ORCID Profile
0000-0001-8704-3254
Current Organisations
Jilin University
,
University College London
,
University of Liverpool
,
Partner Institute for Computational Biology Chinese Academy of Sciences and Max Planck Society
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Publications
Measurement of the anomalous precession frequency of the muon in the Fermilab Muon
g −
Publisher:
American Physical Society (APS)
Date:
07-04-2021
Publisher: American Physical Society (APS)
Date: 07-04-2021
Genetic variants underlying differences in facial morphology in East Asian and European populations
Publisher: Springer Science and Business Media LLC
Date: 04-2022
DOI: 10.1038/S41588-022-01038-7
Abstract: Facial morphology-a conspicuous feature of human appearance-is highly heritable. Previous studies on the genetic basis of facial morphology were performed mainly in European-ancestry cohorts (EUR). Applying a data-driven phenotyping and multivariate genome-wide scanning protocol to a large collection of three-dimensional facial images of in iduals with East Asian ancestry (EAS), we identified 244 variants in 166 loci (62 new) associated with typical-range facial variation. A newly proposed polygenic shape analysis indicates that the effects of the variants on facial shape in EAS can be generalized to EUR. Based on this, we further identified 13 variants related to differences between facial shape in EUR and EAS populations. Evolutionary analyses suggest that the difference in nose shape between EUR and EAS populations is caused by a directional selection, due mainly to a local adaptation in Europeans. Our results illustrate the underlying genetic basis for facial differences across populations.
Genetic mechanisms underlying East Asian and European Facial differentiation
Publisher: Research Square Platform LLC
Date: 23-06-2021
DOI: 10.21203/RS.3.RS-604881/V1
Abstract: Facial morphology, the most conspicuous feature of human appearance, is highly heritable. Previous studies on the genetic basis of facial morphology were mainly performed in European populations. Applying a proven data-driven phenotyping and multivariate genome-wide scanning protocol to the largest collection of 3D facial images of an East Asian population to date, we identified 244 leading variants associated with normal-range facial variation, of which 130 are novel. A newly proposed polygenic shape analysis indicates that the effects of the variants on East Asian facial shape can be generalized into the European population. Based on this analysis, we further identified 13 variants mainly related to differences between European and East Asian facial shape. Natural selection analyses suggest that the difference in European and East Asian nose shape is caused by a directional selection, mainly due to a local adaptation in Europeans. Our results expand the knowledge of human facial genetics and illustrates for the first time the underlying genetic basis for facial differences across populations.
Magnetic-field measurement and analysis for the Muon
g − 2
Publisher: American Physical Society (APS)
Date: 07-04-2021
Beam dynamics corrections to the Run-1 measurement of the muon anomalous magnetic moment at Fermilab
Publisher: American Physical Society (APS)
Date: 27-04-2021
Measurement of the Positive Muon Anomalous Magnetic Moment to 0.46 ppm
Publisher: American Physical Society (APS)
Date: 07-04-2021
Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm
Publisher: American Physical Society (APS)
Date: 17-10-2023
Related Organisations
University College London
Location: United Kingdom of Great Britain and Northern Ireland
University Of Liverpool
Location: United Kingdom of Great Britain and Northern Ireland
Partner Institute For Computational Biology Chinese Academy Of Sciences And Max Planck Society
Location: China
Related Funding Activities
No related grants have been discovered for Dominika Vasilkova.