ORCID Profile
0000-0002-2330-3982
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Publisher: Herald Scholarly Open Access
Date: 03-09-2021
DOI: 10.24966/SRDT-2060/100077
Abstract: In this peculiar setting, the infiltrations with BMA proved to be an efficient alternative tool for the treatment of severe thoracic rib trauma and delayed union. The patient returned with no complaints and CT evidence indicated that all of the fractured ribs had complete consolidation. Pain and functional outcome of the chest wall in terms of stability improved with the help of this orthobiologic alternative.
Publisher: MDPI AG
Date: 09-03-2021
DOI: 10.3390/IJMS22052762
Abstract: The rise in musculoskeletal disorders has prompted medical experts to devise novel effective alternatives to treat complicated orthopedic conditions. The ever-expanding field of regenerative medicine has allowed researchers to appreciate the therapeutic value of bone marrow-derived biological products, such as the bone marrow aspirate (BMA) clot, a potent orthobiologic which has often been dismissed and regarded as a technical complication. Numerous in vitro and in vivo studies have contributed to the expansion of medical knowledge, revealing optimistic results concerning the application of autologous bone marrow towards various impactful disorders. The bone marrow accommodates a erse family of cell populations and a rich secretome therefore, autologous BMA-derived products such as the “BMA Matrix”, may represent a safe and viable approach, able to reduce the costs and some drawbacks linked to the expansion of bone marrow. BMA provides —it eliminates many hurdles associated with its preparation, especially in regards to regulatory compliance. The BMA Matrix represents a suitable alternative, indicated for the enhancement of tissue repair mechanisms by modulating inflammation and acting as a natural biological scaffold as well as a reservoir of cytokines and growth factors that support cell activity. Although promising, more clinical studies are warranted in order to further clarify the efficacy of this strategy.
Publisher: Elsevier BV
Date: 2019
Publisher: Dougmar Publishing Group, Inc.
Date: 05-12-2022
Abstract: Low back pain is a common symptom in patients with chronic musculoskeletal conditions, affecting several in iduals. In most cases, low back pain can often prove to be nonspecific or even multifactorial. Current treatment approach is based on surgical and noninvasive interventions, including pharmacological, psychological, physiotherapeutic, or complementary strategies. Extracorporeal shock wave therapy (ESWT) is a type of noninvasive mechanotherapy that has become popular in recent years due to its applicability in the treatment of various musculoskeletal disorders, especially in the lumbar spine of in iduals with osteopo-rosis, sacroiliitis, and even spinal cord disorders. The objective of this manuscript is to review the scientific evidence supporting the application of this therapy in the management of low back pain, and give a brief description of the treatment techniques used in clinical settings. The articles included in this descriptive review were selected from databases using the Google Scholar tool, from which a total of 13 applicable studies matching the topic were included. Despite the need for more clinical trials, shock waves have been applied in medical health for many years with satisfactory results. Its application in the treatment of lumbar spine disorders has been shown to be advantageous in the management of pathological progression, such as the natural wear and tear process of musculoskeletal structures. In this sense, shockwave therapy may represent a viable alternative for the treatment of lumbar spine disorders however, its therapeutic effects andmechanisms require further elucidation.
