ORCID Profile
0000-0002-8080-4134
Current Organisation
Soochow University
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Publisher: Elsevier BV
Date: 03-2023
Publisher: Elsevier BV
Date: 08-2019
DOI: 10.1016/J.COLSURFB.2019.04.027
Abstract: With the increase of vascular diseases in recent years, it is of importance to develop an anti-occlusion stent graft, which can meet the requirements of transplants for a long term. In this paper, we describe a silk fibroin (SF)/heparin-functionalized bifurcated stent graft (BSG) using textile forming technology. The BSGs were prototyped based on seamless weaving technology, and the surface was modified with SF-loaded heparin under steam/air treatment to improve their patency. The physical properties such as thickness, water permeability, contact angle, mechanical properties, and in vitro drug release and coagulation time of the BSGs were examined. The results showed that heparin modification can improve its coagulation time, and the water permeability resistance of the BSGs reached 1.154 ± 0.854 mL/(cm
Publisher: Elsevier BV
Date: 10-2021
Publisher: SAGE Publications
Date: 11-03-2015
Abstract: This paper presents a study of heat-setting treatment on tubular polydioxanone stents which can be used as intestinal implants. Two PDO monofilaments with linear densities of 100 ± 2 and 150 ± 2 tex respectively were used for producing a set of weft-knitted tubular stents using a small-diameter, circular weft knitting machine. The heat-setting treatment was used for the stents to restore a tubular shape. The physical, mechanical and thermal properties of the stents were examined before and after the heat-setting treatment. The results of mechanical testing illustrated that the prototype stents in this work could achieve higher radial forces than Wall stents and Z stents on the market. The heat setting with temperature of 80℃ and time of 5 min were found to be more appropriate for the stents. In conclusion, the stents were successfully developed and have potential application for the treatment of intestinal stenosis or obstruction.
Publisher: American Chemical Society (ACS)
Date: 27-05-2021
Publisher: Springer Science and Business Media LLC
Date: 09-08-2016
DOI: 10.1038/SREP31149
Abstract: Antimicrobial peptides, produced by innate immune system of hosts in response to invading pathogens, are capable of fighting against a spectrum of bacteria, viruses, fungi, parasites and cancer cells. Here, a recombinant silkworm AMP Bmattacin2 from heterologous expression is studied, indicating a broad spectrum of antibacterial activity and showing selective killing ability towards skin and colon cancer cells over their normal cell counterparts. For the purpose of biomedical application, the electrospinning fabrication technique is employed to load Bmattacin2 into PLLA nanofibrous membrane. In addition to a good compatibility with the normal cells, Bmattacin2 loaded nanofibrous membranes demonstrate instant antibacterial effects and sustained anticancer effects. The cancer cell and bacteria targeting dynamics of recombinant Bmattacin2 are investigated. With these characteristics, PLLA/Bmattacin2 composite membranes have a great potential for developing novel biomedical applications such as cancer therapies and wound healing treatments.
Publisher: Elsevier BV
Date: 10-2016
DOI: 10.1016/J.BIOMATERIALS.2016.06.049
Abstract: The development of more effective cancer therapeutic strategies are still critically required. The maximization of the therapeutic effect in combination with avoiding the severe side effects on normal tissues when using chemotherapy drugs is still an urgent problem that requires improvements urgently. Here we provide implantable and controllable drug-release that utilises silk fibroin (SF) as a nanofibrous drug delivery system (DDS) for cancer treatment. A nanofibrous structure with controllable fibre diameter ( 5 μg/mL. The mechanism could be explained by the cell cycle being held in the S phase. The toxic effect on normal cells (NCM460) was minimized by using a treatment concentration range (5-20 μg/mL). Implantation of this DDS into the tumour site inhibited the growth of solid tumour this offers an alternative approach for novel cancer therapy.
Publisher: Elsevier BV
Date: 03-2016
Publisher: Wiley
Date: 23-11-2018
Abstract: In-stent restenosis caused by tumor ingrowth is a major problem for patients undergoing stent placement because conventional stents often lack sustainable antitumor capabilities. The aim of this work is to develop a silk fibroin (SF)-based nanofibrous membrane that is loaded with combined-therapy drugs by using electrospinning technologies, which is further coated on a polydioxanone (PDO) stent and used for the treatment of colorectal cancer (CRC). In order to improve treatment effectiveness, a combination of therapeutic drugs, i.e., curcumin (CUR) and 5-fluorouracil (5-FU), is dissolved into SF solution and then eletrospun onto the surface of the PDO stent. The morphology, secondary structure, and in vitro drug release profiles of the membranes are characterized. The antitumor efficacy is assessed in vitro and in vivo using a human CRC cell line and normal cells, and tumor-bearing nude mice. In vitro and in vivo studies on the nanofibrous memembrane-coating demonstrate improved antitumor effects for the CUR/5-FU dual drug system which can be attributed to cell cycle arrest in the S phase in association with induced apoptosis in tumor cells by blocking signal transducer and activator of transcription3 (Stat3) and nuclear factor kappa beta (NF-kB) signaling pathways, suggesting potential in the treatment of CRC in the future.
Publisher: Elsevier BV
Date: 2021
Publisher: Wiley
Date: 25-01-2021
Publisher: SAGE Publications
Date: 28-04-2016
Abstract: The epoxidized styrene–butadiene–styrene nanofibers, which were prepared by epoxidation of the styrene–butadiene–styrene in toluene with peroxyformic acid generated in situ, were successfully embedded with nanometer titania dioxide by electrospinning. The optimum blended electrospinning parameters on preparing the nanometer titania dioxide/epoxidized styrene–butadiene–styrene fibers were obtained. The morphology and antiultraviolet property of nanometer titania dioxide/epoxidized styrene–butadiene–styrene composite fiber were examined using scanning electron microscope and an antiultraviolet transmission tester according to American Association of Textile Chemists and Colorists (AATCC183-2004) standard. The scanning electron microscope results showed that nanometer titania dioxide and the epoxy group could lead to the cementation of electrospinning fibers. The ultraviolet protection factor of rutile nanometer titania dioxide/epoxidized styrene–butadiene–styrene fiber membrane is the largest one of the four fiber membranes. The epoxidized styrene–butadiene–styrene nanofibers embedded with nanometer titania dioxide have great potential in the applications of antiultraviolet textiles.
Publisher: Elsevier BV
Date: 12-2021
No related grants have been discovered for Gang Li.