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0000-0003-2371-9037
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Full Face Orthodontics Pty Ltd
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Publisher: Walter de Gruyter GmbH
Date: 07-2021
Abstract: The importance of assessing patients for paediatric obstructive sleep apnoea (OSA) cannot be more highly stressed and orthodontists may play an essential role in risk screening. The Paediatric Sleep Questionnaire (PSQ) is a validated tool to identify whether a child is at risk for paediatric OSA. The likelihood of paediatric OSA in school-aged children residing in Far North Queensland (FNQ) will be assessed using the PSQ. Parents of children aged between 4 and 18 years were invited to participate through schools and social media messaging to complete an online PSQ questionnaire to assess their OSA risk and demographics. The final s le consisted of 404 school-aged children of whom 62.5% were found to be at a high-risk for paediatric OSA. The high risk was significantly associated with males and those of overweight/obese BMI status ( p 0.001). Race and age were not significant associations ( p 0.05). Within the contributing s le of school-aged children in FNQ, a significant number were found to be at high-risk of paediatric OSA. Males and overweight/obese children were measured risk factors.
Publisher: Walter de Gruyter GmbH
Date: 07-2021
Abstract: Objective: The present study aimed to determine how the popularity of ‘Do It Yourself’ (DIY) aligner videos available on YouTube relates to authorship, video content, quality and reliability, and to determine why DIY aligners appeal to consumers. Methods: The Google Trends website was interrogated to identify the most frequently used search terms regarding DIY aligners which were subsequently applied to a search of the YouTube website. One hundred twenty-three videos were assessed for completeness of content, reliability (using a modified version of the DISCERN tool) and quality using the Global Quality Score (GQS). The relationship between the variables and authorship, popularity, financial interest, and recommendations were assessed using Pearson Correlation Coefficients. Results: Laypeople produced the majority of the videos (73%). Dentists/Orthodontists uploaded only 4% of the videos, and dental professional bodies uploaded none. Most videos (86%) were content poor, unreliable (average DISCERN score of 1) and of low quality (average GQS of 2). The more popular, reliable and superior the quality of the video, the greater the number of views, likes and viewing rate ( p 0.05). Conversely, authors with a financial interest and lower quality and less reliable videos were more likely to recommend DIY aligners. Consumers sought DIY aligner treatment due to a reduced cost. Conclusions: YouTube should not be considered as a viable nor reliable source of DIY aligner information for patients or the public. Dentists/Orthodontists should be encouraged to publish comprehensive and more informative YouTube content related to DIY aligners.
Publisher: Scientific Scholar
Date: 04-02-2022
Abstract: This case report describes the orthodontic-orthognathic management of a 17-year-old male patient with extremely severe skeletal Class III malocclusion due to a marked mandibular protrusion with a small and narrowed upper jaw which increased the remarkable concave facial profile. Dental articulation was entirely lacking, resulting in great difficulty in masticating food. A two-jaw surgery combined with mandibular body ostectomy was performed to correct mandibular asymmetry and the severe sagittal skeletal discrepancy (Wits appraisal –36.5 mm and ANB angle –14.3°). Bi-maxillary surgery was performed in two-stages the first surgery consisted of maxillary advancement with Le Fort I osteotomy followed by a second surgery where a combination of sagittal split ramus osteotomy (SSRO) and mandibular body ostectomy was performed to correct the severe mandibular prognathism. A partial glossectomy was also carried out to address macroglossia. After a total treatment time of 32 months, a Class I occlusion with a favorable facial profile and lip competence were obtained. The occlusion was made approximately ideal, and mastication improved remarkably. Three years after retention, the occlusion was stable and no relapse was observed. The patient’s complaints and orthodontic problems were completely resolved. Therefore, a combination of two-jaw surgeries with Le Fort I maxillary osteotomy, mandibular SSRO, mandibular ostectomy, and glossectomy may be a viable option in the correction of extremely severe anteroposterior skeletal discrepancy.
