ORCID Profile
0000-0002-4730-6328
Current Organisations
RISE Research Institutes of Sweden
,
Linköping University
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Publisher: Elsevier BV
Date: 06-2023
Publisher: Frontiers Media SA
Date: 28-04-2022
DOI: 10.3389/FPHYS.2022.840179
Abstract: Perturbations to nutrition during critical periods are associated with changes in embryonic, fetal or postnatal developmental patterns that may render the offspring more likely to develop cardiovascular disease in later life. The aim of this study was to evaluate whether autonomic nervous system imbalance underpins in the long-term hypertension induced by dietary protein restriction during peri-pubertal period. Male Wistar rats were assigned to groups fed with a low protein (4% protein, LP) or control diet (20.5% protein NP) during peri-puberty, from post-natal day (PN) 30 until PN60, and then all were returned to a normal protein diet until evaluation of cardiovascular and autonomic function at PN120. LP rats showed long-term increased mean arterial pressure ( p = 0.002) and sympathetic arousal increased power of the low frequency (LF) band of the arterial pressure spectral ( p = 0.080) compared with NP animals. The depressor response to the ganglion blocker hexamethonium was increased in LP compared with control animals ( p = 0.006). Pulse interval variability showed an increase in the LF band and LF/HF ratio ( p = 0.062 and p = 0.048) in LP animals. The cardiac response to atenolol and/or methylatropine and the baroreflex sensitivity were similar between groups. LP animals showed ventricular hypertrophy ( p = 0.044) and increased interstitial fibrosis ( p = 0.028) compared with controls. Reduced protein carbonyls (PC) ( p = 0.030) and catalase activity ( p = 0.001) were observed in hearts from LP animals compared with control. In the brainstem, the levels of PC ( p = 0.002) and the activity of superoxide dismutase and catalase ( p = 0.044 and p = 0.012) were reduced in LP animals, while the levels of GSH and total glutathione were higher ( p = 0.039 and p = 0.038) compared with NP animals. Protein restriction during peri-pubertal period leads to hypertension later in life accompanied by sustained sympathetic arousal, which may be associated with a disorganization of brain and cardiac redox state and structural cardiac alteration.
Publisher: Elsevier BV
Date: 07-2022
Publisher: Elsevier BV
Date: 2022
Publisher: Elsevier BV
Date: 03-2023
Publisher: Frontiers Media SA
Date: 02-11-2017
Publisher: Springer Science and Business Media LLC
Date: 06-08-2021
DOI: 10.1007/S11249-021-01485-Z
Abstract: Improving the tactile aesthetics of products that can be described as touch intensive is an increasing priority within many sectors, including the furniture industry. Understanding which physical characteristics contribute to the haptic experience of a surface, and how, is therefore highly topical. It has earlier been shown that both friction and topography affect tactile perception. Thus, two series of stimuli have been produced using standard coating techniques, with systematic variation in (physical) friction and roughness properties. This was achieved through appropriate selection of matting agents and resins. The stimuli sets were then evaluated perceptually to determine the extent to which discrimination between pairs of surfaces followed the systematic materials variation. In addition to investigating the role of the physical properties in discrimination of the surfaces, their influence on perceived pleasantness and naturalness was also studied. The results indicate that changes in tactile perception can be understood in terms of friction and roughness, and that varying the matting agents (topography) and resins (material properties) in the coatings provide the controlling factors for furniture applications. Perceived pleasantness is associated with low friction and smoother topography, whilst perceived naturalness is found to be described by an interaction between tactile friction and the average maximum peak height of the surface features. Graphic Abstract
Publisher: Elsevier BV
Date: 12-2021
No related grants have been discovered for Elizabeth Hörlin.