Publisher: Elsevier BV
Date: 10-2019
Publisher: MDPI AG
Date: 27-01-2022
DOI: 10.3390/IJMS23031494
Abstract: Some say that all diseases begin in the gut. Interestingly, this concept is actually quite old, since it is attributed to the Ancient Greek physician Hippocrates, who proposed the hypothesis nearly 2500 years ago. The continuous breakthroughs in modern medicine have transformed our classic understanding of the gastrointestinal tract (GIT) and human health. Although the gut microbiota (GMB) has proven to be a core component of human health under standard metabolic conditions, there is now also a strong link connecting the composition and function of the GMB to the development of numerous diseases, especially the ones of musculoskeletal nature. The symbiotic microbes that reside in the gastrointestinal tract are very sensitive to biochemical stimuli and may respond in many different ways depending on the nature of these biological signals. Certain variables such as nutrition and physical modulation can either enhance or disrupt the equilibrium between the various species of gut microbes. In fact, fat-rich diets can cause dysbiosis, which decreases the number of protective bacteria and compromises the integrity of the epithelial barrier in the GIT. Overgrowth of pathogenic microbes then release higher quantities of toxic metabolites into the circulatory system, especially the pro-inflammatory cytokines detected in osteoarthritis (OA), thereby promoting inflammation and the initiation of many disease processes throughout the body. Although many studies link OA with GMB perturbations, further research is still needed.
Publisher: Innovative Journal
Date: 03-02-2021
Publisher: Elsevier BV
Date: 10-2019
Publisher: Elsevier BV
Date: 04-2021
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 08-2021
DOI: 10.1016/J.CYTO.2021.155560
Abstract: Orthobiologics continue to gain popularity in many areas of medical science, especially in the field of regenerative medicine. Platelet-rich plasma derivatives are orthobiologic tools of particular interest. These biologic products can be obtained via centrifugation of a patient's whole blood and the components can then be subsequently isolated, concentrated and ultimately administered into injured tissues, particularly in areas where standard healing is disrupted. The elevated concentration of platelets above the basal value enables accelerated growth of various tissues with minimal side effects. The application of autologous orthobiologics is a relatively new biotechnology undergoing expansion which continues to reveal optimistic results in the stimulation and enhanced healing of various sorts of tissue injuries. The local release of growth factors and cytokines contained in platelet alpha granules accelerates and ameliorates tissue repair processes, mimicking and supporting standard wound healing. This effect is greatly enhanced upon combination with the fibrinolytic system, which are essential for complete regeneration. Fibrinolytic reactions can dictate proper cellular recruitment of certain cell populations such as mesenchymal stem cells and other immunomodulatory agents. Additionally, these reactions also control proteolytic activity in areas of wound healing and regenerative processes of mesodermal tissues including bone, cartilage, and muscle, which makes it particularly valuable for musculoskeletal health, for instance. Although many investigations have demonstrated significant results with platelet-rich plasma derivatives, further studies are still warranted.
Publisher: Elsevier BV
Date: 05-2020
Publisher: Elsevier BV
Date: 12-2021
Publisher: Baishideng Publishing Group Inc.
Date: 26-04-2020
Publisher: Elsevier BV
Date: 10-2020
Publisher: Gratis Open Access Publishers LLC
Date: 05-10-2018
Abstract: This literature review explores recent and past investigations carried out by researchers in various settings pertaining to the orthopaedic field of medicine, in attempts to show a possible connection between the deficit in sex hormone levels and the potential consequences it brings about on orthopaedic health, namely, osteoarthritis. There is some evidence in the literature suggesting that suboptimal concentrations of steroid hormones can negatively impact bone health, making it more susceptible to physical injury, especially when the hormone in question is estrogen. Several studies have shown that this biomolecule is quite essential to human health due to its effects on not only sexual development and function but also on bone metabolism, in both men and women. Investigations revolving around estrogenic compounds reveal their significance in physical capacitation of adult in iduals, since it has already been found that estrogens play a pivotal role on bone maintenance by directly interacting with osteocytes, osteoblasts, osteoclasts and even T-cells, to name a few ex les. Large scale studies also bring up plausible evidence by evaluating the links between measured sex steroid concentrations and incidence of osteoarthritic joint replacement in adults. Taking that into consideration, there is sufficient motivation to look into hormonal fluctuation in adult in iduals, calling for suitable medical intervention in order to keep a patient’s health under control, avoiding and even treating the detrimental effects caused by the deficiency of certain steroid hormones.
Location: Brazil
No related grants have been discovered for José Fábio Santos Duarte Lana.