Publisher: Wiley
Date: 14-12-2007
DOI: 10.1002/JCB.21167
Abstract: Focusing on the final step of osteoclastogenesis, we studied cell fusion from tartrate-resistant acid phosphatase (TRAP)-positive mononuclear cells into multinuclear cells. TRAP-positive mononuclear cells before generation of multinuclear cells by cell fusion were differentiated from RAW264.7 cells by treatment with receptor activator of nuclear factor kappa B ligand (RANKL), and then the cells were treated with lipopolysaccharide (LPS), followed by culturing for further 12 h. LPS-induced cell fusion even in the absence of RANKL. Similarly, tumor necrosis factor (TNF)-alpha and peptidoglycan (PGN) induced cell fusion, but M-CSF did not. The cell fusion induced by RANKL, TNF-alpha, and LPS was specifically blocked by osteoprotegerin (OPG), anti-TNF-alpha antibody, and polymyxin B, respectively. LPS- and PGN-induced cell fusion was partly inhibited by anti-TNF-alpha antibody but not by OPG. When TRAP-positive mononuclear cells fused to yield multinuclear cells, phosphorylation of Akt, Src, extracellular signal-regulated kinase (ERK), p38MAPK (p38), and c-Jun NH2-terminal kinase (JNK) was observed. The specific chemical inhibitors LY294002 (PI3K), PP2 (Src), U0126 (MAPK-ERK kinase (MEK)/ERK), and SP600125 (JNK) effectively suppressed cell fusion, although SB203580 (p38) did not. mRNA of nuclear factor of activated T-cells c1 (NFATc1) and dendritic cell-specific transmembrane protein (DC-STAMP) during the cell fusion was quantified, however, there was no obvious difference among the TRAP-positive mononuclear cells treated with or without M-CSF, RANKL, TNF-alpha, LPS, or PGN. Collectively, RANKL, TNF-alpha, LPS, and PGN induced cell fusion of osteoclasts through their own receptors. Subsequent activation of signaling pathways involving PI3K, Src, ERK, and JNK molecules was required for the cell fusion. Although DC-STAMP is considered to be a requisite for cell fusion of osteoclasts, cell fusion-inducing factors other than DC-STAMP might be necessary for the cell fusion.
Publisher: Elsevier BV
Date: 11-2011
DOI: 10.1016/J.AJODO.2011.05.017
Abstract: The major side effect of orthodontic treatment is orthodontically induced inflammatory root resorption. Fluoride was previously shown to reduce the volume of the root resorption craters in rats. However, the effect of fluoride on orthodontically induced inflammatory root resorption in humans has not yet been investigated. The aim of this study was to investigate the effect of high and low amounts of fluoride intake from birth on orthodontically induced inflammatory root resorption under light (25 g) and heavy (225 g) force applications. Forty-eight patients who required maxillary premolar extractions as part of their orthodontic treatment were selected from 2 cities in Turkey with high and low fluoride concentrations in the public water of ≥ 2 and ≤ 0.05 ppm, respectively. The patients were randomly separated into 4 groups of 12 each: group 1, high fluoride intake and heavy force group 2, low fluoride intake and heavy force group 3, high fluoride intake and light force and group 4, low fluoride intake and light force. Light or heavy buccal tipping orthodontic forces were applied on the maxillary first premolars for 28 days. At day 28, the teeth were extracted, and the s les were analyzed with microcomputed tomography. Fluoride reduced the volume of root resorption craters in all groups however, this effect was significantly different with high force application (P = 0.015). It was also found that light forces caused less root resorption than heavy forces. There was no statistical difference in the amount of root resorption observed on root surfaces (buccal, lingual, mesial, and distal) in all groups. However, the middle third of the roots showed the least root resorption. With high fluoride intake and heavy force application, less root resorption was found in all root surfaces and root thirds. Fluoride may reduce the volume of root resorption craters. This effect is significant with heavy force applications (P <0.05). The cervical and apical thirds of the root showed significantly greater root resorption after the application of buccal tipping force for 4 weeks.
