ORCID Profile
0000-0002-6336-5571
Current Organisation
Universidad Austral de Chile
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Publisher: Wiley
Date: 04-11-2018
DOI: 10.1111/DMCN.14036
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2017
Publisher: Wiley
Date: 05-05-2017
DOI: 10.1111/OBR.12548
Abstract: Skeletal muscle extracellular matrix remodelling has been proposed as a new feature associated with obesity and metabolic dysfunction. Exercise training improves muscle function in obesity, which may be mediated by regulatory effects on the muscle extracellular matrix. This review examined available literature on skeletal muscle extracellular matrix remodelling during obesity and the effects of exercise. A non-systematic literature review was performed on PubMed of publications from 1970 to 2015. A total of 37 studies from humans and animals were retained. Studies reported overall increases in gene and protein expression of different types of collagen, growth factors and enzymatic regulators of the skeletal muscle extracellular matrix in obesity. Only two studies investigated the effects of exercise on skeletal muscle extracellular matrix during obesity, with both suggesting a regulatory effect of exercise. The effects of exercise on muscle extracellular matrix seem to be influenced by the duration and type of exercise training with variable effects from a single session compared with a longer duration of exercise. More studies are needed to elucidate the mechanisms behind skeletal muscle extracellular matrix remodelling during obesity and the effects of exercise.
Publisher: Elsevier BV
Date: 05-2021
Publisher: Wiley
Date: 10-2018
DOI: 10.14814/PHY2.13848
Publisher: Elsevier BV
Date: 10-2015
Publisher: SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
Date: 06-2013
Publisher: Springer Science and Business Media LLC
Date: 20-09-2017
Publisher: Elsevier BV
Date: 07-2018
Publisher: Colegio Mayor de Nuestra Senora del Rosario
Date: 13-09-2016
Publisher: FapUNIFESP (SciELO)
Date: 2021
DOI: 10.1590/1809-2950/20009228032021
Abstract: ABSTRACT The six-minute walk test (6MWT) is widely used to measure functional capacity in special populations. However, the factors associated with its performance in candidates for bariatric surgery are unclear. Therefore, this study aimed to investigate the influence of anthropometric and physiological factors in the 6MWT performance in bariatric surgery candidates. This cross-sectional study included 107 candidates for bariatric surgery. Anthropometric factors considered: gender, weight, height, body mass index (BMI), waist-to-hip, and waist-to-height ratios. Along with distance covered during 6MWT, physiological factors such as ratings of perceived exertion (RPE) and heart rate reserve percentage used (%HRR) were recorded. Among the 107 patients (mean age: 39.6 years), 83 volunteers were accepted to perform the 6MWT. No gender differences were observed in terms of distance covered, %HRR, and RPE during the 6MWT. Moreover, BMI and %HRR explained 21% of the 6MWT distance covered. Furthermore, participants with BMI ≤41.5 kg/m2 walked ~50 meters more than their peers above this level (p=0.05). Interestingly, heart rate increase during the 6MWT was lower than described for healthy populations. BMI and %HRR partially explain the variability of the 6MWT performance in bariatric surgery candidates.
Publisher: Elsevier BV
Date: 07-2014
Publisher: Elsevier BV
Date: 11-2020
Publisher: American Diabetes Association
Date: 09-07-2020
DOI: 10.2337/DC20-0342
Abstract: To study the effect of 12 weeks of high-intensity interval training (HIIT) on glycemic control in adults with type 1 diabetes and overweight or obesity. Thirty inactive adults with type 1 diabetes who had BMI ≥25 kg/m2 and HbA1c ≥7.5% were randomized to 12 weeks of either HIIT exercise intervention consisting of 4 × 4-min HIIT (85–95% peak heart rate) performed thrice weekly or usual care control. In a partial crossover design, the control group subsequently performed the 12-week HIIT intervention. The primary end point was the change in HbA1c from baseline to 12 weeks. Glycemic and cardiometabolic outcomes were measured at 0, 12, and 24 weeks. Participants were aged 44 ± 10 years with diabetes duration 19 ± 11 years and BMI 30.1 ± 3.1 kg/m2. HbA1c decreased from 8.63 ± 0.66% at baseline to 8.10 ± 1.04% at 12 weeks in the HIIT intervention group (P = 0.01) however, this change was not significantly different from the control group (HIIT −0.53 ± 0.61%, control −0.14 ± 0.48%, P = 0.08). In participants who undertook at least 50% of the prescribed HIIT intervention, the HbA1c reduction was significantly greater than control (HIIT −0.64 ± 0.64% [n = 9], control −0.14 ± 0.48% [n = 15], P = 0.04). There were no differences in insulin dose, hypoglycemia on continuous glucose monitoring, blood pressure, blood lipids, body weight, or body composition between groups. Overall, there was no significant reduction in HbA1c with a 12-week HIIT intervention in adults with type 1 diabetes. However, glycemic control may improve for people who undertake HIIT with greater adherence.
