ORCID Profile
0000-0003-1043-5772
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Publisher: Wiley
Date: 12-04-2022
Abstract: Unlocking the potential of personalized medicine in point‐of‐care settings requires a new generation of biomarker and proteomic assays. Ideally, assays could inexpensively perform hundreds of quantitative protein measurements in parallel at the bedsides of patients. This goal greatly exceeds current capabilities. Furthermore, biomarker assays are often challenging to translate from benchtop to clinic due to difficulties achieving and assessing the necessary selectivity, sensitivity, and reproducibility. To address these challenges, we developed an efficient ( min), robust (comparatively lower CVs), and inexpensive (decreasing reagent use and cost by %) immunoassay method. Specifically, the immunoblot membrane is dotted with the s le and then developed in a vortex fluidic device (VFD) reactor. All assay steps—blocking, binding, and washing—leverage the unique thin‐film microfluidics of the VFD. The approach can accelerate direct, indirect, and sandwich immunoblot assays. The applications demonstrated include assays relevant to both the laboratory and the clinic.
Publisher: Wiley
Date: 25-04-2022
Publisher: Wiley
Date: 25-04-2022
Publisher: American Chemical Society (ACS)
Date: 22-01-2019
Publisher: Wiley
Date: 12-04-0006
Abstract: Unlocking the potential of personalized medicine in point‐of‐care settings requires a new generation of biomarker and proteomic assays. Ideally, assays could inexpensively perform hundreds of quantitative protein measurements in parallel at the bedsides of patients. This goal greatly exceeds current capabilities. Furthermore, biomarker assays are often challenging to translate from benchtop to clinic due to difficulties achieving and assessing the necessary selectivity, sensitivity, and reproducibility. To address these challenges, we developed an efficient ( min), robust (comparatively lower CVs), and inexpensive (decreasing reagent use and cost by %) immunoassay method. Specifically, the immunoblot membrane is dotted with the s le and then developed in a vortex fluidic device (VFD) reactor. All assay steps—blocking, binding, and washing—leverage the unique thin‐film microfluidics of the VFD. The approach can accelerate direct, indirect, and sandwich immunoblot assays. The applications demonstrated include assays relevant to both the laboratory and the clinic.
Location: Switzerland
No related grants have been discovered for Emily Sanders.