ORCID Profile
0000-0002-0118-1056
Current Organisation
Australian National University
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Publisher: Springer Science and Business Media LLC
Date: 04-07-2016
Publisher: Proceedings of the National Academy of Sciences
Date: 23-06-2015
Abstract: Apoptosis, a type of programmed cell death, is critical for the removal of diseased or superfluous cells and is essential in maintaining tissue homeostasis. At the molecular level, apoptosis leads to the highly coordinated selective proteolysis of more than a thousand cellular proteins. Until now, determining the in idual molecular consequence of proteolysis has been largely out of reach. Our article reports biotechnological advances that enable rapid and reliable posttranscriptional gene replacement for robust inducible and selective proteolysis of the replacement allele. We go on to further show the utility of our technology in deciphering synthetic lethality resulting from coordinated proteolysis of caspase substrates that control the apoptotic hallmark of chromatin fragmentation.
Publisher: Elsevier BV
Date: 10-2017
Publisher: Springer Science and Business Media LLC
Date: 26-02-2021
Publisher: Elsevier
Date: 2014
Publisher: Wiley
Date: 08-01-2009
Publisher: American Chemical Society (ACS)
Date: 22-03-2021
DOI: 10.1021/JACS.0C11958
Publisher: American Chemical Society (ACS)
Date: 06-05-2016
Location: United States of America
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Charles Morgan.