Publisher: Elsevier BV
Date: 2012
DOI: 10.1016/J.AJODO.2011.06.032
Abstract: Extrusive tooth movement has been overlooked in the literature on root resorption. The aims of this study were to quantify the effects of light and heavy controlled extrusive forces on root resorption and to localize the sites of prevalence in premolars. Ten patients (7 girls, 3 boys) who required bilateral maxillary first premolar extractions as part of their orthodontic treatment participated in this study. The total s le consisted of 20 maxillary first premolars. Light (25 g) or heavy (225 g) forces were applied to the right or left first premolar for 28 days. After the experimental period, the teeth were extracted without root damage and analyzed with microcomputed tomography. Each specimen was studied in 3 dimensions, and specially designed software was used to measure the volume of each crater. Wilcoxon signed rank tests were used for the statistical analysis. There was a significant difference in the total root resorption caused by light and heavy forces (P = 0.037). The discrepancy between the light and heavy groups was not significant for the cervical, middle, and apical regions separately. Only the distal surfaces were significantly different between the light and heavy forces (P = 0.008). Greater root resorption was observed after heavy extrusive forces when compared with light forces. The distal surfaces of the tooth root were significantly more affected than other root surfaces and might be influenced by root morphology and initial angulation of the tooth. There was no significant difference in the cervical, middle, and apical thirds in relation to root resorption after light or heavy extrusive forces.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 07-2009
DOI: 10.2319/071308-366.1
Abstract: Objective: To investigate the precise longitudinal change in the periodontal ligament (PDL) space width and three-dimensional tooth movement with continuous-force magnitudes in living rats. Materials and Methods: Using nickel-titanium closed-coil springs for 28 days, 10-, 25-, 50-, and 100-g mesial force was applied to the maxillary left first molars. Micro-CT was taken in the same rat at 0, 1, 2, 3, 10, 14, and 28 days. The width of the PDL was measured in the pressure and tension sides from 0 to 3 days. Angular and linear measurements were used to evaluate molar position at day 0, 10, 14, and 28. The finite element model (FEM) was constructed to evaluate the initial stress distribution, molar displacement, and center of rotation of the molar. Results: The initial evaluation of PDL width showed no statistical differences among different force magnitudes. Tooth movement was registered 1 hour after force application and gradually increased with time. From day 10, greater tooth movement was observed when 10 g of force was applied. The FEM showed that the center of rotation in the molar is located in the center of five roots at the apical third of the molar roots. Conclusion: The rat's molar movement mainly consists of mesial tipping, extrusion of distal roots, intrusion of mesial root, palatal inclination, and mesial rotation. Although the initial tooth movement after the application of different force magnitudes until day 3 was not remarkably different, 10 g of force produced more tooth movement compared with heavier forces at day 28.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 20-12-2021
DOI: 10.2319/041921-316.1
Abstract: To identify malocclusion characteristics generated after using oral appliances (OAs) for at least 5 years for the management of snoring and obstructive sleep apnea (OSA) in adults. PubMed, MEDLINE (Ovid), Scopus, CINAHL, and Informit were searched without language restrictions through January 20, 2021. Unpublished literature was searched on ClinicalTrials.gov, the National Research Register, and the Pro-Quest Dissertation Abstracts and Thesis database. Authors were contacted when necessary, and reference lists of the included studies were screened. Risk of bias was assessed through the revised Cochrane Risk of Bias tool for randomized controlled trials (RoB2) and Non-Randomized Studies of Interventions for non-RCTs and uncontrolled before–after studies (ROBINS-I). A random-effects meta-analysis was conducted only on studies that used the same OAs to exclude biomechanical differences. Risk of bias across studies was assessed with the Grading of Recommendations, Assessment, Development and Evaluation tool. A total of 12 studies were included in the final qualitative synthesis. Eight included studies had high, one had moderate, and three had low risks of bias. Significant progressive decreases of overjet (OJ −1.43 mm 95% confidence interval [CI], −1.66 to −1.20) and overbite (OB −1.94 mm 95% CI, −2.14 to −1.74) associated with maxillary incisor retroclination and mandibular incisor proclination were reported long term. Although most studies showed no sagittal skeletal changes, some degree of vertical skeletal changes were noted. Based on a very low evidence level, inevitable anterior teeth positional changes seem to be a common long-term adverse effect of OAs. The magnitude of those changes could be considered clinically irrelevant for most pretreatment occlusions, but in occlusions with limited OJ and OB, it may be worth clinical consideration.
