ORCID Profile
0000-0001-6961-9977
Current Organisations
The University of Auckland
,
Cawthron Institute
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Publisher: Wiley
Date: 15-06-2018
DOI: 10.1002/JCB.26754
Abstract: Breast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti‐neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR‐21 and miR‐155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC. MCF‐7 cells were tested with and without oleuropein and the cell viability, apoptosis, and migration were examined. The effect of oleuropein on miR‐21 and miR‐155 expression was assessed through qRT‐PCR. It was found that oleuropein induced apoptosis and retarded cell migration and invasion in a dose‐dependent manner in the human MCF7 BC cell line. It was observed that oleuropein significantly decreased expression of both miR‐21 and miR‐155 over time in a dose‐dependent manner. These results demonstrate that oleuropein is a potential therapeutic and preventive agent for BC. Oleuropein exhibits an anti‐cancer effect by modulation of tumor suppressor gene expression, which is targeted by oncomiRs.
Publisher: Elsevier BV
Date: 2015
Publisher: American Geophysical Union (AGU)
Date: 15-04-2001
DOI: 10.1029/1999JC000144
Publisher: American Geophysical Union (AGU)
Date: 11-2007
DOI: 10.1029/2006JC003764
Publisher: Acoustical Society of America (ASA)
Date: 10-2013
DOI: 10.1121/1.4818896
Abstract: Observations are presented of the vocal behavior and three dimensional (3D) underwater movements of sperm whales measured with a passive acoustic array off the coast of Kaikoura, New Zealand. Visual observations and vocal behaviors of whales were used to ide e tracks into different phases, and depths and movements of whales are reported for each of these phases. Diving depths and movement information from 75 3D tracks of whales in Kaikoura are compared to one and two dimensional tracks of whales studied in other oceans. While ing, whales in Kaikoura had a mean swimming speed of 1.57 m/s, and, on average, ed to a depth of 427 m (SD = 117 m), spending most of their time at depths between 300 and 600 m. Creak vocalizations, assumed to be the prey capture phase of echolocation, occurred throughout the water column from sea surface to sea floor, but most occurred at depths of 400–550 m. Three dimensional measurement of tracking revealed several different “foraging” strategies, including active chasing of prey, lining up slow-moving or unsuspecting prey, and foraging on demersal or benthic prey. These movements provide the first 3D descriptions underwater behavior of whales at Kaikoura.
Publisher: Elsevier BV
Date: 06-2013
Location: United States of America
No related grants have been discovered for Ross Vennell.