ORCID Profile
0000-0001-6461-4464
Current Organisation
Hong Kong Polytechnic University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Chemical Society (ACS)
Date: 07-02-2019
Abstract: Growing literature has documented varying toxic potencies of source- or site-specific fine particulate matter (PM
Publisher: Elsevier BV
Date: 03-2019
DOI: 10.1016/J.CHEMOSPHERE.2018.11.079
Abstract: Atmospheric fine particulate matters (PM
Publisher: Springer Science and Business Media LLC
Date: 27-01-2022
DOI: 10.1186/S40168-021-01197-5
Abstract: Threats of antimicrobial resistance (AMR) to human health are on the rise worldwide. Airborne fine particulate matter (PM 2.5 ), especially those emitted from hospitals, could serve as a substantial yet lesser-known environmental medium of inhalable antibiotic resistomes. A genome-centric understanding of the hosting bacterial taxa, mobility potential, and consequent risks of the resistomes is needed to reveal the health relevance of PM 2.5 -associated AMR from clinical settings. Compared to urban ambient air PM 2.5 , the hospital s les harbored nearly twice the abundance of antibiotic resistantance genes (ARGs, ~ 0.2 log 10 (ARGs/16S rRNA gene)) in the summer and winter s led. The profiled resistome was closely correlated with the human-source-influenced (~ 30% of the contribution) bacterial community (Procrustes test, P 0.001), reflecting the potential antibiotic-resistant bacteria (PARB), such as the human commensals Staphylococcus spp. and Corynebacterium spp. Despite the reduced abundance and ersity of the assembled metagenomes from summer to winter, the high horizontal transfer potential of ARGs, such as the clinically relevant bla OXA and bac A, in the human virulent PARB remained unaffected in the hospital air PM s les. The occurring patterns of β-lactam resistance genes and their hosting genomes in the studied hospital-emitting PM 2.5 were closely related to the in-ward β-lactam-resistant infections (SEM, std = 0.62, P 0.01). Featured with more abundant potentially virulent PARB (2.89 genome copies/m 3 -air), the hospital s les had significantly higher resistome risk index scores than the urban ambient air s les, indicating that daily human exposure to virulent PARB via the inhalation of PM 2.5 was ten times greater than from the ingestion of drinking water. The significance of AMR in the studied hospital-emitting PM 2.5 was highlighted by the greater abundance of ARGs, the prevalence of potentially virulent PARB, and the close association with hospital in-ward β-lactam infections. A larger-scale multi-source comparison of genome-resolved antibiotic resistomes is needed to provide a more holistic understanding to evaluate the importance of airborne AMR from the “One-Health” perspective.
Publisher: American Chemical Society (ACS)
Date: 22-01-2018
Publisher: Informa UK Limited
Date: 06-12-2021
Publisher: Elsevier BV
Date: 07-2020
Publisher: Proceedings of the National Academy of Sciences
Date: 10-10-2022
Abstract: Airborne bacteria are an influential component of the Earth’s microbiomes, but their community structure and biogeographic distribution patterns have yet to be understood. We analyzed the bacterial communities of 370 air particulate s les collected from 63 sites around the world and constructed an airborne bacterial reference catalog with more than 27 million nonredundant 16S ribosomal RNA (rRNA) gene sequences. We present their biogeographic pattern and decipher the interlacing of the microbiome co-occurrence network with surface environments of the Earth. While the total abundance of global airborne bacteria in the troposphere (1.72 × 10 24 cells) is 1 to 3 orders of magnitude lower than that of other habitats, the number of bacterial taxa (i.e., richness) in the atmosphere (4.71 × 10 8 to 3.08 × 10 9 ) is comparable to that in the hydrosphere, and its maximum occurs in midlatitude regions, as is also observed in other ecosystems. The airborne bacterial community harbors a unique set of dominant taxa (24 species) however, its structure appears to be more easily perturbed, due to the more prominent role of stochastic processes in shaping community assembly. This is corroborated by the major contribution of surface microbiomes to airborne bacteria (averaging 46.3%), while atmospheric conditions such as meteorological factors and air quality also play a role. Particularly in urban areas, human impacts weaken the relative importance of plant sources of airborne bacteria and elevate the occurrence of potential pathogens from anthropogenic sources. These findings serve as a key reference for predicting planetary microbiome responses and the health impacts of inhalable microbiomes with future changes in the environment.
Publisher: American Chemical Society (ACS)
Date: 10-12-2019
Abstract: Airborne transmission is one of the environmental dissemination pathways of antibiotic resistance genes (ARGs), and has critical implications for human exposure through inhalation. In this study, we focused on three regions of China to reveal some unique spatiotemporal features of airborne bacteria and ARGs in fine aerosols (PM
Publisher: American Chemical Society (ACS)
Date: 18-01-2022
Abstract: Antibiotic resistance genes (ARGs) are commonly detected in the atmosphere, but questions remain regarding their sources and relative contributions, bacterial hosts, and corresponding human health risks. Here, we conducted a qPCR- and metagenomics-based investigation of inhalable fine particulate matter (PM
Publisher: American Chemical Society (ACS)
Date: 20-01-2021
No related grants have been discovered for JIAWEN XIE.