Publisher: Springer Science and Business Media LLC
Date: 25-09-2014
DOI: 10.1186/S40510-014-0056-7
Abstract: The technology surrounding temporary skeletal anchorage devices has improved in leaps and bounds. However, no specific auxiliary exists for the intrusion of molars in conjunction with these devices and currently clinicians are forced to make do with available force delivery materials. A new intrusion auxiliary, the Sydney Intrusion Spring (SIS), was designed to facilitate intrusion without frequent need for reactivation or tissue irritation. The subjects consisted of 16 adolescent patients (12 females and 4 males) with an average age of 13.1 years (range 12.2 to 14.3 years). All patients were in the permanent dentition with an anterior open bite of ?2 mm. Four self-drilling miniscrews were placed into the posterior maxillary buccal alveolar bone. The intrusion appliance consisted of a bonded acrylic appliance and the SIS, activated to produce an initial intrusive force of 500 g. Cone beam computed tomograms were taken after miniscrew placement and at the end of active intrusion. Rendered lateral cephalograms were produced and measurements were taken and compared. All study objectives were achieved in 4.91 months (range 2.5 to 7.75 months). The mean molar intrusion was 2.9 0.8 mm ( P .001), resulting in over bite increase of 3.0 1.5 mm ( P .001). The intrusion led to a 2.6 1.3 ( P .001) clockwise occlusal plane rotation and a 1.2 1.3 ( P .01) counter-clockwise rotation of the mandible. Dental measurements showed a significant uprighting and elongation of the incisors. There was no significant extrusion of the lower molars. The SIS is an effective appliance for the intrusion of maxillary posterior teeth, in conjunction with miniscrews.
Publisher: Oxford University Press (OUP)
Date: 09-01-2013
DOI: 10.1093/EJO/CJS100
Abstract: The purpose of the present study was to clarify the prevalence and degree of root resorption induced by orthodontic treatment in patients with and without open bite. One hundred and eleven patients treated with multibracket appliances were retrospectively selected from the patients and ided into non-open bite (NOB) and open bite (OB) groups. The severity of root resorption and the root shape were classified into five groups on periapical radiographs before and after treatment. Moreover, only in the OB group, all teeth were sub- ided into functional and hypofunctional ones that are occluding and non-occluding. As the results of multiple linear regression analysis of patient characteristics and clinical variables with the number of overall root resorption, the independent variables that were found to contribute significantly to root resorption were bite and abnormal root shape. The prevalences of root resorption evaluated in the number of patients were significantly higher in OB group than in NOB group, and those in the number of teeth were significantly higher in OB group than in NOB group, in particular anterior and premolar teeth. The prevalence of resorbed teeth with abnormal root shapes was also significantly higher in OB group than in NOB group. On the other hand, in OB group, the prevalences of root resorption and teeth with abnormal root shape were significantly greater in hypofunctional teeth than in normal functional teeth. There are more teeth with root resorption and abnormal root shape in open bite cases than in normal bite cases, and more teeth with abnormal root shapes and root resorption in hypofunctional teeth than in functional teeth.
Publisher: Elsevier BV
Date: 04-2010
DOI: 10.1016/J.AJODO.2008.05.018
Abstract: Root resorption is a side effect of orthodontic treatment that occurs with the removal of hyalinized tissue. Studies have shown that a reparative process in the periodontium begins when the applied orthodontic force is discontinued or reduced below a certain level. However, quantitative 3-dimensional evaluation of root resorption repair has not been done. The aim of this study was to quantitatively assess the 2- and 3-dimensional changes of root resorption craters after 2 weeks of continuous mesially applied orthodontic forces of 50 g on rat molars and 2- to 16-week retention periods. We used 60 male Wistar rats (10 weeks old). Nickel-titanium closed-coil springs were used to apply 50-g mesial forces for 2 weeks to move the maxillary left first molars. The rats were randomly allocated to 6 groups. Those in the zero-week retention group were killed after force application. In the remaining 5 groups, the interdental spaces between the maxillary first and second molars were filled with resin to retain the molars. The molars were extracted after periods of retention from 2 and 16 weeks. The maxillary right molars were used as the controls. Mesial and distal roots (distobuccal and distopalatal) were examined by using scanning electron and 3-dimensional scanning laser microscopes. The surface area, depth, volume, and roughness of the root resorption craters were measured. The area, depth, and volume of the craters decreased gradually and showed similar trends over the retention time, approaching a plateau at the 12th week. After 16 weeks of retention, the volumes of the resorption craters of the distobuccal and distopalatal roots reached recovery peaks of 69.5% and 66.7%, respectively. Small pits on the mesial roots showed recovery of 62.5% at the 12th week. The healing patterns in distal roots with severe resorption and mesial roots with shallow resorption had no significant differences. The resorption and repair processes during the early stages of retention are balanced, and most of the reparative process occurs after 4 weeks of passive retention after the application of orthodontic force. Frequent orthodontic reactivations should be avoided to allow recovery and repair of root surface damage.
