ORCID Profile
0000-0003-2956-4857
Current Organisation
University of Cambridge
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Publisher: Wiley
Date: 19-09-2023
Abstract: Image contrast is often limited by background autofluorescence in steady‐state bioimaging microscopy. Upconversion bioimaging can overcome this by shifting the emission lifetime and wavelength beyond the autofluorescence window. Here we demonstrate the first ex le of triplet‐triplet annihilation upconversion (TTA‐UC) based lifetime imaging microscopy. A new class of ultra‐small nanoparticle (NP) probes based on TTA‐UC chromophores encapsulated in an organic‐inorganic host has been synthesized. The NPs exhibit bright UC emission (400‐500 nm) in aerated aqueous media with a UC lifetime of ~1 μs, excellent colloidal stability and little cytotoxicity. Proof‐of‐concept demonstration of TTA‐UC lifetime imaging using these NPs shows that the long‐lived anti‐Stokes emission is easily discriminable from typical autofluorescence. Moreover, fluctuations in the UC lifetime can be used to map local oxygen diffusion across the subcellular structure. Our TTA‐UC NPs are highly promising stains for lifetime imaging microscopy, affording excellent image contrast and potential for oxygen mapping that is ripe for further exploitation.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0TA11229A
Abstract: MOF crystal-glass composites (MOF CGCs) are materials with crystalline MOFs embedded within a MOF glass. Here we develop two novel MOF CGCs, and explore the gas uptake and guest-size limitations within these materials.
Publisher: Elsevier BV
Date: 2022
Publisher: Wiley
Date: 19-09-2023
Abstract: Image contrast is often limited by background autofluorescence in steady‐state bioimaging microscopy. Upconversion bioimaging can overcome this by shifting the emission lifetime and wavelength beyond the autofluorescence window. Here we demonstrate the first ex le of triplet‐triplet annihilation upconversion (TTA‐UC) based lifetime imaging microscopy. A new class of ultra‐small nanoparticle (NP) probes based on TTA‐UC chromophores encapsulated in an organic‐inorganic host has been synthesized. The NPs exhibit bright UC emission (400‐500 nm) in aerated aqueous media with a UC lifetime of ~1 μs, excellent colloidal stability and little cytotoxicity. Proof‐of‐concept demonstration of TTA‐UC lifetime imaging using these NPs shows that the long‐lived anti‐Stokes emission is easily discriminable from typical autofluorescence. Moreover, fluctuations in the UC lifetime can be used to map local oxygen diffusion across the subcellular structure. Our TTA‐UC NPs are highly promising stains for lifetime imaging microscopy, affording excellent image contrast and potential for oxygen mapping that is ripe for further exploitation.
Publisher: American Chemical Society (ACS)
Date: 04-06-2021
Publisher: Wiley
Date: 09-06-2022
Abstract: Luminescent solar concentrators (LSCs) are an emerging technology to collect and channel light from a large absorption area into a smaller one. They are a complementary technology for traditional solar photovoltaics (PV), particularly suitable for application in urban or indoor environments where their custom colors and form factors, and performance under diffuse light conditions may be advantageous. Förster resonance energy transfer (FRET) has emerged as a valuable approach to overcome some of the intrinsic limitations of conventional single lumophore LSCs, such as reabsorption or reduced quantum efficiency. This review outlines the potential of FRET to boost LSC performance, using highlights from the literature to illustrate the key criteria that must be considered when designing an FRET‐LSC, including both the photophysical requirements of the FRET lumophores and their interaction with the host material. Based on these criteria, a list of design guidelines intended to aid researchers when they approach the design of a new FRET‐LSC system is presented. By highlighting the unanswered questions in this field, the authors aim to demonstrate the potential of FRET‐LSCs for both conventional solar‐harvesting and emerging LSC‐inspired technologies and hope to encourage participation from a erse researcher base to address this exciting challenge.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Rachel Evans.