Publisher: SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
Date: 09-2013
Publisher: Frontiers Media SA
Date: 25-04-2019
Publisher: American Society of Neuroradiology (ASNR)
Date: 17-05-2018
DOI: 10.3174/AJNR.A5679
Publisher: Elsevier BV
Date: 2020
DOI: 10.1016/J.METABOL.2019.154008
Abstract: Recent scientific efforts have focused on the detrimental effects that obesity has on the metabolic function of skeletal muscles and whether exercise can improve this dysfunction. In this regard, adiponectin, with important metabolic functions (e.g. insulin-sensitizer and anti-inflammatory), has been recently described as a myokine that acts in an autocrine aracrine manner. Earlier studies reported that muscle adiponectin could be induced by pro-inflammatory mediators (e.g. lipopolysaccharide), cytokines, and high-fat diets, providing a protective mechanism of this tissue against metabolic insults. However, when metabolic insults such as high-fat diets are sustained this protective response becomes dysregulated, making the skeletal muscle susceptible to metabolic impairments. Recent studies have suggested that exercise could prevent or even reverse this process. Considering that most scientific knowledge on adiponectin dysregulation in obesity is from the study of adipose tissue, the present review summarizes and discusses the literature available to date regarding the effects of obesity on skeletal muscle adiponectin induction, along with the potential effects of different exercise prescriptions on this response in an obesity context.
Publisher: Wiley
Date: 02-2018
DOI: 10.14814/PHY2.13599
Publisher: Instituto Nacional de Salud (Colombia)
Date: 06-02-2015
Publisher: FapUNIFESP (SciELO)
Date: 12-2013
DOI: 10.1590/S0004-27302013000900008
Abstract: OBJETIVOS: Comparar o equilíbrio estático em pacientes com diabetes melito tipo 2 (DM2) com ou sem polineuropatia diabética (PND) e correlacionar os escores da escala de Exame da Neuropatia Diabética (EDN) com a média da relação do centro de pressão (CoP). SUJEITOS E MÉTODOS: Vinte pacientes, com idades entre 40 e 54 anos, que apresentavam DM2 e classificados, de acordo com a escala EDN, em grupos com (n = 10) e sem (n = 10) PDN foram comparados. O equilíbrio estático foi avaliado segundo a média da relação do CoP em um Wii Balance Board® na condição com os olhos abertos e os olhos fechados. Depois da verificação da normalidade (Shapiro-Wilk), o equilíbrio entre os dois grupos foi comparado por meio dos testes t de Student e U de Mann-Whitney, como aplicável. O escore na EDN foi correlacionado com a média da relação do CoP no grupo com PND, considerando um nível de significância de p 0,05. RESULTADOS: Diferenças significativas (p = 0,049) foram observadas nas condições de olhos fechados, com uma maior média da relação do CoP no grupo com PND (0,548 cm vs. 0,442 cm). O grupo com PND mostrou uma tendência (p = 0,059) para maior média da relação do CoP na condição com os olhos abertos (0,351 cm vs. 0,239 cm). Foi observada uma forte correlação (r = 0,751) entre o escore EDN e a média da relação do CoP na condição com os olhos fechados (p = 0,012). CONCLUSÕES: Os pacientes com PND demonstraram pior equilíbrio estático do que os pacientes sem PND na condição com os olhos fechados. Além disso, quanto maior o escore no EDN, mais forte o deslocamento do CoP, o que pode estar associado com maior risco de quedas.
