ORCID Profile
0000-0002-8047-3830
Current Organisation
Wuxi AppTec (China)
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 04-2021
Publisher: American Chemical Society (ACS)
Date: 28-11-2016
Abstract: A concise total synthesis of aetheramide A in an overall yield of 4.7% with a longest linear sequence of 15 steps is described. This synthetic strategy features macrocyclization via an intramolecular trapping of acylketene generated from dioxinone precursor, and stereoselective late-stage methylation of β-ketoamide. Aetheramide B could be synthesized via the ester migration of aetheramide A.
Publisher: Springer Science and Business Media LLC
Date: 16-05-2017
Publisher: American Chemical Society (ACS)
Date: 08-01-2020
DOI: 10.1021/ACSSENSORS.9B01093
Abstract: Hydrogen sulfide (H
Publisher: American Chemical Society (ACS)
Date: 07-09-2016
DOI: 10.1021/ACS.ORGLETT.6B02371
Abstract: The concise total syntheses of the potent HIV inhibitors aetheramides A and B (IC50 values of 15 and 18 nM), as well as three pairs of their stereoisomers, were achieved, which allowed the complete stereochemical assignment of aetheramides for the first time. With a longest linear sequence of 15 steps, the convergent, fully stereocontrolled route provided aetheramides A and B in 5.3% and 3.6% yields, respectively. The synthetic strategy features efficient Stille coupling for macrocyclization, asymmetric aldol reactions to establish the ambiguous stereochemistries at C-17 and C-26, and implementation of mild conditions to avoid the epimerization of the sensitive polyketide moiety and the migration of the labile lactone.
No related grants have been discovered for Zhanlong Wang.