Publisher: Elsevier BV
Date: 02-2011
DOI: 10.1016/J.AJODO.2009.05.029
Abstract: Even though the beneficial effects of fluoride on enamel and root caries have been well documented, limited data are available concerning the effect of fluoride on orthodontically induced root resorption and tooth movement. Our objective was to investigate the effect of systemic fluoride administered from birth to 12 weeks on orthodontically induced root resorption and tooth movement in rat molars. Fifty male Wistar rats were randomly ided into 5 groups. The negative control group received no sodium fluoride and had no tooth movement. The positive control group received no sodium fluoride but had tooth movement. Three experimental groups received sodium fluoride at 45 ppm from birth to 2, 4, and 12 weeks, respectively. At week 10, a 50-g nickel-titanium coil spring was applied to the maxillary left first molar for 2 weeks. The rats were killed at 12 weeks of age. Movement of the maxillary first molars was measured in relation to the maxillary second molar on digitized cephalometric radiographs. Mesial and distal roots were examined by using scanning electron and 3-dimensional laser microscopes. Fluoride reduced the depth, volume, and roughness of the resorption craters in the experimental groups. However, the area was similar to that in the positive control group. Regarding the duration of fluoride intake, the longer fluoride was administered via drinking water, the smaller the amount of tooth movement observed. Fluoride in drinking water from birth reduced the severity of orthodontically induced root resorption, but the amount of tooth movement was also decreased.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 11-2009
Abstract: Objective: To determine optimal loading conditions such as height of retraction force on the power arm and its position on the archwire in sliding mechanics. Materials and Methods: A 3D finite element method (FEM) was used to simulate en masse anterior teeth retraction in sliding mechanics. The degree of labiolingual tipping of the maxillary central incisor was calculated when the retraction force was applied to different heights of a power arm set mesial or distal to the canine. Results: When the power arm was placed mesial to the canine, at the level of 0 mm (bracket slot level), uncontrolled lingual crown tipping of the incisor was observed and the anterior segment of the archwire was deformed downward. At a power arm height of 5.5 mm, bodily movement was produced and the archwire was less deformed. When the power arm height exceeded 5.5 mm, the anterior segment of the archwire was raised upward and lingual root tipping occurred. When the power arm was placed distal to the canine, lingual crown tipping was observed up to a level of 11.2 mm. Conclusions: Placement of the power arm of an archwire between the lateral incisor and canine enables orthodontists to maintain better control of the anterior teeth in sliding mechanics. Both the biomechanical principles associated with the tooth's center of resistance and the deformation of the archwire should be taken into consideration for predicting and planning orthodontic tooth movement.