Publisher: American Diabetes Association
Date: 07-2018
DOI: 10.2337/DB18-746-P
Abstract: Obesity associates highly with metabolic disorders including insulin resistance. To determine if two exercise prescriptions exert differential metabolic benefits in insulin sensitive tissues, we compared isocaloric programs of constant-moderate endurance (END) and high intensity interval training (HIIT), in a mouse model of diet-induced obesity. Male 10 week old C57BL/6 mice were fed a high fat diet (HFD 45% kcal fat) ab libitum for 10 weeks, achieving 25% excess weight, and for a further 10 weeks they then underwent isocaloric END or HIIT (3x40min sessions/week). Untrained HFD and chow-fed mice acted as controls. At 30 weeks of age, mice were sacrificed and quadriceps muscle, subcutaneous adipose tissue (SAT) and liver were excised. Neither END or HIIT altered the body weight or the fat/lean mass proportion in HFD mice. An insulin tolerance test (0.65 IU/kg*BW) showed HIIT but not END improved insulin sensitivity in HFD mice (p& .vs. untrained). In quadricep, HFD induced down-regulation of high-molecular weight adiponectin protein, which was similarly normalized by END and HIIT. In contrast HIIT but not END reversed the HFD-driven downregulation of adiponectin receptor 1 (AdipoR1 p& .05). In SAT, both programs tended to decrease collagen VI protein (p=0.08), whereas only HIIT induced an upregulation in mRNA (3-fold vs. HFD untrained) and protein (2-fold vs. HFD untrained) of UCP1. In liver, only END was able to reverse the collagen I accumulation (2-fold p& .05) and downregulation of CTGF (0.5-fold protein) seen in HFD untrained mice (p& .05). Our results suggest that HIIT may promote better systemic metabolic effects, compared to END during high-fat fed conditions, which could be explained by the normalization of muscle AdipoR1 and higher UCP1 induction in SAT. However, END was more effective in normalizing liver changes, suggesting differential metabolic effects of END and HIIT during obesity. S.F. Martinez-Huenchullan: None. L.A. Ban: None. L.F. Olaya: None. B.R. Maharjan: None. C. Tam: None. S. McLennan: None. S.M. Twigg: Advisory Panel Self Abbott. Consultant Self Abbott. Advisory Panel Self Novo Nordisk Inc., Sanofi-Aventis, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company. Speaker's Bureau Self AstraZeneca, Merck Sharp & Dohme Corp.. Other Relationship Self Abbott.
Publisher: Elsevier BV
Date: 11-2015
DOI: 10.1016/J.REGG.2015.03.004
Abstract: It has recently been proposed that there is a close relationship between oxidative stress and low-grade chronic inflammation. Both processes have been related separately to muscle function in older adults (OA). Nevertheless, it still has not been determined if this relationship is present particularly in OA. The objective of this study was to determine the relationship between the plasma levels of TNF-α and carbonyl proteins (CP) and muscle strength in a group of young and older women. An exploratory study was conducted on 13 older and 8 young women, in whom the plasma levels of CP and TNF-α were measured. Muscle strength was measured by handgrip test, quadriceps voluntary maximal isometric strength, arm curl, and the 30 second sit to stand test. There were no differences in the plasma levels of CP and TNF-α between the groups, but there was relationship between the biomarkers only in the OA group. A non-linear relationship was observed between CP and quadriceps voluntary maximal isometric strength only in the OA group (R(2)=36.2 P=.038). For TNF-α there were no significant association with any of the applied tests. There is an association between CP and quadriceps voluntary maximal isometric strength only in the OA group, which could indicate a deleterious action of oxidative stress on muscle function, particularly in aging.
