ORCID Profile
0000-0003-1822-9607
Current Organisations
University of California, San Diego
,
University of Basel
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Publisher: Oxford University Press (OUP)
Date: 28-11-2016
DOI: 10.1105/TPC.16.00186
Publisher: Wiley
Date: 03-2021
DOI: 10.1002/PLD3.309
Publisher: Springer Science and Business Media LLC
Date: 10-06-2019
Publisher: Cold Spring Harbor Laboratory
Date: 14-06-2018
DOI: 10.1101/346775
Abstract: The Golgi lumen is the site of many different glycosylation events, including cell wall polysaccharide biosynthesis and lipid glycosylation. Transporters are necessary for the import of the substrates required for glycosylation (nucleotide sugars) from the cytosol where they are synthesized. Plants use four GDP-linked sugars to glycosylate macromolecules: GDP-L-Fucose, GDP-D-Mannose, GDP-L-Galactose and GDP-D-Glucose. Of the predicted fifty-one members of the nucleotide sugar transporter/triose phosphate transporter family in Arabidopsis, only four appear to contain the conserved motif needed for the transport of GDP-linked sugars, GOLGI LOCALIZED NUCLEOTIDE SUGAR TRANSPORTER (GONST) 1-4. Previously, we have demonstrated that GONST1 provides GDP-D-Mannose for glycosylation of a class of sphingolipids, the glycosylinositolphosphorylceramides (GIPCs). Here, we characterize its closest homologue, GONST2, and conclude that it also specifically provides substrate for GIPC glycosylation. Expression of GONST2 driven by the GONST1 promoter is able to rescue the severe growth phenotype of gonst1 . Loss of GONST2 exacerbates the gonst1 constitutive hypersensitive response, as well as the reduced cell wall cellulose content. The gonst2 mutant grows normally under standard conditions, but has enhanced resistance to the powdery mildew-causing fungus Golovinomyces orontii .
Location: United States of America
Location: United States of America
No related grants have been discovered for Gosia Murawska.