ORCID Profile
0000-0001-9700-3344
Current Organisation
University of Sydney
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Geriatrics and Gerontology | Biomaterials | Regenerative Medicine (incl. Stem Cells and Tissue Engineering) | Biomedical Engineering
Health Related to Ageing | Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences |
Publisher: American Chemical Society (ACS)
Date: 07-02-2018
DOI: 10.1021/ACS.INORGCHEM.7B02697
Abstract: Magnetic porous metal-organic framework nanocomposite was obtained by an easy, efficient, and environmentally friendly fabrication method. The material consists in magnetic spinel iron oxide nanoparticles incorporated in an iron(III) carboxylate framework. The magnetic composite was fabricated by a multistep mechanochemical approach. In the first step, iron oxide nanoparticles were obtained via ball milling inducing mechanochemical reaction between iron chlorides and NaOH using NaCl as dispersing agent. Magnetic nanoparticles (MNs) were functionalized by neat grinding with benzene-1,3,5-tricarboxylic acid (1, 3, 5 BTC) and were then subjected to liquid assisted milling using hydrated FeCl
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6FD00059B
Abstract: Magnetic nanoparticles (MNPs) are widely investigated due to their potential use in various applications, ranging from electronics to biomedical devices. The magnetic properties of MNPs are strongly dependent on their size and shape ( i.e. , morphology), thus appropriate tools to investigate their morphology are fundamental to understand the physics of these systems. Recently a new approach to study nanoparticle morphology by Transmission Electron Microscopy (TEM) analysis has been proposed, introducing the so-called Aspect Maps (AMs). In this paper, a further evolution of the AM method is presented, allowing determination of the nanoparticles’ 3D shape by TEM image. As a case study, this paper will focus on magnetite nanoparticles (Fe 3 O 4 ), with a mean size of ∼45 nm extracted from Magnetospirillum gryphiswaldense magnetostatic bacteria (MTB). The proposed approach gives a complete description of the nanoparticles’ morphology, allowing estimation of an average geometrical size and shape. In addition, preliminary investigation of the magnetic properties of MTB nanoparticles was performed, giving some insight into interparticle interactions and on the reversal mechanism of the magnetization.
Publisher: Elsevier BV
Date: 05-2015
DOI: 10.1016/J.MICRON.2015.02.003
Abstract: The morphological properties of cellulose nanofibrils obtained from eucalyptus pulp fibres were assessed. Two s les were produced with the same chemical treatment (NaClO/NaBr/TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical) oxidation), but distinct mechanical treatment intensities during homogenization. It was shown that the nanofibrils production yield increases with the mechanical energy. The effect of mechanical treatment on the yield was confirmed by laser profilometry of air-dried nanocellulose films. However, no significant differences were detected regarding the nanofibrils width as measured by atomic force microscopy (AFM) of air-dried films. On the other hand, differences in size were found either by laser diffraction spectroscopy or by dynamic light scattering (DLS) of the cellulose nanofibrils suspensions as a consequence of the differences in the length distribution of both s les. The nanofibrils length of the more nanofibrillated s le was calculated based on the width measured by AFM and the hydrodynamic diameter obtained by DLS. A length value of ca. 600 nm was estimated. The DLS hydrodynamic diameter, as an equivalent spherical diameter, was used to estimate the nanofibrils length assuming a cylinder with the same volume and with the diameter (width) assessed by AFM. A simple method is thus proposed to evaluate the cellulose nanofibrils length combining microscopy and light scattering methods.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA02471D
Abstract: The size of functional molecules influences the immobilization efficiency and properties of lipase immobilized on amine-functionalized magnetite–silica nanocomposite particles.
Publisher: IOP Publishing
Date: 07-03-2022
Abstract: A photonic nanojet (PNJ) from a microcavity is a narrow and intense beam of light used to enhance the emerging electric field. Metal nanoparticles (NPs), on the other hand, confine a strong field in their vicinity due to the resonance of the free electrons with the incident field. A hybrid combination of a microcavity with a NP can drastically enhance the output field. In this work, a systematic numerical study of the microcavity-NP system has been carried out to investigate the effect of the shape of the metal NPs on the output field strength. The single and their dimer NPs with different dimer nanogaps with PNJ producing microcavity have been investigated. Splitting of the broad dipole mode of the NP has also been observed. As an application of this study, the surface enhanced Raman spectroscopy factor of the order of 10 7 has been estimated for nano-cube dimer NP-microcavity hybrid system.