Publisher: Galenos Yayinevi
Date: 31-12-2019
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 05-2008
DOI: 10.2319/052007-240.1
Abstract: Objective: To test the hypothesis that there is no difference in the effect of different continuous moderate to very heavy forces on root resorption or amount of tooth movement. Materials and Methods: In the study, 10, 25, 50 and 100 g mesial force were applied to the maxillary first molars of rat using nickel titanium closed-coil springs for 3 days, 14 days, and 28 days. The molars were extracted and the surface areas of the root resorption craters were measured using scanning electron microscope. The depths of the root resorption craters were measured using a three-dimensional laser scanning microscope. Tooth movement of the maxillary first molar was measured in relation to the maxillary second molar on digitized lateral cephalometric radiographs. Results: Three days after force application, the tooth movement was not proportionally related to force magnitude. However, 14 days of force application resulted in significantly more tooth movement in the 10, 25, and 50 g force groups than in the 100 g force group. A force application of 10 g produced significantly more tooth movement at 28 days than all the other three force applications. The largest and deepest resorption craters were observed in the disto-buccal root followed by disto-palatal, middle-buccal, middle-palatal, and mesial root. Root resorption and tooth movement increased over time from 3 to 28 days. As heavier forces were applied, greater root resorption occurred. Conclusion: The hypothesis is rejected. The light mesially oriented forces, as applied in this study, produced more tooth movement and less root resorption compared with heavier forces.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 13-11-2013
DOI: 10.2319/081812-661.1
Abstract: To investigate the effects of long-term, artificially created, hypofunctional occlusion and its recovery on the morphology of rat molar roots. Eighteen 5-week-old Wistar-strain male rats were randomly ided according to their periodontal conditions into normal, hypofunctional, and recovery groups (n = 6 in each). In the experimental hypofunctional and recovery groups, a bite-raising appliance was set to produce hypofunction at the molar region. All groups were analyzed at 16 weeks of age using three-dimensional micro-computed tomography. Root length, width, and area as well as the thickness and the area of the periodontal ligament (PDL) space of the maxillary first molar were calculated. Roots were longer and narrower in the hypofunctional group than in the control group. The mesial root in particular showed a dramatic change. Root area also decreased significantly in the hypofunctional group compared to the other groups. Moreover, the PDL thickness and area decreased significantly in the hypofunctional group compared to the control group, but increased in the recovery group compared to the hypofunctional group. These findings suggest that root size and PDL structure may be reduced due to disuse atrophy resulting from a defect in occlusal function, but may be recovered following a gain of occlusal stimuli.
Publisher: Walter de Gruyter GmbH
Date: 11-2011
Abstract: Aims: The aim of the present study was to determine whether high and low fluoride concentrations in drinking water affected the early stages of tooth movement when heavy and light orthodontic forces were applied for 4 weeks. A further aim was to compare and evaluate the resulting two-dimensional (2-D) and three-dimensional (3-D) orthodontic tooth movement. Methods: The s le consisted of 96 maxillary upper first premolars from 48 patients who required premolar extractions as part of their orthodontic treatment. Patients were selected from two different cities in Turkey with low and high fluoride concentrations of 0.05 and 2 ppm, respectively. The patient s le was ided into four groups according to the magnitude of force applied to the first premolars and the concentration of fluoride in the public water supply Group 1, High fluoride intake (≥ 2 ppm)-Heavy force (225 g) Group 2, Low fluoride intake (≤ 0.05 ppm)-Heavy force Group 3, High fluoride intake-Light force (25 g) and Group 4, Low fluoride intake-Light force. A light or heavy buccal tipping orthodontic force was applied to the upper first premolars for 4 weeks. The first three palatal rugae were used for the superimposition of patient casts in a 2-D and 3-D evaluation of generated movements. Results: It was found that heavy force application and fluoride intake increased the average rate of tooth movement. It was further shown that age was negatively correlated with tooth movement in the 2-D and 3-D measurements. Conclusions: The average rate of tooth movement was found to be greater in the heavy force and high fluoride intake group (Group 1HH). Age was negatively correlated with orthodontic tooth movement. Two- and three-dimensional methods were accurate for the assessment of tooth movement after four weeks of buccal tipping force application when the palatal rugae were used for superimposition.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 11-2009
