ORCID Profile
0000-0002-4971-3752
Current Organisation
University of Queensland
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Publisher: Elsevier BV
Date: 10-2014
DOI: 10.1016/J.IJPHARM.2014.07.012
Abstract: A new continuous dissolution-permeation system, consisting of an intrinsic dissolution apparatus and an Ussing chamber, was developed for screening and identification of high-bioavailability polymorphisms at pre-formulation stages. Three different solid forms of two model drugs (agomelatine and carbamazepine) were used to confirm the system's predictive ability. Ranks for cumulative permeation of the three solids were: Form III>Form I>Form II for agomelatine, and Form III>Form I>the dihydrate form for carbamazepine. Regression analysis of these parameters and published pharmacokinetics confirmed linear IVIVCs (most correlation coefficients >0.9). To confirm dissolution-absorption relationships, permeability coefficients were calculated. Relatively constant values among various polymorphisms for each drug supported a linear dependency between polymorphism-increased dissolution and polymorphism-enhanced permeation. A combined analysis of intrinsic dissolution rates and permeability coefficients revealed that both drugs are of the BCS II class and have dissolution-limited absorption. In conclusion, our new system was valuable not only for high-bioavailability polymorphism screening, but also for drug classification within the BCS system.
Publisher: Elsevier BV
Date: 2017
DOI: 10.1016/J.IJPHARM.2016.11.051
Abstract: Because of the peculiarity of the bone microstructure, the uptake of chemotherapeutics often happens at non-targeted sites, which induces side effects. In order to solve this problem, we designed a bone-targeting drug delivery system that can release drug exclusively in the nidus of the bone. Alendronate (ALN), which has a high ability to target to hydroxyapatite, was used to fabricate double ALN-conjugated poly (ethylene glycol) 2000 material (ALN-PEG
Publisher: Elsevier BV
Date: 10-2017
DOI: 10.1016/J.JCONREL.2017.08.024
Abstract: Bone is the most common organ affected by metastatic breast cancer. Targeting cancers within the bone remains a great challenge due to the inefficient delivery of therapeutic to bone. In this study, a polyethylene glycol (PEG) coated nanoparticles (NPs) made of a Zn
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR02662E
Abstract: The constructed nanoparticles showed reduced systemic toxicity of cisplatin (CDDP) without compromising its in vivo antitumor activity.
Publisher: American Chemical Society (ACS)
Date: 05-05-2023
Publisher: Informa UK Limited
Date: 10-2014
DOI: 10.2147/IJN.S69729
Publisher: Elsevier BV
Date: 06-2016
No related grants have been discovered for Weijing Chu.