Publisher: Elsevier BV
Date: 10-2021
Publisher: American Diabetes Association
Date: 07-2018
DOI: 10.2337/DB18-1923-P
Abstract: Whether obesity and diabetes (DM) similarly affect composition and function of skeletal muscle extracellular matrix (ECM) has not been resolved. This study examines the effects of long term high fat diet (HFD) and DM on rodent skeletal muscle ECM were addressed. Five week old C57BL/6 male mice were randomly allocated to standard chow (control n=26) or HFD (45% kcal fat n=25). After 15 weeks chow and HFD mice were rendered diabetic (by low dose STZ, 65mg/kgx3d, I.P.) (DM, n=14 HFD+DM, n=14) nondiabetic mice acted as controls. Mice were euthanased after 30 weeks and plasma and quadriceps muscle were collected for analysis. Body weight and plasma insulin expectedly decreased with DM induction and increased with HFD (all p& .05). High glucose occurred only in DM mice (∼14 mM p& .05), whereas only HFD increased muscle triglyceride (p& .05). Both conditions induced a decrease in quadriceps weight and in grip strength performance (p& .05). Quadriceps of DM mice showed increased CTGF/CCN2 (1.5-fold p& .05), TIMP-1 (2-fold p& .05), collagen-I (3-fold p& .05), -IV (2-fold p& .05), and -VI (2-fold p& .05) protein. In contrast, HFD induced a downregulation of CTGF/CCN2 (0.6-fold p& .05), MMP-1 (0.6-fold p& .05), and TIMP-2 (0.4-fold p& .05). In DM mice quadriceps centralized nuclei (p& .05) and caspase 3 (protein 1.5-fold p& .05) were increased, whereas caspase 3 was decreased in HFD (0.5-fold p& .05). Moreover, HFD induced a downregulation of ubiquitin ligase atrogin-1 protein (0.5-fold p& .05) and mRNA levels of serine/threonine kinase p70S6k (0.75-fold p& .05). Notably, no greater dysregulation of the muscle changes observed with DM alone or with HFD alone, was seen in HFD+DM mice. These data suggest that DM and HFD differentially affect skeletal muscle ECM: DM promotes a pro-fibrotic profile with signs of muscle damage, and HFD impairs regulatory protein turnover pathways, each inducing muscle dysfunction. S.F. Martinez-Huenchullan: None. L.A. Ban: None. A. Tao: None. S.S. Sutanto: None. C. Tam: None. S. McLennan: None. S.M. Twigg: Advisory Panel Self Abbott. Consultant Self Abbott. Advisory Panel Self Novo Nordisk Inc., Sanofi-Aventis, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company. Speaker's Bureau Self AstraZeneca, Merck Sharp & Dohme Corp.. Other Relationship Self Abbott.
Publisher: Elsevier BV
Date: 04-2022
DOI: 10.1016/J.METABOL.2022.155137
Abstract: Fibroblast growth factor 21 (FGF21) has been suggested to improve metabolism during aerobic exercise in obesity. However, the variability of exercise interventions gives rise to discrepancies in the field. Therefore, we aimed to systematically review the available literature regarding the effects of aerobic exercise on FGF21 in the context of overweight and obesity. Our search included original articles published between 2009 and November 2021 found in PubMed, Science Direct, and Medline. Clinical and preclinical studies were included. Studies, where subjects or animals presented with other conditions (e.g., cancer, stroke), were excluded. From an initial 43 studies, 19 (clinical studies = 9 preclinical studies = 10) were eligible for inclusion in this review. The main findings were that acute exercise tended to increase circulatory levels of FGF21. In contrast, chronic exercise programs (≥4 weeks) had the opposite effect along with inducing mRNA and protein increases of FGF receptors and β-klotho in adipose tissue, liver, and skeletal muscle. In conclusion, both clinical and preclinical studies showed that aerobic exercise exerts changes in circulatory and tissue FGF21, along with its receptors and co-receptor. Future research is needed to elucidate the mechanisms, along with the physiological and clinical implications of these changes.