Publisher: Wiley
Date: 09-12-2010
Abstract: Surfaces with micro‐ and nanometer‐scale patterns have many potential applications, particularly in lifescience. This article reports on a versatile, straightforward, and inexpensive approach for the creation of chemical patterns using fabricated binary colloid crystals, consisting of small and large particles, as masks for the deposition of an amino‐functionalised ultrathin film by plasma polymerization. After removal of the binary colloidal mask, the characterization techniques [scanning electron microscopy (SEM) and atomic force microscopy (AFM)] reveal a surface contrast that depicts an ability of the small particles to allow diffusion of the plasma to the substrate. A plasma‐polymer film is created under the small particles and the region of substrate in direct contact with the large particle remains uncoated. Numerous types of patterns and feature heights can be produced with good fidelity over areas of several cm 2 by appropriate tuning of the binary colloid crystal mask morphology and the plasma‐polymer deposition time. Finally, the amine groups of the patterned surface are used for covalent grafting poly(ethylene glycol) propionaldehyde (PEG‐PALD) by reductive amination under conditions of reduced solubility to produce a patterned surface for directed adsorption of protein. AFM investigations show that the proteins are preferentially attached to the nanometer‐scale regions of the pattern without PEG‐PALD.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4FD00265B
Abstract: Self-assembly of inorganic nanoparticles has been studied extensively for particles having different sizes and compositions. However, relatively little attention has been devoted to how the shape and surface chemistry of magnetic nanoparticles affects their self-assembly properties. Here, we undertook a combined experiment–theory study aimed at better understanding of the self-assembly of cubic magnetite (Fe 3 O 4 ) particles. We demonstrated that, depending on the experimental parameters, such as the direction of the magnetic field and nanoparticle density, a variety of superstructures can be obtained, including one-dimensional filaments and helices, as well as C-shaped assemblies described here for the first time. Furthermore, we functionalized the surfaces of the magnetic nanocubes with light-sensitive ligands. Using these modified nanoparticles, we were able to achieve orthogonal control of self-assembly using a magnetic field and light.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4SM02669A
Abstract: A colloid-probe AFM based approach investigates the interaction between protein coatings on colloid probes and surfaces decorated with close-packed colloidal crystal layers.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-09-2014
Abstract: Assembly of inorganic nanoparticles into complex structures often requires a template. Researchers can now assemble helical nanowires out of cubic magnetite nanocrystals by tuning interactions that bind or separate them. Singh et al. floated the nanocrystals on a liquid and aligned them with a magnetic field. After the liquid evaporated, different twisted nanowires remained. The helices varied according to the concentration of nanocrystals, their shape, and the strength of the magnetic field. Competition between weak forces drives this self-assembly and can lead to arrays with the same twist direction. Science , this issue p. 1149
Publisher: American Chemical Society (ACS)
Date: 24-03-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5NR01284H
Abstract: Transferrin (Tf) conjugated to gold nanoparticles and clusters combine the protein's site-specific receptor targeting capabilities with the optical properties imparted by the nano-sized gold.
Publisher: IOP Publishing
Date: 04-11-2015
DOI: 10.1088/0957-4484/26/47/475703
Abstract: The question of the dominant interparticle magnetic interaction type in random closely packed assemblies of different diameter (6.2-11.5 nm) bare maghemite nanoparticles (NPs) is addressed. Single-particle magnetic properties such as particle anisotropy and exchange bias field are first of all studied in dilute (reference) systems of these same NPs, where interparticle interactions are neglible. Substantial surface spin disorder is revealed in all particles except the smallest, viz. for diameters d = 8-11.5 nm but not for d = 6.2-6.3 nm. X-ray diffraction analysis points to a crystallographic origin of this effect. The study of closely packed assemblies of the d ≥ 8 nm particles observes collective (superspin) freezing that clearly appears to be governed by interparticle dipole interactions. However, the dense assemblies of the smallest particles exhibit freezing temperatures that are higher than expected from a simple (dipole) extrapolation of the corresponding temperatures found in the d ≥ 8 nm assemblies. It is suggested that the nature of the dominant interparticle interaction in these smaller particle assemblies is superexchange, whereby the lack of significant surface spin disorder allows this mechanism to become important at the level of interacting superspins.
