ORCID Profile
0000-0001-8830-4954
Current Organisation
Guangxi University
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Publisher: Wiley
Date: 07-01-2014
DOI: 10.1096/FJ.13-244103
Publisher: American Chemical Society (ACS)
Date: 27-04-2021
Publisher: Elsevier BV
Date: 12-2017
Publisher: Elsevier BV
Date: 04-2015
Publisher: American Chemical Society (ACS)
Date: 25-09-2018
DOI: 10.1021/ACS.JMEDCHEM.8B00967
Abstract: The α3β4 nicotinic acetylcholine receptor (nAChR) is an important target implicated in various disease states. α-Conotoxin TxID (1) is the most potent antagonist of α3β4 nAChR, but it also exhibits inhibition of α6/α3β4 nAChR. The results of alanine scanning of 1 suggested a vital role for Ser9 in the selectivity of the peptide. In this study, Ser9 was substituted with a series of 14 amino acids, including some non-natural amino acids, displaying different physicochemical characteristics to further improve the selectivity of 1 toward α3β4 nAChR. The pharmacological activities of the mutants were evaluated using an electrophysiological approach. The best selectivity was obtained with [S9K]TxID, 12, which inhibited α3β4 nAChR with an IC
Publisher: MDPI AG
Date: 15-01-2014
Publisher: Proceedings of the National Academy of Sciences
Date: 13-07-2015
Abstract: The α9α10 nicotinic AChR (nAChR) subtype is a recently identified target for the development of breast cancer chemotherapeutics and analgesics, particularly to treat neuropathic pain. Structure/function analyses of antagonists of this subtype are therefore essential for the development of specific therapeutic compounds. The Conus genus is a rich source of pharmacologically active peptides, and we report here that the αO-conotoxin GeXIVA is a potent and selective antagonist of the α9α10 nAChR subtype. GeXIVA displays unique structural properties among other Conus peptides and represents a previously unidentified template for molecules active against neuropathic pain.
Publisher: American Chemical Society (ACS)
Date: 22-01-2023
Publisher: Elsevier BV
Date: 2013
Publisher: Elsevier BV
Date: 04-2010
Publisher: American Chemical Society (ACS)
Date: 21-06-2017
Publisher: American Chemical Society (ACS)
Date: 22-11-2013
DOI: 10.1021/JM401254C
No related grants have been discovered for xiaopeng zhu.