ORCID Profile
0000-0002-1312-688X
Current Organisation
University of Oxford
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Elsevier BV
Date: 03-2021
Publisher: Wiley
Date: 29-04-2019
Publisher: Oxford University Press (OUP)
Date: 26-08-2019
DOI: 10.1093/BRAIN/AWZ241
Abstract: Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifies brain inflammation and ameliorates disease progression in P301S tauopathy mice. CSF1R inhibition may have therapeutic potential in tau-mediated neurodegenerative diseases.
Publisher: SAGE Publications
Date: 09-2022
DOI: 10.1177/02698811221099643
Abstract: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippoc us in patients with schizophrenia. Other studies have reported increased glutamate in striatum in schizophrenia patients. It has been hypothesised that NMDAR hypofunction leads to the disinhibition of glutamatergic signalling however, this has not been tested in vivo. In this study, we investigated the relationship between hippoc al NMDAR and striatal glutamate using simultaneous positron emission tomography-magnetic resonance (PET-MR) imaging. We recruited 40 volunteers to this cross-sectional study 21 patients with schizophrenia, all in their first episode of illness, and 19 healthy controls. We measured hippoc al NMDAR availability using the PET ligand [ 18 F]GE179. This was indexed relative to whole brain as the distribution volume ratio (DVR). Striatal glutamatergic indices (glutamate and Glx) were acquired simultaneously, using combined PET-MR proton magnetic resonance spectroscopy ( 1 H-MRS). A total of 33 in iduals (15 healthy controls, 18 patients) were included in the analyses (mean (SD) age of controls, 27.31 (4.68) years mean (SD) age of patients, 24.75 (4.33), 27 male and 6 female). We found an inverse relationship between hippoc al DVR and striatal glutamate levels in people with first-episode psychosis (rho = −0.74, p 0.001) but not in healthy controls (rho = −0.22, p = 0.44). This study show that lower relative NMDAR availability in the hippoc us may drive increased striatal glutamate levels in patients with schizophrenia. Further work is required to determine whether these findings may yield new targets for drug development in schizophrenia.
Publisher: Elsevier BV
Date: 09-2023
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 2021
Publisher: Elsevier BV
Date: 09-2021
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Nisha Singh.