Publisher: Wiley
Date: 06-2017
DOI: 10.1113/EP086328
Publisher: Elsevier BV
Date: 2021
Publisher: Wiley
Date: 08-2021
DOI: 10.14814/PHY2.14929
Publisher: Universidad Catolica del Maule
Date: 2022
DOI: 10.29035/RCAF.23.2.8
Abstract: Objetivos: la valoración de la tolerancia al ejercicio es clave para prescribir ejercicio en candidatos a cirugía bariátrica. El test de lanzadera (TL) se ha propuesto para este objetivo. Sin embargo, la evidencia que describe el rendimiento y respuesta fisiológica asociados a esta prueba en dicha población es escasa. El objetivo de este estudio fue describir la respuesta fisiológica a la realización del TL en candidatos a cirugía bariátrica. Métodos: este estudio transversal incluyó a 56 participantes. Se midieron factores antropométricos como la edad, peso, estatura y circunferencia de cintura, así como el nivel de actividad física espontáneo. Se valoró el rendimiento en el TL en metros, la respuesta fisiológica asociada en términos de frecuencia cardiaca de reserva (FCR) utilizada, presión arterial sistólica y diastólica, oximetría de pulso, sensación subjetiva al esfuerzo (SSE) y de fatiga de extremidades inferiores, antes y después del TL. Resultados: todos los participantes completaron la prueba sin complicaciones. Caminaron una mediana de 465 metros, equivalente al 61% de la distancia esperada. Utilizaron un 56% de la FCR, mientras que la SSE y fatiga de extremidades inferiores alcanzó valores 7/10 y 6/10 respectivamente. Fueron observadas asociaciones significativas entre el rendimiento en el TL vs factores antropométricos e indicadores de respuesta fisiológica. Conclusión: el TL es una prueba segura para valorar la tolerancia al esfuerzo en candidatos a cirugía bariátrica, la cual induce respuestas fisiológicas asociadas a intensidades moderadas. Se sugiere incluir esta prueba para la valoración de la condición física de estos sujetos.
Publisher: Elsevier BV
Date: 03-2021
Publisher: Federacion Espanola de Asociaciones de Docentes de Educacion Fisica (FEADEF)
Date: 02-2022
DOI: 10.47197/RETOS.V44I0.91770
Abstract: Background: Hyperglycaemia induces dysregulations in skeletal muscle mass and function. Myostatin (Mstn) and follistatin (Fs) are two key regulators of muscle mass, which are known to be dysregulated in people with hyperglycaemia. Exercise is frequently prescribed to counteract these changes however, the influence of exercise intensity is unknown. The purpose of this study was to compare two training programs, moderate-intensity constant (MICT) and high-intensity interval training (HIIT), on soleus mRNA levels of Mstn and Fs in an animal model of hyperglycaemia. Material and Methods: 36 male Wistar rats, were ided into control (n=18) and hyperglycaemic (HG, n=18 induced by a single intraperitoneal dose of Streptozotocin) groups. Subsequently, these groups were randomly sub ided into control untrained, control+moderate-intensity constant training (MICT), control+high-intensity interval training (HIIT), HG untrained, HG+MICT, and HG+HIIT (n=6 each subgroup). Training programs were performed for 8 weeks, with a frequency of 5 sessions per week. The total distance covered per session in MICT and HIIT was equal. 48 hours following the last training session, rats were anesthetized and soleus muscles were excised. Results: HIIT reduced and increased significantly the Mstn and Fs mRNA levels respectively, irrespective of hyperglycaemia (p .05). When Mstn:Fs ratio was analysed, only HIIT induced a significant increase in hyperglycaemic rats (p .05). Conclusion: HIIT over MICT, changed the Mstn and Fs soleus mRNA levels, irrespective of hyperglycaemia. This could indicate that the regulation of these genes is exercise intensity-dependent, whereas hyperglycaemia seems to not blunt this response. Resumen. Antecedentes: La hiperglicemia induce alteraciones en la masa y fuerza del músculo esquelético. La miostatina (Mstn) y folistatina (Fs) son reguladores de masa muscular, los cuales son alterados por hiperglicemia. El ejercicio es utilizado para neutralizar estos cambios sin embargo, la influencia de la intensidad del mismo no está aclarada. Este estudio comparó dos programas de ejercicio, intensidad moderada y constante (MICT) e interválico de alta intensidad (HIIT), sobre los niveles de ARN mensajero (ARNm) muscular de Mstn y Fs en ratas hiperglicémicas. Material y Métodos: 36 ratas Wistar fueron ididas en controles (n=18) y con hiperglicemia (HG, n=18 inducida con Streptozotocina intraperitoneal). Además, estos grupos fueron sub ididos aleatoriamente en: control no-entrenado, control+entrenamiento moderado constante (MICT), control+entrenamiento interválico de alta intensidad (HIIT), HG no-entrados, HG+MICT y HG+HIIT (cada subgrupo n=6). El entrenamiento duró 8 semanas, con 5 sesiones por semana. La distancia total recorrida por sesión en cada programa de entrenamiento fue igual. 48 horas posterior a la última sesión, las ratas fueron anestesiadas y los músculos sóleos fueron extraídos. Resultados: El entrenamiento HIIT redujo e incrementó significativamente los niveles de Mstn y Fs respectivamente, independiente de la presencia de hiperglicemia (p .05). Además, la razón Mstn:Fs se incrementó significativamente sólo en el grupo de ratas hiperglicémicas entrenadas con HIIT (p .05). Conclusión: El entrenamiento HIIT, no MICT, cambió los niveles de ARNm de Mstn y Fs en el músculo sóleo, independiente de la presencia de hiperglicemia. Esto sugiere que la regulación de estos genes es dependiente de la intensidad del ejercicio, en donde la hiperglicemia parece no aminorar esta respuesta.
