ORCID Profile
0000-0002-3490-0037
Current Organisations
University of Applied Sciences Utrecht
,
University of Iowa Healthcare
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Publisher: SPIE
Date: 13-03-2014
DOI: 10.1117/12.2043203
Publisher: Public Library of Science (PLoS)
Date: 10-2015
Publisher: The Optical Society
Date: 11-2013
DOI: 10.1364/BOE.4.002712
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 24-05-2013
Publisher: SPIE
Date: 23-02-2012
DOI: 10.1117/12.911491
Publisher: The Optical Society
Date: 27-07-2011
DOI: 10.1364/BOE.2.002403
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 25-09-2012
Publisher: Cambridge University Press (CUP)
Date: 2016
DOI: 10.1017/S0952523816000067
Abstract: Studies into the mechanisms underlying the active emmetropization process by which neonatal refractive errors are corrected, have described rapid, compensatory changes in the thickness of the choroidal layer in response to imposed optical defocus. While high frequency A-scan ultrasonography, as traditionally used to characterize such changes, offers good resolution of central (on-axis) changes, evidence of local retinal control mechanisms make it imperative that more peripheral, off-axis changes also be tracked. In this study, we used in vivo high resolution spectral domain-optical coherence tomography (SD-OCT) imaging in combination with the Iowa Reference Algorithms for 3-dimensional segmentation, to more fully characterize these changes, both spatially and temporally, in young, 7-day old chicks ( n = 15), which were fitted with monocular +15 D defocusing lenses to induce choroidal thickening. With these tools, we were also able to localize the retinal area centralis, which was used as a landmark along with the ocular pectin in standardizing the location of scans and aligning them for subsequent analyses of choroidal thickness (CT) changes across time and between eyes. Values were derived for each of four quadrants, centered on the area centralis, and global CT values were also derived for all eyes. Data were compared with on-axis changes measured using ultrasonography. There were significant on-axis choroidal thickening that was detected after just one day of lens wear (∼190 µ m), and regional (quadrant-related) differences in choroidal responses were also found, as well as global thickness changes 1 day after treatment. The ratio of global to on-axis choroidal thicknesses, used as an index of regional variability in responses, was also found to change significantly, reflecting the significant central changes. In summary, we demonstrated in vivo high resolution SD-OCT imaging, used in combination with segmentation algorithms, to be a viable and informative approach for characterizing regional (spatial), time-sensitive changes in CT in small animals such as the chick.
Publisher: SPIE
Date: 04-03-2010
DOI: 10.1117/12.843928
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 11-2010
DOI: 10.1167/IOVS.10-5527
No related grants have been discovered for Michael Abramoff.