Publisher: AIP Publishing
Date: 10-10-2016
DOI: 10.1063/1.4964517
Abstract: We highlight the relevance of demagnetizing-field corrections in the characterization of dense magnetic nanoparticle assemblies. By an analysis that employs in-plane and out-of-plane magnetometry on cylindrical assemblies, we demonstrate the suitability of a simple analytical formula-based correction method. This allows us to identify artifacts of the demagnetizing field in temperature-dependent susceptibility curves (e.g., shoulder peaks in curves from a disordered assembly of essentially bare magnetic nanoparticles). The same analysis approach is shown to be a straightforward procedure for determining the magnetic nanoparticle packing fraction in dense, disordered assemblies.
Publisher: Wiley
Date: 22-06-2020
Publisher: Wiley
Date: 06-2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MA00275E
Abstract: The reproducible synthesis of anisotropic magnetite (Fe 3 O 4 ) nanoparticles is demonstrated by a thermal decomposition approach. The shape and size of the nanoparticles are controlled via the reaction environment, the heating rate and the solvent volume.
Publisher: American Chemical Society (ACS)
Date: 06-03-2015
DOI: 10.1021/CM5038815
Publisher: Wiley
Date: 03-05-2011
Publisher: Elsevier BV
Date: 04-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6TB02854C
Abstract: Herein, we report the synthesis of differently sized gadolinium oxide nanodisks and gadolinium doped iron oxide spherical and cubic nanoparticles through the thermal decomposition of an oleate precursor.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1NR01389K
Abstract: Optimization of the carbon dots synthetic parameters, including type of solvent, heating time, dopant quantity, and particle size distribution range, to gain a better understanding of their effect on carbon dots photophysical and biological behavior.
Publisher: Hindawi Limited
Date: 2016
DOI: 10.1155/2016/4350952
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0SM01360A
Publisher: Wiley
Date: 18-06-2008
Publisher: IOP Publishing
Date: 20-04-2016
Publisher: American Chemical Society (ACS)
Date: 02-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2RA22479H
Publisher: American Physical Society (APS)
Date: 19-11-2020
Publisher: Elsevier BV
Date: 10-2014
Publisher: MDPI AG
Date: 13-03-2022
DOI: 10.3390/MA15062111
Abstract: Functional nanoporous materials are categorized as an important class of nanostructured materials because of their tunable porosity and pore geometry (size, shape, and distribution) and their unique chemical and physical properties as compared with other nanostructures and bulk counterparts. Progress in developing a broad spectrum of nanoporous materials has accelerated their use for extensive applications in catalysis, sensing, separation, and environmental, energy, and biomedical areas. The purpose of this review is to provide recent advances in synthesis strategies for designing ordered or hierarchical nanoporous materials of tunable porosity and complex architectures. Furthermore, we briefly highlight working principles, potential pitfalls, experimental challenges, and limitations associated with nanoporous material fabrication strategies. Finally, we give a forward look at how digitally controlled additive manufacturing may overcome existing obstacles to guide the design and development of next-generation nanoporous materials with predefined properties for industrial manufacturing and applications.
Publisher: Elsevier BV
Date: 03-2022
Publisher: American Chemical Society (ACS)
Date: 25-01-2013
DOI: 10.1021/JP3104886
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0NA00991A
Abstract: Here, we demonstrate the design of l -dopamine coated manganese oxide nanoparticle based theranostics for MRI imaging and drug delivery. The release of drug molecules can be controlled by altering the size and chemical composition of nanoparticles.
Publisher: Wiley
Date: 11-05-2014
Publisher: American Chemical Society (ACS)
Date: 30-05-2012
DOI: 10.1021/JP300754B
Publisher: American Chemical Society (ACS)
Date: 31-03-2021
Publisher: American Chemical Society (ACS)
Date: 06-05-2011
DOI: 10.1021/NN102867Z
Abstract: We demonstrate the use of binary colloidal assemblies as lithographic masks to generate tunable Au patterns on SiO(2) substrates with dimensions ranging from micrometers to nanometers. Such patterns can be modified with different chemistries to create patterns with well-defined sites for selective adsorption of proteins, where the pattern size and spacing is adjustable depending on particle choice. In our system, the binary colloidal assemblies contain large and small particles of similar or different material and are self-assembled from dilute dispersions with particle size ratios ranging from 0.10 to 0.50. This allows masks with variable morphology and thus production of chemical patterns of tunable geometry. Finally, the Au or SiO(2) regions of the pattern are surface modified with protein resistant oligoethyleneglycol self-assembled molecules, which facilitates site selective adsorption of proteins into the unmodified regions of the pattern. This we show with fluorescently labeled bovine serum albumin.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA23423A
Abstract: While the size-dependent optical properties of BSA-stabilized gold nanoclusters are well known, the time-dependent growth mechanism remains to be described.
