ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0002-5775-8256

Current Organisations
Jamia Millia Islamia , Jamia Hamdard , Apeejay Stya University , University of Texas Rio Grande Valley , Jamia Hamdard Faculty of Pharmacy , Indian Institute of Technology Delhi

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.

Publications

Publication

Nanotechnological based miRNA intervention in the therapeutic management of neuroblastoma

Publisher: Elsevier BV

Date: 02-2021

DOI: 10.1016/J.SEMCANCER.2019.09.017

Abstract: Neuroblastoma (NB) is a widely diagnosed cancer in children, characterized by lification of the gene encoding the MYCN transcription factor, which is highly predictive of poor clinical outcome and metastatic disease. microRNAs (a class of small non-coding RNAs) are regulated by MYCN transcription factor in neuroblastoma cells. The current research is focussed on identifying differential role of miRNAs and their interactions with signalling proteins, which are intricately linked with cellular processes like apoptosis, proliferation or metastasis. However, the therapeutic success of miRNAs is limited by pharmaco-technical issues which are well counteracted by nanotechnological advancements. The nanoformulated miRNAs unload anti-cancer drugs in a controlled and prespecified manner at target sites, to influence the activity of target protein in amelioration of NB. Recent advances and developments in the field of miRNAs-based systems for clinical management of NBs and the role of nanotechnology to overcome challenges with drug delivery of miRNAs have been reviewed in this paper.