ORCID Profile
0000-0002-2018-6792
Current Organisation
University of Dhaka
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Publisher: Springer Science and Business Media LLC
Date: 10-08-2021
DOI: 10.1007/S11033-021-06612-6
Abstract: Bidirectional promoters are the transcription regulatory regions of genes positioned head-to-head on opposite strands. Specific sequence signals, chromatin modifications and three-dimensional structures of the transcription site facilitate the unconventional yet tightly regulated transcription proceeding in both directions from these promoters. Mutations or aberrant epigenetic changes can lead to abnormal enhanced or reduced expression from either of the bidirectionally transcribed genes resulting in tumorigenesis. Moreover, bidirectionally transcribed genes might also contribute towards the immune regulation in tumor microenvironment. In this review, we aimed to expound the characteristic features of bidirectional promoters alongside their transcriptional regulations, and ultimately, the association of these enigmatic genomic elements in different cancers.
Publisher: Future Medicine Ltd
Date: 09-2020
Abstract: Background: Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2. Materials & methods: We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed genes. Results: Our analyses uncover 21 differentially expressed lncRNAs broadly involved in cell survival and regulation of gene expression. These lncRNAs can directly interact with six differentially expressed protein-coding genes, and ten host genes that interact with SARS-CoV-2 proteins. Also, they can block the suppressive effect of nine microRNAs induced in viral infections. Conclusion: Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome.
Publisher: Elsevier BV
Date: 2021
Publisher: Bentham Science Publishers Ltd.
Date: 02-2024
DOI: 10.2174/1570180819666220621164014
Abstract: Current treatments of Rheumatoid Arthritis (RA), an inflammatory disorder driven by autoimmune response, target pain management and control of progression, but risk of toxicity and increased side-effects lead to limited success. Macrophage Migration Inhibitory Factor (MIF), a cytokine that signals for inflammatory response, has been implicated in multiple inflammatory disorders including RA. Inhibition of MIF activity by anti-MIF inhibitors can lead to improved prognosis and increased quality of life. Development of a medically viable MIF inhibitor has been pursued without success, and no inhibitor that binds to MIF active site has been approved as a drug. Our goal was to search for drug-like lead compounds that bind more potently to MIF active site than current inhibitors. We selected ten classes of chemical compounds that have previously shown in vitro MIF inhibitory activity and screened ~47,000 compounds belonging to these classes through virtual docking, alongside ~900,000 compounds from ZINC and TCM (Traditional Chinese Medicine) databases. The ligands with higher energy of binding than current inhibitors were analyzed for ADMET profiles and drug-likeness properties. In total, 75 ligands showed binding energies higher than the threshold of -7.5 kcal/mol, and 5 lead compounds were identified with suitable pharmacokinetic profiles and drug-like characteristics. Among them, molecular dynamics simulation showed a stable ligand-protein complex for 3-[3-fluoro-4-(trifluoromethyl)phenyl] propanoic acid. With the identification of this lead compound, new avenues can be sought in pursuit of a novel treatment for Rheumatoid Arthritis.
No related grants have been discovered for Rafeed Rahman Turjya.