ORCID Profile
0000-0001-5128-9789
Current Organisation
Springer Nature (Germany)
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Publisher: Springer Science and Business Media LLC
Date: 27-03-2020
DOI: 10.1038/S41467-020-15394-7
Abstract: ELONGATED HYPOCOTYL 5 (HY5), a basic domain/leucine zipper (bZIP) transcription factor, acts as a master regulator of transcription to promote photomorphogenesis. At present, it’s unclear whether HY5 uses additional mechanisms to inhibit hypocotyl elongation. Here, we demonstrate that HY5 enhances the activity of GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 (BIN2), a key repressor of brassinosteroid signaling, to repress hypocotyl elongation. We show that HY5 physically interacts with and genetically acts through BIN2 to inhibit hypocotyl elongation. The interaction of HY5 with BIN2 enhances its kinase activity possibly by the promotion of BIN2 Tyr 200 autophosphorylation, and subsequently represses the accumulation of the transcription factor BRASSINAZOLE-RESISTANT 1 (BZR1). Leu 137 of HY5 is found to be important for the HY5-BIN2 interaction and HY5-mediated regulation of BIN2 activity, without affecting the transcriptional activity of HY5. HY5 levels increase with light intensity, which gradually enhances BIN2 activity. Thus, our work reveals an additional way in which HY5 promotes photomorphogenesis, and provides an insight into the regulation of GSK3 activity.
Publisher: Proceedings of the National Academy of Sciences
Date: 05-10-2016
Abstract: Box C (RUGAUGA)/D (CUGA) and H (ANANNA)/ACA small nucleolar RNAs (snoRNAs) are important for the modification and processing of rRNA during ribosome biogenesis in eukaryotes. However, the molecular role of snoRNAs throughout the multiple steps of pre-rRNA processing remains poorly understood. This study shows that an uncharacterized C/D box snoRNA, HIDDEN TREASURE 2 ( HID2 ) , functions as a prominent player in the monitoring of efficient pre-rRNA processing, which, in turn, is essential for accurate ribosome assembly in Arabidopsis . Our data explore a link between a spatially regulated snoRNA and the complexity and the precise control of ribosome biogenesis. Further, the conservation of HID2 ’ s signature motif and function highlights its importance in multicellular organisms. hid2 appears to be a representative snoRNA mutant exhibiting pleiotropic developmental defects in plants.
Publisher: Wiley
Date: 2020
DOI: 10.1111/JIPB.12903
Abstract: The COP9 signalosome (CSN) is a conserved protein complex, typically composed of eight subunits (designated as CSN1 to CSN8) in higher eukaryotes such as plants and animals, but of fewer subunits in some lower eukaryotes such as yeasts. The CSN complex is originally identified in plants from a genetic screen for mutants that mimic light-induced photomorphogenic development when grown in the dark. The CSN complex regulates the activity of cullin-RING ligase (CRL) families of E3 ubiquitin ligase complexes, and play critical roles in regulating gene expression, cell proliferation, and cell cycle. This review aims to summarize the discovery, composition, structure, and function of CSN in the regulation of plant development in response to external (light and temperature) and internal cues (phytohormones).
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Nanxun (Nancy) Qin.