ORCID Profile
0000-0002-4758-319X
Current Organisation
Karolinska Institutet
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Publisher: American Physiological Society
Date: 21-09-2023
Publisher: Human Kinetics
Date: 04-2022
Abstract: Exercise training beneficially moderates the effects of vascular aging. This study compared the efficacy of Peripheral Remodeling through Intermittent Muscular Exercise (PRIME), a novel training regimen, versus aerobic training on hemodynamic profiles in participants ≥70 years at risk for losing functional independence. Seventy-five participants (52 females, age: 76 ± 5 years) were assessed for hemodynamic and vascular function at baseline, after 4 weeks of either PRIME or aerobic training (Phase 1) and again after a further 8 weeks of aerobic and resistance training (Phase 2). Data were analyzed using 2 × 2 repeated-measures analysis of variance models on the change in each dependent variable. PRIME demonstrated reductions in brachial and aortic mean arterial pressure and diastolic blood pressure ( p .05) from baseline after Phase 1, which were sustained throughout Phase 2. Earlier and greater reductions in blood pressure following PRIME support the proposal that peripheral muscular training could beneficial for older in iduals commencing an exercise program.
Publisher: American Physiological Society
Date: 05-2020
DOI: 10.1152/JAPPLPHYSIOL.00850.2019
Abstract: This is the largest study to date to examine the effects of inorganic nitrate supplementation in patients with heart failure with reduced ejection fraction (HFrEF) and the first to include measures of vascular function and mitochondrial respiration. Although daily supplementation increased plasma nitrite, our data indicate that supplementation with inorganic nitrate as a standalone treatment is ineffective at improving exercise capacity, vascular function, or mitochondrial respiration in patients with HFrEF.
Publisher: Wiley
Date: 02-11-2019
DOI: 10.1113/JP278683
Publisher: American Physiological Society
Date: 11-2023
Publisher: MDPI AG
Date: 22-11-2017
DOI: 10.3390/NU9111270
Publisher: American Physiological Society
Date: 02-2018
DOI: 10.1152/AJPHEART.00414.2017
Abstract: Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which can be converted to nitric oxide in low oxygen conditions. The associated beneficial physiological effects include a reduction in blood pressure, modification of platelet aggregation, and increases in limb blood flow. There have been numerous studies of nitrate supplementation in healthy recreational and competitive athletes however, the ergogenic benefits are currently unclear due to a variety of factors including small s le sizes, different dosing regimens, variable nitrate conversion rates, the heterogeneity of participants’ initial fitness levels, and the types of exercise tests used. In clinical populations, the study results seem more promising, particularly in patients with cardiovascular diseases who typically present with disruptions in the ability to transport oxygen from the atmosphere to working tissues and reduced exercise tolerance. Many of these disease-related, physiological maladaptations, including endothelial dysfunction, increased reactive oxygen species, reduced tissue perfusion, and muscle mitochondrial dysfunction, have been previously identified as potential targets for nitric oxide restorative effects. This review is the first of its kind to outline the current evidence for inorganic nitrate supplementation as a therapeutic intervention to restore exercise tolerance and improve quality of life in patients with cardiovascular diseases. We summarize the factors that appear to limit or maximize its effectiveness and present a case for why it may be more effective in patients with cardiovascular disease than as ergogenic aid in healthy populations.
Publisher: Wiley
Date: 12-2022
DOI: 10.14814/PHY2.15531
Publisher: American Physiological Society
Date: 12-10-2023
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Joaquin Ortiz de Zevallos.