Publisher: Elsevier BV
Date: 11-2014
DOI: 10.1016/J.JCIS.2014.07.013
Abstract: The absence of targetability is the primary inadequacy of conventional chemotherapy. Targeted drug delivery systems are conceptualized to overcome this challenge. We have designed a targetable magnetic nanocarrier consisting of a superparamagnetic iron oxide (SPIO) core and biocompatible and biodegradable poly(sebacic anhydride)-block-methyl ether poly(ethylene glycol) (PSA-mPEG) polymer shell. The idea is that this type of carriers should facilitate the targeting of cancer cells. PSA-mPEG was synthesized with poly-condensation and the in vitro degradation rate of the polymer was monitored by gel permeation chromatography (GPC). The magnetic nanocarriers were fabricated devoid of any surfactants and were capable of carrying high payload of hydrophobic dye. The successful encapsulation of SPIO within the polymer shell was confirmed by TEM. The results we obtained from measuring the size of SPIO loaded in polymeric NPs (SPIO-PNP) by dynamic light scattering (DLS) and iron content measurement of these particles by ICP-MS, indicate that SPIO is the most suitable carrier for cancer drug delivery applications. Measuring the hydrodynamic radii of SPIO-PNPs by DLS over one month revealed the high stability of these particles at both body and room temperature. We further investigated the cell viability and cellular uptake of SPIO-PNPs in vitro with MDA-MB-231 breast cancer cells. We found that SPIO-PNPs induce negligible toxicity within a concentration range of 1-2μg/ml. The TEM micrographs of thin cross-sectioned MDA-MBA-231 cells showed internalization of SPIO-PNPs within size range of 150-200nm after 24h. This study has provided a foundation for eventually loading these nanoparticles with anti-cancer drugs for targeted cancer therapy using an external magnetic field.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6RA28491D
Abstract: We demonstrate the applicability of colloid-probe AFM to detect different surface chemistries on binary colloidal crystal layers of different chemical and protein patterns.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1NA00312G
Abstract: This paper shed lights on the interplay among intra- and inter-particle interactions in different hard/soft bi-magnetic core/shell nanoarchitecture.
Publisher: Elsevier BV
Date: 08-2014
Publisher: American Chemical Society (ACS)
Date: 30-06-2022
DOI: 10.1021/ACSBIOMATERIALS.1C01298
Abstract: The tissue engineering approach for repair and regeneration has achieved significant progress over the past decades. However, challenges remain in developing strategies to solve the declined or impaired innate cell and tissue regeneration capacity that occurs with aging. Cellular senescence is a key mechanism underlying organismal aging and is responsible for the declined tissue regeneration capacity in the aging population. Therefore, to promote the diminished tissue regeneration ability in the aged population, it is critical to developing a feasible and promising strategy to target senescent cells. Recent advances in nanomaterials have revolutionized biomedical applications ranging from biosensing to bioimaging and targeted drug delivery. In this perspective, we review and discuss the nature and influences of cell-intrinsic and cell-extrinsic factors on reduced regenerative abilities through aging and how nanotechnology can be a therapeutic avenue to sense, rejuvenate, and eliminate senescent cells, thereby improving the tissue regeneration capacity in the aging population.
Publisher: MDPI AG
Date: 12-03-2023
DOI: 10.3390/PHARMACEUTICS15030922
Abstract: Significant progress in nanotechnology has enormously contributed to the design and development of innovative products that have transformed societal challenges related to energy, information technology, the environment, and health. A large portion of the nanomaterials developed for such applications is currently highly dependent on energy-intensive manufacturing processes and non-renewable resources. In addition, there is a considerable lag between the rapid growth in the innovation/discovery of such unsustainable nanomaterials and their effects on the environment, human health, and climate in the long term. Therefore, there is an urgent need to design nanomaterials sustainably using renewable and natural resources with minimal impact on society. Integrating sustainability with nanotechnology can support the manufacturing of sustainable nanomaterials with optimized performance. This short review discusses challenges and a framework for designing high-performance sustainable nanomaterials. We briefly summarize the recent advances in producing sustainable nanomaterials from sustainable and natural resources and their use for various biomedical applications such as biosensing, bioimaging, drug delivery, and tissue engineering. Additionally, we provide future perspectives into the design guidelines for fabricating high-performance sustainable nanomaterials for medical applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8MH01112E
Abstract: Focused ion beam milling of self-assembled magnetic superstructures is demonstrated as a novel approach to fabricate porous materials with tunable porosity. During exposure to the ion beam, nanoparticles in the superstructure are subjected to combined milling and melting, thus merging together into a porous network.