Publisher: Wiley
Date: 22-02-2018
DOI: 10.1111/DMCN.13697
Abstract: To systematically review the predictive validity of spontaneous early infant movements for later cerebral palsy (CP). Cohort studies with published data to calculate predictive validity of early spontaneous movements for later CP were searched in four electronic databases: CINAHL, Embase, MEDLINE, and PsycINFO. Forty-seven studies met inclusion criteria. The Prechtl General Movements Assessment (GMA) during the fidgety period (10-20wks corrected age) had the strongest sensitivity: 97 per cent (95% confidence interval [CI] 93-99) and specificity: 89% (95% CI 83-93). The sensitivity and specificity of the Prechtl GMA during the writhing period (birth-6wks) was 93% (95% CI 86-96) and 59% (95% CI 45-71) respectively. Cr ed-synchronized movements in the writhing period according to Prechtl had the best specificity (sensitivity: 70% [95% CI 54-82] specificity: 97% [95% CI 74-100]). Hadders-Algra's method of assessing general movements had a pooled sensitivity and specificity of 89% (95% CI 66-97) and 81% (95% CI 64-91) respectively. Presence of asymmetric postures and movement quality/quantity were reported under the Hammersmith Infant Neurological Examination, Hammersmith Neonatal Neurological Examination, and Movement Assessment of Infants but had weak associations with later CP. Fidgety movements assessed by the Prechtl GMA have the strongest predictive validity for later CP, but cannot be considered in isolation because of the presence of false positive results. Fidgety general movements (Prechtl) are most predictive for later cerebral palsy compared with other spontaneous movements. False positive results are high among all spontaneous movement assessments.
Publisher: Wiley
Date: 11-08-2020
Publisher: Elsevier BV
Date: 11-2018
DOI: 10.1016/J.JPEDS.2018.07.003
Abstract: To assess the effectiveness of Cogmed Working Memory Training compared with a placebo program in improving academic functioning 24 months post-training in extremely preterm/extremely low birth weight 7-year-olds. A multicenter double-blind, placebo-controlled randomized controlled trial was conducted across all tertiary neonatal hospitals in the state of Victoria, Australia. Participants were 91 extremely preterm/extremely low birth weight 7-year-old children born in Victoria in 2005. Children were randomly assigned to either the Cogmed or placebo arm and completed the Cogmed or placebo program (20-25 sessions of 35-40 minutes duration) at home over 5-7 weeks. Academic achievement (word reading, spelling, sentence comprehension, and mathematics) was assessed 24 months post-training, as well as at 2 weeks and 12 months post-training, via standardized testing inclusive of working memory, attention, and executive behavior assessments. Data were analyzed using an intention-to-treat approach with mixed-effects modeling. There was little evidence of any benefits of Cogmed on academic functioning 24 months post-training, as well as on working memory, attention, or executive behavior at any age up to 24 months post-training compared with the placebo program. We currently do not recommend administration of Cogmed for early school-aged children born extremely preterm/extremely low birth weight to improve academic functioning. Australian New Zealand Clinical Trials Registry: ACTRN12612000124831.
Publisher: Informa UK Limited
Date: 25-07-2020
Publisher: Elsevier BV
Date: 04-2018
Publisher: Elsevier BV
Date: 07-2014
Publisher: Elsevier BV
Date: 05-2018
Publisher: Elsevier BV
Date: 02-2017
DOI: 10.1016/J.NEUROIMAGE.2016.09.068
Abstract: Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T
Publisher: American Thoracic Society
Date: 15-11-2017
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2017
Start Date: Start date not available
End Date: End date not available
Funder: Agencia Nacional de Investigación y Desarrollo
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