ORCID Profile
0000-0002-2262-7205
Current Organisations
Capital Medical University
,
Capital Medical University Beijing Obstetrics and Gynecology Hospital
,
University of Oxford
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Publisher: JMIR Publications Inc.
Date: 25-01-2022
DOI: 10.2196/29644
Abstract: Maternal and child health (MCH)–related mobile apps are becoming increasingly popular among pregnant women however, few apps have demonstrated that they lead to improvements in pregnancy outcomes. This study aims to investigate the use of MCH apps among pregnant women in China and explore associations with pregnancy outcomes. A retrospective study was conducted at 6 MCH hospitals in northern China. Women who delivered a singleton baby at weeks’ gestation at the study hospitals were sequentially recruited from postnatal wards from October 2017 to January 2018. Information was collected on the women’s self-reported MCH app use during their pregnancy, along with clinical outcomes. Women were categorized as nonusers of MCH apps and users (further ided into intermittent users and continuous users). The primary outcome was a composite adverse pregnancy outcome (CAPO) comprising preterm birth, birth weight g, birth defects, stillbirth, and neonatal asphyxia. The association between app use and CAPO was explored using multivariable logistic analysis. The 1850 participants reported using 127 different MCH apps during pregnancy. App use frequency was reported as never, 24.7% (457/1850) intermittent, 47.4% (876/1850) and continuous, 27.9% (517/1850). Among app users, the most common reasons for app use were health education (1393/1393, 100%), self-monitoring (755/1393, 54.2%), and antenatal appointment reminders (602/1393, 43.2%). Nonusers were older, with fewer years of education, lower incomes, and higher parity (P .01). No association was found between any app use and CAPO (6.8% in nonusers compared with 6.3% in any app users odds ratio 0.77, 95% CI 0.48-1.25). Women in China access a large number of different MCH apps, with social disparities in access and frequency of use. Any app use was not found to be associated with improved pregnancy outcomes, highlighting the need for rigorous development and testing of apps before recommendation for use in clinical settings.
Publisher: Wiley
Date: 30-12-2020
DOI: 10.1111/ITOR.12929
Abstract: We study a feasibility‐seeking problem with percentage violation constraints (PVCs). These are additional constraints that are appended to an existing family of constraints, which single out certain subsets of the existing constraints and declare that up to a specified fraction of the number of constraints in each subset is allowed to be violated by up to a specified percentage of the existing bounds. Our motivation to investigate problems with PVCs comes from the field of radiation therapy treatment planning (RTTP) wherein the fully discretized inverse planning problem is formulated as a split feasibility problem and the PVCs give rise to nonconvex constraints. Following the CQ algorithm of Byrne (2002, Inverse Problems , Vol. 18 , pp. 441–53), we develop a string‐averaging CQ‐method that uses only projections onto the in idual sets that are half‐spaces represented by linear inequalities. The question of extending our theoretical results to the nonconvex sets case is still open. We describe how our results apply to RTTP and provide a numerical ex le.
Publisher: Elsevier BV
Date: 02-2020
Publisher: JMIR Publications Inc.
Date: 15-04-2021
Abstract: aternal and child health (MCH)–related mobile apps are becoming increasingly popular among pregnant women however, few apps have demonstrated that they lead to improvements in pregnancy outcomes. his study aims to investigate the use of MCH apps among pregnant women in China and explore associations with pregnancy outcomes. retrospective study was conducted at 6 MCH hospitals in northern China. Women who delivered a singleton baby at & weeks’ gestation at the study hospitals were sequentially recruited from postnatal wards from October 2017 to January 2018. Information was collected on the women’s self-reported MCH app use during their pregnancy, along with clinical outcomes. Women were categorized as nonusers of MCH apps and users (further ided into intermittent users and continuous users). The primary outcome was a composite adverse pregnancy outcome (CAPO) comprising preterm birth, birth weight & g, birth defects, stillbirth, and neonatal asphyxia. The association between app use and CAPO was explored using multivariable logistic analysis. he 1850 participants reported using 127 different MCH apps during pregnancy. App use frequency was reported as never, 24.7% (457/1850) intermittent, 47.4% (876/1850) and continuous, 27.9% (517/1850). Among app users, the most common reasons for app use were health education (1393/1393, 100%), self-monitoring (755/1393, 54.2%), and antenatal appointment reminders (602/1393, 43.2%). Nonusers were older, with fewer years of education, lower incomes, and higher parity ( i P /i & .01). No association was found between i any app /i use and CAPO (6.8% in nonusers compared with 6.3% in any app users odds ratio 0.77, 95% CI 0.48-1.25). omen in China access a large number of different MCH apps, with social disparities in access and frequency of use. i Any app /i use was not found to be associated with improved pregnancy outcomes, highlighting the need for rigorous development and testing of apps before recommendation for use in clinical settings.
Publisher: IOP Publishing
Date: 08-06-2022
Abstract: Purpose. To introduce a methodology to predict tissue sparing effects in pulsed ultra-high dose rate radiation exposures which could be included in a dose-effect prediction system or treatment planning system and to illustrate it by using three published experiments. Methods and materials. The proposed system formalises the variability of oxygen levels as an oxygen dose histogram (ODH), which provides an instantaneous oxygen level at a delivered dose. The histogram concept alleviates the need for a mechanistic approach. At each given oxygen level the oxygen fixation concept is used to calculate the change in DNA-damage induction compared to the fully hypoxic case. Using the ODH concept it is possible to estimate the effect even in the case of multiple pulses, partial oxygen depletion, and spatial oxygen depletion. The system is illustrated by applying it to the seminal results by Town (Nat. 1967) on cell cultures and the pre-clinical experiment on cognitive effects by Montay-Gruel et al (2017 Radiother. Oncol. 124 365–9). Results. The proposed system predicts that a possible FLASH-effect depends on the initial oxygenation level in tissue, the total dose delivered, pulse length and pulse repetition rate. The magnitude of the FLASH-effect is the result of a redundant system, in that it will have the same specific value for a different combination of these dependencies. The cell culture data are well represented, while a correlation between the pre-clinical experiments and the calculated values is highly significant ( p 0.01). Conclusions . A system based only on oxygen related effects is able to quantify most of the effects currently observed in FLASH-radiation.
Location: China
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 2017
End Date: 2021
Funder: Clarendon Fund
View Funded ActivityStart Date: 2017
End Date: 2021
Funder: University Of Oxford
View Funded ActivityStart Date: 2017
End Date: 2021
Funder: Cancer Research UK Oxford Centre
View Funded Activity