ORCID Profile
0000-0003-1736-0806
Current Organisation
Universidade Federal de Juiz de Fora
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Publisher: Wiley
Date: 09-2021
Abstract: 2D heterostructures exhibit a considerable potential in electrolytic water splitting due to their high specific surface areas, tunable electronic properties, and erse hybrid compositions. However, the fabrication of well‐defined 2D mesoporous amorphous‐crystalline heterostructures with highly active heterointerfaces remains challenging. Herein, an efficient 2D heterostructure consisting of amorphous nickel boron oxide (Ni‐B i ) and crystalline mesoporous iridium (meso‐Ir) is designed for water splitting, referred to as Ni‐B i /meso‐Ir. Benefiting from well‐defined 2D heterostructures and strong interfacial coupling, the resulting mesoporous dual‐phase Ni‐B i /meso‐Ir possesses abundant catalytically active heterointerfaces and boosts the exposure of active sites, compared to their crystalline and amorphous mono‐counterparts. The electronic state of the iridium sites is tuned favorably by hybridizing with Ni‐B i layers. Consequently, the Ni‐B i /meso‐Ir heterostructures show superior and stable electrochemical performance toward both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in an alkaline electrolyte.
Publisher: Frontiers Media SA
Date: 05-12-2019
Publisher: Elsevier BV
Date: 05-2022
DOI: 10.1016/J.YEXCR.2022.113086
Abstract: In 2015, Brazil reported an outbreak identified as Zika virus (ZIKV) infection associated with congenital abnormalities. To date, a total of 86 countries and territories have described evidence of Zika infection and recently the appearance of the African ZIKV lineage in Brazil highlights the risk of a new epidemic. The spectrum of ZIKV infection-induced alterations at both cellular and molecular levels is not completely elucidated. Here, we present for the first time the gene expression responses associated with prenatal ZIKV infection from ocular cells. We applied a recently developed non-invasive method (impression cytology) which use eye cells as a model for ZIKV studies. The ocular profiling revealed significant differences between exposed and control groups, as well as a different pattern in ocular transcripts from Congenital Zika Syndrome (CZS) compared to ZIKV-exposed but asymptomatic infants. Our data showed pathways related to mismatch repair, cancer, and PI3K/AKT/mTOR signaling and genes probably causative or protective in the modulation of ZIKV infection. Ocular cells revealed the effects of ZIKV infection on primordial neuronal cell genes, evidenced by changes in genes associated with embryonic cells. The changes in gene expression support an association with the gestational period of the infection and provide evidence for the resulting clinical and ophthalmological pathologies. Additionally, the findings of cell death- and cancer-associated deregulated genes raise concerns about the early onset of other potential pathologies including the need for tumor surveillance. Our results thus provide direct evidence that infants exposed prenatally to the Zika virus, not only with CZS but also without clinical signs (asymptomatic) express cellular and molecular changes with potential clinical implications.
Publisher: American Chemical Society (ACS)
Date: 14-12-2020
Abstract: Amorphous bimetallic borides are an emerging class of catalytic nanomaterial that has demonstrated excellent catalytic performance due to its glass-like structure, abundant unsaturated active sites, and synergistic electronic effects. However, the creation of mesoporous Earth-abundant bimetallic metal borides with tunable metal proportion remains a challenge. Herein, we develop a sophisticated and controllable dual-reducing agent strategy to synthesize the mesoporous nickel-cobalt boron (NiCoB) amorphous alloy spheres (AASs) with adjustable compositions by using a soft template-directed assembly approach. The selective use of tetrabutylphosphonium bromide (Bu
Publisher: American Chemical Society (ACS)
Date: 19-07-2020
Publisher: The American Association of Immunologists
Date: 15-04-2017
Abstract: Eosinophils are multifunctional cells of the innate immune system linked to allergic inflammation. Asthmatics were more likely to be hospitalized but less likely to suffer severe morbidity and mortality during the 2009 influenza pandemic. These epidemiologic findings were recapitulated in a mouse model of fungal asthma wherein infection during heightened allergic inflammation was protective against influenza A virus (IAV) infection and disease. Our goal was to delineate a mechanism(s) by which allergic asthma may alleviate influenza disease outcome, focused on the hypothesis that pulmonary eosinophilia linked with allergic respiratory disease is able to promote antiviral host defenses against the influenza virus. The transfer of eosinophils from the lungs of allergen-sensitized and challenged mice into influenza virus–infected mice resulted in reduced morbidity and viral burden, improved lung compliance, and increased CD8+ T cell numbers in the airways. In vitro assays with primary or bone marrow–derived eosinophils were used to determine eosinophil responses to the virus using the laboratory strain (A/PR/08/1934) or the pandemic strain (A/CA/04/2009) of IAV. Eosinophils were susceptible to IAV infection and responded by activation, piecemeal degranulation, and upregulation of Ag presentation markers. Virus- or viral peptide–exposed eosinophils induced CD8+ T cell proliferation, activation, and effector functions. Our data suggest that eosinophils promote host cellular immunity to reduce influenza virus replication in lungs, thereby providing a novel mechanism by which hosts with allergic asthma may be protected from influenza morbidity.
No related grants have been discovered for Rossana Melo.