ORCID Profile
0000-0002-7377-2955
Current Organisation
Friedrich-Alexander-Universität Erlangen-Nürnberg
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Publisher: IOP Publishing
Date: 07-07-2020
Abstract: Biofabrication can be a tool to three-dimensionally (3D) print muscle cells embedded inside hydrogel biomaterials, ultimately aiming to mimic the complexity of the native muscle tissue and to create in-vitro muscle analogues for advanced repair therapies and drug testing. However, to 3D print muscle analogues of high cell alignment and synchronous contraction, the effect of biofabrication process parameters on myoblast growth has to be understood. A suitable biomaterial matrix is required to provide 3D printability as well as matrix degradation to create space for cell proliferation, matrix remodelling capacity, and cell differentiation. We demonstrate that by the proper selection of nozzle size and extrusion pressure, the shear stress during extrusion-bioprinting of mouse myoblast cells (C2C12) can achieve cell orientation when using oxidized alginate-gelatin (ADA-GEL) hydrogel bionk. The cells grow in the direction of printing, migrate to the hydrogel surface over time, and differentiate into ordered myotube segments in areas of high cell density. Together, our results show that ADA-GEL hydrogel can be a simple and cost-efficient biodegradable bioink that allows the successful 3D bioprinting and cultivation of C2C12 cells in-vitro to study muscle engineering.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0BM02117B
Abstract: Cell containing hydrogels represent a key strategy in tissue engineering. Complex mechanical analyses show that the stiffness significantly drops for high concentrations of cells and microgel-bead fillers in non-fibrous alginate-based hydrogels.
Publisher: American Chemical Society (ACS)
Date: 06-04-2018
Publisher: Informa UK Limited
Date: 17-04-2023
Publisher: Wiley
Date: 06-04-2018
DOI: 10.1111/IJAC.12899
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Aldo Boccaccini.