sufficient for the regeneration and repair of myocardial damage.
Publisher: Zenodo
Date: 2022
Publisher: Human Resources Management Academic Research Society (HRMARS)
Date: 07-09-2023
Start Date: 2023
End Date: 2025
Funder: INTI International University and Colleges
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