Publisher: Wiley
Date: 30-08-2012
Abstract: Dual-responsive nanoparticles are designed by functionalizing magnetic cores with light-responsive ligands. These materials respond to both light and magnetic fields and can be assembled into various higher-order structures, depending on the relative contributions of these two stimuli.
Publisher: Wiley
Date: 03-01-2012
Abstract: Well-defined metallic nanobowls can be prepared by extending the concept of a protecting group to colloidal synthesis. Magnetic nanoparticles are employed as "protecting groups" during the galvanic replacement of silver with gold. The replacement reaction is accompanied by spontantous dissociation of the protecting groups, leaving behind metallic nanobowls.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA08405A
Abstract: Surface chemistry/charge and concentration of mesoporous silica nanoparticles have a great impact on the fibrillation process of α-Syn protein.
Publisher: IOP Publishing
Date: 04-2011
DOI: 10.1088/0957-4484/22/22/225601
Abstract: We report a simple, rapid and cost-effective method based on evaporation induced assembly to grow 3D binary colloidal assemblies on a hydrophobic/hydrophilic substrate by simple drop casting. The evaporation of a mixed colloidal drop results in ring-like or uniform area deposition depending on the concentration of particles, and thus assembly occurs at the periphery of a ring or uniformly all over the drop area. Binary colloidal assemblies of different crystal structure are successfully prepared over a wide range of size ratios (γ = small/large) from 0.06 to 0.30 by tuning the γ of the micro- and nanoparticles used during assembly. The growth mechanism of 3D binary colloidal assemblies is investigated and it is found that electrostatic forces facilitate assembly formation until the end of the evaporation process, with capillary forces also playing a role. In addition, the effects of solvent type, humidity, and salt concentration on crystal formation and ordering behaviour are also examined. Furthermore, long range, highly ordered binary colloidal assemblies can be fabricated by the choice of a low conducting solvent combined with evaporation induced assembly.
Publisher: Wiley
Date: 16-09-2019
Publisher: Wiley
Date: 30-04-2015
DOI: 10.1002/CMMI.1639
Abstract: Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology platform incorporating multiple functionalities, including imaging and therapy in a single system consisting of MBs stabilized by polyethylene glycol (PEG)-coated polymeric nanoparticles (NPs). The NPs, containing lipophilic drugs and/or contrast agents, are composed of the widely used poly(butyl cyanoacrylate) (PBCA) polymer and prepared in a single step. MBs stabilized by these NPs are subsequently prepared by self-assembly of NPs at the MB air-liquid interface. Here we show that these MBs can act as contrast agents for conventional ultrasound imaging. Successful encapsulation of iron oxide NPs inside the PBCA NPs is demonstrated, potentially enabling the NP-MBs to be used as magnetic resonance imaging (MRI) and/or molecular ultrasound imaging contrast agents. By precise tuning of the applied ultrasound pulse, the MBs burst and the NPs constituting the shell are released. This could result in increased local deposit of NPs into target tissue, providing improved therapy and imaging contrast compared with freely distributed NPs.
Publisher: Wiley
Date: 04-02-2011
Publisher: Wiley
Date: 30-11-2015
Abstract: Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn(2+) and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.
Publisher: Elsevier BV
Date: 03-2017
Publisher: MDPI AG
Date: 08-11-2021
DOI: 10.3390/MAGNETOCHEMISTRY7110146
Abstract: Bi-magnetic core/shell nanoparticles were synthesized by a two-step high-temperature decomposition method of metal acetylacetonate salts. Transmission electron microscopy confirmed the formation of an ultrathin shell (~0.6 nm) of NiO and NiFe2O4 around the magnetically hard 8 nm CoFe2O4 core nanoparticle. Magnetization measurements showed an increase in the coercivity of the single-phase CoFe2O4 seed nanoparticles from ~1.2 T to ~1.5 T and to ~2.0 T for CoFe2O4/NiFe2O4 and CoFe2O4/NiO, respectively. The NiFe2O4 shell also increases the magnetic volume of particles and the dipolar interparticle interactions. In contrast, the NiO shell prevents such interactions and keeps the magnetic volume almost unchanged.
Start Date: 03-2022
End Date: 02-2025
Amount: $505,000.00
Funder: Australian Research Council
View Funded Activity