Abstract: Objective: To test the efficacy of an animal model of pain and stress and evaluate the effects of celecoxib administered when orthodontic force is applied. Materials and Methods: A 20-g reciprocal force was applied via an orthodontic appliance to the maxillary left first and second molars of 7-week-old male Sprague-Dawley rats. Rat behavior was evaluated at 5, 24, and 48 hours after the appliance was set. Behavior was assessed in a test field by the number of lines crossed in the first 30 seconds and 5 minutes following force application number of lines crossed to the center rearing time and facial grooming time. Experimental group 1 received intraperitoneal administration of 30 mg/kg celecoxib before every behavioral test. Experimental group 2 received 90 mg/kg before the first behavioral test, and physiologic saline was administered before the remaining behavioral tests. Control groups received saline before every behavioral test and were given passive (passive control group) and active (active control group) appliances, respectively. Results: Parameters related to pain increased in the active controls, whereas the parameters in the experimental groups decreased to the level seen in the passive controls. Statistically significant differences in pain-related behavior between control and experimental groups were found at 5 and 24 hours after placing the appliance. Stress-related behavior was significantly less in the experimental groups compared to the active control group during experimental periods. Conclusions: The administration of celecoxib relieves pain- and stress-related behavior evoked by orthodontic tooth movement in the rat. This model might be a useful tool for the evaluation of pain and stress.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 12-11-2013
DOI: 10.2319/072512-606.1
Abstract: To evaluate the null hypothesis that fluoride intake via drinking water has no effect on orthodontic root resorption in humans after orthodontic force application for 4 weeks and 12 weeks of retention. Forty-eight patients who required maxillary premolar extractions as part of their orthodontic treatment were selected from two cities in Turkey. These cities had a high and low fluoride concentration in public water of ≥2 pm and ≤0.05 pm, respectively. The patients were randomly separated into four groups of 12 each: group 1HH, high fluoride (≥2 ppm) and heavy force (225 g) group 2LH, low fluoride (≤0.05 ppm) and heavy force group 3HL, high fluoride and light force (25 g) and group 4LL, low fluoride and light force. Light or heavy buccal tipping force was applied on the upper first premolars for 28 days. At day 28, the left premolars were extracted (positive control side) the right premolars (experimental side) were extracted after 12 weeks of retention. The s les were analyzed with microcomputed tomography. On the positive control side, under heavy force application, the high fluoride groups exhibited less root resorption (P = .015). On the experimental side, it was found that fluoride reduced the total volume of root resorption craters however, this effect was not statistically significant (P = .237). Moreover, the results revealed that under heavy force application experimental teeth exhibited more root resorption than positive control groups. The null hypothesis could not be rejected. High fluoride intake from public water did not have a beneficial effect on the severity of root resorption after a 4-week orthodontic force application and 12 weeks of passive retention.
Publisher: Springer Science and Business Media LLC
Date: 12-2017
Publisher: Elsevier BV
Date: 05-2012
DOI: 10.1016/J.AJODO.2011.11.016
Abstract: The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. Fifteen 10-week-old female Wistar rats were ided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption. There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption. Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats.
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 07-2011
DOI: 10.2319/101710-607.1
Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)
Date: 07-2009
DOI: 10.2319/072108-381.1
Abstract: Objective: To test the hypothesis that the administration of aspirin, acetaminophen, meloxicam, celecoxib, and prednisolone have no effect on root resorption and tooth movement. Materials and Methods: A mesial force of 50 g was applied to the left maxillary first molars of sixty 10-week-old male Wistar rats using nickel titanium closed coil springs attached to the cervical area of the incisors. The rats were randomly ided into 12 groups of 5 each. High and low doses of aspirin, acetaminophen, meloxicam, celecoxib, and prednisolone were administered via drinking water for 2 weeks. The experimental control group had tooth movement but received no drug. The negative control group received neither tooth movement nor drugs. The amount of tooth movement was measured on digitized lateral cephalometric radiographs. Rats were sacrificed after 2 weeks. Mesial and distal roots (distobuccal and distopalatal) were examined using scanning electron and three-dimensional (3D) scanning laser microscopes. The surface area, depth, volume, and roughness of the root resorption craters were measured. Results: When compared with experimental control rats, only prednisolone- and high-dose celecoxib-treated groups showed significantly less root resorption and less tooth movement. Although low dose celecoxib-treated group significantly decreased the tooth movement, root resorption was similar to the control group. Furthermore, resorption craters showed a smoother surface in the prednisolone-treated rats. Conclusions: The hypothesis was rejected. Administration of prednisolone and high-dose celecoxib reduces root resorption and interferes with tooth movement in rats. Both drugs may interfere in the arachidonic acid cascade depending on dose thresholds.
No related grants have been discovered for Carmen Karadeniz.