ORCID Profile
0000-0002-5647-9212
Current Organisations
Noakhali Science and Technology University
,
University of Chittagong
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Publisher: Informa UK Limited
Date: 30-08-2022
Publisher: Springer Science and Business Media LLC
Date: 31-07-2021
DOI: 10.1186/S42269-021-00597-9
Abstract: Gastroenteritis is a common infectious disease in children, which results in high mortality and morbidity, especially in resource-poor countries. This study presents the selected main gastroenteritis causing bacteria, including Escherichia coli O157, Salmonella and Shigella species delineating their prevalence and resistance pattern to the clinically used antibiotics. A total of 346 stool specimens from children of clinically suspected gastroenteritis below five years have been obtained, and bacterial pathogens were recovered using selective media, biochemical and serologic tests. We found that 35 (10%) of them were confirmed bacterial gastroenteritis (BGE) with either Escherichia coli O157 (14%), Salmonella spp. (43%), and Shigella spp. (43%). Nevertheless, the prevalence of E. coli O157, Salmonella spp., and Shigella spp. in this study were documented as 1.45%, 4.34%, and 4.34%, respectively. Moreover, 2 (40%) of E. coli O157, 4 (26.67%) of Salmonella spp., and 14 (93%) of the Shigella spp. were found as multidrug-resistant. Nonetheless, Shigella spp. isolates showed 100%, 87%, and 73% resistance to cotrimoxazole, ciprofloxacin, and azithromycin respectively, while E. coli O157 showed 80% resistance to cotrimoxazole and 60% to ciprofloxacin and azithromycin. On the contrary, cotrimoxazole, ciprofloxacin, azithromycin, and tetracycline were resistant in 40%, 47%, 27%, and 53% of Salmonella spp. isolates respectively. These findings generate significant insights on the prevalence and antibiotic resistance of the three major gastroenteritis causing bacteria in the study area. Therefore, it will help physicians and policymakers selecting the right antibiotics in essential cases, particularly, reevaluation of recommending cotrimoxazole, ciprofloxacin, and azithromycin in the management of bacterial gastroenteritis.
Publisher: Wiley
Date: 24-09-2020
DOI: 10.1002/VMS3.360
Publisher: Wiley
Date: 09-07-2021
Abstract: The overexpression of heme oxygenase‐1 (HO‐1) contributes to the development of several types of cancers. The inhibition of HO‐1 through imidazole‐based drugs, which is non‐competitive with heme, is a focus of anticancer drug research. We designed the four following novel HO‐1 inhibiting compounds: 2‐(1‐cyclopentyl‐4‐(1H‐imidazol‐4‐yl)butan‐2‐yl)pyrazine ( M11 ), 2‐[(2‐chloro‐3‐methylcyclohexyl)methyl]‐1H‐imidazole ( M26 ), 2‐(2‐phenethyl‐1H‐imidazol‐4‐yl)ethanesulfonamide ( M28 ), and 5‐chloro‐2‐[2‐(2,5‐dihydro‐1H‐imidazol‐2‐yl)propan‐2‐yl]‐1H‐imidazole ( M31 ). All compounds showed a strong binding affinity with HO‐1 in molecular docking studies. The in silico absorption, distribution, metabolism, excretion and toxicity (ADMET) data showed that the compounds would be available orally in an acceptable manner. The bioactivity scores revealed that they were moderately active substances. They were found as non‐mutagen, non‐tumorigenic, non‐irritant, and non‐detrimental to the reproductive system. Finally, the drug‐likeness values of the compounds were obtained as −0.71, −1.64, −2.04, and 0.4 respectively, with the final drug‐score of 0.60, 0.54, 0.51, and 0.77 respectively.
Publisher: Springer Science and Business Media LLC
Date: 03-08-2021
DOI: 10.1186/S43088-021-00131-W
Abstract: Multiple antibiotic-resistant (MAR) Pseudomonas aeruginosa ( P. aeruginosa ) plays a significant role in triggering nosocomial infection in clinical settings. While P. aeruginosa isolated from the environment is often regarded as non-pathogenic, the progressive development of antibiotic resistance necessitates exploring the MAR patterns and transposable genetic elements like plasmid in the isolates . Using ecfX gene-based PCR, 32 P. aeruginosa isolates among 48 soil s les collected from the industrial region have been confirmed. The antibiotic susceptibility pattern of those isolates revealed that 5 (15.63%) of them were resistant to a range of antibiotics, and they were categorized as MAR isolates. Nevertheless, all MAR isolates were found resistant to piperacillin and gentamicin, but none of them to ceftazidime, aztreonam, and ciprofloxacin. Moreover, the isolates were also showed resistance to amikacin (60%), tobramycin (80%), netilmicin (80%), imipenem (60%), doripenem (40%), meropenem (60%), and cefixime (40%). Furthermore, 60% of MAR isolates possessed double plasmids of 1000–2000 bp sizes which indicates the distribution of antibiotic resistance genes in MAR P. aeruginosa might be correlated with the presence of those plasmids. The MAR index’s high threshold values ( 0.20) implied that the isolates were from high-risk environmental sites where the presence of numerous antibiotic residues happened. These findings highlighted the presence of multiple antibiotic resistance in P. aeruginosa of the industrial soil and a considerable prospect of transferring antibiotic resistance genes in the microbial community by plasmids. We recommend taking immediate stringent measures to prohibit the unnecessary and overuse of antibiotics in agricultural, industrial, or other purposes.
Publisher: Springer Science and Business Media LLC
Date: 04-05-2022
DOI: 10.1186/S43088-022-00245-9
Abstract: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. Mucor spp. and Rhizopus spp. were commonly known as black fungi, whereas Aspergillus spp. and Candida spp. were designated as white fungi implicated in those infections. In this review, we focused on the global outbreaks of fungal coinfection with SARS-CoV-2, the role of the human immune system, and a detailed understanding of those fungi to delineate the contribution of such coinfections in deteriorating the health conditions of COVID-19 patients based on current knowledge. Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the host cells and, consequently, cause severe fungal coinfections, including candidiasis and candidemia, mucormycosis, invasive pulmonary aspergillosis (IPA), and COVID-19-associated pulmonary aspergillosis (CAPA). Among them, mucormycosis and CAPA have been reported with a mortality rate of 66% in India and 60% in Colombia. Moreover, IPA has been reported in Belgium, Netherlands, France, and Germany with a morbidity rate of 20.6%, 19.6%, 33.3%, and 26%, respectively. Several antifungal drugs have been applied to combat fungal coinfection in COVID-19 patients, including Voriconazole, Isavuconazole, and Echinocandins. SARS-CoV-2 deteriorates the immune system so that several fungi could take that opportunity and cause life-threatening health situations. To reduce the mortality and morbidity of fungal coinfections, it needs immunity boosting, proper hygiene and sanitation, and appropriate medication based on the diagnosis.
Publisher: Springer Science and Business Media LLC
Date: 02-2022
Publisher: Journal of Applied Pharmaceutical Science
Date: 10-05-2021
Location: Bangladesh
No related grants have been discovered for Asma Talukder.